EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX

Progress on Chemistry and application of Chitin and its Derivatives ◽

10.15259/pcacd.26.015 ◽

2021 ◽

Vol 26 ◽

pp. 170-177

Author(s):

Katarzyna Małolepsza-Jarmołowska ◽

Keyword(s):

Lactic Acid ◽

Rheological Properties ◽

Sodium Alginate ◽

Contact Time ◽

Experimental Studies ◽

Vaginal Mucosa

An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.

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PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

Progress on Chemistry and application of Chitin and its Derivatives ◽

10.15259/pcacd.23.13 ◽

2018 ◽

Vol XXIII ◽

pp. 130-139

Author(s):

Katarzyna Małolepsza-Jarmołowska

Keyword(s):

Lactic Acid ◽

Sodium Alginate ◽

Dynamic Viscosity ◽

Work Of Adhesion ◽

Application Site ◽

Vaginal Mucosa ◽

Physiological Conditions ◽

Prolonged Contact ◽

Wide Range ◽

The Impact

The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.

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Studying dispersed and rheological properties of hydrocarbon-containing acid emulsions and their efficiency in removing asphalt-resin-paraffin deposits

Oil and Gas Studies ◽

10.31660/0445-0108-2020-2-128-139 ◽

2020 ◽

pp. 128-139

Author(s):

M. Yu. Shumakher ◽

V. V. Konovalov ◽

A. P. Melnikov

Keyword(s):

Aqueous Solution ◽

Hydrochloric Acid ◽

Rheological Properties ◽

Reaction Rate ◽

Experimental Studies ◽

Efficient Removal ◽

Reservoir Properties ◽

Hydrocarbon Solvents ◽

Formation Zone ◽

Effect Of The Composition

Currently, the treatment of the bottomhole formation zone with acidic compositions is one of the most common methods to intensify the oil inflow. The use of various modified acid compositions increases the efficiency of acid treatments on the bottomhole formation zone. Acid compositions, including those containing hydrocarbon solvents, which contribute to more efficient removal of organic colmatants, affect the reaction rate of the reagent with the rock and processing equipment, change the reservoir properties, etc.The article presents the results of experimental studies, which are aimed at establishing the effect of the composition of hydrocarbon-containing acidic emulsions consisting of an aqueous solution of hydrochloric acid, toluene and Neonol AF 9-10 on their dispersed and rheological properties, as well as their efficiency in removing paraffin deposits.

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