scholarly journals New adrenergic baroreflex evaluation in Valsalva maneuver

2015 ◽  
Vol 42 (S1) ◽  
pp. S29-S29
Author(s):  
IS Palamarchuk ◽  
J Baker ◽  
K Kimpinski
Keyword(s):  
Internal Consistency ◽  
Baroreflex Sensitivity ◽  
Valsalva Maneuver ◽  
Current Approach ◽  
Invasive Technique ◽  
Healthy Individuals ◽  
Non Invasive ◽  
Time Assessment

Background: Valsalva maneuver (VM) is a simple and non-invasive technique extensively utilized clinically to detect dysautonomia. VM provides detailed information of baroreflex sensitivity (BRS) which is an important cardiovascular and autonomic marker. However, the current approach for calculating its adrenergic component (BRSa1) is moderately reliable and fails to evaluate atypical VM patterns. Methods: We analyzed typical and atypical VM patterns of 89 young, healthy individuals (30 ±13 years) with the aim of improving BRSa evaluation. Objectives: 1) To determine a new BRSa calculation (BRSa2) applicable to different VM patterns; 2) correlate BRSa2 to BRSa1; 3) compare the internal consistency (ICC) between BRSa1 and BRSa2. Results: The BRSa2 calculation is a complex hemodynamic and time assessment equivalent to the slope in vagal BRS. In contrast to BRSa1, BRSa2 operates with hemodynamic indices easily detectable in any VM pattern. In atypical VM patterns, BRSa2 correlated with BRSa1: “flat-top responses” (r = 0.774, p < 0.01); rapid hemodynamic recovery (r = 0.461, p < 0.05). Most importantly, BRSa2 was more reliable than BRSa1 (ICC= 0.759 versus 0.469). Conclusion: BRSa2 is more reliable and allows atypical responses to VM to be analyzed, which clinically, could help differentiate natural physiological variances and mild adrenergic dysfunction.

Pelvic Congestion Syndrome: current approach and future diagnostic perspectives

2021 ◽  
Vol 20 (2) ◽  
pp. 258-262
Author(s):  
Corina Adelina Zah ◽  
Paul Grama
Keyword(s):  
Valsalva Maneuver ◽  
Standard Procedure ◽  
Medical Science ◽  
Current Approach ◽  
Pelvic Congestion Syndrome ◽  
Non Invasive ◽  
Current Trends ◽  
Golden Standard ◽  
Ultrasound Parameters ◽  
Pelvic Congestion

Objective: The aim of this review is to present the ways of approaching Pelvic Congestion Syndrome (PCS) and to emphasize on the current trends and problems of diagnosis. Background: PCS represents a cause of chronic pelvic pain, affecting mainly women and suspected frequently during pregnancies. It is underdiagnosed partly because patients do not tend to investigate their symptomatology, but also because of the invasive character of the golden standard procedure for diagnosis, venography. Treatment includes interventional, medical and surgical alternatives. Conclusions: Currently, ultrasound parameters are being assessed in order to replace venography, as it is usually performed in most patients in gynecology and most important it is non-invasive. Transvaginal approach, the use of Doppler mode and Valsalva maneuver, vein diameters can help orientate the diagnosis, pointing that US should have the potential to be used both as a screening test and diagnostic procedure in the future. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.258-262

USING DOPPLER TO ASSESS THE FETAL HEALTH FOR THE PREDICTION OF GESTATIONAL OUTCOME

2014 ◽  
pp. 9-18
Author(s):  
Thi Linh Giang Truong ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Umbilical Artery ◽  
Functional Method ◽  
Invasive Technique ◽  
Routine Practice ◽  
Fetal Health ◽  
Uterine Arteries ◽  
Non Invasive ◽  
Key Words Doppler

Background: Assessment of fetal health plays the most important role in prenatal care because of influence of the prediction of gestational outcome. One of the main aims of routine antenatal care is to identify the ‘ at risk ‘ fetus in order to apply clinical interventions which could results in reduced perinatal morbidity and mortality. Doppler ultrasound is a non invasive technique whereby the movement of blood is studied by detecting the change in frequence of reflected sound, Doppler blood flow velocity waves form of fetal side (umbilical artery, middle cerebral artery ...) and maternal side ( uterine arteries) are discussed and monograms for routine practice are presented. Recently this method is important tool for qualifying high risk pregnancies and help early forecasts the health of the babies and mothers disorder. Doppler sonography in obstetrics is a widely accepted functional method of examining the prediction of gestational outcome. Key words: Doppler, umbilical artery, middle cerebral artery, uterine arteries

CURRENT APPROACH ON CUTANEOUS MELANOMA DIAGNOSTICS

2019 ◽  
Vol 65 (5) ◽  
pp. 638-644
Author(s):  
Mariya Ebert ◽  
Georgiy Gafton ◽  
Grigoriy Zinovev ◽  
I. Gafton
Keyword(s):  
Physical Examination ◽  
Cutaneous Melanoma ◽  
Growth Dynamics ◽  
Current Approach ◽  
Clinical Diagnostics ◽  
Skin Tumors ◽  
Steady Increase ◽  
Non Invasive ◽  
Early Stages ◽  
Other Information

Melanoma is on the first place in mortality among all skin tumors. Over the past 50 years, there has been a steady increase in the incidence of cutaneous melanoma compared to other types of tumors. Rates of 5-year survival are fairly high, if melanoma is diagnosed in the early stages, which requires adequate diagnostics and treatment. Melanoma diagnostic, especially in the early stages, can be problematic even for an experienced dermatologist. However, primary contact doctor can be any specialty. Melanoma and other skin tumors can be detected by physical examination during treatment for another disease. Phenotypic risks factors, anamnestic data, and physical examination data are important in cutaneous melanoma diagnostics. The sensitivity of clinical diagnosis during a visual examination by an experienced dermatologist is approximately 70 percent. However, dermascopy can significantly increase the accuracy of a clinical diagnostics. In recent years there has been an active research for new non-invasive methods and algorithms for cutaneous melanoma diagnostics. The main goal of non-invasive diagnostics is to determine need for biopsy. This decision should be based on a combination of clinical and dermascopic examinations and other information, including growth dynamics, symptoms and medical history. Thus, an adequate diagnostic of cutaneous melanoma, including non-invasive and invasive methods, is a simple and economically viable way to early detection of cutaneous melanoma and to reduce mortality from this aggressive disease.

scholarly journals Increased Serum Levels of Activated Caspases in Murine and Human Biliary Atresia

2021 ◽  
Vol 10 (12) ◽  
pp. 2718
Author(s):  
Omid Madadi-Sanjani ◽  
Gunnar Bohlen ◽  
Fabian Wehrmann ◽  
Julia Andruszkow ◽  
Karim Khelif ◽  
...  
Keyword(s):  
Liver Injury ◽  
Biliary Atresia ◽  
Caspase 3 ◽  
Serum Levels ◽  
Healthy Individuals ◽  
Serological Detection ◽  
Caspase Activation ◽  
Hepatocyte Apoptosis ◽  
Non Invasive ◽  
Cholestatic Diseases

In biliary atresia (BA), apoptosis is part of the pathomechanism, which results in progressive liver fibrosis. There is increasing evidence suggesting that apoptotic liver injury can be non-invasively detected by measuring the caspase activity in the serum. The purpose of this study was to investigate whether serological detection of caspase activation mirrors apoptotic liver injury in the infective murine BA-model and represents a suitable biomarker for BA in humans. Analysis showed increased caspase-3 activity and apoptosis in the livers of cholestatic BALB/c mice, which correlated significantly with caspase activation in the serum. We then investigated caspase activation and apoptosis in liver tissues and sera from 26 BA patients, 23 age-matched healthy and 11 cholestatic newborns, due to other hepatopathies. Compared to healthy individuals, increased caspase activation in the liver samples of BA patients was present. Moreover, caspase-3 activity was significantly higher in sera from BA infants compared to patients with other cholestatic diseases (sensitivity 85%, specificity 91%). In conclusion, caspase activation and hepatocyte apoptosis play an important role in experimental and human BA. We demonstrated that serological detection of caspase activation represents a reliable non-invasive biomarker for monitoring disease activity in neonatal cholestatic liver diseases including BA.

scholarly journals Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis

2020 ◽  
Vol 11 (1) ◽  
pp. 25
Author(s):  
Sonia Hermoso-Durán ◽  
Guillermo García-Rayado ◽  
Laura Ceballos-Laita ◽  
Carlos Sostres ◽  
Sonia Vega ◽  
...  
Keyword(s):  
Liquid Biopsy ◽  
Pancreatic Cyst ◽  
Point Of View ◽  
Invasive Technique ◽  
Background Current ◽  
Interesting Point ◽  
Pancreatic Lesion ◽  
Non Invasive ◽  
Patient Diagnosis ◽  
New Biomarkers

Background: Current efforts in the identification of new biomarkers are directed towards an accurate differentiation between benign and premalignant cysts. Thermal Liquid Biopsy (TLB) has been previously applied to inflammatory and tumor diseases and could offer an interesting point of view in this type of pathology. Methods: In this work, twenty patients (12 males and 8 females, average ages 62) diagnosed with a pancreatic cyst benign (10) and premalignant (10) cyst lesions were recruited, and biological samples were obtained during the endoscopic ultrasonography procedure. Results: Proteomic content of cyst liquid samples was studied and several common proteins in the different groups were identified. TLB cyst liquid profiles reflected protein content. Also, TLB serum score was able to discriminate between healthy and cysts patients (71% sensitivity and 98% specificity) and between benign and premalignant cysts (75% sensitivity and 67% specificity). Conclusions: TLB analysis of plasmatic serum sample, a quick, simple and non-invasive technique that can be easily implemented, reports valuable information on the observed pancreatic lesion. These preliminary results set the basis for a larger study to refine TLB serum score and move closer to the clinical application of TLB providing useful information to the gastroenterologist during patient diagnosis.

278 Assessing effects of lateral tilt on cardiac output using a Non-invasive technique

2021 ◽  
Vol 224 (2) ◽  
pp. S182-S183
Author(s):  
Zaid Diken ◽  
Antonio F. Saad ◽  
Sema Hajmurad ◽  
Rakesh Vadhera ◽  
Michelle Simon ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Invasive Technique ◽  
Lateral Tilt ◽  
Non Invasive

Non-invasive methods in the assessment of portal hypertension severity

2021 ◽  
Vol 75 (2) ◽  
pp. 125-133
Author(s):  
Soňa Franková ◽  
Jan Šperl
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Transient Elastography ◽  
Venous Pressure ◽  
Liver Stiffness ◽  
Invasive Technique ◽  
Hepatic Veins ◽  
Oesophageal Varices ◽  
Non Invasive

Portal hypertension represents a wide spectrum of complications of chronic liver diseases and may present by ascites, oesophageal varices, splenomegaly, hypersplenism, hepatorenal and hepatopulmonary syndrome or portopulmonary hypertension. Portal hypertension and its severity predicts the patient‘s prognosis: as an invasive technique, the portosystemic gradient (HPVG – hepatic venous pressure gradient) measurement by hepatic veins catheterisation has remained the gold standard of its assessment. A reliable, non-invasive method to assess the severity of portal hypertension is of paramount importance; the patients with clinically significant portal hypertension have a high risk of variceal bleeding and higher mortality. Recently, non-invasive methods enabling the assessment of liver stiffness have been introduced into clinical practice in hepatology. Not only may these methods substitute for liver biopsy, but they may also be used to assess the degree of liver fibrosis and predict the severity of portal hypertension. Nowadays, we can use the quantitative elastography (transient elastography, point shear-wave elastrography, 2D-shear-wave elastography) or magnetic resonance imaging. We may also assess the severity of portal hypertension based on the non-invasive markers of liver fibrosis (i.e. ELF test) or estimate clinically signifi cant portal hypertension using composite scores (LSPS – liver spleen stiff ness score), based on liver stiffness value, spleen diameter and platelet count. Spleen stiffness measurement is a new method that needs further prospective studies. The review describes current possibilities of the non-invasive assessment of portal hypertension and its severity.

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