Schiff bases and their metal complexes with biologically compatible metal ions; biological importance, recent trends and future hopes

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ezzat Khan ◽  
Muhammad Hanif ◽  
Muhammad Salim Akhtar
Keyword(s):  
Photodynamic Therapy ◽  
Metal Ions ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Free Ligand ◽  
Material Chemistry ◽  
Potential Applications ◽  
Long Time ◽  
Recent Trends ◽  
Almost All

Abstract Schiff bases are in the field of medicinal and material chemistry for a long time. There are several advancements from time to time towards facile synthesis and potential applications. As medicines they have been applied as organic molecules as well as their metal complexes. The activities of metal complexes have been found to increase due to increase lipophilicity in comparison to the corresponding free ligand. Besides simple coordination compounds they have been applied as ionic liquid (IL)- supported and IL-tagged species with far enhanced efficiency. Among metal complexes recent advancement deals with photodynamic therapy to treat a number of tumors with fewer side effects. Schiff bases are efficient ligands and their complexes with almost all metal ions are reported. This mini-review article deals with complexes of Schiff bases with biologically compatible metal ions, Co(II), Cu(II), Zn(II), Pd(II), Ag(I), Pt(II) and their potential uses to combat cancerous cells. Strong hopes are associated with photodynamic therapy and IL-tagged and IL-supported Schiff bases and their complexes.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

scholarly journals Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Gehad G. Mohamed ◽  
Walaa H. Mahmoud ◽  
Ahmed M. Refaat
Keyword(s):  
Crystal Structure ◽  
Contact Angle ◽  
Molecular Docking ◽  
Metal Ions ◽  
Metal Complexes ◽  
Biological Activities ◽  
Thermal Studies ◽  
Free Ligand ◽  
Aminobenzoic Acid ◽  
Azo Ligand

Metal complexes of the 2,2'-(1,3-phenylenebis(diazene-2,1-diyl))bis(4-aminobenzoic acid) diazo ligand (H2L) derived from m-phenylenediamine and p-aminobenzoic acid were synthesized and characterized by different spectral, thermal, and analytical tools. The H2L ligand reacted with the metal ions Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) as 1 : 1 stoichiometry. All complexes displayed an octahedral geometry according to the electronic and magnetic moment measurements. The IR spectra revealed the binding of the azo ligand to the metal ions via two azo nitrogen atoms and protonated carboxylate O in a neutral tetradentate manner. Both IR and 1H NMR spectra documented the involvement of the carboxylate group without proton displacement. The thermal studies pointed out that the complexes had higher thermal stability comparable with that of the free ligand. SEM images revealed the presence of the diazo ligand and its Cd(II) complex in a nanostructure form. The contact angle measurements proved that the Cd(II) complex can be considered as a superhydrophobic material. The molecular and electronic structure of H2L and [Cd(H2L)Cl2].H2O were optimized theoretically, and the quantum chemical parameters were calculated. The biological activities of the ligand, as well as its metal complexes, have been tested in vitro against some bacteria and fungi species. The results showed that all the tested compounds have significant biological activities with different sensitivity levels. The binding between H2L and its Cd(II) complex with receptors of the crystal structure of S. aureus (PDB ID: 3Q8U), crystal structure of protein phosphatase (PPZ1) of Candida albicans (PDB ID: 5JPE), receptors of breast cancer mutant oxidoreductase (PDB ID: 3HB5), and crystal structure of Escherichia coli (PDB ID: 3T88) was predicted and given in detail using molecular docking.

scholarly journals Applications of Chitosan Based Schiff bases and its Complexes – A Review

2021 ◽  
pp. 157-170
Author(s):  
Veena R Nair ◽  
Meera Jacob ◽  
Texin Joseph ◽  
Jaya T Varkey
Keyword(s):  
Schiff Base ◽  
Metal Ions ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Schiff Base Complexes ◽  
Amino Group ◽  
Chemical Modifications ◽  
Research Fields ◽  
Chitosan Schiff Base ◽  
Chitosan Schiff Bases

Chitosan, a natural polysaccharides biopolymer is a versatile and promising biomaterial. Chitosan metal complexes stand out in their applicability in different research fields due to their biocompatibility and biodegradability properties. Presence of primary aliphatic amino group along the polymer chain allows for a variety of chemical modifications, of which the most significant is imine functionalization. The ability to easily perform complexation between chitosan Schiff bases and metal ions results in metal complexes, enhancing its application, resulting in further innovation in various fields. The most recent advances of chitosan Schiff base complexes in various fields, including biomedical, catalysis, environmental, and adsorption are summarised in this review.

scholarly journals Synthesis, characterization, chelation with transition metal ions, and antibacterial and antifungal studies of the 4-[(E)- -phenyldiazenyl]-2-[(E)-(phenylimino)methyl]phenol dye

2009 ◽  
Vol 74 (8-9) ◽  
pp. 917-926 ◽  
Author(s):  
Nurcan Kurtoglu
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Micrococcus Luteus ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Molar Conductance ◽  
Ionic Character ◽  
Rhodotorula Rubra

New Ni(II), Cu(II) and Co(II) complexes were synthesized with the bidentate azo-azomethine dye, 4-[(E)-phenyldiazenyl]-2-[(E)-(phenylimino)methyl] phenol (dmpH), which was prepared by the reaction of 2-hydroxy-5-[(E)- phenyldiazenyl]benzaldehyde with aniline in EtOH. The syntheses of the metal chelates of the azo-azomethine dye were realized by the precipitation technique. The synthesized metal complexes were characterized by elemental analysis, molar conductance measurements, as well as infrared and UV-Vis spectral data. Based on these characterizations, the metal complexes of the transition metal ions may be formulated as [M(dmp)Cl(H2O)] where M = Ni(II), Cu(II) and Co(II). The metal complexes were formed by the coordination of N and O atoms of the ligand. The molar conductance values of the Ni(II), Cu(II) and Co(II) complexes of the bidentate ligand indicate their non-ionic character. The free ligand and its metal complexes were tested for their in vitro antimicrobial properties against eight bacteria: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudomonas aeruginosa, Enterococcus cloacae, Bacillus megaterium, and Micrococcus luteus, and three fungi, Kluyveromyces fragilis, Rhodotorula rubra and Saccharomyces cerevisiae, in order to assess their antimicrobial potential. The [Ni(dmp)Cl(H2O)] chelate exhibited high activity against all the bacteria and fungi, except Rhodotorula rubra.

Thermally stable oligomer—Metal complexes based on oligo-ortho-aminophenol and oligophenylazomethinephenol

2006 ◽  
Vol 60 (4) ◽  
Author(s):  
H. Mart ◽  
M. Koç ◽  
V. Muradoğlu ◽  
H. Yürük
Keyword(s):  
Thermal Stability ◽  
Thermogravimetric Analysis ◽  
Metal Ions ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Thermally Stable ◽  
Oxidative Polycondensation ◽  
Thermooxidative Decomposition ◽  
Polymer Metal ◽  
Thermal Stability Of

AbstractThe oligo-ortho-aminophenol was synthesized by the oxidative polycondensation of ortho-aminophenol with air oxygen. The oligophenylazomethinephenol was synthesized by the condensation of aniline with oligosalicylaldehyde. Metal complexes of these oligomers with Cu(II), Co(II), Zn(II), and Ni(II) were synthesized and characterized. Based on the results of thermogravimetric analysis, synthesized oligomer—metal complexes were more stable against heat and thermooxidative decomposition than some polymeric Schiff bases and polymer—metal complexes. Additionally, the presence of metal ions increased the thermal stability of oligo-ortho-aminophenol, while the thermal stability of oligophenylazomethinephenol was lowered.

scholarly journals Al(Salen) Metal Complexes in Stereoselective Catalysis

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1716 ◽  
Author(s):  
Andrea Gualandi ◽  
Francesco Calogero ◽  
Simone Potenti ◽  
Pier Giorgio Cozzi
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Chiral Diamine ◽  
The Past ◽  
Aryl Aldehyde ◽  
Salen Ligands

Salen ligands are a class of Schiff bases simply obtained through condensation of two molecules of a hydroxyl-substituted aryl aldehyde with an achiral or chiral diamine. The prototype salen, or N,N′-bis(salicylidene)ethylenediamine has a long history, as it was first reported in 1889, and immediately, some of its metal complexes were also described. Now, the salen ligands are a class of N,N,O,O tetradentate Schiff bases capable of coordinating many metal ions. The geometry and the stereogenic group inserted in the diamine backbone or aryl aldehyde backbone have been utilized in the past to efficiently transmit chiral information in a variety of different reactions. In this review we will summarize the important and recent achievements obtained in stereocontrolled reactions in which Al(salen) metal complexes are employed. Several other reviews devoted to the general applications and synthesis of chromium and other metal salens have already been published.

Impact and correlation of pKaand dnelectrons of some selected thiosemicarbazone Schiff base metal Co, Ni, Cu complexes: a study of electrochemical behavior, excitation and optical energies

2017 ◽  
Vol 41 (12) ◽  
pp. 4853-4861 ◽  
Author(s):  
M. S. El-Shahawi ◽  
W. Ahmad ◽  
G. I. Mohammed ◽  
Y. M. Moustafa ◽  
G. A. Al-Hazmi ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Optical Properties ◽  
Schiff Base ◽  
Metal Ions ◽  
Schiff Bases ◽  
Base Metal ◽  
Electrochemical Behavior ◽  
Coordination Mechanism ◽  
Potential Applications ◽  
Cu Complexes

The electron-transfer and coordination mechanism of thiosemicarbazone Schiff bases with metal ions (Co, Ni, Cu), correlation of the electrochemical and optical properties for their potential applications in various fields of chemistry and biochemistry are underexplored.

Syntheses and Structures of Homodinuclear (Na–Na) and Heterodinuclear (Cu–Na, Cu–K) Metal Complexes

2016 ◽  
Vol 69 (1) ◽  
pp. 20 ◽  
Author(s):  
Rui Jia ◽  
Ting Gao ◽  
Ruoxi Chen ◽  
Yu Yang ◽  
Po Gao ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Ions ◽  
Dimensional Chain ◽  
Solid Materials ◽  
One Dimensional ◽  
X Ray ◽  
Main Group Metal ◽  
Potential Applications ◽  
Polynuclear Metal Complexes

The study of polynuclear metal complexes has gained great recognition over the last decade owing to their fascinating topological structures, various properties, and potential applications as functional solid materials in luminescence, catalysis, and magnetic materials. A large number of heterodinuclear 3d–4f and 3d–3d′ complexes have been widely studied due to their functional applications. To our knowledge, structurally characterised heterodinuclear (3d–Na, 3d–K) and homodinuclear (Na–Na) metal complexes are rare. Three metal complexes, [CuIINaI(HL1)2(SbF6)]n (1), [CuIIKI(HL1)2(PF6)]n (2), and [Na2(H2L2)2] (3), were synthesised by two kinds of ligands, o-vanillin (HL1) and N,N′-ethylene-bis(3-methoxysalicylideneimine) (H2L2). The structures of heterodinuclear complexes 1 and 2 are both one-dimensional chain structures, including transition metal ions (CuII) and main group metal ions (NaI and KI). However, the complex 3, as a homodinuclear metal complex, only has one kind of centre, a NaI ion. The structures of complexes 1–3 were determined by single crystal X-ray crystallographic studies.

scholarly journals DNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes

2020 ◽  
Vol 32 (8) ◽  
pp. 1903-1908
Author(s):  
Murugan Selvamariammal ◽  
Maruthappan Malarvizhi
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Complexes ◽  
Spectral Data ◽  
Schiff Bases ◽  
Electronic Absorption ◽  
Free Ligand ◽  
Spectral Techniques ◽  
Intercalative Mode ◽  
Calf Thymus

Some novel series of 5-chloro isatin and 4-aminoantipyrine based Schiff bases with transition metal(II) complexes of (Cu, Co, Ni and Zn) have been prepared and characterized by physical, analytical and spectral data. The synthesized ligand behaves as a neutral tridentate is confirmed by spectral techniques. During the complexation, the stoichiometry ratio 1:2 (metal:ligand) is followed and an octahedral arrangement is adopted by all the metal complexes. The calf-thymus DNA interacts with complexes via an intercalative mode is studied by electronic absorption titration. Moreover, all these synthesized metal(II) complexes were tested against a set of bacterial and fungal strains reveals that complexes exhibit better activity than free ligand.

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