scholarly journals Usefulness of Reticulocyte Hemoglobin Equivalent in Management of Regular Hemodialysis Patients with Iron Deficiency Anemia

2016 ◽  
Vol 54 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Naomi Niari Dalimunthe ◽  
Abdurrahim Rasyid Lubis
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Intravenous Iron ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
Dialysis Session ◽  
Early Predictor ◽  
Regular Hemodialysis ◽  
Intravenous Iron Supplementation

Introduction. Reticulocyte hemoglobin equivalent (RET-He) is a new parameter for evaluating iron status. This study aims to assess diagnostic value and investigate RET-He as early predictor of response to intravenous iron supplementation. Methods. Seventy-two regular hemodialysis patients at Adam Malik Hospital were studied from April to May 2011. RET-He was compared with conventional iron parameters for identification of iron deficiency. Fifteen patients with iron deficiency anemia were selected to receive 100 mg iron sucrose intravenous during every dialysis session (2x/weeks) for 4 weeks. Results. Receiver operating characteristic (ROC) curve for RET-He revealed the value of area under the curve was 0.818 (p < 0.0001). Using cutoff level 31.65 pg, RET-He showed 81.5% sensitivity and 61.6% specificity. Serum ferritin (r = 0.499, p < 0.0001) and transferrin saturation/ TSAT (r = 0.592, p<0.0001) were correlated to RET-He. Significant improvement in hemoglobin, hematocrit and RET-He were found after intervention (p = 0.023, p = 0.049 and p = 0.019, respectively). Conclusion. RET-He is a useful marker of iron deficiency and early predictor of response to intravenous iron supplementation in regular hemodialysis patients.

scholarly journals Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4008
Author(s):  
Dagmara Mahadea ◽  
Ewelina Adamczewska ◽  
Alicja Ewa Ratajczak ◽  
Anna Maria Rychter ◽  
Agnieszka Zawada ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Clinical Symptoms ◽  
Intravenous Iron ◽  
Chronic Fatigue ◽  
Deficiency Anemia ◽  
Surgical Removal ◽  
Adequate Treatment ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. IBD has been associated with numerous symptoms and complications, with the most common being iron deficiency anemia (IDA). Iron deficiency in IBD is caused by inadequate intake, malabsorption (including duodenal involvement and surgical removal), and chronic blood loss by mucosal ulcerations. Therefore, an appropriate diet should be enforced. Iron deficiency and iron supplementation have been associated with alterations to gut microbiota. IBD-associated anemia, in particular iron deficiency anemia, is associated with a significant decrease in quality of life and with clinical symptoms such as chronic fatigue, headaches and dizziness, reduced exercise tolerance, pale skin, nails, conjunctiva, and fainting. However, despite these numerous adverse symptoms, IDA remains undertreated. The European Crohn’s and Colitis Organisation (ECCO) guidelines state that patients should be monitored for anemia. Adequate treatment, whether oral or intravenous, should be implemented while taking into consideration C-reactive protein values (CRP), hemoglobin levels, and therapeutic response. It should be stressed that every case of anemia in IBD patients should be treated. Intravenous iron formulations, which are more superior compared to the oral form, should be used. There is a need to increase awareness and implementation of international guidelines on iron supplementation in patients with IBD.

scholarly journals Gastric Siderosis and Ulceration from Intravenous Iron Supplementation Manifesting as Chronic Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Donald Ewing ◽  
Ava Brozovich ◽  
Ethan Burns ◽  
Gonzalo Acosta ◽  
Courtney Hatcher ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Gastrointestinal Bleeding ◽  
Iron Supplementation ◽  
Upper Gastrointestinal Bleeding ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Red Blood Cell Transfusions ◽  
Upper Gastrointestinal ◽  
Intravenous Iron Supplementation

Iron deficiency is the most common etiology of anemia worldwide and is often managed with varying methods of iron supplementation. Although rare, oral iron supplementation can perpetuate iron deficiency anemia by causing gastric ulceration and upper gastrointestinal bleeding in high-risk populations. However, this complication has not been previously described with intravenous iron supplementation. We present a case of a 63-year-old male with severe iron deficiency anemia on biweekly intravenous iron infusions and weekly packed red blood cell transfusions who presented with melena over several months. Upper endoscopy demonstrated a clean-based gastric body ulcer and nonbleeding gastric varices. Histology of the gastric ulcer was suggestive of iron-induced gastric mucosal injury. This case demonstrates that frequent utilization of intravenous iron and packed red blood cell transfusions may predispose certain patients to the development of iron-induced gastritis and ulceration.

The Role of Iron Adequacy for Maternal and Fetal Health

2021 ◽  
Vol 5 (1-1) ◽  
pp. 10-15
Author(s):  
Ali Sungkar
Keyword(s):  
Iron Deficiency ◽  
Blood Transfusion ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Vitamin A Deficiency ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Parasite Infections ◽  
Hereditary Disorders

Nearly half of pregnant women in the world are reported to suffer anemia. And most of them are caused by iron deficiency, while the others by folate, vitamin B12 or vitamin A deficiency, chronic inflammation, parasite infections and hereditary disorders. Anemia in pregnant women is characterized when < 11 g / dL or any time during pregnancy. And when followed by low iron, it's called iron deficiency anemia. Iron plays an important role in many metabolic processes by transporting oxygen and allowing cells to generate energy. Low iron levels during pregnancy leading to anemia, related to an heightened risk of mother and fetus disease. Iron deficiency anemia can affect fetal development and persist long-term, while mild and serious pregnancy anemia can lead to premature birth, maternal and child mortality, bleeding, and infectious disease. The iron requirement during pregnancy exceeds 1000 mg for red cell expansion, 300 mg – 350 mg for developing fetus and placenta, and 250 mg for variable blood loss at delivery. Iron adequacy during pregnancy can be assured by proper nutrition, iron supplementation and fortification, and intravenous iron or blood transfusion. Iron supplementation is only enough to cover the prenatal iron requirements. Summary: Iron deficiency leading to anemia, rising risk of negative pregnancy outcomes. To meet increasing iron requirements during pregnancy including iron supplementation, fortification of staple iron foods, and intravenous iron or blood transfusion if required.

scholarly journals Association of Iron Supplementation Programs with Iron-Deficiency Anemia Outcomes among Children in Brazil

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1524
Author(s):  
Carolina Thalya da Silva Paulino ◽  
Marislei Nishijima ◽  
Flavia Mori Sarti
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Fixed Effects ◽  
Iron Supplementation ◽  
Deficiency Anemia ◽  
Federal Programs ◽  
Government Programs ◽  
Lengths Of Stay ◽  
Social Inequities ◽  
High Prevalence

Anemia remains a condition with high prevalence in populations worldwide, and the prevalence of anemia among children under five years old in Brazil is approximately 40%, being higher in communities marked by social inequities. Diverse government programs during recent decades targeted iron-deficiency anemia, considering its impacts throughout the lifetime. The objective of this study was to investigate the effects of two government iron supplementation programs on health outcomes related to iron-deficiency anemia among children up to 4 years old in Brazilian municipalities. A longitudinal panel encompassing data from 5570 municipalities from 1998 to 2019 was investigated using a difference-in-differences framework with multiple interventions and distinct times of adhesion, and fixed-effects models were estimated to control for invariant municipal characteristics throughout the period in order to ensure comparability. The results indicate significant effects of the federal programs in reducing hospitalizations and lengths of stay due to iron-deficiency anemia, especially in non-poor municipalities. There was complementarity in the effects of the programs; however, neither of the programs influenced mortality rates. Thus, it is important to consider possible improvements in the operationalization of the programs, in order to achieve better results in the reduction of severe iron-deficiency anemia among children up to 4 years old.

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