Neopterin and kynurenine concentrations in aqueous humour of the anterior chamber of the eye and in serum of cataract patients with pseudoexfoliation

Pteridines ◽  
2000 ◽  
Vol 11 (3) ◽  
pp. 94-99 ◽  
Author(s):  
Guna Laganovska ◽  
Agris Martinsons ◽  
Bronislavs Pitrans ◽  
Bernhard Widner ◽  
Dietmar Fuchs
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Anterior Chamber ◽  
Aqueous Humour ◽  
Serum Concentrations ◽  
Selenium Content ◽  
Immune System Activation ◽  
System Activation ◽  
Cataract Patients

Summary In 40 cataract patients and in 51 patients without pseudoexfoliation (PES) we determined serum concentrations of neopterin, kynurenine, and selenium and concentrations of neopterin in aqueous humour from the anterior chamber of the eye. In addition, selenium content in lenses was determined. Significantly increased kynurenine and neopterin concentrations in serum and neopterin concentrations in aqueous humour were observed in mature cataract patients with PES compared to those without. These patients also presented with the lowest content of selenium in serum and lens, compared with cataract patients without PES. Increased concentrations of neopterin in serum and aqueous humour of the anterior chamber of eyes suggest an increased degree of oxidative stress in patients with PES. Thus, the results support the role of oxidative stress in the development of PES in cataract patients. The decreased content of selenium may elicit immune system activation via an increased oxidative stress as it is indicated by the increased formation of kynurenine and neopterin.

Neopterin and Oxidation Products in the Blood of Patients with Various Forms of Dementia

Pteridines ◽  
2003 ◽  
Vol 14 (3) ◽  
pp. 88-93 ◽  
Author(s):  
Barbara Frick ◽  
Gabriele Neurauter ◽  
Antonio Diez-Ruiz ◽  
Katharina Schroecksnadel ◽  
Barbara Wirleitner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Immune System ◽  
Reactive Oxygen ◽  
Human Monocyte ◽  
Oxidation Products ◽  
Serum Concentrations ◽  
Healthy Elderly ◽  
Immune System Activation

Abstract Human monocyte-derived macrophages and dendritic cells produce increased amounts of neopterin derivatives upon stimulation with interferon-γ (IFN-γ). In parallel, such stimulated cells release a record of oxidizing specics as part of their cytocidal repertoire. Production of reactive oxygen species by stimulated immunocompetent cells may be the reason for the depletion of antioxidant vitamins and the development of oxidative stress during diseases with stimulated immune system. Noteworthy also neopterin derivatives are able to interfere with reactive oxygen, chlorine, and nitrogen species, and neopterin itself could contribute to oxidative stress. In vivo, neopterin concentrations thus allow not only to monitor cell-mediated immune response, they also allow to estimate the extent of oxidative stress which emerges during immune response. In certain diseases associations between higher neopterin levels and markers of oxidative stress have been reported. In neurodegenerative diseases, neopterin concentrations in scrum and cerebrospinal fluid also correlate with the cognitive decline in patients. In this studv we compared serum concentrations of neopterin with serum concentrations of peroxides and homocysteine in patients with various forms of dementia and in 5 healthy elderly controls. In patients of either form of dementia serum concentrations of peroxides and neopterin were increased compared to controls. There existed a positive correlation between age and concentrations of peroxides, neopterin and homocysteine. The data further supportile view that increased neopterin concentrations are associated with oxidative stress which could underlie c¡r increased demand of antioxidants in neurodegenerative disorders. It appears important that such changes can h> detected in the blood of patients with dementia, albeit its pathogenesis is considered to be confined to the brain The results further suggest that aging is associated with immune system activation which may lead to the increased production of peroxides.

Immune system activation and fatigue during treadmill running: role of interferon

1998 ◽  
Vol 30 (6) ◽  
pp. 863-868 ◽  
Author(s):  
J. M. DAVIS ◽  
J. A. WEAVER ◽  
M. L. KOHUT ◽  
L. H. COLBERT ◽  
A. GHAFFAR ◽  
...  
Keyword(s):  
Immune System ◽  
Treadmill Running ◽  
Immune System Activation ◽  
System Activation

scholarly journals Comparisons of lung and gluteus transcriptome profiles between yaks at different ages

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jin-Wei Xin ◽  
Zhi-Xin Chai ◽  
Cheng-Fu Zhang ◽  
Qiang Zhang ◽  
Yong Zhu ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Function ◽  
Muscle Injury ◽  
Tibet Plateau ◽  
Immune Functions ◽  
Immune System Activation ◽  
System Activation ◽  
Qinghai Tibet Plateau ◽  
Activation Status

Abstract The yak, Bos grunniens, is the only large mammal in the Qinghai-Tibet Plateau and has been bred to provide meat, milk, and transportation. Previous studies indicate that the immune system contributes to the yak’s adaptation to high-altitude environments. In order to further investigate changes in immune function during yak development, we compared the transcriptome profiles of gluteus and lung tissues among yaks at 6, 30, 60, and 90 months of age. Analyses of significantly differentially expressed genes (DEGs) in lung tissues revealed that immune function was more activated at 6-months and less activated at 90-months than in the 30 and 60-month-old animals. DEG exploration in gluteal tissues revealed that immune functions were more highly activated at both 6 and 90-months, compared with 30 and 60-months. Immune system activation in the muscle and lung tissues of 30-month-old yaks may increase their resistance to infections, while decreased may be due to aging. Furthermore, the higher immune activation status in the gluteal tissues in 90-month-old yaks could be due to muscle injury and subsequent regeneration, which is supported by the fact that 5 unigenes related with muscle injury and 3 related to muscle regeneration displayed greater expression levels at 90-months than at 30 and 60-months. Overall, the present study highlights the important role of the immune system in yak development, which will facilitate future investigations.

scholarly journals Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension

2014 ◽  
Vol 306 (2) ◽  
pp. H184-H196 ◽  
Author(s):  
Cameron G. McCarthy ◽  
Styliani Goulopoulou ◽  
Camilla F. Wenceslau ◽  
Kathryn Spitler ◽  
Takayuki Matsumoto ◽  
...  
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Cell Injury ◽  
Receptor Activation ◽  
Innate Immune ◽  
Immune System Activation ◽  
System Activation ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

Low-grade systemic inflammation is a common manifestation of hypertension; however, the exact mechanisms that initiate this pathophysiological response, thereby contributing to further increases in blood pressure, are not well understood. Aberrant vascular inflammation and reactivity via activation of the innate immune system may be the first step in the pathogenesis of hypertension. One of the functions of the innate immune system is to recognize and respond to danger. Danger signals can arise from not only pathogenic stimuli but also endogenous molecules released following cell injury and/or death [damage-associated molecular patterns (DAMPs)]. In the short-term, activation of the innate immune system is beneficial in the vasculature by providing cytoprotective mechanisms and facilitating tissue repair following injury or infection. However, sustained or excessive immune system activation, such as in autoimmune diseases, may be deleterious and can lead to maladaptive, irreversible changes to vascular structure and function. An initial source of DAMPs that enter the circulation to activate the innate immune system could arise from modest elevations in peripheral vascular resistance. These stimuli could subsequently lead to ischemic- or pressure-induced events aggravating further cell injury and/or death, providing more DAMPs for innate immune system activation. This review will address and critically evaluate the current literature on the role of the innate immune system in hypertension pathogenesis. The role of Toll-like receptor activation on somatic cells of the vasculature in response to the release of DAMPs and the consequences of this activation on inflammation, vasoreactivity, and vascular remodeling will be specifically discussed.

IMMUNE SYSTEM ACTIVATION AND FATIGUE DURING TREADMILL RUNNING IN MICE: ROLE OF INTERFERON-α/β

1995 ◽  
Vol 27 (Supplement) ◽  
pp. S67
Author(s):  
J. M. Davis ◽  
J. A. Weaver ◽  
M. L. Kohut ◽  
A. Ghaffar ◽  
E. P. Mayer
Keyword(s):  
Immune System ◽  
Treadmill Running ◽  
Interferon Α ◽  
Immune System Activation ◽  
System Activation

scholarly journals The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective

2021 ◽  
Vol 8 ◽  
Author(s):  
Kai Guo ◽  
Shuxuan Ma
Keyword(s):  
Acute Lung Injury ◽  
Immune System ◽  
Lung Injury ◽  
Therapeutic Strategy ◽  
Potential Role ◽  
Physical Trauma ◽  
Immune System Activation ◽  
Prevention And Treatment ◽  
System Activation

As an initiator of respiratory distress, transfusion-related acute lung injury (TRALI) is regarded as one of the rare complications associated with transfusion medicine. However, to date, the pathogenesis of TRALI is still unclear, and specific therapies are unavailable. Understanding the mechanisms of TRALI may promote the design of preventive and therapeutic strategies. The immune system plays vital roles in reproduction, development and homeostasis. Sterile tissue damage, such as physical trauma, ischemia, or reperfusion injury, induces an inflammatory reaction that results in wound healing and regenerative mechanisms. In other words, in addition to protecting against pathogens, the immune response may be strongly associated with TRALI prevention and treatment through a variety of immunomodulatory strategies to inhibit excessive immune system activation. Immunotherapy based on immune cells or immunological targets may eradicate complications. For example, IL-10 therapy is a promising therapeutic strategy to explore further. This review will focus on ultramodern advances in our understanding of the potential role of the immune system in TRALI prevention and treatment.

Association between Urinary Zinc and Neopterin Excretion: A Manifestation of the Acute Phase Response in the Kidney?

Pteridines ◽  
1993 ◽  
Vol 4 (4) ◽  
pp. 174-177 ◽  
Author(s):  
Bohuslm Melichar
Keyword(s):  
Immune System ◽  
Acute Phase ◽  
Protective Role ◽  
Simultaneous Increase ◽  
Phase Reaction ◽  
Immune System Activation ◽  
Oxidative Processes ◽  
System Activation ◽  
Urine Zinc

Summary An elevation in urinary neopterin excretion is established to be a sensitive index of immune system activation in various disorders. In many of these conditions, a simultaneous increase in urine zinc output is observed, but this phenomenon remains largely unexplained. In previous studies in patients with different diseases, a significant correlation between urine zinc and neopterin was demonstrated. This suggests that the immune system may be involved in inducing an augmentation in urine zinc loss. As both zinc and neopterin are now known to influence oxidative processes, and lipid peroxidation has been demonstrated 10 play an important role in renal pathology, a protective role of the increase in urine zinc and neopterin, which might represent a manifestation of the acute phase reaction in the kidney, is discussed.

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