scholarly journals Metabolic syndrome and insulin resistance: can they be predicted by clinical indicators in obese prepubertal children?

2016 ◽  
Author(s):  
Elpis Vlachopapadopoulou ◽  
Eirini Dikaiakou ◽  
Vasilis Petrou ◽  
Elli Anagnostou ◽  
Feneli Karachaliou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Clinical Indicators ◽  
Prepubertal Children

The role of metabolic syndrome components and adipokines in insulin resistance in prepubertal children

2011 ◽  
Vol 24 (5-6) ◽  
Author(s):  
Isabel Rey Madeira ◽  
Maria Alice Neves Bordallo ◽  
Cecilia Noronha Miranda Carvalho ◽  
Fernanda Mussi Gazolla ◽  
Flavio Moutinho de Souza ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Prepubertal Children ◽  
Metabolic Syndrome Components

scholarly journals Early Clinical Indicators of Metabolic Syndrome and Insulin Resistance in A Cohort of Greek Children with Obesity

2020 ◽  
Vol 4 (1) ◽  
pp. 6-12
Author(s):  
Elpis Athina Vlachopapadopoulou ◽  
Eirini Dikaiakou ◽  
Elli Anagnostou ◽  
Fani Athanasouli ◽  
Ioanna Patinioti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Clinical Indicators

scholarly journals Associations of Size at Birth and Metabolic Syndrome Antecedents With Serum Spexin Levels in Prepubertal Children

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A709-A710
Author(s):  
Fatma Duygu Ozturk Onsal ◽  
Ahmet Ucar ◽  
Ali Bulbul ◽  
Zeynep Yildiz Yildirmak ◽  
Gizem Kara Elitok
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Model Assessment ◽  
Prepubertal Children ◽  
Excess Adiposity ◽  
Significant Difference ◽  
Idefics Study ◽  
Size At Birth

Abstract Background: Spexin is a novel peptide implicated in food intake and obesity. The primary aim of this study was to analyze whether serum spexin levels, along with total leptin and active ghrelin levels were different in prepubertal children born small for gestational age(SGA) and appropriate for gestational(AGA). Secondary aims were to analyze whether serum spexin, leptin and active ghrelin levels correlated with metabolic syndrome(MS)antecedents according to the Dietary and lifestyle-induced health effects in children and infants (IDEFICS)study. Subjects and Methods: We conducted a cross-sectional study on prepubertal37SGA- (median:5.6yr)and50prepubertalAGA-born children(median:5.9yr). Anthropometric data, homeostasis model assessment of insulin resistance(HOMAIR),plasma lipids, serum spexin, total leptin and active ghrelin levels were analyzed. Associations of serum spexin levels with MS antecedents according to the IDEFICS study were investigated. Results: Children bornSGA had higher body mass index and waist circumference than AGA-born peers(p <0.05). Serum total leptin levels were higher in SGA-born children than in AGA-born peers (p<0.05). Plasma active ghrelin and spexin levels were not different between the subgroups(p>0.05). Children bornSGA had higher MS risk scores than AGA-born peers(p <0.05). Small for gestational age- born children had higher plasma glucose,insulin and HOMA-IR than AGA-born peers(p<0.05). In children born SGA, the number of subjects with excess adiposity (NSGA=18(43.9%)andNAGA=7(14%),p=0.016)and insulin resistance(NSGA=14(34%) andNAGA=6(12%),p=0.035)was higher than in AGA-born peers. There was no significant difference in frequency of dyslipidemia between the subgroups(p=0.19). The frequency of children with more than one MS antecedent was higher in SGA-born children than in AGA-born peers(Chi-Square p <0.01). Metabolic syndrome risk score according to IDEFICS was higher in SGA born children than in AGA-born peers(2.2±1.8vs1.1±1.8;p=0.008). Serum spexin levels were lower in children with MS antecedents than those without MS antecedents in both AGA -and SGA-born children[Serum spexin levels in AGA-born children with and without MS antecedents: 48,5pg/mL(25-75%IQR:19.8-93.8pg/mL)and143pg/mL(25-75%IQR:104-211pg/mL),p<0.001;respectively, serum spexin levels inSGAborn children with and without MS antecedents: 31,0pg/mL(25-75%IQR:16.5-47.0 pg/mL) and79.5pg/mL(25-75% IQR:49.5-274.8pg/mL),p=0,0016;respectively]. In the whole study group, the most important factor associated with excess adiposity was history of being born SGA(OddsRatio=91.3[95%CI:2.2-374;p=0.017] Conclusions: Serum spexin levels were not different inSGA- and AGA-born children. Serum spexin levels were reduced in children with MS antecedents independent of size at birth.

scholarly journals The effect of diet composition and multiplicity on weight, body fat and HOMA-IR in patients with metabolic syndrome.

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Nataliia Samoilenko ◽  
Vira Khorunzha ◽  
Olga Bezugla ◽  
Karina Deineko ◽  
Marta Lisevych ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Food Intake ◽  
Body Fat ◽  
Treatment Effect ◽  
Diet Composition ◽  
Composition Analysis ◽  
Model Assessment ◽  
Clinical Indicators ◽  
Diet Records

AbstractIntroductionMany studies have shown relationships between timing of food intake and insulin sensitivity. In addition to this, composition of food could be an important contributor to disruptions of the normal metabolism. The aim of this study was to assess the effect of diet composition and multiplicity on weight, body fat and insulin resistance in patients with metabolic syndrome (MS).Materials and MethodsWe tested 56 patients with MS (25 men and 31 women) who were 19 to 61 years of age. Patients were on 3-fold meal (food intake was at 8–9 a.m., 1–2 p.m. and 6–7 p.m.) with very low-carbohydrate (LC) breakfast and supper, lunch consisted of proteines (P), LC, polyunsaturated fatty acids (PUFAs) and non-starchy vegetables(V); there were no snacks during a day; diet intervension lasted 6 weeks. No drugs were used during this period. Body composition analysis was performed by bioimpedance analyzer (Omron BF511, Japan). Homeostatic model assessment-insulin resistance (HOMA-IR) was used to index IR. Self-reported diet records were used to assess dietary intake. Statistical analysis was based on using pair t-test with assessment of the dynamics of clinical indicators with 95% CI and calculation of the standardized effect size based on mean comparison (Cohen's d).Results46 patients (82,1%) completed the trial, physical activity didn't change substantially during this period. After 6-weeks BMI had reduced from 30,95 ± 5,31 kg/m2 to 29,14 ± 5,13 kg/m2 (treatment effect −1,81; 95%CI −2,25 to −1,37, p < 0,001). Mean body fat was 39,4 ± 7,87% at baseline, and 36,08 ± 8,72% after 6 weeks of diet, treatment effect −3,32; 95%CI −4,34 to −2,29, p < 0,001 - treatment effect was mostly observed among men (-4,9) than in women (-2,4). The most significant changes were observed in HOMA-IR score - it decreased from 4,03 ± 2,21 to 2,28 ± 1,37, treatment effect −1,74; 95%CI −2,29 to −1,21, p < 0,001 - treatment effect was also mostly observed among men (-2,46) than in women (-1,25).DiscussionOur findings demonstrate that this diet associated with statistically different changes in BMI, body fat and HOMA-IR. Individuals with obesity, particularly men, turned to group of overweight (BMI < 30kg/m2). Maximum effet size was in HOMA-IR changes - in 35 patients (76,1%) there were no insulin resistance markers after 6 week of diet intervention. So, 3-fold meal with very LC breakfast and supper, mixed lunch (LC + P + PUFAs + V), without any snacks could be good addition or even alternative to pharmacological treatment of MS.

scholarly journals Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity

2021 ◽  
Vol 9 ◽  
Author(s):  
Rosario Valle-Martos ◽  
Miguel Valle ◽  
Rosario Martos ◽  
Ramón Cañete ◽  
Luis Jiménez-Reina ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Interleukin 6 ◽  
Liver Enzymes ◽  
Normal Weight ◽  
Intercellular Adhesion Molecule ◽  
Model Assessment ◽  
Alcoholic Fatty Liver ◽  
Prepubertal Children

Background: Metabolic syndrome (MetS) can start in children with obesity at very young ages. Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of metabolic syndrome. If left untreated, the clinical course of NAFLD can be progressive and can become chronic if not detected at an early stage.Objective: We aimed to quantify the differences in liver enzymes between prepubertal children with obesity and children with normal weight to determine any associations between them and parameters related to MetS, adipokines, or markers of endothelial dysfunction and inflammation.Methods: This cross-sectional study included 54 prepuberal children with obesity (aged 6–9 years) and 54 children with normal weight, matched by age and sex. Liver enzymes, C-reactive protein (CRP), interleukin-6, soluble intercellular adhesion molecule-1 (sICAM-1), adipokines, and parameters related to metabolic syndrome (MetS) were all measured.Results: Alanine aminotransferase (ALT) levels, serum butyryl cholinesterase (BChE), leptin, CRP, sICAM-1, triglycerides, blood pressure, and homeostasis model assessment for insulin resistance were significantly higher in children with obesity, while Apolipoprotein A-1, HDL-cholesterol, and adiponectin were significantly lower. In the children with obesity group, ALT and BChE levels correlated with anthropometric measurements, insulin resistance, and lipid parameters, leptin, interleukin-6, CRP, and sICAM-1 while BChE levels negatively correlated with adiponectin.Conclusions: Compared to children with normal weight, prepubertal children with obesity had elevated values for liver enzymes, leptin, markers of insulin resistance, inflammation, and endothelial dysfunction, and variables associated with MetS. There was also a correlation between these disorders and liver enzyme levels.

Metabolic Syndrome and Insulin Resistance in Obese Prepubertal Children in Lebanon: A Primary Health Concern

2010 ◽  
Vol 57 (2) ◽  
pp. 135-142 ◽  
Author(s):  
L. Nasreddine ◽  
K. Ouaijan ◽  
M. Mansour ◽  
N. Adra ◽  
D. Sinno ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Health Concern ◽  
Prepubertal Children ◽  
Primary Health

Metabolic Syndrome and Prediabetes Fail to Detect a High Prevalence of Early Insulin Resistance—The PREMIER Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1534-P
Author(s):  
DAVID P. CISTOLA ◽  
ALOK K. DWIVEDI ◽  
JAMY D. ARD
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Prevalence
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