Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring

2009 ◽  
Vol 5 (9) ◽  
pp. 1023-1038 ◽  
Author(s):  
Patrick Y Muller ◽  
Frank Dieterle
Keyword(s):  
Safety Assessment ◽  
Safety Monitoring ◽  
Clinical Safety ◽  
Tissue Specific ◽  
Non Invasive ◽  
Toxicity Biomarkers ◽  
Preclinical Safety

scholarly journals Preclinical safety assessment of a combined vaccine against Hepatitis a virus and enterovirus 71

Vaccine ◽  
2021 ◽  
Author(s):  
Ting Yang ◽  
Baofeng Liu ◽  
Lei Yue ◽  
Tianhong Xie ◽  
Hua Li ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Enterovirus 71 ◽  
Combined Vaccine ◽  
Preclinical Safety

Clinical Safety Assessment of an Ultra Absorbency Menstrual Tampon

2010 ◽  
Vol 19 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Anne E. Hochwalt ◽  
Michaelle B. Jones ◽  
Sandy J. Meyer
Keyword(s):  
Safety Assessment ◽  
Clinical Safety

Clinical safety assessment of iotrolan 280 in European clinical studies

1995 ◽  
Vol 5 (S2) ◽  
pp. S85-S88 ◽  
Author(s):  
O. M. Silvay-Mandeau ◽  
C. Meissner ◽  
B. I. Wenzel-Hora
Keyword(s):  
Clinical Studies ◽  
Safety Assessment ◽  
Clinical Safety

Preclinical safety assessment of aqueous medicinal plant extracts containing thujone

2018 ◽  
Vol 295 ◽  
pp. S236
Author(s):  
C. Turek ◽  
P. Molnar-Pfitzner ◽  
N. Mörbt ◽  
M.B. Müller ◽  
P. Vögele ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Plant Extracts ◽  
Safety Assessment ◽  
Medicinal Plant Extracts ◽  
Preclinical Safety

Confirmation of in vitro and clinical safety assessment of behentrimonium chloride-containing leave-on body lotions using post-marketing adverse event data

2013 ◽  
Vol 27 (8) ◽  
pp. 2203-2212 ◽  
Author(s):  
D.M. Cameron ◽  
D.A. Donahue ◽  
G.-E. Costin ◽  
L.E. Kaufman ◽  
J. Avalos ◽  
...  
Keyword(s):  
Adverse Event ◽  
Safety Assessment ◽  
Event Data ◽  
Clinical Safety ◽  
Adverse Event Data ◽  
Post Marketing

809: Non-invasive tissue-specific glucose uptake in pregnancy using the dual imaging of MRI and mPet

2014 ◽  
Vol 210 (1) ◽  
pp. S394
Author(s):  
Hye Heo ◽  
Yelena Kogelman ◽  
Wade Koba ◽  
Linda Jelicks ◽  
Kamalakar Ambadipudi ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Tissue Specific ◽  
Non Invasive ◽  
Dual Imaging ◽  
In Pregnancy

Enzymology in Preclinical Safety Evaluation

1992 ◽  
Vol 20 (3-2) ◽  
pp. 501-505 ◽  
Author(s):  
Dai T. Davies
Keyword(s):  
Enzyme Activities ◽  
Drug Effect ◽  
Safety Evaluation ◽  
Diagnostic Information ◽  
Maximum Amount ◽  
Adverse Drug Effect ◽  
Short Paper ◽  
Clinical Safety ◽  
Blood Samples ◽  
Preclinical Safety

This short paper will briefly discuss the merits of determining plasma enzyme activities in pre-clinical safety evaluation. Emphasis is placed on the value of selecting the appropriate enzymes and collecting blood samples at the appropriate times during the study, so as to gain the maximum amount of diagnostic information. Examples of actual results will be cited to illustrate some of the points. These examples are drawn from the 2 commonly used toxicology species—the laboratory white rat and the beagle—and serve to demonstrate the importance of enzymology in monitoring the progress or resolution of an adverse drug effect.

A non‐invasive tissue‐specific molecular delivery method of cancer gene therapy

2006 ◽  
Vol 15 (4) ◽  
pp. 226-229 ◽  
Author(s):  
Tetsuya Kodama ◽  
Atsuko Aoi ◽  
Georges Vassaux ◽  
Shiro Mori ◽  
Hidehiro Morikawa ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Delivery Method ◽  
Tissue Specific ◽  
Non Invasive ◽  
Molecular Delivery
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