VASOPRESSIN-INDUCED INCREASE IN PERIPHERAL PLASMA PROGESTERONE LEVELS DURING EARLY HUMAN PREGNANCY

1971 ◽  
Vol 66 (2) ◽  
pp. 273-282 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Adenosine Monophosphate ◽  
First Trimester ◽  
Progesterone Level ◽  
Control Group ◽  
Moderate Increase ◽  
Slight Effect ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Dose Dependent ◽  
Early Human

ABSTRACT Vasopressin, adrenaline and theophyllamine infusions administered to pregnant women in the first trimester had a marked stimulating effect on the progesterone* level of peripheral plasma. The effect was dose-dependent within the range tested, and the vasopressin effect was potentiated when theophyllamine was added to the infusion medium. Vasopressin infusion, however, had no effect on the human chorionic gonadotrophin (HCG) level in peripheral blood. Oxytocin had only a slight effect on the progesterone levels as compared with a control group receiving only saline infusion. 3′,5′-adenosine monophosphate (cyclic AMP) infusion given over a period of 40 minutes (0.4 mg/kg/min) to one pregnant woman resulted in a moderate increase in the progesterone level.

PROPRANOLOL-BLOCKADE OF VASOPRESSIN INDUCED INCREASE IN PLASMA PROGESTERONE IN EARLY HUMAN PREGNANCY

1971 ◽  
Vol 66 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Cyclic Amp ◽  
Uterine Cervix ◽  
Adenosine Monophosphate ◽  
First Trimester ◽  
Blocking Agent ◽  
Simultaneous Administration ◽  
Plasma Progesterone ◽  
Human Pregnancy ◽  
Peripheral Plasma ◽  
Early Human

ABSTRACT Following continuous dilation of the uterine cervix or intravenous infusion of vasopressin during the first trimester of human pregnancy, a marked increase in the peripheral plasma progesterone levels was observed. This effect was blocked by simultaneous administration of propranolol (Inderal®), a β-blocking agent. It is suggested that both these stimulating and inhibiting effects might be related to 3′, 5′-adenosine monophosphate (cyclic AMP). The results indicate the existence of β-receptors in steroid producing tissues.

DEXAMETHASONE-BLOCKADE OF INCREMENTAL RESPONSE OF PLASMA PROGESTERONE TO CERVICAL DILATION OR VASOPRESSIN INFUSION IN EARLY HUMAN PREGNANCY

1972 ◽  
Vol 69 (4) ◽  
pp. 602-607 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Uterine Cervix ◽  
Intramuscular Injection ◽  
Oral Treatment ◽  
First Trimester ◽  
Depressant Effect ◽  
Dexamethasone Treatment ◽  
Cervical Dilation ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Early Human

ABSTRACT The effect of dexamethasone on the peripheral plasma levels of progesterone was investgated in pregnant women during the first trimester. Neither oral treatment (2.5 mg × 4 for two days) nor intramuscular injection (24–64 mg) had any depressant effect in otherwise untreated women. The incremental response in the plasma progesterone levels consistently seen in women subjected to continuous dilation of the uterine cervix or vasopressin infusions, was markedly reduced by dexamethasone treatment.

DEXAMETHASONE OR PROPRANOLOL BLOCKADE OF INDUCED INCREASE IN PLASMA PROGESTERONE IN EARLY HUMAN PREGNANCY

1973 ◽  
Vol 72 (3) ◽  
pp. 569-572 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Adrenergic Receptor ◽  
First Trimester ◽  
Inhibitory Effect ◽  
The Other ◽  
Simultaneous Administration ◽  
Plasma Progesterone ◽  
Human Pregnancy ◽  
Peripheral Plasma ◽  
Receptor Sites ◽  
Early Human

ABSTRACT Following continuous intravenous infusion of vasopressin or theophyllamine during the first trimester of human pregnancy, a marked increase in the peripheral plasma progesterone levels was observed. By simultaneous administration of propranolol the vasopressin effect was blocked, but not that of theophyllamine. When dexamethasone was infused, the incremental response of both vasopressin and theophyllamine was blocked or reduced. The present results may indicate that propranolol exerts its inhibitory effect on the steroidogenesis at the β-adrenergic receptor sites. Dexamethasone, on the other hand, seems to act distal to the β-receptors probably by direct interference with steroidogenesis.

PROGESTERONE AND HUMAN CHORIONIC GONADOTROPHIN (HCG) LEVELS IN PLASMA DURING DILATION OF THE UTERINE CERVIX IN EARLY HUMAN PREGNANCY

1970 ◽  
Vol 65 (2) ◽  
pp. 293-301 ◽  
Author(s):  
Petter Fylling ◽  
Nils Norman
Keyword(s):  
Plasma Level ◽  
Uterine Cervix ◽  
First Trimester ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Control Group ◽  
Human Pregnancy ◽  
Medial Side ◽  
The Mean ◽  
Early Human

ABSTRACT Dilation of the uterine cervix for 16 hours as a preliminary to the induction of legal abortion during the first trimester of human pregnancy resulted in a marked increase in the plasma level of both progesterone and human chorionic gonadotrophin (HCG). In a control group (with the dilating instrument taped on the medial side of the upper thigh) no increase in progesterone occurred. The increase in the plasma level of HCG was more pronounced than that of progesterone, the mean increase being 80 and 50 per cent respectively. Following the termination of the pregnancy, the half life (t½) of endogenous HCG in peripheral plasma could be calculated, and was found to be about 7 hours.

PREMATURE PARTURITION FOLLOWING DEXAMETHASONE ADMINISTRATION TO PREGNANT EWES

1971 ◽  
Vol 66 (2) ◽  
pp. 289-295 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Marked Decrease ◽  
Progesterone Level ◽  
Appreciable Effect ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Pregnant Sheep ◽  
Daily Dose

ABSTRACT Various doses of dexamethasone were administered to pregnant sheep starting from the 133rd day of gestation. A daily dose of 6–10 mg caused a marked decrease in the peripheral plasma progesterone level and premature parturition occurred alter treatment for 4 to 5 days. A daily dose of 4 mg had no appreciable effect on plasma progesterone and premature parturition did not occur*.

Role of plasma progesterone concentration in early pregnancy of the ewe

1981 ◽  
Vol 21 (113) ◽  
pp. 562 ◽  
Author(s):  
FD Brien ◽  
IA Cumming ◽  
IJ Clarke ◽  
CS Cocks
Keyword(s):  
Early Pregnancy ◽  
Progesterone Level ◽  
Progesterone Concentration ◽  
Plasma Progesterone ◽  
Peripheral Plasma

Eighty-eight maiden and 125 mature Merino ewes were grazed on green irrigated pasture or given dry hay on a fallow area with or without a lupin grain supplement just before and during mating. Progesterone concentrations in peripheral plasma were measured at 12 d after coitus. Progesterone concentration was lower (2.27 vs 2.87 ng/ml, P < 0.001 ) when lupins were fed, and maiden ewes had higher progesterone concentrations than mature ewes (2.75 vs 2.36 ng/ml, P < 0.05). Pregnant ewes had higher progesterone concentrations than non-pregnant ewes (2.77 vs 2.36 ng/ml, P < 0.05), and ewes with two ovulations had higher progesterone concentrations than ewes with a single ovulation (3.13 vs 2.08 ng/ml, P < 0.001). There was an interaction between pasture type and lupin supplement, with lupins depressing progesterone level more on green irrigated pasture (lupins 2.11 ng/ml, no lupins 3.00 ng/ml, P < 0.05) than on dry pasture (lupins 2.45 ng/ml, no lupins 2.74 ng/ml, P < 0.05). The results confirm that a high plane of nutrition at mating lowers progesterone levels in plasma and suggest that this may be a factor in the increase in embryo deaths when ewes are fed lupin grain supplements.

PROGESTERONE CONCENTRATIONS IN THE PERIPHERAL PLASMA OF THE BLUE FOX (ALOPEX LAGOPUS) DURING PREGNANCY AND THE OESTROUS CYCLE

1973 ◽  
Vol 59 (3) ◽  
pp. 429-438 ◽  
Author(s):  
O. M. MØLLER
Keyword(s):  
Binding Assay ◽  
Post Partum ◽  
Progesterone Level ◽  
Alopex Lagopus ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Protein Binding Assay ◽  
Competitive Protein Binding Assay ◽  
Competitive Protein Binding ◽  
Blue Fox

SUMMARY A competitive protein-binding assay was evaluated and employed in the measurement of progesterone in serial plasma samples obtained from pregnant, non-pregnant and non-receptive blue-fox vixens. At the beginning of the period of pro-oestrous vulval swelling, the plasma progesterone concentration was always found to be below 2 ng/ml. Towards the end of pro-oestrus and during the period of oestrus (sexual receptivity) the concentration increased rather quickly. On the 3rd and the 4th days of oestrus, i.e. when most of the vixens were mated, the plasma progesterone concentrations were about 30 ng/ml (range: 18–36 ng/ml). During gestation (53 or 54 days) the plasma progesterone level rose very steeply and attained a maximum plateau (> 80 ng/ml) between days 5 and 8 post coitum, remained high until about day 20, but thereafter fell rather quickly to below 30 ng/ml between days 35 and 40. Later on the progesterone level fell gradually to below 5 ng/ml at the day of parturition, and, 4 days post partum and later, the levels were below the limit of the sensitivity of the assay used (< 2 ng/ml). The progesterone values and profiles obtained from the non-pregnant vixens (mated vixens which failed to whelp) corresponded clearly to those obtained in the pregnant vixens. Indeed, even in two non-receptive vixens (unwilling to mate during the mating season) typical progesterone profiles were obtained during a period of about 70 days.

EFFECT OF HCG ON PLASMA PROGESTERONE DURING THE LUTEAL PHASE OF THE MENSTRUAL CYCLE AND DURING PREGNANCY

1972 ◽  
Vol 69 (4) ◽  
pp. 739-746 ◽  
Author(s):  
B. Runnebaum ◽  
K. Holzmann ◽  
A.-M. Bierwirth-v. Münstermann ◽  
J. Zander
Keyword(s):  
Menstrual Cycle ◽  
Early Pregnancy ◽  
Luteal Phase ◽  
Late Pregnancy ◽  
Progesterone Level ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Healthy Women ◽  
Stimulation Experiments

ABSTRACT The influence of intravenous HCG infusions lasting for 2 hours on the peripheral plasma progesterone concentrations was investigated in healthy women on day 5 during the hyperthermic phase of the menstrual cycle and during week 6–19 and 31–39 of pregnancy. During the luteal phase the peripheral plasma progesterone level can be increased, on an average, up to 70 % with 5000 IU and up to 250 % with 20 000 IU. The highest plasma progesterone concentrations were reached about 8 hours after the beginning of the HCG infusion. In some experiments significantly elevated progesterone concentrations were still observed 20 hours after starting the HCG infusion. The results of intravenous HCG stimulation experiments during early pregnancy (10 000–20 000 IU) and during late pregnancy (5000–20 000 IU) showed no marked changes in the peripheral plasma progesterone concentrations.

PERIPHERAL PLASMA LEVELS OF 17α-HYDROXYPROGESTERONE DURING HUMAN PREGNANCY

1972 ◽  
Vol 71 (4) ◽  
pp. 765-772 ◽  
Author(s):  
Tore H:son Holmdahl ◽  
Elof D. B. Johansson
Keyword(s):  
Plasma Levels ◽  
Gradual Increase ◽  
First Trimester ◽  
Gradual Decline ◽  
Plasma Progesterone ◽  
Blood Samples ◽  
Human Pregnancy ◽  
Peripheral Plasma ◽  
Normal Human ◽  
The Mean

ABSTRACT Peripheral plasma levels of 17α-hydroxyprogesterone* were measured during normal human pregnancy. During the first trimester measurements of peripheral plasma progesterone were also included. Five cases of early pregnancies were followed with frequent blood-sampling until the 14th week of gestation. In one of the women daily blood samples were collected from 10 days prior to conception until the beginning of the 6th week. From the 18th week on, a total of 173 blood-samples were obtained from individual patients. During the 7th week the average plasma levels of 17α-hydroxyprogesterone reached a maximum of 3.7 ng per ml followed by a gradual decline. From week 14 to week 34 the mean level was around 0.5 ng per ml. Thereafter an increase towards term was noted with a mean plasma level of 17α-hydroxyprogesterone of about 2 ng per ml in week 40. Peripheral plasma progesterone decreased from a mean level of 27.0 ng per ml in week 5 to reach a nadir of 16.0 ng per ml in weeks 8 and 9 followed by a gradual increase. No correlation between the plasma levels of 17α-hydroxyprogesterone and the clinical outcome of pregnancy could be demonstrated.

THE EFFECT OF PREGNANCY, OVARIECTOMY AND PARTURITION ON PLASMA PROGESTERONE LEVEL IN SHEEP

1970 ◽  
Vol 65 (2) ◽  
pp. 273-283 ◽  
Author(s):  
Petter Fylling
Keyword(s):  
Plasma Levels ◽  
Gradual Increase ◽  
Mean Value ◽  
Progesterone Level ◽  
Maximum Plasma ◽  
Plasma Progesterone ◽  
Peripheral Plasma ◽  
Marked Decline ◽  
The Mean ◽  
Twin Pregnancies

ABSTRACT In sheep a gradual increase in the progesterone* level in peripheral plasma was observed during pregnancy. The maximum plasma levels were reached at about day 140, the mean value in two ewes, each carrying one lamb being 13.2 ng/ml, and in four twin pregnancies 20.0 ng/ml. During the last week of pregnancy a marked decline in plasma progesterone levels in all the intact animals was observed with a mean value of 2.1 ng/ml at parturition. Following ovariectomy the increase in plasma progesterone in advancing stages of pregnancy which has been observed in intact animals, was blocked. In the ovariectomized animals too a decrease in plasma progesterone levels prior to parturition was demonstrated.

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