Tear Film Stability in Patients with Pseudexfoliation

Abstract Pseudoexfoliation syndrome is an age related disorder, characterized by abnormal fibrous fiber production and accumulation in different visceral organs as well as in the eye and periocular tissues. Hystological examination recorded the presence of the pseudoexfoliation in the conjunctiva, and they can disturb the accessory lacrimal gland and goblet cell function. This can explain tear film instability in patients with pseudoexfoliations. In our study, we examined the tear film stability in patients with and without pseudoexfoliation, using Schirmer test and tear break up time test. Our results indicated that patients with pseudoexfoliation had lower values of Schirmer and tear break up time tests than patients without it. Pseudoexfoliation is the main reason for the instability of the tear film, because of its negative impact on the conjucntival goblet cells. In conclusion, ophthalmologists must have these data on their mind in the process of the pseudoexfoliation glaucoma treatment and controlling.

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Dry Eye Syndrome in Glaucomatous Patients using Topical Anti-Glaucoma Therapy

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v36i1.980 ◽

2020 ◽

Vol 36 (1) ◽

Author(s):

Nabila Zulfiqar ◽

Muhammad Sufyan Aneeq Ansari ◽

Khurram Nafees ◽

Rabia Nawaz ◽

Manzra Shaheen

Keyword(s):

Observational Study ◽

Study Design ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Syndrome ◽

Film Stability ◽

Glaucoma Therapy ◽

Tear Film Stability ◽

Time Test ◽

Break Up

Purpose: To determine the frequency of Dry eye in Glaucoma patients using topical anti-glaucoma therapy. Study Design: Descriptive Observational study. Place and Duration of Study: Study was conducted in outpatient department of Fatima Memorial Hospital Shadman, Lahore, from October 2016 to February 2017. Material & Methods: In this study, 61 diagnosed cases of glaucoma were included. Patients with significant dermatological problems that may be associated with dry eye such as rosacea and blepharitis were excluded from the study. The individuals were assessed by consultant Ophthalmologist for Dry eye syndrome having symptoms of stinging and burning sensations itching, watering, irritation, due to regular use of topical anti-glaucoma drugs. A written consent was taken from every patient before the test. The ocular surfaces of the patients were evaluated using Tear film break-up time test and Basal Schrimer’s test. Patients having TBUT less than 11 seconds were categorized as having dry eye. The degree of dryness was categorized as mild, moderate and sever Dry eye. Results: Among 61 patients of glaucoma using topical anti-glaucoma therapy, 22 (36.1%) were male and 39 (63.9%) were female. Mean age of the patients was 50.76 ± 15.67 years. On the basis of Tear film Break-up time test, 49 (81%) patients had Tear Break-up time less than 10 seconds and 12 (19%) patients were normal. On the basis of Schrimer`s test 51 (83.66%) patients had Dry eye. Conclusion: Topical use of anti-glaucoma therapy affects tear film stability and its functions leading to Dry eye syndrome.

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Role of Tear Substitutes on Ocular Comfort and Tear Film Stability after Phacoemulsification for Age-Related Cataract

10.47275/0032-745x-341 ◽

2021 ◽

Vol 107 (5) ◽

Author(s):

Sohaib Ahmed Mahmood ◽

Loay Abdulmutalib Almusawi ◽

Sura Abdulrahman Alqaisi ◽

Bashar Alwash

Keyword(s):

Tear Film ◽

Film Stability ◽

Age Related ◽

Tear Film Stability ◽

Ocular Comfort

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Tear Film Stability and Tear Break Up Time (TBUT) in Laboratory Rabbits—A Systematic Review

Current Eye Research ◽

10.1080/02713683.2018.1457164 ◽

2018 ◽

Vol 43 (8) ◽

pp. 961-964 ◽

Cited By ~ 1

Author(s):

Michael J. Doughty

Keyword(s):

Systematic Review ◽

Tear Film ◽

Film Stability ◽

Tear Film Stability ◽

Break Up

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Post-Operative Evaluation of Tear Film Instability After Cataract Surgery

10.53902/mrvo.2021.01.000501 ◽

2021 ◽

Vol 1 (1) ◽

Author(s):

Asma Batool

Keyword(s):

Cataract Surgery ◽

Teaching Hospital ◽

Tear Film ◽

Sampling Technique ◽

Cross Sectional Study ◽

Cross Sectional ◽

Film Stability ◽

Mean Values ◽

Film Instability ◽

Break Up

Purpose of Study: To evaluate tear film instability after cataract surgery by measuring tear break up time. Place of Study: This study was carried out in Teaching Hospital, University of Lahore, Lahore, Pakistan. Materials and Methods: A descriptive cross- sectional study was conducted in Teaching Hospital, UOL. Tear break up time was measured on patients post-operatively who under -went cataract surgery. A total of 60 patients were included in study after non –probability convenient sampling technique. Both male and female patients were included in study age 45-65 years. Data was collected through self-designed questionnaire based proforma. Further results were analyzed using SPSS version 20. Results: Tear break up time was found statistically reduced at 1 week, 2 week and after one month postoperatively(P =.0002, P<.0001). However, the tear film stability had reverted to approximately the preoperative measurement 1 month after surgery. The mean values of postoperative results were altered from preoperative measurement values. BUT outcomes had reduced considerably at 1 week postoperatively (P=.0001) but had resumed to very nearly the preoperative value 1 month after of cataract surgery. While goblet cell density (GCD) had reduced considerably at 1 week, 2 weekand 1 month postoperatively (P<.0001). Conclusion: This study concludes that tear breakup time is significantly reduced after cataract surgery due to destruction of goblet cells as shown in above tables. But tear break up time is significantly improved after one week, two weeks and one month of follow ups respectively

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Effect of ocular demodicosis on the stability of the tear film and the tear break up time

Scientific Reports ◽

10.1038/s41598-021-03801-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Aleksandra Sędzikowska ◽

Witold Tarkowski ◽

Joanna Moneta-Wielgoś ◽

Krzysztof Grzyliński ◽

Grzegorz Tarkowski ◽

...

Keyword(s):

Tear Film ◽

Hair Follicles ◽

Film Stability ◽

Mean Values ◽

Non Invasive ◽

Tear Film Stability ◽

Break Up ◽

The Difference ◽

The Stability ◽

The Impact

AbstractThe aim of the study was to analyze the correlation between the presence of Demodex mites in the hair follicles of patients' eyelashes and the stability and break up time of the tear film assessed with the Non-Invasive Tear Break Up Times (NIBUT) method. 319 patients were included in the study (195 women, 124 men). The patients were divided into two groups: those with Demodex infestation and without visible symptoms of eyelid or eye surface diseases, and asymptomatic non-infested patients. The NIBUT analysis was performed with a 5 M keratograph (oculus). Non-invasive tests were performed to identify the first and mean values of the tear break up time. The first and mean tear break up time in the Demodex-infested group was lower than in the non-infested subjects. The difference was a highly statistically significant. There was a significant correlation with the age of the patients for the first break up time. The first break up time in both eyes decreased with the age of the Demodex-infested and non-infested patients. The NIBUT analyses indicate the impact of Demodex mites on the tear film stability. This may suggest possible association of demodicosis with dry eye syndrome.

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Tear Film Break Up Patterns (TFBUP) — A Novel Method of Evaluating Tear Film Stability

The Ocular Surface ◽

10.1016/s1542-0124(12)70519-0 ◽

2005 ◽

Vol 3 ◽

pp. S100 ◽

Cited By ~ 3

Author(s):

George W. Ouslerf ◽

Michael A. Lemp ◽

Michael R. Schindelar ◽

Mark B. Abelson

Keyword(s):

Tear Film ◽

Film Stability ◽

Tear Film Stability ◽

Novel Method ◽

Break Up

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Tear film parameters before and after intracorneal ring segment implantation in keratoconic eyes

European Journal of Ophthalmology ◽

10.1177/1120672120958301 ◽

2020 ◽

pp. 112067212095830

Author(s):

Iraklis Vastardis ◽

Zisis Gatzioufas ◽

Cameron McLintock ◽

Markus Kohlhaas ◽

Samer Hamada ◽

...

Keyword(s):

Tear Film ◽

Schirmer Test ◽

Film Stability ◽

Non Invasive ◽

Tear Film Stability ◽

Before And After ◽

Ring Segment ◽

Time Test ◽

Intracorneal Ring Segment ◽

Breakup Time

Purpose: To assess signs of dry eye syndrome in keratoconic eyes following intracorneal ring segment (ICRS) implantation. Patient and methods: Twenty eyes of 20 consecutive patients with keratoconus were assessed for tear film changes following ICRS implantation at 6 months postoperatively. Evaluated parameters included tear osmolarity, non-invasive tear breakup time test (NI-BUT test) and Schirmer test I and II before and after treatment. Results: No significant changes were found with respect to osmolarity, Schirmer I and II ( p = 0.9, p < 0.64, and p < 0.91, respectively). The NITUBT was significantly lower after surgery ( p = 0.04). Conclusion: Our results suggest that implantation of ICRS does not result in a significant change in tear film osmolarity, or tear film volume nor improves the tear film stability.

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