BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

<div> <div> <div> <p>Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family protein degraders. </p> </div> </div> </div>

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Faculty Opinions recommendation of Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001461.4105 ◽

2001 ◽

Author(s):

Gary Koretzky

Keyword(s):

Lymphocyte Migration ◽

Haematopoietic Cell ◽

Family Protein

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Faculty Opinions recommendation of Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001461.13154 ◽

2001 ◽

Author(s):

Ed Manser

Keyword(s):

Lymphocyte Migration ◽

Haematopoietic Cell ◽

Family Protein

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Faculty Opinions recommendation of Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1010425.186122 ◽

2003 ◽

Author(s):

David Tarlinton

Keyword(s):

B Cell ◽

Tyrosine Kinases ◽

Essential Role ◽

Cell Development ◽

B Cell Development ◽

Protein Tyrosine Kinases ◽

Protein Tyrosine ◽

Family Protein ◽

Nf Kappab

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Faculty Opinions recommendation of The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1018570.215503 ◽

2004 ◽

Author(s):

Talila Volk

Keyword(s):

Negative Regulator ◽

Commissural Axons ◽

Midline Crossing ◽

Family Protein

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Faculty Opinions recommendation of The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1018799.324919 ◽

2005 ◽

Author(s):

Juergen Wendland

Keyword(s):

Candida Albicans ◽

Cell Polarity ◽

Hyphal Growth ◽

Family Protein

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Faculty Opinions recommendation of CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718113603.793484039 ◽

2013 ◽

Author(s):

John Cambier ◽

Thomas Packard

Keyword(s):

Tyrosine Kinase ◽

B Lymphocytes ◽

Protein Tyrosine Kinase ◽

Kinase Activation ◽

Protein Tyrosine ◽

Family Protein

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Faculty Opinions recommendation of An IcmF family protein, ImpLM, is an integral inner membrane protein interacting with ImpKL, and its walker a motif is required for type VI secretion system-mediated Hcp secretion in Agrobacterium tumefaciens.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718180335.793487063 ◽

2013 ◽

Author(s):

Alain Filloux

Keyword(s):

Agrobacterium Tumefaciens ◽

Membrane Protein ◽

Secretion System ◽

Type Vi Secretion System ◽

Inner Membrane ◽

Type Vi Secretion ◽

Family Protein ◽

Inner Membrane Protein

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Anticancer Agents Based on Vulnerable Components in a Signalling Pathway

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666200212105417 ◽

2020 ◽

Vol 20 (10) ◽

pp. 886-907 ◽

Cited By ~ 4

Author(s):

Ankur Vaidya ◽

Shweta Jain ◽

Sanjeev Sahu ◽

Pankaj Kumar Jain ◽

Kamla Pathak ◽

...

Keyword(s):

Anticancer Agents ◽

Dna Methyltransferase ◽

Leucine Zipper ◽

Molecular Mechanisms ◽

Resistance Mechanisms ◽

Sphingosine Kinase 2 ◽

Family Protein ◽

Rational Combination ◽

Protein Kinase Akt ◽

Parp 1

Traditional cancer treatment includes surgery, chemotherapy, radiotherapy and immunotherapy that are clinically beneficial, but are associated with drawbacks such as drug resistance and side effects. In quest for better treatment, many new molecular targets have been introduced in the last few decades. Finding new molecular mechanisms encourages researchers to discover new anticancer agents. Exploring the mechanism of action also facilitates anticipation of potential resistance mechanisms and optimization of rational combination therapies. The write up describes the leading molecular mechanisms for cancer therapy, including mTOR, tyrosine Wee1 kinase (WEE1), Janus kinases, PI3K/mTOR signaling pathway, serine/threonine protein kinase AKT, checkpoint kinase 1 (Chk1), maternal embryonic leucine-zipper kinase (MELK), DNA methyltransferase I (DNMT1), poly (ADP-ribose) polymerase (PARP)-1/-2, sphingosine kinase-2 (SK2), pan-FGFR, inhibitor of apoptosis (IAP), murine double minute 2 (MDM2), Bcl-2 family protein and reactive oxygen species 1 (ROS1). Additionally, the manuscript reviews the anticancer drugs currently under clinical trials.

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