scholarly journals Synchronization Of Autonomic Control Loops Of Blood Circulation In Patients With COVID-19

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Viktoriia V. Skazkina ◽  
Natalia S. Krasikova ◽  
Ekaterina I. Borovkova ◽  
Yurii M. Ishbulatov ◽  
Alexander Yu. Gorshkov ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Vascular Tone ◽  
Phase Synchronization ◽  
Viral Disease ◽  
Autonomic Control ◽  
Healthy Individuals ◽  
Control Loops ◽  
Average Value ◽  
Non Invasive ◽  
Screening Diagnostics

This study aims to investigate the strength of synchronization between the autonomic control loops of the cardiovascular system (CVS) in patients with COronaVIrus Disease 2019 (COVID-19). Methods — We calculated the total percent of phase synchronization index (S index) between the loops of autonomic control of heart rate and vascular tone in two sample groups: healthy individuals and COVID-19 patients. Results — The group-average value of the S index in COVID-19 patients is lower comparing to healthy individuals, the Mann-Whitney U-test confirmed that the differences are statistically significant. Conclusion — Obtained results suggest that the decreased value of the S index reflects the presence of a viral disease, and the S index is a promising basis for non-invasive screening diagnostics of viral diseases, particularly of COVID-19.

scholarly journals Analysis of coupling between autonomic control loops of blood circulation in patients with Covid-19

2021 ◽  
Author(s):  
Viktoriia Skazkina ◽  
Ekaterina Borovkova ◽  
Natalia Krasikova ◽  
Anton Kiselev ◽  
Alexander Gorshkov ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Autonomic Control ◽  
Control Loops

scholarly journals Increased Serum Levels of Activated Caspases in Murine and Human Biliary Atresia

2021 ◽  
Vol 10 (12) ◽  
pp. 2718
Author(s):  
Omid Madadi-Sanjani ◽  
Gunnar Bohlen ◽  
Fabian Wehrmann ◽  
Julia Andruszkow ◽  
Karim Khelif ◽  
...  
Keyword(s):  
Liver Injury ◽  
Biliary Atresia ◽  
Caspase 3 ◽  
Serum Levels ◽  
Healthy Individuals ◽  
Serological Detection ◽  
Caspase Activation ◽  
Hepatocyte Apoptosis ◽  
Non Invasive ◽  
Cholestatic Diseases

In biliary atresia (BA), apoptosis is part of the pathomechanism, which results in progressive liver fibrosis. There is increasing evidence suggesting that apoptotic liver injury can be non-invasively detected by measuring the caspase activity in the serum. The purpose of this study was to investigate whether serological detection of caspase activation mirrors apoptotic liver injury in the infective murine BA-model and represents a suitable biomarker for BA in humans. Analysis showed increased caspase-3 activity and apoptosis in the livers of cholestatic BALB/c mice, which correlated significantly with caspase activation in the serum. We then investigated caspase activation and apoptosis in liver tissues and sera from 26 BA patients, 23 age-matched healthy and 11 cholestatic newborns, due to other hepatopathies. Compared to healthy individuals, increased caspase activation in the liver samples of BA patients was present. Moreover, caspase-3 activity was significantly higher in sera from BA infants compared to patients with other cholestatic diseases (sensitivity 85%, specificity 91%). In conclusion, caspase activation and hepatocyte apoptosis play an important role in experimental and human BA. We demonstrated that serological detection of caspase activation represents a reliable non-invasive biomarker for monitoring disease activity in neonatal cholestatic liver diseases including BA.

Modification of real-time method for diagnostics of synchronization between the autonomic control loops

2021 ◽  
Author(s):  
Aleksander V. Kurbako ◽  
Danil D. Kulminsky ◽  
Ekaterina I. Borovkova ◽  
Anton R. Kiselev ◽  
Victoria V. Skazkina ◽  
...  
Keyword(s):  
Real Time ◽  
Autonomic Control ◽  
Control Loops

scholarly journals Introduction of a Portable and Non-invasive Technology for Hand and Foot Cooling: A Preclinical Feasibility Study

2021 ◽  
Author(s):  
Shirin Davarpanah Jazi ◽  
Johan Ralf ◽  
Mohammad FazelBakhsheshi
Keyword(s):  
Skin Temperature ◽  
Healthy Subjects ◽  
Cold Water ◽  
Healthy Individuals ◽  
Cooling Performance ◽  
Non Invasive ◽  
Reduced Dose ◽  
Before And After ◽  
Hands And Feet ◽  
Near Future

Abstract Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is caused by damage to neural structures in distal limbs. CIPN can lead to reduced dose or cessation of chemotherapy. Cooling the hands/feet has shown to be effective in reducing or preventing CIPN. However, when using ice bath or ice gloves/socks is no way to maintain the targeted temperature and prevent ice from melting. Also, patients have difficulty tolerating the freezing temperatures over long periods of chemotherapy. The aim of this study was to test the cooling performance of a recently developed non-invasive system that can ultimately replace current cooling methods.Methods: COOLPREVENT circulates cold water at tolerable temperatures into malleable gloves/socks. As well, COOLPREVENT does not require replacing of melted ice. We administered a cooling protocol via COOLPREVENT on three healthy subjects for 60 minutes. Immediately before and after cooling, skin temperature in the hands and feet were measured. Level of discomfort was also recorded during the cooling process.Results: Results showed that COOLPREVENT reduce skin temperature by 14.5±3.8°C and 10.7±1.7°C in the hands and feet, respectively within 60 minutes without significant discomfort.Conclusion: Although our study is limited by the small number of subjects and participation of healthy individuals, but we can conclude that COOLPREVENT can be a safe and appropriate method for hand and foot cooling. We hope that these preliminary findings can pave the way to designing clinical trials we plan to conduct in the near future.

scholarly journals Non-invasive measurement of fasciculation frequency demonstrates diagnostic accuracy in amyotrophic lateral sclerosis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Arina Tamborska ◽  
James Bashford ◽  
Aidan Wickham ◽  
Raquel Iniesta ◽  
Urooba Masood ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Confidence Interval ◽  
Biceps Brachii ◽  
Delayed Diagnosis ◽  
Area Under The Curve ◽  
Motor Neuropathy ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Lateral Sclerosis ◽  
Invasive Measurement

Abstract Delayed diagnosis of amyotrophic lateral sclerosis prevents early entry into clinical trials at a time when neuroprotective therapies would be most effective. Fasciculations are an early hallmark of amyotrophic lateral sclerosis, preceding muscle weakness and atrophy. To assess the potential diagnostic utility of fasciculations measured by high-density surface electromyography, we carried out 30-min biceps brachii recordings in 39 patients with amyotrophic lateral sclerosis, 7 patients with benign fasciculation syndrome, 1 patient with multifocal motor neuropathy and 17 healthy individuals. We employed the surface potential quantification engine to compute fasciculation frequency, fasciculation amplitude and inter-fasciculation interval. Inter-group comparison was assessed by Welch’s analysis of variance. Logistic regression, receiver operating characteristic curves and decision trees discerned the diagnostic performance of these measures. Fasciculation frequency, median fasciculation amplitude and proportion of inter-fasciculation intervals <100 ms showed significant differences between the groups. In the best-fit regression model, increasing fasciculation frequency and median fasciculation amplitude were independently associated with the diagnosis of amyotrophic lateral sclerosis. Fasciculation frequency was the single best measure predictive of the disease, with an area under the curve of 0.89 (95% confidence interval 0.81–0.98). The cut-off of more than 14 fasciculation potentials per minute achieved 80% sensitivity (95% confidence interval 63–90%) and 96% specificity (95% confidence interval 78–100%). In conclusion, non-invasive measurement of fasciculation frequency at a single time-point reliably distinguished amyotrophic lateral sclerosis from its mimicking conditions and healthy individuals, warranting further research into its diagnostic applications.

Neural network-based approach for the non-invasive diagnosis and classification of hepatotropic viral disease

2012 ◽  
Vol 6 (18) ◽  
pp. 3265-3273 ◽  
Author(s):  
S. Ansari ◽  
J. Ahmad ◽  
I. Shafi ◽  
S. Ismail Shah
Keyword(s):  
Neural Network ◽  
Viral Disease ◽  
Non Invasive ◽  
Diagnosis And Classification

scholarly journals New adrenergic baroreflex evaluation in Valsalva maneuver

2015 ◽  
Vol 42 (S1) ◽  
pp. S29-S29
Author(s):  
IS Palamarchuk ◽  
J Baker ◽  
K Kimpinski
Keyword(s):  
Internal Consistency ◽  
Baroreflex Sensitivity ◽  
Valsalva Maneuver ◽  
Current Approach ◽  
Invasive Technique ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Time Assessment

Background: Valsalva maneuver (VM) is a simple and non-invasive technique extensively utilized clinically to detect dysautonomia. VM provides detailed information of baroreflex sensitivity (BRS) which is an important cardiovascular and autonomic marker. However, the current approach for calculating its adrenergic component (BRSa1) is moderately reliable and fails to evaluate atypical VM patterns. Methods: We analyzed typical and atypical VM patterns of 89 young, healthy individuals (30 ±13 years) with the aim of improving BRSa evaluation. Objectives: 1) To determine a new BRSa calculation (BRSa2) applicable to different VM patterns; 2) correlate BRSa2 to BRSa1; 3) compare the internal consistency (ICC) between BRSa1 and BRSa2. Results: The BRSa2 calculation is a complex hemodynamic and time assessment equivalent to the slope in vagal BRS. In contrast to BRSa1, BRSa2 operates with hemodynamic indices easily detectable in any VM pattern. In atypical VM patterns, BRSa2 correlated with BRSa1: “flat-top responses” (r = 0.774, p < 0.01); rapid hemodynamic recovery (r = 0.461, p < 0.05). Most importantly, BRSa2 was more reliable than BRSa1 (ICC= 0.759 versus 0.469). Conclusion: BRSa2 is more reliable and allows atypical responses to VM to be analyzed, which clinically, could help differentiate natural physiological variances and mild adrenergic dysfunction.

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