Application of helium ion microscopy to nanostructured polymer materials

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Valery N. Bliznyuk ◽  
Dennis LaJeunesse ◽  
Adam Boseman
Keyword(s):  
High Resolution ◽  
Imaging Techniques ◽  
Polymer Materials ◽  
Depth Of Field ◽  
Polymer Science ◽  
Surface Charging ◽  
Nanostructured Polymer ◽  
Helium Ion ◽  
Resolution Imaging ◽  
Ion Microscopy

AbstractHelium ion microscopy (HIM) is a relatively new high-resolution nanotechnology imaging and nanofabrication tool. HIM offers a near-molecular resolution (approaching that of TEM) combined with a simplicity of sample preparation and high depth of field similar to SEM. Simultaneously, the technique is not limited by the surface roughness as scanning probe microscopy (SPM) techniques or by the surface charging or radiation damage like SEM. In our review, we consider general principles, advantages, and prospects of HIM application in polymer science. Examples of high-resolution imaging of polymer-based nanocomposites, polymer nanoparticles, nanofibers, nanoporous materials, polymer nanocrystals, biopolymers, and polymer-based photovoltaic and sensor devices are presented. We compare the HIM’s applicability with other modern imaging techniques: SPM and SEM.

High Resolution Imaging Of The Rat Kidney Epithelium By Helium Ion Microscopy

2012 ◽  
Vol 18 (S2) ◽  
pp. 828-829
Author(s):  
W.L. Rice ◽  
A. Van Hoek ◽  
D. Brown ◽  
C. Huynh ◽  
L. Scipioni
Keyword(s):  
High Resolution ◽  
Rat Kidney ◽  
High Resolution Imaging ◽  
Helium Ion ◽  
Resolution Imaging ◽  
Ion Microscopy

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

Application of helium ion microscopy to nanostructured polymer materials

nano Online ◽  
2016 ◽  
Author(s):  
Valery N. Bliznyuk ◽  
Dennis LaJeunesse ◽  
Adam Boseman
Keyword(s):  
Polymer Materials ◽  
Nanostructured Polymer ◽  
Helium Ion ◽  
Ion Microscopy

HIMaging the kidney: High resolution helium ion microscopy

2014 ◽  
pp. 32-35
Author(s):  
Teodor Paunescu ◽  
Sylvie Breton ◽  
Dennis Brown
Keyword(s):  
High Resolution ◽  
Helium Ion ◽  
Ion Microscopy

Use of ultrasound in psoriatic arthritis

2018 ◽  
Author(s):  
Gurjit S. Kaeley
Keyword(s):  
Psoriatic Arthritis ◽  
High Resolution ◽  
Imaging Techniques ◽  
Joint Disease ◽  
Joint Involvement ◽  
Close Link ◽  
Clinical Appearance ◽  
Axial Disease ◽  
Resolution Imaging ◽  
Outcome Tool

Psoriatic arthritis (PsA) is much more than just joint disease. Although previous clinical classifications have categorized by pattern of joint involvement and axial disease, imaging techniques such as MRI and ultrasound have demonstrated that not only are many more joints involved but also a wide variety of adjoining tissues. The concept of enthesitis is evolving and high resolution imaging studies are demonstrating involvement of tissues beyond just the enthesis. Many investigators have chosen to use sonographic entheseal systems designed for Spondyloarthritis in general which may not be appropriate and may lead to excess confounding by obesity. Inclusion of entheses that seem more relevant to PsA may improve the validity and specificity of the sonographic outcome tool. Nail affliction is associated with PsA, as well as enthesitis. Sonography is able to demonstrate the nail apparatus. More recent pathoanatomic findings may help explain the close link with enthesitis. Synovitis in PsA is often involved with inflammation and alteration of neighbouring structures such as the extensor tendons, palmar or plantar plates. Some investigators have proposed that inflammation in PsA may start at the entheseal sites and then spread to the joint. Dactylitis epitomizes the concept of multiple tissues involved in the digit giving rise to the clinical appearance of a uniformly swollen digit. Sonography can image many of these tissues in high resolution and offer insights into the pathophysiology of dactylitis.

scholarly journals Surface cleaning and sample carrier for complementary high-resolution imaging techniques

2020 ◽  
Vol 15 (2) ◽  
pp. 021005
Author(s):  
Pietro Benettoni ◽  
Jia-Yu Ye ◽  
Timothy R. Holbrook ◽  
Federica Calabrese ◽  
Stephan Wagner ◽  
...  
Keyword(s):  
High Resolution ◽  
Imaging Techniques ◽  
Surface Cleaning ◽  
High Resolution Imaging ◽  
Resolution Imaging ◽  
Sample Carrier

scholarly journals High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa

2014 ◽  
Vol 20 (10) ◽  
pp. 929-937 ◽  
Author(s):  
T. G. P unescu ◽  
W. W. C. Shum ◽  
C. Huynh ◽  
L. Lechner ◽  
B. Goetze ◽  
...  
Keyword(s):  
High Resolution ◽  
Epithelial Cells ◽  
Helium Ion ◽  
Ion Microscopy

scholarly journals Ghost imaging with electron microscopy inspired, non-orthogonal phase masks

2021 ◽  
Author(s):  
Akhil Kallepalli ◽  
Daan Stellinga ◽  
Ming-Jie Sun ◽  
Richard Bowman ◽  
Enzo Rotunno ◽  
...  
Keyword(s):  
High Resolution ◽  
Imaging Techniques ◽  
High Energy ◽  
Reconstruction Method ◽  
Ghost Imaging ◽  
Light Modulator ◽  
Transmission Electron ◽  
Resolution Imaging ◽  
Electron Microscopes ◽  
Energy Processes

Abstract Transmission electron microscopes (TEM) achieve high resolution imaging by raster scanning a focused beam of electrons over the sample and measuring the transmission to form an image. While a TEM can achieve a much higher resolution than optical microscopes, they face challenges of damage to samples during the high energy processes involved. Here, we explore the possibility of applying computational ghost imaging techniques adapted from the optical regime to reduce the total, required illumination intensity. The technological lack of the equivalent high-resolution, optical spatial light modulator for electrons means that a different approach needs to be pursued. Using the optical equivalent, we show that a simple six-needle charged device to modulate the illuminating beam, alongside a novel reconstruction method to handle the resulting highly non-orthogonal patterns, is capable of producing images comparable in quality to a raster-scanned approach with much lower peak intensity.

scholarly journals Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI

2019 ◽  
Vol 30 (4) ◽  
pp. 2280-2292 ◽  
Author(s):  
Y. Dawood ◽  
G. J. Strijkers ◽  
J. Limpens ◽  
R. J. Oostra ◽  
B. S. de Bakker
Keyword(s):  
High Resolution ◽  
Best Practices ◽  
High Field ◽  
Imaging Techniques ◽  
Specimen Preparation ◽  
High Resolution Imaging ◽  
Micro Ct ◽  
Ultra High Field ◽  
Scanning Time ◽  
Resolution Imaging

Abstract Background MRI and CT have been extensively used to study fetal anatomy for research and diagnostic purposes, enabling minimally invasive autopsy and giving insight in human fetal development. Novel (contrast-enhanced) microfocus CT (micro-CT) and ultra-high-field (≥ 7.0 T) MRI (UHF-MRI) techniques now enable micron-level resolution that combats the disadvantages of low-field MRI and conventional CT. Thereby, they might be suitable to study fetal anatomy in high detail and, in time, contribute to the postmortem diagnosis of fetal conditions. Objectives (1) To systematically examine the usability of micro-CT and UHF-MRI to study postmortem human fetal anatomy, and (2) to analyze factors that govern success at each step of the specimen preparation and imaging. Method MEDLINE and EMBASE were systematically searched to identify publications on fetal imaging by micro-CT or UHF-MRI. Scanning protocols were summarized and best practices concerning specimen preparation and imaging were enumerated. Results Thirty-two publications reporting on micro-CT and UHF-MRI were included. The majority of the publications focused on imaging organs separately and seven publications focused on whole body imaging, demonstrating the possibility of visualization of small anatomical structures with a resolution well below 100 μm. When imaging soft tissues by micro-CT, the fetus should be stained by immersion in Lugol’s staining solution. Conclusion Micro-CT and UHF-MRI are both excellent imaging techniques to provide detailed images of gross anatomy of human fetuses. The present study offers an overview of the current best practices when using micro-CT and/or UHF-MRI to study fetal anatomy for clinical and research purposes. Key Points • Micro-CT and UHF-MRI can both be used to study postmortem human fetal anatomy for clinical and research purposes. • Micro-CT enables high-resolution imaging of fetal specimens in relatively short scanning time. However, tissue staining using a contrast solution is necessary to enable soft-tissue visualization. • UHF-MRI enables high-resolution imaging of fetal specimens, without the necessity of prior staining, but with the drawback of long scanning time.

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