Dry Eye Syndrome in Glaucomatous Patients using Topical Anti-Glaucoma Therapy

Purpose: To determine the frequency of Dry eye in Glaucoma patients using topical anti-glaucoma therapy. Study Design: Descriptive Observational study. Place and Duration of Study: Study was conducted in outpatient department of Fatima Memorial Hospital Shadman, Lahore, from October 2016 to February 2017. Material & Methods: In this study, 61 diagnosed cases of glaucoma were included. Patients with significant dermatological problems that may be associated with dry eye such as rosacea and blepharitis were excluded from the study. The individuals were assessed by consultant Ophthalmologist for Dry eye syndrome having symptoms of stinging and burning sensations itching, watering, irritation, due to regular use of topical anti-glaucoma drugs. A written consent was taken from every patient before the test. The ocular surfaces of the patients were evaluated using Tear film break-up time test and Basal Schrimer’s test. Patients having TBUT less than 11 seconds were categorized as having dry eye. The degree of dryness was categorized as mild, moderate and sever Dry eye. Results: Among 61 patients of glaucoma using topical anti-glaucoma therapy, 22 (36.1%) were male and 39 (63.9%) were female. Mean age of the patients was 50.76 ± 15.67 years. On the basis of Tear film Break-up time test, 49 (81%) patients had Tear Break-up time less than 10 seconds and 12 (19%) patients were normal. On the basis of Schrimer`s test 51 (83.66%) patients had Dry eye. Conclusion: Topical use of anti-glaucoma therapy affects tear film stability and its functions leading to Dry eye syndrome.

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Frequency of Dry Eye in Glaucoma Patients Using Topical Anti-Glaucoma Therapy

10.53350/pjmhs2115102606 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2606-2608

Author(s):

Nesr Farooq ◽

Hafiz Waqar Ahmad Ghauri ◽

Asad Zaman Khan ◽

Abdul Bari Kakar ◽

Muhammad Amin ◽

...

Keyword(s):

Body Mass Index ◽

Observational Study ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Syndrome ◽

Glaucoma Medication ◽

Glaucoma Therapy ◽

Department Of Ophthalmology ◽

Time Test ◽

Break Up

Aim: To determine the prevalence of dry eye in glaucoma patients using topical anti-glaucoma therapy. Study Design: Descriptive observational study Place and duration of study: Department of Ophthalmology, Shalimar Medical & Dental College Lahore from 1st November 2020 to 30th April 2021. Methodology: Ninety patients of both genders were enrolled. Detailed demographics of enrolled cases age, sex and body mass index were recorded after taking informed written consent. Patients using topical anti-glaucoma therapy for more than 8 months and having symptoms of stinging and burning sensations itching, watering, irritation, due to regular use of topical antiglaucoma drugs were presented. Basal Schrimer’s test and tear film break-up time test was used to measure the frequency of dry eye syndrome as mild, moderate and severe. Results: There were 60 (66.7%) females and 30 (33.3%) patients were males. Mean age of the patients were 45.61±7.66 years with mean BMI 26.24±8.71 kg/m2. We found that 40 (44.4%) patients had burning and stinging sensations, itching found in 21 (23.3%), dry eye sensations were found in 16 (17.8%) patients and watering and irritation found in 13 (14.4%) .According to tear film break-up time test 20 (22.2%) cases did not show dry eye syndrome and 19 (21.1%) patients were normal in Basal Schrimer’s test. Conclusion: Use of topical anti-glaucoma medication resulted in dry eye syndrome as well as a decrease in the tear film's stability. Keywords: Anti-glaucoma therapy, Basal Schrimer`s test, Tear film break-up time, Anti-glaucoma therapy, Dry eye syndrome

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Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

Acta Ophthalmologica ◽

10.1111/aos.13241 ◽

2016 ◽

Vol 95 (3) ◽

pp. e230-e235 ◽

Cited By ~ 12

Author(s):

Ki Won Jin ◽

Jin Woo Ro ◽

Young Joo Shin ◽

Joon Young Hyon ◽

Won Ryang Wee ◽

...

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Tear Film ◽

Dry Eye Syndrome ◽

Film Stability ◽

Vitamin D Levels ◽

Tear Film Stability

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Choosing the optimal method for preoperative risk assessment of dry eye syndrome development in patients with myopia

Reflection ◽

10.25276/2686-6986-2021-1-30-36 ◽

2021 ◽

Vol 11 (1) ◽

pp. 30-36

Author(s):

O.V. Kolenko ◽

◽

Y.V. Kutuzova ◽

I.V. Dutchin ◽

E.L. Sorokin ◽

...

Keyword(s):

Dry Eye ◽

Tear Film ◽

Dry Eye Syndrome ◽

Rupture Time ◽

Film Rupture ◽

Optimal Method ◽

Film Stability ◽

Tear Film Stability ◽

Keratorefractive Surgery ◽

The Stability

Aim. Comparative analysis of the effectiveness of keratotopography methods and classical Norn’s test in assessing the stability of the tear film (TF) in patients with myopia before photorefractive surgery. Methods. The study involved 26 patients. All of them were planned for keratorefractive surgery to correct myopic refraction and astigmatism. Their age averaged 32.5±14.5 years (18-47 years). The stability of pre-corneal tear film was assessed using computed keratotopography and Norn’s test - the tear film rupture time (TFRT) was determined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome (DES). A comparison was made of the indicators of tear film, stability obtained by the methods of keratotopography and Norn’s test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4 %), TFRT index corresponded to the age norm. In the remaining 9 people (34.6 %), indicators of tear film stability were reduced both by keratotopography (12±4 sec) and by Norn’s test (13.5± 4.5 sec), and there were also subjective signs of dry eye syndrome according to questionnaire data. The data turned out to be comparable. Conclusion. The incidence of impaired stability of the TF and subjective manifestations of DES among patients planned for keratorefractive surgery for myopia and myopic astigmatism was significant and, according to our data, made 34.6 %. To prevent complicated postoperative course of photorefractive surgery, it is necessary to assess the condition of the ocular surface immediately before refractive surgery, to identify the risk group for DES development. Key words: dry eye syndrome; tear film; keratotopography; Norn’s test; tear film rupture time.

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Clinical manifestations of the dry eye syndrome for women in menopause

Pediatrician (St Petersburg) ◽

10.17816/ped5225-29 ◽

2014 ◽

Vol 5 (2) ◽

pp. 25-29

Author(s):

Nataliya Nikolayevna Sadovnikova ◽

Galiya Fettyakhovna Kutusheva

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Clinical Manifestations ◽

Tear Film ◽

Dry Eye Syndrome ◽

Menopausal Syndrome ◽

Film Stability ◽

Tear Film Stability ◽

Functional Features ◽

Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

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DRY EYE SYNDROME

The Professional Medical Journal ◽

10.29309/tpmj/2009.16.01.3004 ◽

2009 ◽

Vol 16 (01) ◽

pp. 145-148

Author(s):

TAHIR MUMTAZ MALIK ◽

SYED ABID HASSAN NAQVI ◽

MUHAMMAD SHAHID

Keyword(s):

Study Design ◽

Dry Eye ◽

Rose Bengal ◽

Tear Film ◽

Descriptive Study ◽

Dry Eye Syndrome ◽

Adult Patients ◽

Military Hospital ◽

Break Up ◽

Eye Clinic

Objective: To determine the frequency of dry eye syndrome in adult patients. Study Design: A descriptive study. Setting:Eye Department Military Hospital Rawalpindi. Period: From June 2004 to December 2004. Patients and methods: A total of hundredpatients were randomly selected from the daily OPD at eye department, MH Rawalpindi. They were tested for the presence of dry eyesyndrome by Rose Bengal staining, Schirmer tear strip measurements and Tear film break up time. Results: A total of 67 males and 33females were recruited. Out of these 10 males and 6 females were found to be having dry eye syndrome. Mean patient age was34.3±1.3years (range 20-60 years). Conclusion: The frequency of dry eye syndrome in adult patients attending the eye clinic of MilitaryHospital Rawalpindi is 16%.

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Compliance as an Integral Part of the Dry Eye Syndrome Prevention Using Silicone Hydrogel Contact Lenses

Galician Medical Journal ◽

10.21802/gmj.2016.4.7 ◽

2016 ◽

Vol 23 (4) ◽

pp. 201647

Author(s):

Rimma Skrypnyk ◽

Olga Selezneva

Keyword(s):

Dry Eye ◽

Contact Lenses ◽

Tear Film ◽

Dry Eye Syndrome ◽

Film Stability ◽

Silicone Hydrogel ◽

Clinical Guidance ◽

Schirmer’S Test ◽

Group I ◽

Tear Film Stability

The probability of dry eye syndrome (DES) in the patients using the Silicone-Hydrogel Contact Lenses is examined in many researches. Therefore, adhering to clinical recommendations is an important factor for DES prevention. The urgent issue is also a comprehensive assessment of functional parameters as pathogenetic base of DES.The objective of the research was tostudy DES development depending on compliance of silicone hydrogel contact lenses users.Matherials and methods. 97 patients (194 eyes) were included into the research. They formed 2 groups: group I with incomplete compliance (36 persons) and group II with complete compliance (61 persons). All the patients underwent the Norn’s test, Schirmer’s test, Jones test, tear film stability was defined. The probability of the dry eye syndrome development due to the subjective signs was also analysed.Results. The reliable decrease in the total (р<0.05) and basale lacrimation (р<0.05) indexes, the increase in osmolarity (р<0.05) and decrease in tear film stability (р<0.05) were detected in the patients who did not follow the clinical guidance during the Silicone-Hydrogel Contact Lenses wearing. In the same group the higher risk of dry eye syndrome development was verified (р<0.05).Conclusion. Compliance disorder in the patients using Silicone-Hydrogel Contact Lenses was found to induce the reliable decrease in total and basale lacrimation, increase in osmolarity and tear stability disorder. All of this factors increase the risk of dry eye syndrome.

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Tear Film Stability in Patients with Pseudexfoliation

Serbian Journal of Experimental and Clinical Research ◽

10.1515/sjecr-2017-0002 ◽

2018 ◽

Vol 19 (3) ◽

pp. 243-246

Author(s):

Tatjana Sarenac Vulovic ◽

Sladjana Pavlovic ◽

Katarina Janicijevic ◽

Dusan Todorovic ◽

Mitar Lutovac ◽

...

Keyword(s):

Cell Function ◽

Negative Impact ◽

Tear Film ◽

Film Stability ◽

Related Disorder ◽

Film Instability ◽

Age Related ◽

Tear Film Stability ◽

Time Test ◽

Break Up

Abstract Pseudoexfoliation syndrome is an age related disorder, characterized by abnormal fibrous fiber production and accumulation in different visceral organs as well as in the eye and periocular tissues. Hystological examination recorded the presence of the pseudoexfoliation in the conjunctiva, and they can disturb the accessory lacrimal gland and goblet cell function. This can explain tear film instability in patients with pseudoexfoliations. In our study, we examined the tear film stability in patients with and without pseudoexfoliation, using Schirmer test and tear break up time test. Our results indicated that patients with pseudoexfoliation had lower values of Schirmer and tear break up time tests than patients without it. Pseudoexfoliation is the main reason for the instability of the tear film, because of its negative impact on the conjucntival goblet cells. In conclusion, ophthalmologists must have these data on their mind in the process of the pseudoexfoliation glaucoma treatment and controlling.

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Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity

Clinical ophthalmology ◽

10.32364/2311-7729-2021-21-4-200-204 ◽

2021 ◽

Vol 21 (4) ◽

pp. 200-204

Author(s):

V.V. Brzheskiy ◽

◽

E.L. Efimova ◽

M.A. Kopylova ◽

P.V. Kocharina ◽

...

Keyword(s):

Dry Eye ◽

Sodium Hyaluronate ◽

Tear Film ◽

Dry Eye Syndrome ◽

Critical Parameters ◽

Film Stability ◽

Axis Orientation ◽

Artificial Tear ◽

Diagnostic Unit ◽

Tear Film Stability

Aim: to study the changes in the critical parameters of tear film stability and autorefractometry in patients with mild dry eye syndrome (DES) after instilling artificial tear products of different viscosity. Patients and Methods: thirty patients aged 23–70 with mild bilateral DES were examined using the Visionix VX120+Dry Eye multi-diagnostic unit equipped with the TF-Scan to fix and assess tear film stability and tear breakup time (TBUT). The critical refraction and tear film parameters were evaluated by keratometry, corneal topography, TBUT, and tear meniscus height measurements. Next, an artificial tear product was instilled, i.e., group 1 (14 patients, 28 eyes) received a 0.15% sodium hyaluronate-based preparation, and group 2 (16 patients, 32 eyes) received a 0.4% sodium hyaluronate-based preparation. The examination was repeated after 30 sec and 5 min. Controls were seven healthy individuals (14 eyes). Results: in DES, breaks in the tear film appeared earlier and affected greater corneal surface area. A "Destabilized tear film area" parameter of the Visionix VX120+Dry Eye contributed significantly to the knowledge of tear film functionality, thereby empowering the diagnostic armamentarium in DES. As early as 30 sec after instillation of both artificial tear preparations, breakup-free time tended to increase, while the area of tear film destabilization tended to reduce. After 5 min, this trend continued to increase, particularly after instilling 0.15% sodium hyaluronate-based preparation. At the same time, changes in keratometry readings (i.e., sphere and cylinder) and astigmatism axis orientation were reported. Corneal refractive power (more in the flattest axis) increased, in particular, after the instillations of 0.15% hyaluronic acid. The range of changes was 0.00–0.75 D for the sphere power, 0.00–0.50 D for the cylinder power, and 0–69 degrees for astigmatism axis orientation. Conclusions: our findings with the Visionix VX120+Dry Eye multi-diagnostic unit demonstrate a significant variation of autorefractometry readings in DES depending on the extent of ocular surface hydration. These phenomena raise questions about the accuracy of autorefractometry readings. Therefore, autorefractometry should be performed after normalizing tear film volume and stability. Keywords: dry eye syndrome, Visionix®, autorefractometry, tearscopy, the effect of artificial tears on results. For citation: Brzheskiy V.V., Efimova E.L., Kopylova M.A. et al. Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity. Russian Journal of Clinical Ophthalmology. 2021;21(4):200–204 (in Russ.). DOI: 10.32364/2311-7729-2021-21-4-200-204.

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PENGARUH EMISI DEBU SEMEN TERHADAP STATUS TEAR FILM MASYARAKAT DI SEKITAR PABRIK PT. SEMEN PADANG

Jurnal Kesehatan Andalas ◽

10.25077/jka.v6i3.753 ◽

2018 ◽

Vol 6 (3) ◽

pp. 654

Author(s):

Muhammad Syauqie ◽

Ardizal Rahman ◽

Getry Sukmawati

Keyword(s):

Dry Eye ◽

Tear Film ◽

Cross Sectional Study ◽

Dry Eye Syndrome ◽

Sectional Study ◽

Cross Sectional ◽

Break Up

Permukaan okular rentan terhadap efek iritatif dari debu semen tersebut karena epitel konyungtiva dan kornea hanya dilapisi oleh lapisan tipis tear film. Paparan debu semen jangka panjang menyebabkan terjadinya inflamasi subklinis kronik yang dapat mempengaruhi transdiferensiasi epitel konyungtiva dan densitas sel goblet yang kemudian dapat menyebabkan timbulnya gejala dry eye syndrome. Tujuan penelitian ini adalah menilai status tear film pada masyarakat yang terpapar emisi debu semen dibandingkan dengan masyarakat yang tidak terpapar. Penelitian ini berupa analytic cross sectional study pada dua populasi yaitu kelompok terpapar dan tidak terpapar emisi debu pabrik semen. Semua sampel penelitian dari dua populasi menjalani pemeriksaan pH tear film, Schirmer, Ferning dan Tear Break Up Time (TBUT). Hasil studi mendapatkan peningkatan nilai pH tear film yang bermakna pada penduduk di kelompok terpapar dengan p=0.001. Terdapat juga penurunan kualitas Ferning yang bermakna pada penduduk di kelompok terpapar yang didominasi tipe III dengan p=0.005 dan 0.029. Sedangkan hasil pemeriksaan Schirmer dan TBUT masih dalam batas normal dan tidak terdapat perbedaan yang bermakna antara kedua kelompok. Simpulan studi ini ialah erdapat peningkatan rerata nilai pH tear film dan penurunan kualitas lapisan musin tear film yang bermakna pada masyarakat yang terpapar emisi debu semen namun tidak didapatkan peningkatan kejadian dry eye yang bermakna.

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