Associations between karyotype and long term health outcomes in adults with Turner Syndrome; The Turner Syndrome Life Course Project

2016 ◽  
Author(s):  
Pimblett Antoinette Cameron- ◽  
Rosa Clementina La ◽  
Thomas King ◽  
Lih-Mei Lioa ◽  
Melanie C Davies ◽  
...  
Keyword(s):  
Life Course ◽  
Health Outcomes ◽  
Turner Syndrome

scholarly journals Longitudinal Health Care for Girls and Women With Turner Syndrome

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A733-A734
Author(s):  
Priyanka Ghosh ◽  
Zorkot Zeinab ◽  
Selma Feldman Witchel ◽  
Meredith Snook ◽  
Svetlana Yatsenko
Keyword(s):  
Health Care ◽  
Pilot Study ◽  
Health Outcomes ◽  
Turner Syndrome ◽  
Health Care Providers ◽  
Medical Records ◽  
Delayed Puberty ◽  
Care Providers ◽  
Monosomy X

Abstract Background Turner Syndrome (TS) is the most common chromosomal abnormality seen in females and is often diagnosed in childhood. The transition of patients with TS from pediatric to adult providers is characterized by inconsistency. As such, limited data are available to assess long term health outcomes of women with TS. Objectives: 1) To evaluate the long term health outcomes in women with TS followed at a single academic institution and 2) to establish clinical recommendations for evaluation, counseling, and planned transition of this population. Methods: A retrospective pilot study was performed by examining medical records of women with TS who presented with short stature or delayed puberty and were diagnosed with TS on the basis of cytogenetic analysis. Patients with monosomy X, mosaic monosomy X, or X chromosome structural abnormalities consistent with TS or mosaic TS diagnosis were included. Medical records from an academic children’s hospital and an affiliated women’s hospital were reviewed. Results: To date, 15 females aged 26-32 years were identified. Electronic records were available for 12/15 with age at diagnosis ranging from in utero to 15 years of age. Those with pediatric information available had documentation addressing use of growth hormone and pubertal hormone replacement therapies. Of the 12 patients, 11 had cardiac imaging performed; only one had an MRI. Consistent planned transition to adult health care providers was not evident. Of the 12 patients, 3 had consultation with a Reproductive Endocrinology and Infertility specialist; 3 had a diagnosis of anxiety or depression; 3 had a DEXA scan done (1 had osteopenia); 5 had dyslipidemia; and 2 developed insulin resistance. Conclusions: This pilot study confirms heterogeneity in practice patterns and variable interactions of women with TS with the healthcare system, especially as patients enter adulthood. Although some women were referred to subspecialists, our initial data uncover patient uncertainty about healthcare and transition recommendations. Our preliminary data indicate the need for early patient education in a collaborative, multi-disciplinary fashion. We plan to validate and extend our initial findings by reviewing additional medical records. Ultimately, we plan for expanded education, consistent surveillance recommendations, and planned transition of patients with TS from pediatrics to adult caregivers.

Impact of weight gain on long term outcomes in women with turner syndrome: The turner syndrome life course project

2016 ◽  
Author(s):  
Antoinette Pimblett ◽  
Thomas J King ◽  
Vikram Talaulikar ◽  
Melanie Davies ◽  
Gerard Conway
Keyword(s):  
Weight Gain ◽  
Life Course ◽  
Turner Syndrome ◽  
Long Term Outcomes

Adverse effects of delayed induction of puberty in girls Turner syndrome: Turner Syndrome Life Course Project

2017 ◽  
Author(s):  
Pimblett Antoinette Cameron- ◽  
Vikram Sinai Talaulikar ◽  
Melanie Davi ◽  
Gerard Conway
Keyword(s):  
Adverse Effects ◽  
Life Course ◽  
Turner Syndrome

New data in turner syndrome: Results from a long-term prospective observational study from diagnosis to adulthood

2020 ◽  
Author(s):  
Francesca Corzani ◽  
Carolina Cecchetti ◽  
Claudia Oriolo ◽  
Paola Altieri ◽  
Annamaria Perri ◽  
...  
Keyword(s):  
Observational Study ◽  
Turner Syndrome ◽  
Prospective Observational Study

scholarly journals Long-Term Physical Health Outcomes of Resettled Refugee Populations in the United States: A Scoping Review

2021 ◽  
Author(s):  
Gayathri S. Kumar ◽  
Jenna A. Beeler ◽  
Emma E. Seagle ◽  
Emily S. Jentes
Keyword(s):  
Health Outcomes ◽  
Physical Health ◽  
Public Health Practice ◽  
The United States ◽  
Inclusion Criteria ◽  
Physical Health Outcomes ◽  
Increased Risk ◽  
The Us ◽  
Bhutanese Refugee

AbstractSeveral studies describe the health of recently resettled refugee populations in the US beyond the first 8 months after arrival. This review summarizes the results of these studies. Scientific articles from five databases published from January 2008 to March 2019 were reviewed. Articles were included if study subjects included any of the top five US resettlement populations during 2008–2018 and if data described long-term physical health outcomes beyond the first 8 months after arrival in the US. Thirty-three studies met the inclusion criteria (1.5%). Refugee adults had higher odds of having a chronic disease compared with non-refugee immigrant adults, and an increased risk for diabetes compared with US-born controls. The most commonly reported chronic diseases among Iraqi, Somali, and Bhutanese refugee adults included diabetes and hypertension. Clinicians should consider screening and evaluating for chronic conditions in the early resettlement period. Further evaluations can build a more comprehensive, long-term health profile of resettled refugees to inform public health practice.

Older Adults Diagnosed With Schizophrenia in Long-term Care Facilities: Life Course Theory for Holistic Nursing Research and Practice

2021 ◽  
pp. 089801012110253
Author(s):  
Verónica G. Walker ◽  
Elizabeth K. Walker
Keyword(s):  
Older Adults ◽  
Life Course ◽  
Health Beliefs ◽  
Long Term Care ◽  
Life Course Theory ◽  
Nursing Research ◽  
Term Care ◽  
Holistic Nursing ◽  
Care Facilities

Older adults diagnosed with schizophrenia (OADWS) often enter long-term care facilities with unique challenges related to trauma and stress experienced throughout their life course. Health care workers often report that when they work with this population, they feel unprepared due to limited training. In this article, life course theory is presented as a lens for holistic nursing research and as a way for nurses to adapt interventions already used with cognitively impaired older adults (e.g., those diagnosed with Alzheimer's disease) for OADWS in long-term care. It is hoped that these ideas will facilitate discussion of ways to inform training for holistic long-term care of OADWS. Holistic principles of nursing addressed with life course theory as a lens include the following: (a) accounting for strengths and challenges; (b) honoring experiences, values, and health beliefs; (c) viewing interrelationships with the environment; and (d) nurturing of peace, wholeness, and healing.

scholarly journals Comparing the Efficacy of Multidisciplinary Assessment and Treatment, or Acceptance and Commitment Therapy, with Treatment as Usual on Health Outcomes in Women on Long-Term Sick Leave—A Randomised Controlled Trial

2021 ◽  
Vol 18 (4) ◽  
pp. 1754
Author(s):  
Anna Finnes ◽  
Ingrid Anderzén ◽  
Ronnie Pingel ◽  
JoAnne Dahl ◽  
Linnea Molin ◽  
...  
Keyword(s):  
Sick Leave ◽  
Health Outcomes ◽  
Acceptance And Commitment Therapy ◽  
Significant Interaction ◽  
Treatment As Usual ◽  
Multidisciplinary Assessment ◽  
Commitment Therapy ◽  
Acceptance And Commitment ◽  
Assessment And Treatment

Background: Chronic pain and mental disorders are common reasons for long term sick leave. The study objective was to evaluate the efficacy of a multidisciplinary assessment and treatment program including acceptance and commitment therapy (TEAM) and stand-alone acceptance and commitment therapy (ACT), compared with treatment as usual (Control) on health outcomes in women on long-term sick leave. Method: Participants (n = 308), women of working age on long term sick leave due to musculoskeletal pain and/or common mental disorders, were randomized to TEAM (n = 102), ACT (n = 102) or Control (n = 104). Participants in the multidisciplinary assessment treatment program received ACT, but also medical assessment, occupational therapy and social counselling. The second intervention included ACT only. Health outcomes were assessed over 12 months using adjusted linear mixed models. The results showed significant interaction effects for both ACT and TEAM compared with Control in anxiety (ACT [p < 0.05]; TEAM [p < 0.001]), depression (ACT [p < 0.001]; TEAM [p < 0.001]) and general well-being (ACT [p < 0.05]; TEAM [p < 0.001]). For self-rated pain, there was a significant interaction effect in favour of ACT (p < 0.05), and for satisfaction with life in favour of TEAM (p < 0.001). Conclusion: Both ACT alone and multidisciplinary assessment and treatment including ACT were superior to treatment as usual in clinical outcomes.

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