ANTIOESTROGENIC ACTIVITY IN FAHLI CLOVER HAY AND OAT HAY

1965 ◽  
Vol 49 (1) ◽  
pp. 90-96 ◽  
Author(s):  
J. H. Adler
Keyword(s):  
Plant Extracts ◽  
Avena Sativa ◽  
Inhibitory Activity ◽  
Weight Increase ◽  
Trifolium Alexandrinum ◽  
Uterine Weight ◽  
Extraction Procedures ◽  
Fodder Plants

ABSTRACT The presence of oestrogen inhibitory activity in oat hay (Avena sativa) and Fahli clover hay (Trifolium alexandrinum var. Fahli) has been established. The antioestrogenic effect was demonstrated by the inhibition of uterine weight increase in rats (Astwood test) in response to oestradiol injected together with the above mentioned plant extracts. The extraction procedures are described in detail and the possible biological implications of antioestrogenic and oestrogenic activity in fodder plants is discussed.

Natürliche Hemmstoffe von Keimung und Wachstum, I Ausarbeitung eines quantitativen Biotests und Anwendung auf Extrakte aus Spelzen von Avena sativa L. / Natural Inhibitors of Germination and Growth, I. Development of a Quantitative Biotest and Application upon Extracts from Husks of Avena sativa L.

1982 ◽  
Vol 37 (9) ◽  
pp. 793-801 ◽  
Author(s):  
Rudolf Karl ◽  
Wolfhart Rüdiger
Keyword(s):  
Abscisic Acid ◽  
Root Growth ◽  
Organic Acids ◽  
Avena Sativa ◽  
Inhibitory Activity ◽  
Lepidium Sativum ◽  
Carbonic Acids ◽  
Germination And Growth ◽  
Natural Inhibitors ◽  
Lepidium Sativum L

Extracts from oat husks inhibit germination of a variety of seeds including Avena sativa L., Sorghum spec., Phalleris spec., Raphanus spec., Amaranthus caudatus, Lepidium sativum L. A quantitative assay for this inhibition was developed on the basis of percentage of root growth of Avena in the presence of extracted material compared with root growth of water controls. Fractionation of the extracts revealed that about half of the total inhibitory activity was found in the fraction of free organic acids. The inhibition was not due to known inhibitors. Abscisic acid. was not found in this extract. Phenole carbonic acids were determined in the extract. Their con­centration was too low to significantly contribute to the observed inhibitory activity.

Angiotensin-I Converting Enzyme Inhibitory Activity of Hydrolysates from Oat (Avena sativa) Proteins byIn SilicoandIn VitroAnalyses

2009 ◽  
Vol 57 (19) ◽  
pp. 9234-9242 ◽  
Author(s):  
Imelda W. Y. Cheung ◽  
Satoko Nakayama ◽  
Monica N. K. Hsu ◽  
Anusha G. P. Samaranayaka ◽  
Eunice C. Y. Li-Chan
Keyword(s):  
Avena Sativa ◽  
Inhibitory Activity ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme

Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay

2003 ◽  
Vol 14 (3) ◽  
pp. 145-149 ◽  
Author(s):  
In Kyung Rhee ◽  
Natalie Appels ◽  
Teus Luijendijk ◽  
Hubertus Irth ◽  
Robert Verpoorte
Keyword(s):  
Plant Extracts ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Inhibitory Activity

scholarly journals Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts

2009 ◽  
Vol 2 (4) ◽  
pp. 245-249 ◽  
Author(s):  
Eun-Jin Yang ◽  
Eun-Young Yim ◽  
Gwanpil Song ◽  
Gi-Ok Kim ◽  
Chang-Gu Hyun
Keyword(s):  
Nitric Oxide ◽  
Plant Extracts ◽  
Inhibitory Activity ◽  
Inflammatory Diseases ◽  
No Production ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Raw 264.7 Macrophages ◽  
Oxide Production ◽  
Potent Inhibition

Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extractsNitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed during septic shock and inflammation. Thus, inhibitors of iNOS may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. In this study, we prepared alcoholic extracts of Jeju plants and screened them for their inhibitory activity against NO production in lipopolysaccharide (LPS)-activated macrophages. Among the 260 kinds of plant extract tested, 122 extracts showed potent inhibitory activity towards NO production by more than 25% at a concentration of 100 μg/mL. Plants such asMalus sieboldii, Vaccinium oldhamii, Corylus hallaisanensis, Carpinus laxiflora, Styrax obassia, andSecurinega suffruticosashowed the most potent inhibition (above 70%) at a concentration of 100 μg/mL. The cytotoxic effects of the plant extracts were determined by colorimetric MTT assays and most plant extracts exhibited only moderate cytotoxicity at 100 μg/mL. Therefore, these plants should be considered promising candidates for the further purification of bioactive compounds and would be useful for the treatment of inflammatory diseases accompanying overproduction of NO.

BIOLOGICAL EFFECTS OF HUMAN URINARY FOLLICLE STIMULATING HORMONE

1970 ◽  
Vol 63 (3) ◽  
pp. 454-475 ◽  
Author(s):  
P. Petrusz ◽  
C. Robyn ◽  
E. Diczfalusy
Keyword(s):  
Biological Effects ◽  
Follicle Stimulating Hormone ◽  
Interstitial Cells ◽  
Female Rats ◽  
Male Rats ◽  
Weight Increase ◽  
Uterine Weight ◽  
Immature Female ◽  
Ovarian Weight ◽  
Female Mice

ABSTRACT The biological effects of human follicle stimulating hormone (FSH) preparations were studied in intact immature female mice and in hypophysectomized immature female and male rats, following the complete neutralization of the luteinizing hormone (LH) content of human urinary menopausal gonadotrophin (HMG) preparations having – prior to neutralization – FSH:LH ratios ranging between 1.0 and 500.0. Neutralization of LH was achieved by the addition of rabbit anti-human chorionic gonadotrophin (HCG) sera of known anti-LH potency. The amount of anti-LH employed was 1.5 to 730 times more than that required for 100% neutralization. In intact immature female mice, such »LH-free« FSH preparations induced an increased ovarian weight, follicle stimulation, as well as a uterine weight increase. In immature hypophysectomized female rats, »LH-free« FSH preparations induced ovarian weight increase, growth and maturation of the Graafian follicles without repair of the deficient interstitial cells and without any signs of luteinization. These ovarian changes were associated with an increase in uterine weight and with vaginal cornification. In view of these data, it is concluded that human urinary FSH per se is capable of inducing oestrogen synthesis in hypophysectomized female rats. In immature hypophysectomized male rats, »LH-free« FSH preparations induced testicular enlargement without any stimulation of the testicular interstitial cells and without any growth of the ventral prostate and seminal vesicles. The same effects were obtained following a prolonged administration (3 weeks); spermiogenesis was stimulated, but no mature spermatozoa were found.

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