Physical exercise and Parkinson’s disease: influence on symptoms, disease course and prevention

Complications from Parkinson’s disease may develop over the disease course, sometimes unexpectedly, and require prompt or even urgent medical intervention. The most common are associated with aggravation of motor symptoms; serious non-motor complications, such as psychosis, orthostatic hypotension or sleep attacks, also occur. Here we review such complications, their clinical presentation, precipitating factors and management, including those related to using device-aided therapies. Early recognition and prompt attention to these critical situations is challenging, even for the Parkinson’s disease specialist, but is essential to prevent serious problems.

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Can the disease course in Parkinson’s disease be slowed?

BMC Medicine ◽

10.1186/s12916-015-0534-x ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 12

Author(s):

Amos D. Korczyn ◽

Sharon Hassin-Baer

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Course

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Segmental progression of cardinal motor symptoms in Parkinson's disease: A pilot study suggesting a practical approach to rate disease course in the early stages

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2013.08.015 ◽

2013 ◽

Vol 19 (12) ◽

pp. 1143-1148 ◽

Cited By ~ 2

Author(s):

Marina Picillo ◽

Marianna Amboni ◽

Roberto Erro ◽

Carmine Vitale ◽

Katia Longo ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Pilot Study ◽

Practical Approach ◽

Motor Symptoms ◽

Disease Course ◽

Early Stages

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IMPORTÂNCIA DA PREPARAÇÃO FÍSICA PARA O PACIENTE COM DOENÇA DE PARKINSON

Revista Científica JOPEF ◽

10.34059/ciejop.2019v28i1-3 ◽

2019 ◽

pp. 29-43

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Physical Exercise ◽

Muscular Strength ◽

Review Of Literature ◽

The Subject ◽

Positive Effect

TEIXEIRA, M.E. e PEREIRA, J.L. Importância da preparação física para o paciente com doença de Parkinson. Revista Científica JOPEF, Vol.28, n.1, pp.29-43, 2019. Parkinson's disease (PD) is a chronic progressive neurodegenerative disease described by the first in 1897 as "tremor paralysis." Its symptoms are variable, the most characteristic being tremor of the hands and loss of balance and muscular strength. It usually affects men over the age of 60, but there are forms that can occur in younger individuals. The progression of symptoms causes the quality of life of the patient to deteriorate significantly, leading to the inability to perform daily activities. In addition to pharmacological treatment, physical exercise has been indicated as a way to attenuate and slow the progression of symptoms. The objective of this work is to carry out an integrative review of literature on the subject, in which articles published over the last 10 years have been analyzed, thus seeking to update the theme. In general, it was possible to perceive a positive effect of the practice of specific physical exercise programs in patients with PD, with improvement of the quality of life. In vitro studies also demonstrated the protective effect of physical exercise on the onset of the disease. Keywords: Parkinson's disease; Physical exercise; Neuroprotection; Quality of life.

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Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

Frontiers in Neuroscience ◽

10.3389/fnins.2021.633022 ◽

2021 ◽

Vol 15 ◽

Author(s):

Zubo Wu ◽

Suyuan Wu ◽

Tao Liang ◽

Lin Wang

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Logistic Regression ◽

Risk Factor ◽

Phospholipase A2 ◽

Area Under The Curve ◽

Diagnostic Value ◽

Multivariable Logistic Regression Analysis ◽

Disease Course ◽

Clinical Value

ObjectiveTo explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson’s disease (PD).MethodsA case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. According to the disease course and severity, PD patients were subdivided to analyze the clinical value of Lp-PLA2. Relationship between Lp-PLA2 and PD risk was analyzed by logistic regression. Diagnostic value of Lp-PLA2 in PD patients was investigated using receiver’s operator characteristic curves.ResultsLp-PLA2 level was significantly higher in the PD patients compared with the controls, and was significantly and positively correlated with the Hoehn-Yahr (H&Y) stage. The serum Lp-PLA2 level and H&Y stage of PD patients with a longer disease course were significantly higher than those with a shorter disease course. PD patients with milder conditions had significantly lower serum Lp-PLA2 levels than patients with severe conditions. Multivariable logistic regression analysis indicated higher Lp-PLA2 level was an independent risk factor of PD patients. Moreover, the area under the curve for Lp-PLA2 was 0.703, which was between those of homocysteine and serum amylase A.ConclusionTo our knowledge, this is the first study to show that increased level of Lp-PLA2 is associated with the risk of PD. Lp-PLA2 may be used for early detection of PD, and provides an effective intervention target for clinical treatment of PD.

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Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course

Movement Disorders ◽

10.1002/mds.24045 ◽

2011 ◽

Vol 27 (3) ◽

pp. 393-399 ◽

Cited By ~ 83

Author(s):

Núria Setó-Salvia ◽

Javier Pagonabarraga ◽

Henry Houlden ◽

Berta Pascual-Sedano ◽

Oriol Dols-Icardo ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Course

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G325R GBA mutation in Parkinson's disease: Disease course and long-term DBS outcome

Brain Stimulation ◽

10.1016/j.brs.2021.08.002 ◽

2021 ◽

Author(s):

Claudia Ledda ◽

Carlo Alberto Artusi ◽

Elisa Montanaro ◽

Tiziana Martone ◽

Maurizio Zibetti ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Course

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Consensus-Based Recommendations for Advance Directives of People with Parkinson’s Disease in Regard to Typical Complications by German Movement Disorder Specialists

Journal of Clinical Medicine ◽

10.3390/jcm9020449 ◽

2020 ◽

Vol 9 (2) ◽

pp. 449

Author(s):

Martin Klietz ◽

Johanna M. Berndt ◽

Florian Wegner ◽

Nils Schneider ◽

Günter U. Höglinger ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Health Professionals ◽

Delphi Study ◽

Oral Therapy ◽

Response Rate ◽

Expert Panel ◽

Evidence Based ◽

Disease Course ◽

Dopaminergic Therapy

A huge proportion of people with Parkinson’s disease (PwP) in Germany have written an advance directive (AD). However, the content of these forms in regard to specific Parkinson’s disease (PD)-related complications is rather low. There is an urgent need to specify ADs of PwP and consequently to improve decision-making concerning end-of-life aspects for affected patients. Evidence- and consensus-based PD-specific recommendations for ADs might help to close this gap. A Delphi study with two online Delphi rounds was initiated. Initial recommendations were built on findings from previous studies and derived from evidence-based literature. Consensus on recommendations was defined as ≥80% concordance regarding clarity of formulated aspects and relevance for clinical practice. A total of 22 experts (15.2% response rate) predominantly from the workgroup ‘neuro-palliative care’ in Germany performed two Delphi rounds. Consensus was achieved for 14 of 24 initially presented recommendations. Recommendations relating to dopaminergic therapy as well as to non-oral therapy options were considered important by the expert panel. The recommendations should be taken into account when developing and giving advice on ADs for PwP. Health professionals should be trained in counselling ADs of PwP and in integrating these recommendations in ADs during the disease course of PD.

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