Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

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Non-steroidal anti-inflammatory drugs and hypertension in the elderly: a community-based cross-sectional study.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1993.tb04169.x ◽

1993 ◽

Vol 35 (5) ◽

pp. 455-459 ◽

Cited By ~ 62

Author(s):

AG Johnson ◽

LA Simons ◽

J Simons ◽

Y Friedlander ◽

J McCallum

Keyword(s):

The Elderly ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

Research Society and Development ◽

10.33448/rsd-v10i4.14250 ◽

2021 ◽

Vol 10 (4) ◽

pp. e44210414250

Author(s):

Beatriz da Silva Santos ◽

Manoela Santos da Silva ◽

Isadora Oliveira e Pereira ◽

Lucas Brasileiro Lemos ◽

Gisele da Silveira Lemos

Keyword(s):

Drug Interactions ◽

Cross Sectional Study ◽

Potential Drug ◽

Sectional Study ◽

Electronic Prescription ◽

Cross Sectional ◽

Version 2.0 ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

A Chain

This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.

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Potential and clinical relevant drug-drug interactions among elderly from nursing homes: a multicentre study in Murcia, Spain

Ciência & Saúde Coletiva ◽

10.1590/1413-81232018245.16032017 ◽

2019 ◽

Vol 24 (5) ◽

pp. 1895-1902

Author(s):

Carles Iniesta-Navalón ◽

Juan Jose Gascón-Cánovas ◽

Zenewton André da Silva Gama ◽

José Francisco Sánchez-Ruiz ◽

Erick Angelico Gutiérrez-Estrada ◽

...

Keyword(s):

Nursing Homes ◽

Drug Interactions ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Complex Sampling ◽

Inflammatory Drugs ◽

Multi Level ◽

Relevant Factors

Abstract This study purposes to determine the prevalence of potential and clinical relevant Drug-Drug-Interactions (pDDIs) in institutionalized older adults and to identify the pertinent factors associated. We conduct an observational, multicenter and cross-sectional study during the last quarter of 2010. We selected a sample of 275 subjects (aged ≥ 65 years) from 10 nursing homes of Murcia (Spain) by a two-stage complex sampling. pDDIs were identified using the College of Pharmacists Database. We only considered pDDIs of clinical relevance, and thereafter the relevant factors were identified through uni-level and multi-level regression analyses. A total of 210 pDDIs were identified, 120 of which were considered clinically relevant (57.1%), affecting a total of 70 elderly (25.8%). Eight pharmacological groups made up 70.2% of the clinically relevant pDDIs. More clinically relevant DDIs were found in people suffering several pathologies (OR = 2.3; 95%CI = 1.4-4.5), and also in people who take ten or more drugs daily (OR = 9.6; 95%CI = 4.8-19.1), and people who take anti-inflammatory drugs (OR = 3.9; 95%CI = 1.4-10.4). This study reveals that clinically relevant pDDIs are very common in institutionalized elderly people, and that caregivers should aim at improving their practice in order to reduce the prevalence of this phenomenon.

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National cross-sectional study of nonsteroidal anti-inflammatory drugs use highlights differences between parents and professionals and prompts safety concerns

Acta Paediatrica ◽

10.1111/apa.13566 ◽

2016 ◽

Vol 105 (11) ◽

pp. e543-e548 ◽

Cited By ~ 2

Author(s):

Nathalie Bertille ◽

Gérard Pons ◽

Elisabeth Fournier-Charrière ◽

Babak Khoshnood ◽

Martin Chalumeau

Keyword(s):

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Safety Concerns ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Prevalence of non-steroidal anti-inflammatory drugs usage and assessment of knowledge related to its complications among Saudi population; a cross-sectional study

International Journal of Medicine in Developing Countries ◽

10.24911/ijmdc.51-1571228702 ◽

2020 ◽

pp. 296-302

Author(s):

Omar Asiri ◽

Asim Alzahrani ◽

Khalid Alshehri ◽

Othman Althomali ◽

Abdulmohsen Alameen ◽

...

Keyword(s):

Cross Sectional Study ◽

Saudi Population ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Non-Steroidal Anti-Inflammatory Drugs in Orthopedic Outpatient Cases in a Tertiary Care Teaching Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association ◽

10.31729/jnma.6767 ◽

2021 ◽

Vol 59 (243) ◽

pp. 1116-1119

Author(s):

Aashish Bhattarai ◽

Anna Acharya ◽

Krishna Raj Khanal

Keyword(s):

Confidence Interval ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Outpatient Department ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Drugs ◽

Anti Inflammatory

Introduction: Non-steroidal anti-inflammatory drugs are major drugs in treatment of pain and inflammation of different orthopedic conditions. There are different classes of non-steroidal anti-Inflammatory Drugs based on their selectivity to cyclooxygenase enzyme which has significant differences in safety profile. This study aims to determine the prevalence of non-steroidal anti-inflammatory drugs prescription in the orthopaedic outpatient department of a tertiary care hospital. Methods: This was a descriptive cross-sectional study conducted among the patients in the orthopedic outpatient department of tertiary care hospital from December 2020 to March 2021. Ethical approval was taken from the Institutional Review Committee of the college (Ref: 0311202007). Convenient sampling was done. A structured proforma was used with consent. The data were analyzed with Social Statistical Package for the Social Sciences version 20. Point estimate at 95% Confidence Interval was done and frequency and percentage were calculated. Results: Out of 140 orthopaedic out patient department prescriptions screened, 118 (84.28%) (78.25-90.30 at 95% Confidence Interval) prescriptions included non-steroidal anti-inflammatory drugs. Aceclofenac 76 (64.4%) was the most prescribed non-steroidal anti-inflammatory drug. Conclusions: Aceclofenac was the most preferred agent for the treatment in the department of orthopedics. The most common proton pump inhibitor used alone with non-steroidal anti-inflammatory drugs was rabeprazole.

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