scholarly journals Introduction of a Portable and Non-invasive Technology for Hand and Foot Cooling: A Preclinical Feasibility Study

2021 ◽  
Author(s):  
Shirin Davarpanah Jazi ◽  
Johan Ralf ◽  
Mohammad FazelBakhsheshi
Keyword(s):  
Skin Temperature ◽  
Healthy Subjects ◽  
Cold Water ◽  
Healthy Individuals ◽  
Cooling Performance ◽  
Non Invasive ◽  
Reduced Dose ◽  
Before And After ◽  
Hands And Feet ◽  
Near Future

Abstract Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is caused by damage to neural structures in distal limbs. CIPN can lead to reduced dose or cessation of chemotherapy. Cooling the hands/feet has shown to be effective in reducing or preventing CIPN. However, when using ice bath or ice gloves/socks is no way to maintain the targeted temperature and prevent ice from melting. Also, patients have difficulty tolerating the freezing temperatures over long periods of chemotherapy. The aim of this study was to test the cooling performance of a recently developed non-invasive system that can ultimately replace current cooling methods.Methods: COOLPREVENT circulates cold water at tolerable temperatures into malleable gloves/socks. As well, COOLPREVENT does not require replacing of melted ice. We administered a cooling protocol via COOLPREVENT on three healthy subjects for 60 minutes. Immediately before and after cooling, skin temperature in the hands and feet were measured. Level of discomfort was also recorded during the cooling process.Results: Results showed that COOLPREVENT reduce skin temperature by 14.5±3.8°C and 10.7±1.7°C in the hands and feet, respectively within 60 minutes without significant discomfort.Conclusion: Although our study is limited by the small number of subjects and participation of healthy individuals, but we can conclude that COOLPREVENT can be a safe and appropriate method for hand and foot cooling. We hope that these preliminary findings can pave the way to designing clinical trials we plan to conduct in the near future.

scholarly journals Introduction of a Portable and Non-Invasive Technology for Hand and Foot Cooling: a Preclinical Feasibility Study

2021 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Skin Temperature ◽  
Cold Water ◽  
Healthy Individuals ◽  
Cooling Process ◽  
Non Invasive ◽  
Before And After ◽  
Uniform Manner ◽  
Hands And Feet ◽  
Near Future ◽  
Cooling Methods

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is caused by damage to neural structures in distal limbs. CIPN can lead to reduced dose or cessation of chemotherapy. Cryotherapy has shown to be effective in reducing or preventing CIPN in the hands/feet. However, when using ice bath or ice gloves/socks there is no way to maintain the targeted temperature and prevent ice from melting. Also, patients have difficulty tolerating the freezing temperatures over long periods of chemotherapy. The aim of this study was to test the cooling performance of a recently developed non-invasive system that can ultimately replace current cooling methods. Materials and Methods: COOLPREVENT circulates cold water at tolerable temperatures into malleable gloves/socks that does not require replacing of melted ice. We administered a cooling protocol via COOLPREVENT on three healthy subjects for 60 minutes. Immediately before and after cooling, skin temperature in the hands and feet were measured. Level of discomfort was also recorded during the cooling process. Results: Results showed that COOLPREVENT reduces skin temperature by 14.5±3.8°C and 10.7±1.7°C in the hands and feet, respectively within 60 minutes without significant discomfort. Conclusion: Although our study is limited by the small number of subjects and participation of healthy individuals, but we can conclude that COOLPREVENT can be a safe and appropriate method for hand and foot cooling in a uniform manner. We hope that these preliminary findings can pave the way to designing clinical trials we plan to conduct in the near future.

Gadolinium-Dtpa-Enhanced MR Imaging in Asymptomatic Knees

1996 ◽  
Vol 37 (3P2) ◽  
pp. 877-882 ◽  
Author(s):  
T. Boegård ◽  
Å. Johansson ◽  
O. Rudling ◽  
I. Petersson ◽  
K. Forslind ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Knee Joint ◽  
Healthy Subjects ◽  
Knee Joints ◽  
Age Group ◽  
Healthy Individuals ◽  
Middle Aged ◽  
Gadolinium Dtpa ◽  
Contrast Enhanced ◽  
Before And After

Purpose: To evaluate the occurrence and extent of Gd-DTPA-enhanced synovial structures in asymptomatic knee joints of middle-aged healthy individuals. Material and Methods: MR imaging of the knee joint was performed in 10 healthy subjects aged 40–61 years. The study included a sagittal T1-weighted SE sequence before and after i.v. injection of 0.1 mmol Gd-DTPA/kg b.w. Results: Contrast-enhanced synovial structures were found in all knees. The extent of the synovial structures was usually not uniform within the examined joint. In the intercondylar fossa, the thickness of synovial structures was more often pronounced. In the suprapatellar recess, synovial thickness was constant and minimal. Conclusion: The presence and the varying extent and thickness of synovial structures in asymptomatic knees in middle-aged individuals must be considered in the evaluation of early and mild synovitis of the knee joint with Gd-enhanced MR imaging in this age group.

scholarly journals Facial Anti-Aging Treatments with Soft Peeling and Microneedling Technique

2021 ◽  
Vol 11 (13) ◽  
pp. 6068
Author(s):  
Roberto Amore ◽  
Fiorella Deriu ◽  
Andrea Sbarbati ◽  
Domenico Amuso ◽  
Massimo Vitale ◽  
...  
Keyword(s):  
Experimental Study ◽  
Healthy Subjects ◽  
Recovery Period ◽  
Single Session ◽  
Facial Aging ◽  
Non Invasive ◽  
Different Types ◽  
Before And After ◽  
The Face ◽  
Aesthetic Procedures

Background: The interest in maintaining a young and attractive appearance in an era with increasingly hectic rhythms has generated a pressing demand for effective aesthetic procedures with the shortest possible recovery period, stimulating the search for non-invasive, yet successful, solutions. The aim of this study was to evaluate the effectiveness of the combined soft peeling and MN technique on the various imperfections typical of facial aging. Methods: This multicentric uncontrolled experimental study recruited a population of healthy subjects of both sexes with advanced signs of photo- and chrono-aging. These subjects were provided with a single session of microneedling and peeling at the same time. Recruited subjects were re-evaluated 30 (±4) and 60 (±4) days after treatment by photographic comparison before and after treatment. The physicians evaluated the improvement of facial wrinkles according to the Wrinkle Assessment Scale of Lemperle. Forty-nine subjects completed the study and showed a significant improvement in wrinkles in all areas of the face. Results: There were no significant differences in the different subpopulations compared: males–females, Glogau 3–Glogau 4, smokers–non-smokers, phototypes 1–4, and check up at 30 days–control at 60 days. The adverse events manifested were localized edema in four cases (8.2%) lasting an average of 3–4 days, very fine crustiness in four cases (8.2%), transient post inflammatory dyschromia in two cases (4.1%) lasting 2–3 weeks, and herpetic reactivation in one case (2.0%). Conclusions: The study demonstrates the therapeutic efficacy of the combined needling-peeling treatment in different types of wrinkles.

Non-invasive assessment of left ventricular myocardial work in healthy subjects with echocardiography

2020 ◽  
Vol 1 (14) ◽  
pp. 45-52
Author(s):  
M. N. Alekhin ◽  
S. I. Ivanov ◽  
A. I. Stepanova
Keyword(s):  
Blood Pressure ◽  
Healthy Subjects ◽  
Global Longitudinal Strain ◽  
Negative Relationship ◽  
Left Ventricular ◽  
Healthy Individuals ◽  
Men And Women ◽  
Mean Values ◽  
Non Invasive ◽  
Constructive Work

Purpose: to evaluate the left ventricular (LV) echocardiographic indices of myocardial work using the LV pressure-strain loops method in healthy individuals.Material and methods. The study included 50 healthy subjects (28 men, mean age: 44 ± 14 years). The inclusion criteria were the absence of any cardiovascular diseases and diabetes mellitus. After calculating global longitudinal strain (GLS) from speckle-tracking Echo and inserting values of brachial artery cuff blood pressure (BP), the vendor-specific module constructed non-invasive LV pressure-strain loops. The following parameters were calculated: global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE).Results. The lowest values of GWI in men and women were 1382 mmHg% and 1821 mmHg%, the highest values were 2875 mmHg% and 2589 mmHg%, mean values were 2056 ± 326 mmHg% and 2109 ± 200 mmHg%, respectively. Mean values of GCW were 2292 ± 329 mmHg% in men and 2304 ± 211 mmHg% in women. The median and the highest value of GWW were 66 mmHg% and 313 mmHg% in men and 79,5 mmHg% and 172 mmHg% in women, respectively. The lowest value of GWE were 89% in men and 91% in women. GWI was significantly and naturally correlated only with systolic BP (r = 0,30, р = 0,03) and GLS (r = -0,72, р < 0,001). GCW was significantly correlated with systolic BP (r = 0,36, р = 0,01) and GLS (r = -0,72, р < 0,001) too, however, the negative relationship with the age of the patients was found (r = -0,27, р = 0,04). LV myocardial work indices did not significantly differ between men and women. Coefficients of variation for GWI, GCW and GWE did not exceed 10%, which is typical for good reproducible indices.Conclusion. The study presents values of the echocardiographic LV myocardial work indices, obtained with help of the LV pressure-strain loops method in healthy individuals. The natural correlation of LV myocardial work indices with strain and blood pressure was demonstrated, as well as a dependence on the age of the subjects and good reproducibility.

scholarly journals EFFECTS OF PROBIOTIC INTAKE ON INTESTINAL BIFIDOBACTERIA OF CELIAC PATIENTS

2017 ◽  
Vol 54 (2) ◽  
pp. 85-90 ◽  
Author(s):  
Flávia MARTINELLO ◽  
Camila Fontana ROMAN ◽  
Paula Alves de SOUZA
Keyword(s):  
Healthy Subjects ◽  
Daily Intake ◽  
Microscopic Analysis ◽  
Stool Culture ◽  
Healthy Individuals ◽  
Daily Consumption ◽  
Ph Values ◽  
Significant Difference ◽  
Before And After ◽  
Faecal Ph

ABSTRACT BACKGROUND Healthy individuals exhibit a significantly higher concentration of faecal bifidobacteria in comparison to celiac patients. Even though there are potential benefits in probiotic usage, they have been little explored as an adjunctive therapy in celiac disease. OBJECTIVE This study aimed at the comparison of faecal bifidobacteria concentration and pH among celiac patients and healthy subjects before and after the daily intake of 100 g of yogurt containing probiotic for a thirty-day period. METHODS Feces from 17 healthy subjects and 14 celiac patients were analyzed, in which stool culture was performed for the isolation and quantification of faecal bifidobacteria. Furthermore, Gram’s method was employed for the microscopic analysis of the colonies, while the identification of the Bifidobacterium genus was made through determination of the fructose-6-phosphate phosphoketolase enzyme. Faecal pH was measured using a calibrated pHmeter. RESULTS Faecal bifidobacteria concentration before probiotic consumption was significantly higher in healthy individuals (2.3x108±6.3x107 CFU/g) when compared to celiac patients (1.0x107±1.7x107 CFU/g). Faecal pH values did not show a significant difference. After the daily consumption of probiotic-containing yogurt both groups showed a significant increase in the concentration of faecal bifidobacteria, but healthy subjects presented significantly higher bifidobacteria concentrations (14.7x108±0.2x108 CFU/g) than the celiac group (0.76x108±0.1x108 CFU/g). The obtained pH values from both groups were not significantly different, being 7.28±0.518 for the celiac patients and 7.07±0.570 for healthy individuals after the probiotic intake. CONCLUSION The probiotic supplementation significantly increased the number of bifidobacteria in the feces of celiac patients, although it was not sufficient to reach the concentration found in healthy individuals prior to its consumption.

scholarly journals The study of the effects of 12 weeks of yoga training on respiratory pressures and 40 mm Hg test in healthy individuals

2020 ◽  
pp. 14-16
Author(s):  
Deepa HS
Keyword(s):  
Healthy Subjects ◽  
Inspiratory Pressure ◽  
Control Group ◽  
Healthy Individuals ◽  
Maximum Inspiratory Pressure ◽  
Before And After ◽  
Analysis Of Results ◽  
Pressure Maximum ◽  
Maximum Expiratory Pressure ◽  
Lifestyle Diseases

Background: Yogic exercises have been found to be beneficial for better maintenance of bodily functions even in normal healthy subjects. In view of this, present study was planned to evaluate the effect of Yoga on respiratory pressures and 40 mm Hg test in healthy individuals. Method: The present study included 80 healthy subjects (40 males, 40 females) of 30-40 years age group. Subjects fulfilling the inclusion and exclusion criteria attended a minimum of five Yoga classes per week for a period of twelve weeks. Age, height, weight & BMI of the subjects were recorded. The maximum expiratory pressure, maximum inspiratory pressure and 40 mm Hg test were analysed before & after twelve weeks of Yoga practice. The same subjects were chosen as both study as well as control group in order to minimize the confounding factors and make the study more reproducible. Student’s paired‘t’ test was used to compare the changes in parameters before and after Yoga training. Results: On analysis of results, there was highly significant (p<0.001) increase in maximum expiratory pressure, maximum inspiratory pressure and 40 mm Hg test after twelve weeks of Yoga practise. The response was similar in both the genders. Conclusion: Present study proved that regular practice of Yoga for minimum of 12 weeks is beneficial in improving respiratory pressures and 40 mm Hg test in normal healthy individuals and this improvement is appreciable in both genders. Results of the study would justify the incorporation of Yoga as part of our lifestyle in promoting health. Also Yoga can make an appreciable contribution to primary prevention and management of lifestyle diseases.

A Comparative Evaluation of Serum and Salivary Total Proteins and Immunoglobulins in Patients with Hepatitis A and Healthy Subjects

2018 ◽  
Vol 69 (5) ◽  
pp. 1125-1128
Author(s):  
Daniela G. Balan ◽  
Dan Piperea Sianu ◽  
Iulia I. Stanescu ◽  
Dorin Ionescu ◽  
Andra Elena Stroescu Balcangiu ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Comparative Evaluation ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Point Of View ◽  
Healthy Individuals ◽  
Total Proteins ◽  
Statistical Point ◽  
Immunological Tests ◽  
Acute Hepatitis A

Assessment of changes in total proteins level, serum and saliva IgG and IgA levels, serum IgM level, serum and saliva IgA/IgG ratio. The study was conducted on a group of 40 subjects, divided into 2 lots: the first lot consisting of 20 healthy individuals and the second consisting of 20 patients with hepatitis with hepatitis A virus (HAV). The levels of total proteins, serum and saliva IgG and IgA, serum IgM and serum and saliva IgA/IgG ratio have higher values in patients with hepatitis A, in comparison to healthy subjects, without necessarily exceeding the maximum admitted value. The results are significant from a statistical point of view. Due to the sensitivity and specificity of salivary anti-HAV IgM and IgG in patients with acute hepatitis A, compared with healthy subjects, there is a possibility of using salivary immunological tests instead of serum tests for the diagnosis and epidemiological study of HAV infection.

Comparison of the Aditus ad Antrum Diameter on CT between Patients with Chronic Otitis Media and Healthy Individuals

2019 ◽  
Vol 15 (10) ◽  
pp. 990-993 ◽  
Author(s):  
Elif Gündoğdu ◽  
Uğur Toprak
Keyword(s):  
Computed Tomography ◽  
Otitis Media ◽  
Middle Ear ◽  
Healthy Subjects ◽  
Normal Values ◽  
Chronic Otitis Media ◽  
Healthy Individuals ◽  
Inner Diameter ◽  
Male Patients ◽  
The Right

Background: The middle ear cavity is ventilated through the aditus ad antrum. Aditus blockage contributes to the pathology of otitis media. Objective: To determine the normal values of the aditus ad antrum diameter on computed tomography and to investigate its relationship with chronic otitis media and related pathologies (tympanosclerosis and myringosclerosis). Methods: The temporal CT images of 162 individuals were evaluated retrospectively. In the axial sections, the inner diameter of the aditus was measured at the narrowest point at the cortex. The differences in diameter were compared between diseased and healthy ears. Results: In healthy individuals, the diameter was narrower in women. There was no difference between the right and left ears in healthy subjects. No correlation was found between age and diameter. In male patients with myringosclerosis, the diameter was slightly narrower on both sides but more marked on the left. In female patients with myringosclerosis, the diameter in both ears was slightly narrower. In cases of otitis media and tympanosclerosis, the diameter was less than that of healthy individuals, despite the lack of statistically significant result in all cases. Conclusion: The aditus ad antrum was narrower in diseased ears, indicating that a blocked aditus may contribute to the development of otitis media, as well as mucosal diseases.

Prevalence of Toxoplasma gondii and Toxocara canis among Myositis Patients in Southwest of Iran

2019 ◽  
Vol 20 ◽  
Author(s):  
Jasem Saki ◽  
Karim Mowla ◽  
Reza Arjmand ◽  
Forough Kazemi ◽  
Somayeh Fallahizadeh
Keyword(s):  
Toxoplasma Gondii ◽  
Nested Pcr ◽  
Healthy Subjects ◽  
Toxocara Canis ◽  
Control Group ◽  
Igg Antibodies ◽  
Healthy Individuals ◽  
High Prevalence ◽  
Acute Toxoplasmosis ◽  
Southwest Of Iran

Introduction: Parasitic myositis is caused by some parasites such as T. gondii and T. canis. So, the aim of the study was to evaluate the prevalence T. gondii and T. canis in patients with myositis and healthy individuals. Methods: A total of 108 samples were randomly selected as the control (54 healthy individuals) and test (54 myositis patients) groups. IgG and IgM antibodies against T. gondii and IgG antibodies against T. canis were measured by the ELISA. The detection of chronic and acute toxoplasmosis was performed by the ELISA IgG avidity. The presence of T. gondii in blood was evaluated by the nested-PCR. Results: Of 108, 33 (30.6%) cases were detected positive for IgG against T. gondii that 19 (35.2%) and 14 (25.9%) were observed in myositis patients and healthy individuals, respectively (P=0.296). Of 19 positive cases, 12 (63.2%) and 7 (36.8%) cases were detected as chronic and acute toxoplasmosis, respectively, while, all positive cases in the control group had chronic toxoplasmosis (P=0.013). One (1.9%) sample was detected positive for anti- Toxoplasma gondii IgM and two (3.7%) samples were found positive for IgG against T. canis by the ELISA that these positive cases were observed only in myositis patients (P=1.000 P=0.495, respectively). B1 T. gondii gene was amplified in 12 (63.2%) and 1 (7.1%) in myositis patients and healthy subjects (P=0.001). Conclusions: Our findings showed that there was a relatively high prevalence of acute toxoplasmosis in myositis patients in comparison with the control subjects in southwest of Iran.

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