EFFECT OF EXOGENOUS THYROXINE ON 3H-THYMIDINE UPTAKE IN MOUSE PITUITARY GLAND
Keyword(s):
ABSTRACT Destruction of the thyroid gland in the mouse induces proliferation of pituitary thyrotropes. This phenomenon was studied quantitatively with 3H-thymidine, before and after oral administration of thyroxine. The frequency of radioactive cells in the intact animal is 3.4 per 10 000 pituitary cells. This value rises to 19.6, 18.4 and 56.0 four, eight, and twelve months after thyroidectomy, respectively. All these increased values are brought back to normal levels after 5 to 10 days of thyroxine treatment. Thus, the intense proliferation of pituitary thyrotropes following thyroidectomy is still responsive to the homeostatic action of thyroxine.
Improved immunolabelling of ultrathin cryosections using antibody conjugated with 1nm gold particles
1990 ◽
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pp. 928-929
1982 ◽
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pp. 10128-10135
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1930 ◽
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2009 ◽
Vol 1152
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pp. 165-173
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