A Computer-controlled, Fully Automatic NMR/NQR Double Resonance Spectrometer

1992 ◽  
Vol 47 (1-2) ◽  
pp. 395-400 ◽  
Author(s):  
Feng Zhenye ◽  
Edwin A. C Lücken ◽  
Jacques Diolot

AbstractA completely automatic computer-controlled NMR/NQR double resonance spectrometer is described. It features automatic tuning of the low, variable frequency power amplifier, thus permitting untended use over long periods, with high sensitivity and signal reproducibility. The sample is transferred between the low-frequency, zero-field region and the high-field region using compressed air and the possibility of switching on a field of several tens of gauss during the transfer of the sample is also included

1986 ◽  
Vol 41 (1-2) ◽  
pp. 440-444 ◽  
Author(s):  
A. Bielecki ◽  
D. B. Zax ◽  
A. M. Thayer ◽  
J. M. Millar ◽  
A. Pines

Field cycling methods are described for the time domain measurement of nuclear quadrupolar and dipolar spectra in zero applied field. Since these techniques do not involve irradiation in zero field, they offer significant advantages in terms of resolution, sensitivity at low frequency, and the accessible range of spin lattice relaxation times. Sample data are shown which illustrate the high sensitivity and resolution attainable. Comparison is made to other field cycling methods, and an outline of basic instrumental requirements is given.


1992 ◽  
Vol 7 (6) ◽  
pp. 1317-1327 ◽  
Author(s):  
J.E. Tkaczyk ◽  
C.L. Briant ◽  
J.A. DeLuca ◽  
E.L. Hall ◽  
P.L. Karas ◽  
...  

Three processing routes that generate uniaxial alignment but otherwise yield very different microstructure and critical current are compared. Fine grain size and c-axis alignment are obtained in magnetically aligned ceramics, pyrolyzed thick films, and in situ deposited thin films. The dense, well-aligned microstructure of the in situ process produces the highest zero field critical current Jc > 104 A/cm2 at 77 K. However, the critical current is suppressed in low magnetic field, suggesting that uniaxial alignment is not sufficient to avoid Josephson-type intergranular coupling. Above 1 T, the critical current of the aligned ceramic dominates in spite of its less ideal microstructure. The critical current in this high field region is one to two orders of magnitude greater than that of nonaligned material. This result implies the existence of a 3-d percolative network of strong links.


2005 ◽  
Vol 44 (4B) ◽  
pp. 2469-2471
Author(s):  
Masanori Wada ◽  
Takayuki Nakamoto ◽  
Shinichi Hamayoshi ◽  
Katsuhiko Higuchi

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2022
Author(s):  
Benjamin Spetzler ◽  
Elizaveta V. Golubeva ◽  
Ron-Marco Friedrich ◽  
Sebastian Zabel ◽  
Christine Kirchhof ◽  
...  

Magnetoelectric resonators have been studied for the detection of small amplitude and low frequency magnetic fields via the delta-E effect, mainly in fundamental bending or bulk resonance modes. Here, we present an experimental and theoretical investigation of magnetoelectric thin-film cantilevers that can be operated in bending modes (BMs) and torsion modes (TMs) as a magnetic field sensor. A magnetoelastic macrospin model is combined with an electromechanical finite element model and a general description of the delta-E effect of all stiffness tensor components Cij is derived. Simulations confirm quantitatively that the delta-E effect of the C66 component has the promising potential of significantly increasing the magnetic sensitivity and the maximum normalized frequency change ∆fr. However, the electrical excitation of TMs remains challenging and is found to significantly diminish the gain in sensitivity. Experiments reveal the dependency of the sensitivity and ∆fr of TMs on the mode number, which differs fundamentally from BMs and is well explained by our model. Because the contribution of C11 to the TMs increases with the mode number, the first-order TM yields the highest magnetic sensitivity. Overall, general insights are gained for the design of high-sensitivity delta-E effect sensors, as well as for frequency tunable devices based on the delta-E effect.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Guang ◽  
Halen Baker ◽  
Orilia Ben-Yishay Nizri ◽  
Shimon Firman ◽  
Uri Werner-Reiss ◽  
...  

AbstractDeep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.


Epilepsia ◽  
2021 ◽  
Author(s):  
Abhijeet Gummadavelli ◽  
Reese Martin ◽  
Derek Goshay ◽  
Lim‐Anna Sieu ◽  
Jingwen Xu ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
A. Rose Brannon ◽  
Gowtham Jayakumaran ◽  
Monica Diosdado ◽  
Juber Patel ◽  
Anna Razumova ◽  
...  

AbstractCirculating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS (Memorial Sloan Kettering - Analysis of Circulating cfDNA to Examine Somatic Status), an NGS assay for detection of very low frequency somatic alterations in 129 genes. Analytical validation demonstrated 92% sensitivity in de-novo mutation calling down to 0.5% allele frequency and 99% for a priori mutation profiling. To evaluate the performance of MSK-ACCESS, we report results from 681 prospective blood samples that underwent clinical analysis to guide patient management. Somatic alterations are detected in 73% of the samples, 56% of which have clinically actionable alterations. The utilization of matched normal sequencing allows retention of somatic alterations while removing over 10,000 germline and clonal hematopoiesis variants. Our experience illustrates the importance of analyzing matched normal samples when interpreting cfDNA results and highlights the importance of cfDNA as a genomic profiling source for cancer patients.


1981 ◽  
Vol 25 (1) ◽  
pp. 133-143 ◽  
Author(s):  
T. H. Jensen ◽  
F. W. McClain ◽  
H. Grad

Heating of a doublet plasma by driving an axisymmetric mode at low frequency may be an attractive means for auxiliary heating. The attractiveness of the method stems from (1) the low technology required for low-frequency power sources, (2) the fact that the field-shaping coils required for doublets may also be used as the antennae for transmitting the power, (3) the possibility of transmitting the power through a resistive vacuum wall, (4) the insensitivity to the plasma temperature and density and (5) the relative simplicity of the physical model. The utility of the concept depends on the existence of a special axisymmetric eigenmode in the resistive M.HD approximation which is used. This mode has nodes through the elliptic axes of the doublet equilibrium and an antinode at the hyperbolic axis. It is remarkable that the dissipation per cycle of this mode remains large at low plasma resistivity. This paper describes a linear theory for such heating.


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