Novel indicator of abdominal obesity strongly associated with cardiovascular disease

2018 ◽  
Author(s):  
Dong Sun Kim ◽  
Jung Hwan Park ◽  
Ohk-Hyun Ryu ◽  
Wankyo Chung ◽  
Shinje Moon
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Obesity

scholarly journals Cardiovascular Disease Risk of Abdominal Obesity vs. Metabolic Abnormalities

Obesity ◽  
2011 ◽  
Vol 19 (4) ◽  
pp. 853-860 ◽  
Author(s):  
Rachel P. Wildman ◽  
Aileen P. McGinn ◽  
Juan Lin ◽  
Dan Wang ◽  
Paul Muntner ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Obesity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Metabolic Abnormalities

Metabolic syndrome traits in long-term survivors of pediatric sarcoma at a single institution

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9041-9041
Author(s):  
K. E. Hoffman ◽  
J. Derdak ◽  
D. Bernstein ◽  
J. C. Reynolds ◽  
S. M. Steinberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Activity Level ◽  
Male Adult ◽  
Pediatric Sarcoma ◽  
Long Term Survivors

9041 Multi-modality therapy (MMT) for pediatric sarcoma (SARC) may result in late endocrine abnormalities and increased cardiovascular morbidity. Metabolic syndrome (MS; NCEP ATPIII definition), a cluster of obesity, dyslipidemia, hyperglycemia and hypertension, conveys an increased risk of type 2 diabetes and cardiovascular disease. This cross-sectional study investigated the prevalence of the MS traits (MST) in long-term survivors of MMT for SARC. 32 survivors of SARC (predominantly Ewing’s; median age 36.5 years, range 17–54; f:m = 15:17; median age at MMT of 15 years, range 7–34; median time since completion of MMT 18 years, range 3–33) completed CT evaluation of abdominal obesity, DEXA scan for body mass composition, fasting serum lipid profile (FLP), the Human Activity Profile (HAP) and PAI and beta 2 microglobulin (B2M) analysis. Results, compared to appropriate controls were considered statistically significant if the p-value < 0.01. SARC survivors were more likely to have one or more MST (common OR 4.04, CI:[1.52, 13.55], p=0.0045). Subjects aged 20–39 had a higher pooled prevalence of the MS (common OR 4.29 [1.50, 11.21], p=0.0077), defined as 3 or more traits, compared to controls stratified by gender. Analysis of individual MST demonstrated higher prevalence of hypertension (common OR 2.61,[1.20, 5.59], p=0.015), hypertriglyceridemia (common OR 3.63, [1.75, 7.60], p=0.0006), and male abdominal obesity (common OR 4.52, [1.57, 13.39], p=0.0046). SARC survivors had a higher prevalence of hypercholesterolemia than healthy adults (p=0.012). PAI antigen (p=0.043), PAI activity (p=0.018) and B2M levels (p=0.043) increased with an increasing number of MST. In male subjects, total testosterone declined (p=0.008) as the number of MST increased. Average (p=0.028) and maximum (p=0.041) activity levels decreased as the number of MST increased. After a median follow up of 18 years, adult SARC survivors of MMT have an increased prevalence of MST, especially between ages 20–39 years. The development of MST may be associated with decreased testosterone and decreased activity level. Younger male adult SARC survivors may be at particular risk for type 2 diabetes and cardiovascular disease and should be monitored. No significant financial relationships to disclose.

Abdominal obesity phenotypes and risk of cardiovascular disease in a decade of follow-up: The Tehran Lipid and Glucose Study

2015 ◽  
Vol 238 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Sorena Keihani ◽  
Farhad Hosseinpanah ◽  
Maryam Barzin ◽  
Sara Serahati ◽  
Soraya Doustmohamadian ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Obesity

scholarly journals Relation of R-Spondin 3 Gene expression android obesity and Susceptibility to Cardiovascular disease in Sudanese Patients in Khartoum State.

2019 ◽  
Vol 9 (2) ◽  
pp. 355-361
Author(s):  
Ashraf M.A. Alkinain ◽  
Kamal Eldin Ahmed Abdelsalam ◽  
Mutaz Ibrahim Hassan
Keyword(s):  
Gene Expression ◽  
Cardiovascular Disease ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Negative Control ◽  
Obese Group ◽  
Control Group ◽  
Obese Patients ◽  
Abdominal Adiposity ◽  
Heart Group

Background: Obesity is a major risk factor for the development of cardiovascular disease. A growing database of clinical evidence implicates intra-abdominal adiposity as a powerful driving force for elevated cardiometabolic risk. Addressing intra-abdominal adiposity should play a central role in future strategies aimed at improving cardiovascular outcomes in patients with abdominal obesity and its associated cardiometabolic risk in Sudan. Several studies aimed to identify some factors controlling the size and function of different areas of fat. Our research is focusing on a particular gene called R-SPONDIN3, Objectives: It is to find the amount of R-Spondin3 Gene expression in Abdominal obesity and Susceptibility to Cardiovascular disease in Sudanese Patients in Khartoum State Material and methods: - The study was including 300 participants (156 males and 144 females) classified into three groups. The first group was including one hundred participants with abdominal obesity (obese), the second group was including one hundred participants already diagnosed with CVD entangled with obesity (Heart Group as positive control group), while the third group was include one hundred healthy lean volunteers (negative control group) Results: - The findings of this study showed Conventional PCR results were significantly different (P <0.001) in Heart group subjects as compared to healthy controls and obese group. Among heart group mutation was detected in some subjects (19%) and the rest without mutation (81%) but in obese group no mutation was detected. Comparison between the different studied groups according to gene expression showed significant differences (P <0.001) mean value of gene expression in healthy group subjects was 1.0 ± 0.0, Obesity group was 2.44 ± 0.50 and heart group subjects was 4.54 ± 0.87 respectively.  Conclusion: The amount of R-SPONDIN3 gene expression among the obese and CVD patients is show up significant different and the amount of gene expressing among the CVD patients is higher than obese which is suggested that the amount of gene expressed in obese patients with heart disease more than obese patients without cardiovascular complications  

scholarly journals Association of menopausal symptoms with obesity in Slovak women

2014 ◽  
Vol 77 (1) ◽  
pp. 57-66
Author(s):  
Lenka Luptáková ◽  
Daniela Siváková ◽  
Veronika Čerňanová ◽  
Marta Cvíčelová ◽  
Zuzana Danková
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Obesity ◽  
Sexual Interest ◽  
Menopausal Status ◽  
Menopausal Symptoms ◽  
Midlife Women ◽  
Stepwise Logistic Regression ◽  
Predisposing Factor ◽  
Stepwise Logistic Regression Analysis ◽  
Facial Hair

Abstract A lot of midlife women experience a great deal of menopausal symptoms. Their frequency within a given population may vary and depend on several factors such as age, menopausal status, health factors, including obesity. This study aims to investigate the incidence of menopausal symptoms among obese and non-obese midlife women, and to evaluate contribution of obesity as predisposing factor for menopausal symptoms to their manifestation. The studied cohort consisted of 297 women ranging from 39 to 59 years of age. Among them there were 63 women with obesity (body mass index, BMI ≥ 30.0 kg/m2) and of 39 women with abdominal obesity (waist to hip ratio, WHR>0.89). Women were recruited from the western and middle parts of Slovakia. All participants completed a menopause-specific questionnaire. Anthropometric measurements were taken using the standard anthropometric techniques. All statistical computations were performed by the SPSS 17.0 software programme (SPSS Inc., Chicago, IL). Stepwise logistic regression analysis demonstrated that increase in facial hair was influenced by age (p<0.001) and obesity (p=0.015). Low backache was influenced by WHR (p=0.031), obesity (p=0.008) and cardiovascular disease (p=0.024). The significant impact of BMI was recorded on the involuntary urination (p=0.002). The menopausal symptom „more clumsy then usual“ was influenced by marital status (p=0.044), hypertension (p=0.021) and the presence of cardiovascular disease (p=0.023). We investigated the effect of menopausal status (p=0.010) and abdominal obesity (p=0.035) on the loss of sexual interest. Herein we present evidence that obesity could be involved in menopausal symptomatology among Slovak midlife women. We demonstrate that obese women have a higher susceptibility to increase in facial hair and backache, and women with abdominal obesity to loss of sexual interest.

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