THE EFFECTS OF ACTH AND HCG ON THE URINARY EXCRETION OF TESTOSTERONE IN MALE PATIENTS WITH VARIOUS ENDOCRINE DISORDERS

1966 ◽  
Vol 53 (1) ◽  
pp. 61-72 ◽  
Author(s):  
J. Tamm ◽  
M. Apostolakis ◽  
K. D. Voigt
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Normal Subjects ◽  
Normal Adult ◽  
Endocrine Disorders ◽  
List Type ◽  
Adult Males ◽  
Male Patients ◽  
Secondary Hypogonadism

ABSTRACT The effects of HCG and/or ACTH administration have been investigated in 2 normal subjects and in 12 male patients suffering from various endocrinopathies. It was found that: In normal adult males 3000 IU HCG given daily over three days appear to be sufficient to obtain a significant increase in urinary testosterone excretion. The degree of the increase appears to be dependent on the age of the patient. Prolonged HCG administration in secondary hypogonadism can lead to significant sustained increases of testosterone and epitestosterone excretions. Endogenous HCG of the type produced by chorionepitheliomas does not necessarily have an effect on testosterone and epitestosterone production in male patients. HCG stimulates the testosterone and epitestosterone secretion of the testes only; it thus has no effect on orchiectomized patients. Exogenous ACTH increases the testosterone and epitestosterone production of the adrenal cortex, the latter apparently more than the former; the testosterone/epitestosterone quotient in the urine falls. In orchiectomized patients ACTH administration leads to an increase of oestrogen production from the adrenal cortex and of oestriol excretion in the urine.

THE INFLUENCE OF 17α-METHYL-19-NORTESTOSTERONE ON THE ENDOCRINE FUNCTION OF THE ADRENAL CORTEX

1960 ◽  
Vol XXXIII (III) ◽  
pp. 388-400 ◽  
Author(s):  
L. G. Huis in 't Veld ◽  
B. Louwerens ◽  
P. A. F. van der Spek
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Direct Effect ◽  
Chorionic Gonadotrophin ◽  
Endocrine Function ◽  
List Type ◽  
Prolonged Administration ◽  
Acth Secretion ◽  
Male Patients ◽  
Normal Males

ABSTRACT In two male patients and two castrated males, the influence of corticotrophin (ACTH) on the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period in which patients were treated with 5 mg 17α-methyl-19-nortestosterone (MNT) daily. In two castrated males, moreover, the influence of chorionic gonadotrophin and ACTH + chorionic gonadotrophin on the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period of treatment with 5 mg MNT daily. Prolonged administration of MNT causes a decrease in the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids both in the normal males and in the male castrates. ACTH caused an increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids before and during MNT administration. During MNT administration this increase (expressed in mg/24 hours) was ≤ the increase produced by the same dose of ACTH prior to MNT administration. In two male castrates treated with MNT, chorionic gonadotrophin caused no increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids. The effect obtained before and during MNT administration by administration of ACTH + chorionic gonadotrophin did not exceed the effect obtained by the same dose of ACTH alone. Our conclusion is that the effect of MNT on the excretion of adrenocortical steroids is not due to the inhibition of the ACTH secretion. The possibility of a direct effect of MNT on the adrenal cortex has not been excluded with complete certainty. A change in the corticosteroid metabolism due to the influence of MNT, however, must also be taken into consideration.

scholarly journals Urinary Excretion of Erythropoietin in Normal Men and Women

Blood ◽  
1966 ◽  
Vol 28 (3) ◽  
pp. 344-353 ◽  
Author(s):  
RAYMOND ALEXANIAN ◽  
Brenda Prewitt
Keyword(s):  
Urinary Excretion ◽  
Dose Response ◽  
Normal Subjects ◽  
Adult Males ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Men And Women ◽  
Linear Dose ◽  
Prepubertal Boys ◽  
Normal Men

Abstract The bioassay of erythropoietin in polycythemic mice was modified to include a protein-depletion diet and a divided erythropoietin injection schedule. Although less than 0.05 unit of standard erythropoietin was not detected, a more linear dose/response relationship resulted from increasing doses of erythropoietin in the 0.1 to 1.0 unit range. The amount of erythropoietin in concentrated specimens prepared from the 24-hour urinary excretion of 25 normal subjects was measured in comparison with known quantities of standard erythropoietin. A mean daily erythropoietin excretion in men of 2.8 ± 1.3 units, in women of 0.9 ± 0.4 unit and in prepubertal boys of 1.0 unit was calculated. The higher erythropoietin excretion in adult males may be secondary to a greater production of erythropoietin in this sex.

THE URINARY EXCRETION OF 3α,17α,21-TRIHYDROXY-5β-PREGNAN-20-ONE (TETRAHYDRO S) FOLLOWING ADMINISTRATION OF CORTICOTROPHIN AND METOPIRONE (CIBA SU 4885)

1962 ◽  
Vol 40 (3) ◽  
pp. 375-386 ◽  
Author(s):  
Nils Norman
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Normal Subjects ◽  
Relative Increase ◽  
Endocrine Disorders ◽  
Adrenocorticotrophic Hormone ◽  
Acth Stimulation ◽  
Adrenogenital Syndrome ◽  
Endocrine Disorder ◽  
Simultaneous Measurements

ABSTRACT The results of simultaneous measurements of urinary 17-ketogenic steroids and 3α,17α,21-trihydroxy-5β-pregnan-20-one (tetrahydro S) are reported from patients without any endocrine disorders following administration for 3 days of adrenocorticotrophic hormone (ACTH) (15 patients) and oral administration of Metopirone (9 patients). The data obtained are compared with similar determinations performed in 2 patients with Cushing's syndrome, 1 patient with adrenogenital syndrome, 4 patients with hirsutism, 6 patients with suspected pituitary failure and 2 patients with absence of pituitary function. In the patients with no endocrine disorder, tetrahydro S increases fourfold on ACTH stimulation, and almost 60 times following Metopirone administration. The very magnitude of the relative increase in tetrahydro S excretion in normal subjects given Metopirone allows a better gradation of subnormal responses of pituitary ACTH than can be obtained when the effect of the test is judged by the excretion of 17-ketogenic steroids alone. Examples illustrating this are presented in the paper.

URINARY EXCRETION OF 17-DEOXYCORTICOSTEROIDS BY MAN

1964 ◽  
Vol 29 (3) ◽  
pp. 293-302 ◽  
Author(s):  
D. EXLEY ◽  
J. K. NORYMBERSKI
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Healthy Adults ◽  
Normal Adult

SUMMARY Determinations of urinary 17-deoxycorticosteroids (17H-CS) and, in most instances, the concurrent determination of 17-hydroxycorticosteroids (17OH-CS) led to the following findings. 1. Healthy adults excreted 17H-CS at the rate of 3·4 ± 1·0 mg./24 hr. (mean ± s.d.) with a ratio of 17OH-CS to 17H-CS of 2·8 ± 0·6. 2. The assay of urinary 17H-CS accounted for 14–19% of the corticosterone acetate given orally to an Addisonian patient. 3. Stimulation or suppression of the adrenal cortex gave rise to changes in the excretion of 17H-CS closely paralleling those of 17OH-CS. 4. During the course of pregnancy the excretion of 17H-CS rose more steeply than that of 17OH-CS with the ratio of the latter to the former falling to 0·5–1·2 during the last two trimesters. 5. In children aged 1–12 days, the 17OH-CS: 17-H-CS ratio was 0·3 ± 0·1. In the sole case investigated, this ratio remained essentially unchanged until the age of 2 months; it rose from the 3rd month and attained a normal adult value at the age of 5 months.

THE EFFECT OF THE 11β-HYDROXYLASE BLOCKING SUBSTANCE, SU-4885, ON THE URINARY EXCRETION OF 17-HYDROXYCORTICOSTEROIDS AND OF MELANOCYTE STIMULATING HORMONE-LIKE ACTIVITY

1962 ◽  
Vol 39 (2) ◽  
pp. 253-261 ◽  
Author(s):  
T. Akinci ◽  
M. Apostolakis ◽  
J. Tamm
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Sharp Increase ◽  
Normal Male ◽  
List Type ◽  
Dosage Range ◽  
Melanocyte Stimulating Hormone ◽  
Male Subjects ◽  
Stimulating Hormone

ABSTRACT 1. The effect of an 11β-hydroxylase inhibiting substance (SU–4885) on the urinary excretion of 17-OHCS and MSH-like activity was studied in ten normal male subjects. SU-4885 was administered both orally and intravenously in a dosage range varying from 3 to 16 g. 2. A sharp increase of free and of low polar conjugated 17-OHCS excretion was noted in every case. The 17-OHCS of higher polarity showed no consistent changes. 3. An evident increase in MSH-like activity in urine was found in only 2 subjects. A doubtful effect was present in 3 other cases. 4. It is suggested that there is no exact parallelism between ACTH and MSH response to an inhibition of cortisol biosynthesis in the adrenal cortex.

Characterization of Tamm-Horsfall Urinary Glycoprotein

1973 ◽  
Vol 31 ◽  
pp. 420-421
Author(s):  
John P. Robinson ◽  
J. David Puett
Keyword(s):  
Electron Microscopy ◽  
Circular Dichroism ◽  
Secondary Structure ◽  
Quaternary Structure ◽  
Normal Adult ◽  
Morphological Properties ◽  
Adult Males ◽  
Circular Dichroïsm ◽  
Urinary Glycoprotein

Much work has been reported on the chemical, physical and morphological properties of urinary Tamm-Horsfall glycoprotein (THG). Although it was once reported that cystic fibrotic (CF) individuals had a defective THG, more recent data indicate that THG and CF-THG are similar if not identical.No studies on the conformational aspects have been reported on this glycoprotein using circular dichroism (CD). We examined the secondary structure of THG and derivatives under various conditions and have correlated these results with quaternary structure using electron microscopy.THG was prepared from normal adult males and CF-THG from a 16-year old CF female by the method of Tamm and Horsfall. CF female by the method of Tamm and Horsfall.

ON THE VALUE OF SOME PARAMETERS OF ADRENOCORTICAL GLUCOCORTICOID FUNCTION

1963 ◽  
Vol 44 (4) ◽  
pp. 499-504 ◽  
Author(s):  
M. Van Der Straeten ◽  
A. Vermeulen ◽  
N. Orie ◽  
P. Regniers
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Isotope Dilution ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Steroid Excretion ◽  
Colorimetric Methods

ABSTRACT The authors studied the correlation between cortisol production, as measured by an isotope dilution method, and the urinary excretion of total and free Porter-Silber chromogens, as well as of 17-ketogenic steroids. Although a significant correlation exists between total Porter-Silber chromogens, 17-ketogenic steroid excretion and cortisol production, discrepancies are occasionally observed. Hence, different colorimetric methods should be used to assess the glucocorticoid activity of the adrenal cortex.

ÉTUDES IN VIVO SUR LE MÉTABOLISME DES ANDROGÉNES APRES ADMINISTRATION DE STÉROÏDES INHIBITEURS DE L'OVULATION

1965 ◽  
Vol 50 (1) ◽  
pp. 131-144 ◽  
Author(s):  
P. Mauvais-Jarvis ◽  
M. F. Jayle ◽  
J. Decourt ◽  
J. Louchart ◽  
J. Truffert
Keyword(s):  
Luteinizing Hormone ◽  
Urinary Excretion ◽  
Normal Subjects ◽  
Hormone Activity ◽  
Testosterone Production ◽  
Normal Men ◽  
Ethinyl Oestradiol

ABSTRACT Normal subjects and hirsute women with micropolycystic ovaries were treated with ethinyl-oestrenol + 3-methoxy-ethinyl-oestradiol (Lyndiol®), in view of studying the action of this compound on the production of androgens and on the urinary excretion of their metabolites. In normal men, the production of testosterone and the excretion of androsterone and aetiocholanolone are suppressed, whereas the excretion of other 17-ketosteroids and the production of dehydroepiandrosterone sulphate are unchanged. Moreover, the luteinizing hormone activity (LH) in plasma is depressed. It seems that the preparation inhibits specifically the testicular androgen production, by suppressing the hypothalamo-hypophyseal control of LH. Testosterone production and urinary 17-ketosteroid excretion are modified in the same way in women with Stein-Leventhal's syndrome. Physiopathological and therapeutical implications which come from these results are discussed.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

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