Use of Lego® to explain genetic variations in type 1 collagen - a pilot study

2019 ◽  
Author(s):  
Jeremy Allgrove ◽  
Mark Heathfield ◽  
Karen Edwards ◽  
Chris Clark ◽  
Emilie Hupin ◽  
...  
Keyword(s):  
Pilot Study ◽  
Genetic Variations

Glycemic Variability and Insulin Needs in Patients with Type 1 Diabetes Mellitus Supplemented with Vitamin D: A Pilot Study Using Continuous Glucose Monitoring System

2018 ◽  
Vol 14 (4) ◽  
pp. 395-403 ◽  
Author(s):  
Karem Mileo Felício ◽  
Ana Carolina Contente Braga de Souza ◽  
Joao Felicio Abrahao Neto ◽  
Franciane Trindade Cunha de Melo ◽  
Carolina Tavares Carvalho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Pilot Study ◽  
Type 1 Diabetes Mellitus ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Glycemic Variability

scholarly journals Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207065 ◽  
Author(s):  
Catherine A. Sullivan ◽  
Jose M. Cacicedo ◽  
Iniya Rajendran ◽  
Devin W. Steenkamp
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Pilot Study ◽  
Type 1 Diabetes Mellitus ◽  
C Peptide ◽  
Peptide Secretion

scholarly journals Is Thermal Imaging a Useful Predictor of the Healing Status of Diabetes-Related Foot Ulcers? A Pilot Study

2018 ◽  
Vol 13 (3) ◽  
pp. 561-567
Author(s):  
Behzad Aliahmad ◽  
Aye Nyein Tint ◽  
Sridhar Poosapadi Arjunan ◽  
Priya Rani ◽  
Dinesh Kant Kumar ◽  
...  
Keyword(s):  
Temperature Distribution ◽  
Pilot Study ◽  
Thermal Imaging ◽  
Color Image ◽  
Foot Ulcer ◽  
Clinic Visit ◽  
Color Images ◽  
Thermal Images ◽  
Reduction In Area

Introduction: In clinical practice, both area and temperature of the ulcer have been shown to be effective in tracking the healing status of diabetes-related foot ulcer (DRFU). However, traditionally, the area of the DRFU is measured regardless of the temperature distribution. The current prospective, observational study used thermal imaging, as a more accurate tool, to measure both the area and the temperature of DRFU. We aimed to predict healing of DRFU using thermal imaging within the first 4 weeks of ulceration. Method: A pilot study was conducted where thermal and color images of 26 neuropathic DRFUs (11 healing vs 15 nonhealing) from individuals with type 1 or 2 diabetes were taken at the initial clinic visit (baseline), at week 2, and at week 4. The thermal images were segmented into isothermal patches to identify the wound boundary and area corresponding to temperature distribution. Five parameters were obtained: temperature of the wound bed, area of the isothermal patch of the wound bed, area of isothermal patch of periwound, number of isolated isothermal patches of the wound region, and physical wound bed area from color image. The ulcers were also measured by experienced podiatrists over 4 consecutive weeks and used as the healing reference. Results: For healing cases, the ratio of the area of the wound bed to its baseline measured using thermal images was found to be significantly lower at 2 weeks compared to nonhealing cases and this corresponded with a 50% reduction in area of DRFU at 4 weeks (group rank-based nonparametric analysis of variance P = .036). In comparison, neither the planimetric area measured using color images nor the temperature of the wound bed was associated with the healing. Conclusion: This study of 26 patients demonstrates that change in the isothermal area of DRFU can predict the healing status at week 4. Thermal imaging of DRFUs has the advantage of incorporating both area and temperature allowing for early prediction of the healing of these ulcers. Further studies with greater sample sizes are required to test the significance of these results.

The Microtomographic Evaluation of Marginal Bone Resorption of Immediately Loaded Scalloped Design Implant With Various Microthread Configurations in Canine Mandible: Pilot Study

2010 ◽  
Vol 36 (5) ◽  
pp. 357-362 ◽  
Author(s):  
Young-Seok Park ◽  
Seung-Pyo Lee ◽  
Chong-Hyun Han ◽  
Joo Hyun Kwon ◽  
Young-Chul Jung
Keyword(s):  
Pilot Study ◽  
Bone Resorption ◽  
Bone Loss ◽  
Titanium Implant ◽  
Marginal Bone Loss ◽  
Future Studies ◽  
Preliminary Study ◽  
Type 3

Abstract This study was undertaken to evaluate the effect of microthread geometry of scalloped design implant on marginal bone resorption. Four types of scalloped design titanium implant specimens were prepared. The type 1 implant had a machined scalloped collar, type 2 had a sandblasted and acid-etched scalloped collar, type 3 had horizontal microthreads, and type 4 had parabolic microthreads, which are parallel with the scalloped conical margin. Two implants of a type were randomly installed immediately after extraction in the mandible of a beagle dog. Definitive prostheses were delivered immediately after surgery. After 12 weeks of healing, the dog was sacrificed and microtomography was performed. Type 4 specimens showed a marginal bone loss pattern definitively analogous to the scalloped margin. In this preliminary study, microthread geometry affected the marginal bone resorption pattern of scalloped design implants. However, additional specimens and more controlled conditions should be applied in future studies to confirm these results.

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