scholarly journals Absence of major fibrotic adverse events in hyperprolactinemic patients treated with cabergoline

2010 ◽  
Vol 162 (4) ◽  
pp. 667-675 ◽  
Author(s):  
M Lafeber ◽  
A M E Stades ◽  
G D Valk ◽  
M J Cramer ◽  
F Teding van Berkhout ◽  
...  
Keyword(s):  
Adverse Events ◽  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
Adverse Reactions ◽  
Valvular Regurgitation ◽  
X Ray ◽  
Increased Risk ◽  
Function Test ◽  
Additional Imaging ◽  
Chest X Ray

BackgroundCabergoline, a dopamine agonist used to treat hyperprolactinemia, is associated with an increased risk of fibrotic adverse reactions, e.g. cardiac valvular fibrosis, pleuropulmonary, and retroperitoneal fibrosis.ObjectiveThis study evaluated the prevalence and risk of fibrotic adverse reactions during cabergoline therapy in hyperprolactinemic and acromegalic patients.DesignA cross-sectional study was conducted in a University Hospital.PatientsA total of 119 patients with hyperprolactinemia and acromegaly who were on cabergoline therapy participated in the study.MethodsAll patients were requested to undergo a cardiac assessment, pulmonary function test, chest X-ray, and blood tests as recommended by the European Medicine Agency. Matched controls were recruited to compare the prevalence of valvular regurgitation. Cardiac valvular fibrosis was evaluated by assessing valvular regurgitation and the mitral valve tenting area (MVTa). The risk of pleuropulmonary fibrosis was assessed by a pulmonary function test, a chest X-ray, and if indicated, by additional imaging studies.ResultsThe prevalence of clinically relevant valvular regurgitation was not significantly different between cases (11.3%) and controls (6.1%; P=0.16). The mean MVTa was 1.27±0.17 and 1.24±0.21 cm2 respectively (P=0.54). Both valvular regurgitation and the MVTa were not related to the cumulative dose of cabergoline. A significantly decreased pulmonary function required additional imaging in seven patients. In one patient, possible early interstitial fibrotic changes were seen. Lung function impairment was not related to the cumulative cabergoline dose.ConclusionCabergoline, typically dosed for the long-term treatment of hyperprolactinemia or acromegaly, appears not to be associated with an increased risk of fibrotic adverse events.

scholarly journals Adherence to Monitoring Guidelines of Amiodarone Adverse Reactions

2019 ◽  
Vol 6 ◽  
pp. 233339281984463 ◽  
Author(s):  
Ophir Lavon ◽  
Ron Goldman
Keyword(s):  
Clinical Guidelines ◽  
Chart Review ◽  
Adverse Reactions ◽  
Retrospective Chart Review ◽  
X Ray ◽  
Liver Functions ◽  
Function Test ◽  
Improve Compliance ◽  
Amiodarone Treatment ◽  
Chest X Ray

Background: Amiodarone treatment frequently causes adverse reactions. Clinical guidelines warrant a comprehensive assessment prior to chronic treatment with amiodarone and repeated monitoring for the appearance of adverse reactions. Objective: To evaluate adherence to these guidelines. Methods: A retrospective chart review of electronic medical records of adult patients treated with oral amiodarone for at least 12 months. Results: One hundred patient records were analyzed; 97% of patients were evaluated for thyroid and liver functions prior to treatment. Liver functions were properly monitored every 6 months in 96% of patients and thyroid function in only 59%. Most (84%) patients completed a chest X-ray before treatment; only 2% completed a respiratory function test. None have performed a chest X-ray annually. Sixty-four percent of the patients were examined by an ophthalmologist prior to treatment; periodic ophthalmic surveillance was not consistent. Neurological and dermatological evaluations were not recorded for any of the patients, unless symptoms appeared. Only 50% were adherent to annual cardiac reassessment. Conclusions: Adherence to recommended clinical guidelines for monitoring amiodarone adverse reactions is poor. Interventions to improve compliance with these guidelines are needed.

scholarly journals Pulmonary Function, Aerobic Capacity, Obesity and Stress Level in Bus Drivers and Conductors in Gujarat State Road Transport Corporation: An Evidence Based Study

2021 ◽  
Vol 6 (3) ◽  
pp. 230-235
Author(s):  
Anand Jagdishchandra Patel ◽  
Anjali Ravindra Bhise
Keyword(s):  
Pulmonary Function ◽  
Stress Level ◽  
Aerobic Capacity ◽  
Pulmonary Function Test ◽  
Evidence Based ◽  
Bus Drivers ◽  
Gujarat State ◽  
Increased Risk ◽  
Function Test ◽  
Bus Conductors

Background: In rapidly growing cities there is increased use of motor vehicles. Bus drivers are exposed to toxic gases from the diesel exhaust and atmospheric pollutants, there is an increased risk of decrease in pulmonary function in bus drivers as well as bus conductors. They have irregular shift patterns; prolonged period of driving in congested areas there is an increased stress level thus an increase in cardiovascular risk factors in bus drivers. Due to prolonged period of sitting during driving and irregular meals there is increased risk of obesity in bus drivers and conductors. Purpose: To conduct an evidence based study to find whether pulmonary function, aerobic capacity, obesity and stress level is increased bus drivers and conductors in Gujarat state. Methodology: The study was conducted according to Preferred Reporting Items for systematic reviews and meta-analysis guidelines. Evidences selected since year 1994-February 2020 from PubMed, Google Scholar, Physiotherapy Evidence Database (PEDro), ResearchGate, ScienceDirect and Cumulative Index of Nursing and Allied Health Literature. Key words used were: Pulmonary function test, Aerobic capacity, Stress level, Obesity, Bus drivers and Bus conductors. Analysis was done using Modified Sackett Scale Version 4.0. Total 30 articles were found, out of which 20 articles were relevant and from those 14 articles were included in the study and other articles were excluded as per eligibility criteria. Results: 8 studies showed high prevalence of reduced lung volumes. 2 studies showed prevalence of high level of stress. 2 studies showed prevalence of Overweight and obesity. Conclusion: Based on evidences from search engines like Google scholar, PubMed, PEDro, ScienceDirect and ResearchGate from the year 1994- 2020, it can be concluded that bus drivers and conductors may suffer from chronic respiratory disease, high stress level and may have obesity and there is no evidence on aerobic capacity. Keywords: Pulmonary function test, Aerobic capacity, Stress level, Obesity, Bus drivers and Bus conductors.

Air Trapping on HRCT in Asthmatics: Correlation with Pulmonary Function Test

1997 ◽  
Vol 36 (2) ◽  
pp. 235
Author(s):  
Jung Hwa Hwang ◽  
Chull Hee Cha ◽  
Jai Soung Park ◽  
Young Beom Kim ◽  
Hae Kyung Lee ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
Air Trapping ◽  
Function Test

Pulmonary function test in Petrol Pump workers of Ahmedabad

2012 ◽  
Vol 2 (7) ◽  
pp. 380-381
Author(s):  
Dr. Rajula Tyagi ◽  
◽  
Dr.Devanshi U Dr.Devanshi U
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
Function Test ◽  
Petrol Pump

AB0796 THE EVALUATION OF LUNG DIAGNOSTIC PROCEDURE AT THE ONSET OF INFLAMMATORY RHEUMATIC DISEASES WITH INTERSTITIAL LUNG DISEASE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1422.3-1423
Author(s):  
T. Hoffmann ◽  
P. Oelzner ◽  
F. Marcus ◽  
M. Förster ◽  
J. Böttcher ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Interstitial Lung Disease ◽  
Lung Function ◽  
Lung Disease ◽  
Sensitivity And Specificity ◽  
Lung Function Test ◽  
Inflammatory Rheumatic Diseases ◽  
X Ray ◽  
Function Test ◽  
Chest X Ray

Background:Interstitial lung disease (ILD) in inflammatory rheumatic diseases (IRD) is associated with increased mortality. Moreover, the lung is one of the most effected organs on IRD. Consequently, screening methods were required to the detect ILD in IRD.Objectives:The objective of the following study is to evaluate the diagnostic value of lung function test, chest x-ray and HR-CT of the lung in the detection of ILD at the onset of IRD.Methods:The study is designed as a case-control study and includes 126 patients with a newly diagnosed IRD. It was matched by gender, age and the performance of lung function test and chest x-ray. The sensitivity and specificity were verified by crosstabs and receiver operating characteristic (ROC) curve analysis. The study cohort was divided in two groups (ILD group: n = 63 and control group: n = 63). If possible, all patients received a lung function test and optional a chest x-ray. Patients with pathological findings in the screening tests (chest x-ray or reduced diffusing capacity for carbon monoxide (DLCO) < 80 %) maintained a high-resolution computer tomography (HR-CT) of the lung. Additionally, an immunological bronchioalveolar lavage was performed in the ILD group as gold standard for the detection of ILD.Results:The DLCO (< 80 %) revealed a sensitivity of 83.6 % and specificity of 45.8 % for the detection of ILD. Other examined parameter of lung function test showed no sufficient sensitivity as screening test (FVC = Forced Vital Capacity, FEV1 = Forced Expiratory Volume in 1 second, TLC = Total Lung Capacity, TLCO = Transfer factor of the Lung for carbon monoxide). Also, a combination of different parameter did not increase the sensitivity. The sensitivity and specificity of chest x-ray for the verification of ILD was 64.2 % versus 73.6 %. The combination of DLCO (< 80 %) and chest x-ray showed a sensitivity with 95.2 % and specificity with 38.7 %. The highest sensitivity (95.2 %) and specificity (77.4 %) was observed for the combination of DLCO (< 80 %) and HR-CT of the lung.Conclusion:The study highlighted that a reduced DLCO in lung function test is associated with a lung involvement in IRD. DLCO represented a potential screening parameter for lung manifestation in IRD. Especially patients with suspected vasculitis should receive an additional chest x-ray. Based on the high sensitivity of DLCO in combination with chest x-ray or HR-CT for the detection of ILD in IRD, all patients with a reduced DLCO (< 80%) should obtained an imaging of the lung.Disclosure of Interests:None declared

scholarly journals Pulmonary function test values due to a diaphragmatic hernia

2016 ◽  
pp. bcr2016216542
Author(s):  
Jesper Rømhild Davidsen ◽  
Leo Nygaard ◽  
Christian B Laursen ◽  
Daniel Pilsgaard Henriksen
Keyword(s):  
Pulmonary Function ◽  
Diaphragmatic Hernia ◽  
Pulmonary Function Test ◽  
Function Test
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