scholarly journals Diabetes Mellitus And Reparative Response Of Dental Pulp

2016 ◽  
Vol 63 (2) ◽  
pp. 85-90
Author(s):  
Jugoslav Ilić
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Connective Tissue ◽  
Dental Pulp ◽  
Therapeutic Approaches ◽  
Clinical Procedures ◽  
Microcirculatory System ◽  
Additional Challenge ◽  
Patients With Diabetes ◽  
Pulp Vitality

Abstract Anatomically, dental pulp is connective tissue and specific microcirculatory system with significant reparatory abilities intending to preserve pulp vitality. Various therapeutic approaches in the treatment of affected pulp may be compromised by various factors leading to treatment failure. Due to microcirculatory system disorders, treatment of affected dental pulp in patients with diabetes mellitus (DM) is additional challenge. The function and levels of growth factors could be altered in various diabetic tissues including dental pulp. Among them are growth factors important for reparative response of the pulp. There are experimental evidences that DM impede dental pulp reparation. Therefore, clinical procedures aiming to preserve vitality of diabetic dental pulp should be applied with caution. The aim of this paper is to present basic factors and parameters that affect reparative response of dental pulp in patients with DM.

scholarly journals Disorders of Proteoglycan and Collagen Metabolism in the Kidneys in Diabetes Mellitus: Clinical and Pathogenetic Mechanisms and Laboratory Markers

2020 ◽  
Vol 5 (6) ◽  
pp. 355-361
Author(s):  
D. V. Morozenko ◽  
◽  
R. F. Yeromenko ◽  
K. V. Gliebova ◽  
O. P. Timoshenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Connective Tissue ◽  
Interstitial Fibrosis ◽  
Renin Angiotensin System ◽  
Basement Membranes ◽  
Oxidative Modification ◽  
Collagen Metabolism ◽  
Collagen Types ◽  
Patients With Diabetes

The article considers the issue of disorders of connective tissue metabolism in diabetes mellitus. Glycosylation of structural components of connective tissue and glucose toxicity have been found to determine the pathogenesis of late complications of diabetes mellitus. The most common concept of the pathogenesis of diabetes is metabolic, according to which all variants of diabetes mellitus, including blood vessels, their basement membrane, are associated with primary disorders of lipid, glycoprotein, protein and carbohydrate metabolism due to complete or partial insufficiency. It has been found that the formation of interstitial fibrosis in the kidneys of patients with diabetes begins in the preclinical stages of diabetic nephropathy. The leading cause of interstitial fibrogenesis is hyperglycemia; exacerbate proteinuria fibrosis, activation of the renin-angiotensin system, chronic inflammation and the formation of myofibroblasts in the interstitium. According to the results of the study of aspects of early diagnosis of kidney damage in type 1 diabetes mellitus, it was found that the development of diabetic nephrosclerosis is characterized by qualitative and quantitative changes in collagen composition in the glomeruli and interstitium, rebalance between collagen synthesis and breakdown, glycosaminoglycans, increased synthesis of fibrogenic growth factors and oxidative modification of proteins. The formation of diabetic nephropathy in patients with diabetes is also characterized by the accumulation of collagen types IV and VI, the appearance of interstitial collagen types III and I in the glomeruli, as well as the accumulation of collagen of all types in tubulointerstitium. Quantitative and qualitative characteristics of sulfated glycosaminoglycans of urine in human diabetes indicated different degrees of development of diabetic nephropathy. Glycosaminoglycans hyperexcretion was observed in patients with diabetes mellitus without proteinuria. In patients with microalbuminuria, glycosaminoglycans hyperexcretion was even more pronounced. It was also found that in diabetes, the total excretion of sulfated glycosaminoglycans in the urine doubles. Conclusion. Thus, in diabetes mellitus, an important pathogenetic link in the violation of the morpho-functional state of the kidneys is the degradation of collagen and proteoglycans of the basement membranes of the glomeruli, as well as interstitial fibrosis. This is reflected in changes in urinary glycosaminoglycans excretion, in particular heparansulfate and chondroitin sulfate, which may serve as a marker of proteoglycan metabolism disorders in the kidneys. Patients with diabetes also have an increase in the urine of hydroxyproline, which indicates an increase in the intensity of collagen metabolism in patients

EARLY AND ALTERNATIVE MARKERS OF CHRONIC HEART FAILURE IN PATIENTS WITH DIABETES MELLITUS

2021 ◽  
Vol 5 (1) ◽  
pp. 1122-1127
Author(s):  
V. Vasilkova ◽  
◽  
T. Mokhort ◽  
L. Korotaeva ◽  
Y. Yarets ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Growth Factor ◽  
Natriuretic Peptide ◽  
Inflammatory Cytokines ◽  
Tnf Alpha ◽  
Reactive Protein ◽  
Patients With Diabetes ◽  
Fgf 23 ◽  
Pro Inflammatory Cytokines

Aim: to assess the relationship of proinflammatory cytokines and chemokines with the levels of natriuretic peptides in patients with diabetes mellitus (DM). Materials and methods. A total of 155 patients (14 men and 61 women) with type 1 and type 2 diabetes, aged 34 to 84 years, were examined. All patients underwent standard clinical and laboratory examination, with an assessment of the levels of pro-inflammatory cytokines (interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-alpha), chemokines (monokine induced by interferon-gamma (MIG), regulated upon activation, normal T cell expressed and presumably secreted (RANTES), growth factors (fibroblast growth factor-23 (FGF-23), vascular endothelial growth factor (VEGF-A), natriuretic peptides (B‐type natriuretic peptide (BNP), N‐terminal fragment of B‐type natriuretic peptide (proBNP). Renal function was assessed based on the levels of serum creatinine, glomerular filtration rate (GFR), which was calculated according to the CKD-EPI formula, and albuminuria, which was assessed as albumin/creatinine ratio (A/C). An echocardiographic examination was conducted according to the standard protocol with the calculation of dimensional, volume and speed characteristics. Statistical data analysis was performed using smSTATA 14.2 for Mac (2018). Results. 57% DM patients had BNP and proBNP levels exceeding the diagnostic values of BNP >35 pg/ml and/or proBNP >125 pg/ml. The levels of BNP and proBNP positively correlated with the levels of homocysteine, uric acid, IL-6, С-reactive protein (CRP), high-sensitivity C-reactive protein (hsCRP), A/С, creatinine, cystatin C, TNF-alpha, chemokines (MIG, RANTES), growth factors (FGF-23, VEGF-A) (p <0.05). According to multiple regression analysis, predictors for increased proBNP were IL-6, A/K, creatinine (ß=0.70, p<0.001, ß=3.51, p=0.01, ß=0.97, p=0.01, respectively). ROC analysis determined the highest diagnostic significance of creatinine for the prediction of increased proBNP. The significance of IL-6 proved higher than A/С (AUC-0.777). Thus, when the level of IL-6 (AUC-0.789) was 3.1 mg/ml, the sensitivity and specificity for increased proBNP concentration were 71.9% and 71.2%, respectively. Conclusion. IL-6 might be an independent predictor of increased levels of natriuretic peptide in patients with diabetes. Further study of the role of pro-inflammatory cytokines in the development of cardiovascular diseases will make it possible to finally decode the mechanisms of their pathogenesis, which will further allow us to understand their complex effect on the body and obtain information for the development of new effective and safe specific medicines.

scholarly journals The role of pro-inflammatory cytokines in diabetic nephropathy in pregnant women with type 1 diabetes mellitus

2013 ◽  
Vol 94 (1) ◽  
pp. 105-110
Author(s):  
G R Gazizova
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Growth Factors ◽  
Pregnant Women ◽  
Inflammatory Cytokines ◽  
Interstitial Fibrosis ◽  
Inflammatory Reactions ◽  
Patients With Diabetes ◽  
Pro Inflammatory Cytokines

Diabetic nephropathy is one of the most frequent and unfavorable complications of pregnancy in terms of prognosis in patients with diabetes mellitus. The combination of pregnancy and uncompensated diabetes with such complications as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, leads to overproduction of pro-inflammatory cytokines, thromboses and ischemic necroses of the fetoplacental tissues, and low blood level of immunosuppressive cytokines increases the severity of the disease. This mechanism may be one of the reasons of the spontaneous abortion and pregnancy loss in early pregnancy term in women with diabetes. For a long time the leading role in diabetic nephropathy formation was acknowledged for hyperglycemia, dyslipidemia, oxidative stress, and arterial and renal intraglomerular hypertension. Diabetic nephropathy was recognized as non-immune and non-inflammatory process. Currently diabetic nephropathy is considered as a series of inflammatory reactions involving inflammatory cytokines and chemokines, consisting in the migration of monocytes or macrophages to the kidneys and glomerular and interstitial fibrosis development. Recent studies prove the role of immune-inflammatory reactions in diabetic kidney damage development and confirm an imbalance of the collagen exchange regulating factors, even at the stage of reversible renal dysfunction - microalbuminuria. The close relationship found between hyperglycemia, overproduction of growth factors and nephrosclerosis development in diabetes mellitus. The detection of pro-inflammatory cytokines and fibrogenic growth factors in the urine of patients with diabetes, especially in pregnant women with diabetes, can be used to prompt diagnosis and evaluation of processes occurring in the kidneys, to study the degree of sclerosis, and as a consequence, to predict kidney functional disorders development. Keywords: diabetes mellitus, pregnancy, diabetic nephropathy, cytokines, growth factors.

scholarly journals “FEATURES OF APPLICATION OF AUTOPLAZMA FOR TREATMENT OF THE ODONTOGENNY INFECTION OF MAXILLOFACIAL AREA AT PATIENTS WITH DIABETES”

2021 ◽  
Vol 58 (1) ◽  
pp. 4925-4927
Author(s):  
Khamitova Firuza Artikovna, Safarova Mashhura Sulaymonovna
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Inflammatory Process ◽  
Multimodality Therapy ◽  
Local Application ◽  
Surrounding Tissue ◽  
Structural Units ◽  
Highly Active ◽  
Patients With Diabetes ◽  
Regeneration Processes

The article is dedicated to the advanced multimodality therapy of the patients with odontogenic osteomyelitis of the jaws and its complications with local application of platelet enriched with plasma in the patients with diabetes mellitus taking into account the nature of the course of the inflammatory process. Platelet auto plasma is a highly active biological stimulator of regeneration processes owing to various growth factors contained in alpha granules of platelets, acting on all structural units of the surrounding tissue and stimulating regeneration processes. The article defines the use of platelet autoplasma and their advantage in the treatment of abscesses and phlegmon of the maxillofacial area in patients with diabetes mellitus.

scholarly journals An evaluation of the efficacy of therapeutic approaches to correcting the indices of the systems of coagulation and fibrinolysis, inflammation markers in patients with diabetes mellitus of type 2 with obesity

2013 ◽  
Vol 17 (2 (66)) ◽  
pp. 55-60
Author(s):  
K. F. Kehiopulo
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Combined Therapy ◽  
Body Weight Loss ◽  
The Body ◽  
Therapeutic Approaches ◽  
Metformin Monotherapy ◽  
Patients With Diabetes ◽  
Coagulation And Fibrinolysis

The paper investigates the state of the systems of coagulation and fibrinolysis, the level of proinflammatory markers in patients with diabetes mellitus (DM) of type 2 and obesity, in a correlation with risk factors of the development of cardiovascular diseases, as well as the efficacy of different therapeutic approaches to a correction of disturbed indicators of inflammation, hemostasis and fibrinolysis. It has been established that rational hypocaloric feeding, measures of a modification of the life style and the intake of metformin contribute to a statistically significant body weight loss, however, they are ineffective for correcting proinflammatory and procoagulant disorders. Combined therapy, including the intake of metformin and liraglutide is condurive to a more significal reduction of the body weight as compared with metformin monotherapy and contributes to an improvement of the parameters of lipid metabolism, a correction of proinflammatory disturbances and fibrinolytic insufficiency associated with DM.

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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