scholarly journals Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy

2009 ◽  
Vol 161 (2) ◽  
pp. 267-273 ◽  
Author(s):  
Toshiyuki Yasui ◽  
Ayako Saijo ◽  
Hirokazu Uemura ◽  
Toshiya Matsuzaki ◽  
Naoko Tsuchiya ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Adhesion Molecule ◽  
Vascular Inflammation ◽  
Estrogen Therapy ◽  
Intercellular Adhesion Molecule ◽  
Serum Concentrations ◽  
Intercellular Adhesion Molecule 1 ◽  
Cytokines And Chemokines ◽  
Markers Of Inflammation ◽  
Circulating Levels

ObjectiveThe aim of the present study was to determine the different effects of oral estrogen therapy (ET) and transdermal ET on changes in circulating levels of cytokines and chemokines in relationship to changes in markers of inflammation in postmenopausal women with hysterectomy.MethodsFifty-five postmenopausal women with hysterectomy were randomly assigned in open, parallel-group fashion to an oral ET group and a transdermal ET group. Serum levels of cytokines and chemokines were simultaneously measured using a multiplexed human cytokine assay. Serum concentrations of high-sensitive C-reactive protein, soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, and E-selectin were measured as vascular inflammation markers.ResultsBoth oral ET and transdermal ET significantly decreased serum interleukin (IL)-7 concentrations at 12 months (P=0.020 and P=0.015 respectively). Transdermal ET decreased serum concentrations of IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1β (P=0.05, P=0.019, and P=0.029), but oral ET increased IL-8 level (P=0.025). There were significant differences in percentage changes in IL-8 and MIP-1β between the oral and transdermal ET groups. Oral ET significantly decreased E-selectin level after 12 months.ConclusionTransdermal ET reduces circulating levels of IL-8, MCP-1, and MIP-1β, while both oral ET and transdermal ET reduce circulating level of IL-7.

scholarly journals Circulating cell adhesion molecules in metabolically healthy obesity

2020 ◽  
Author(s):  
Arij Mulhem ◽  
Yusef Moulla ◽  
Nora Klöting ◽  
Thomas Ebert ◽  
Anke Tönjes ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecules ◽  
Intercellular Adhesion Molecule ◽  
Serum Concentrations ◽  
Metabolically Healthy Obesity ◽  
Intercellular Adhesion Molecule 1 ◽  
Increased Risk ◽  
Metabolically Healthy

Abstract Background/Objectives People with metabolically healthy obesity (MHO) may still have an increased risk for cardiovascular mortality compared to metabolically healthy lean (MHL) individuals. However, the mechanisms linking obesity to cardiovascular diseases are not entirely understood. We therefore tested the hypothesis that circulating cell adhesion molecules (CAMs) are higher in MHO compared to MHL individuals. Subjects/Methods Serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), E-selectin and P-selectin were measured in age- and sex-matched groups of MHL (n = 32), MHO categorized into BMI-matched insulin sensitive (IS, n = 32) or insulin resistant (IR) obesity (n = 32) and people with metabolically unhealthy obesity (MUO, n = 32). Results Indeed, individuals with MHO have significantly higher sICAM-1, E-selectin, and P-selectin serum concentrations compared to MHL people. However, these CAMs are still significantly lower in IS compared to IR MHO. There was no difference between the groups in sVCAM-1 serum concentrations. Compared to all other groups, circulating adhesion molecules were significantly higher in individuals with MUO. Conclusions These findings suggest that obesity-related increased cardiovascular risk is reflected and may be mediated by significantly higher CAMs. The mechanisms causing elevated adhesion molecules even in the absence of overt cardio-metabolic risk factors and whether circulating CAMs could predict cardiovascular events need to be explored.

Increased Serum Concentrations of Adhesion Molecules after Coronary Angioplasty

1994 ◽  
Vol 87 (6) ◽  
pp. 627-633 ◽  
Author(s):  
Robert W. Kurz ◽  
Bernhard Graf ◽  
Franz Gremmel ◽  
Christian Wurnig ◽  
Felix Stockenhuber
Keyword(s):  
Coronary Angiography ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Coronary Angioplasty ◽  
Interleukin 2 ◽  
Intercellular Adhesion Molecule ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Concentrations ◽  
Intercellular Adhesion Molecule 1

1. Reocclusion is still a significant complication after percutaneous transluminal coronary angioplasty. The injury of coronary arteries resulting from PTCA plays an important role in the pathophysiology of both abrupt closure and late restenosis after an initially successful procedure. Cytokines play a pivotal role in the accumulation of circulating blood cells at the endothelium and are known to regulate their interaction with the vessel wall. 2. To obtain further information about this interaction, serum concentrations of soluble endothelial leukocyte adhesion molecule 1 (sELAM-1), leucocyte endothelial cell adhesion molecule 1 (sL-selectin), intercellular adhesion molecule 1 (sICAM-1), interleukin 2 receptor (sIL-2R) and interleukin 8 (IL-8) detected by enzyme-linked immunosorbent assay were monitored in 30 consecutive patients referred for elective PTCA. Fifteen patients who underwent elective coronary angiography without PTCA served as controls. 3. All patients underwent successful first PTCA. Within 24 h the serum concentrations of sELAM-1 increased gradually from 21.7 (SD 7.1) to 48.2 (SD 8.6) ng/ml (P < 0.01); levels of sL-selectin rose from 982.1 (SD 128.7) to 1541.3 (SD 104.6) ng/ml after 48h (P < 0.01). Serum levels of IL-8 remained stable initially, but peaked at the end of the observation time of 72 h (9.4, SD 3.8, versus 16.1, SD 4.9 ng/ml; P < 0.05). A positive correlation was found between the number of dilatations and the rise in these parameters (P < 0.01). No significant changes were found in the serum concentrations of sICAM-1 and sIL-2R after PTCA or in any of the parameters in patients after coronary angiography. 4. We conclude that PTCA induces a significant rise in the concentration of certain adhesion molecules in serum. Thus, we provide preliminary data on the potential role of cytokines for blood cell-endothelium interaction after PTCA. Further investigations and larger numbers of patients are needed to clarify the role of circulating cytokines for endothelial injury and restenosis after PTCA.

Baseline ICAM-1 and VCAM-1 are Increased in Initially Healthy Middle-Aged Men who Develop Cardiovascular Disease during 6.6 Years of Follow-Up

Angiology ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 108-114 ◽  
Author(s):  
Caroline Schmidt ◽  
Johannes Hulthe ◽  
Björn Fagerberg
Keyword(s):  
Adhesion Molecule ◽  
Femoral Artery ◽  
Cardiovascular Events ◽  
High Serum ◽  
Intercellular Adhesion Molecule ◽  
Serum Concentrations ◽  
Intercellular Adhesion Molecule 1 ◽  
Baseline Serum ◽  
Increased Risk

The objective of the present study was to investigate if there was a difference in baseline serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) between groups with and without cardiovascular events during a mean follow-up of 6.6 years in a group of initially healthy 58-year-old men. A further aim was to examine if high serum concentrations of ICAM-1 and VCAM-1 were associated with carotid and femoral artery plaque occurrence, separately. Men with cardiovascular events during follow-up had higher median serum ICAM-I and VCAM-I than those without events ( P < .05). The median of serum ICAM-I and VCAM-1 in the event group was used as the cutoff level, and in those with ICAM-1 and VCAM-1 above the cutoff value, there was an increased risk of having a plaque in the femoral artery (OR = 2.8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively).

scholarly journals Tomato-rich (Mediterranean) diet does not modify inflammatory markers

2007 ◽  
Vol 30 (2) ◽  
pp. 70 ◽  
Author(s):  
Arnon Blum ◽  
Merei Monir ◽  
Khalid Khazim ◽  
Aviva Peleg ◽  
Nava Blum
Keyword(s):  
Mediterranean Diet ◽  
Inflammatory Markers ◽  
Cardiovascular Events ◽  
Vascular Inflammation ◽  
Plasma Concentrations ◽  
Diet Group ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Markers Of Inflammation ◽  
Hs Crp

Background: The Mediterranean diet is rich in lycopene and has been reported to reduce cardiovascular events. The mechanism of prevention of cardiovascular events has not been clearly established. Our aim was to study the effects of a tomatoes-rich diet on markers of vascular inflammation. Methods: Plasma concentrations of E-selectin, intercellular adhesion molecule 1 (ICAM-1), and high sensitivity C-reactive protein (hs-CRP) were determined by ELISA in 103 apparently healthy volunteers. Volunteers were randomly assigned to two groups: 50 participants ate 300 g tomatoes daily for 1 month, and 53 participants ate their usual diet with tomatoes prohibited during that period. Markers of inflammation were measured before enrollment and 1 month after their assigned diet. Results: The two diet groups had similar baseline clinical characteristics and similar baseline levels of inflammatory markers. After 30 days of assigned diet concentrations of hs-CRP, E-selectin and ICAM-1 were unchanged compared with baseline in the tomato-rich diet. However, ICAM-1 concentraion was increased in the regular diet group from 247.55±55ng/ml to 264.71±60.42ng/ml (P=0.01). Conclusions: The mechanisms of benefit of the tomato-rich diet are not directly related to inhibition of markers of vascular inflammation.

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