Gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs

Background/Aim. The use and adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with rheumatic diseases has not yet been studied enough. The aim of this study was to evaluate the data about the efficacy and safety of NSAIDs obtained from the questionnaires submitted to the outpatients receiving these drugs. Methods. The patients who had been prescribed any of NSAIDs within the period from June to September, 2004 were included in the study. The answers obtained from the questionnaires were statistically analyzed by means of ?2-test. Results. At the time of the study, 150 patients had been prescribed ibuprofen or some other NSAID. Out of the total number of dispensed questionnaires (n = 150), only 45 (30%) were shown to be correctly filled-in. Their analysis showed that 64.4% of the patients had suffered from rheumatic diseases for more than five years, and had regularly used NSAIDs. The average age of these patients was about 70 years, and the number of females was double as high as that of the males. The most frequently used NSAIDs were diclofenac and ibuprofen (46.14%, and 23.24%, respectively). According to the answers given by the patients, the most often adverse reactions were gastric complaints such as nausea (11.1%), and stomach pain (8.9%). Due to this, the majority of the patients (64.4%) used some of the antiulcer drugs, most often ranitidine (31.1%). Conclusion. The results of this pilot study revealed that among the outpatients suffering from rheumatic diseases, the number of females was double as high as the number of males, that these patients were of the mean age of 70 years, and that their diseases lasted longer than five years. Gastric complains such as nausea and gastric pain of mild intensity were the most often adverse effects of NSAIDs reported by our patients. It could be the consequence of the predominant use of diclofenac and ibuprofen, NSAIDs with mild to moderate ulcerogenic potential, as well as the concomitant use of H2-receptor antagonists.

Download Full-text

Peripheral Tramadol in Dentistry: A New Use for an Old Drug

Odovtos - International Journal of Dental Sciences ◽

10.15517/ijds.v0i0.23490 ◽

2016 ◽

Vol 18 (2) ◽

pp. 10

Author(s):

Daniel Chavarría DDS, MSc, PhD ◽

Amaury Pozos DDS, MSc, PhD

Keyword(s):

Adverse Effects ◽

Opioid Receptors ◽

Analgesic Effect ◽

Health Sciences ◽

Analgesic Drug ◽

Orofacial Region ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

New Perspective ◽

Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain. Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”.

Download Full-text

Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs on the Small and Large Bowel

Endoscopy ◽

10.1055/s-1999-75 ◽

1999 ◽

Vol 31 (9) ◽

pp. 761-767 ◽

Cited By ~ 21

Author(s):

Schneider ◽

Benz ◽

Beermann ◽

Schiebeler ◽

Riemann

Keyword(s):

Adverse Effects ◽

Large Bowel ◽

Inflammatory Drugs ◽

Anti Inflammatory

Download Full-text

Pattern Recognition Analysis for the Prediction of Adverse Effects by Nonsteroidal Anti-Inflammatory Drugs Using1H NMR-Based Metabolomics in Rats

Analytical Chemistry ◽

10.1021/ac9000282 ◽

2009 ◽

Vol 81 (12) ◽

pp. 4734-4741 ◽

Cited By ~ 25

Author(s):

So Young Um ◽

Myeon Woo Chung ◽

Kyu-Bong Kim ◽

Seon Hwa Kim ◽

Ji Seon Oh ◽

...

Keyword(s):

Pattern Recognition ◽

Adverse Effects ◽

Pattern Recognition Analysis ◽

Inflammatory Drugs ◽

Anti Inflammatory

Download Full-text

Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

10.21203/rs.2.19183/v1 ◽

2019 ◽

Author(s):

Nuru Abdu ◽

Samuel Teweldemedhin ◽

Asmerom Mosazghi ◽

Luwam Asfaha ◽

Makda Teshale ◽

...

Keyword(s):

Adverse Effects ◽

Drug Interactions ◽

The Elderly ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Female Ratio ◽

Protective Agents ◽

Inflammatory Drugs ◽

Anti Inflammatory

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

Download Full-text

#19 Risk estimation of fetal adverse effects after short-term second trimester exposure to non-steroidal anti-inflammatory drugs based on a literature review

Reproductive Toxicology ◽

10.1016/j.reprotox.2019.05.028 ◽

2019 ◽

Vol 88 ◽

pp. 139

Author(s):

Katarina Dathe ◽

Stefanie Hultzsch ◽

Lucas William Pritchard ◽

Christof Schaefer

Keyword(s):

Literature Review ◽

Adverse Effects ◽

Risk Estimation ◽

Second Trimester ◽

Short Term ◽

Inflammatory Drugs ◽

Trimester Exposure ◽

Anti Inflammatory

Download Full-text

Defining the role of glucocorticoids in inflammation

Clinical Science ◽

10.1042/cs20171505 ◽

2018 ◽

Vol 132 (14) ◽

pp. 1529-1543 ◽

Cited By ~ 16

Author(s):

Simona Ronchetti ◽

Graziella Migliorati ◽

Stefano Bruscoli ◽

Carlo Riccardi

Keyword(s):

Clinical Practice ◽

Side Effects ◽

Adverse Effects ◽

Molecular Mechanisms ◽

Molecular Targets ◽

Great Promise ◽

Body Of Knowledge ◽

Inflammatory Drugs ◽

Anti Inflammatory

An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the very well-known adverse effects associated with their treatment hampers continuation of therapy with glucocorticoids. Analyses of the molecular mechanisms underlying the actions of glucocorticoids have led to the discovery of several mediators that add complexity and diversity to the puzzling world of these hormones and anti-inflammatory drugs. Such mediators hold great promise as alternative pharmacologic tools to be used as anti-inflammatory drugs with the same properties as glucocorticoids, but avoiding their metabolic side effects. This review summarizes findings about the molecular targets and mediators of glucocorticoid function.

Download Full-text