DEXAMETHASONE OR PROPRANOLOL BLOCKADE OF INDUCED INCREASE IN PLASMA PROGESTERONE IN EARLY HUMAN PREGNANCY
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ABSTRACT Following continuous intravenous infusion of vasopressin or theophyllamine during the first trimester of human pregnancy, a marked increase in the peripheral plasma progesterone levels was observed. By simultaneous administration of propranolol the vasopressin effect was blocked, but not that of theophyllamine. When dexamethasone was infused, the incremental response of both vasopressin and theophyllamine was blocked or reduced. The present results may indicate that propranolol exerts its inhibitory effect on the steroidogenesis at the β-adrenergic receptor sites. Dexamethasone, on the other hand, seems to act distal to the β-receptors probably by direct interference with steroidogenesis.
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1975 ◽
Vol 54
(1)
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pp. 57-63
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1978 ◽
Vol 30
(4)
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pp. 398-402
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Keyword(s):
1971 ◽
Vol 110
(5)
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pp. 630-632
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