CON: Surgical treatment of phaeochromocytoma - query pre-treatment?

2019 ◽  
Author(s):  
Martin Walz
2021 ◽  
Vol 39 (28_suppl) ◽  
pp. 251-251
Author(s):  
Meghan Brooke Taylor ◽  
Meredith Ray ◽  
Nicholas Faris ◽  
Matthew Smeltzer ◽  
Carrie Fehnel ◽  
...  

251 Background: Lung cancer care is complex, but, for quality improvement, can be simplified into five ‘nodal points’: lesion detection, diagnostic biopsy, radiologic staging, invasive staging, and treatment. We previously demonstrated great heterogeneity in passage through these nodal points in patients who received surgical resection for lung cancer in our healthcare system. However, examining only surgical patients may underestimate the enormity of the opportunity for quality improvement. With the aim of identifying quality gaps in pre-treatment evaluation for lung cancer, we evaluated the flow of care through these nodal points within a community-based healthcare system. Methods: We classified lung cancer care procedures received by all suspected lung cancer patients treated within the Multidisciplinary Thoracic Oncology Program at Baptist Cancer Center, Memphis TN between 2014 and 2019, into five nodal points. We compared the frequency of, and time intervals between, nodal points among patients receiving surgical, nonsurgical (chemotherapy/radiation), or no definitive treatment, using Chi-square or Kruskal Wallis tests, where appropriate. Results: Of 1304 eligible patients: 11% had no pre-treatment diagnostic procedure, 20% no PET/CT, and 39% no invasive staging. 39% of patients underwent surgical resection, 51% received non-surgical treatment, and 10% received no treatment. Patients who had surgery were less likely than those who had non-surgical treatment to get a diagnostic test, radiologic staging, and invasive staging (Table). Patients who had non-surgical treatment were more likely to pass through all five nodal points (50% v 68%, p<0.0001). The median (IQR) duration from initial lesion identification to treatment (n=1126) was 77 days (45-190); 27 days (10-90) from lesion identification to diagnostic biopsy (n=1115); and 38 days (26-63) from diagnostic biopsy to treatment (n=1041). Patients who had surgery received less timely care than those who had non-surgical or no treatment: median 122 v 66 v 68 days from lesion identification to treatment; 40 v 21 v 29 days from lesion identification to diagnostic biopsy; 46 v 38 v 31 days from diagnostic biopsy to treatment (p<0.0001 all comparisons). Conclusions: Quality improvement initiatives within our healthcare system, such as the establishment of a coordinated multidisciplinary program, enhanced care quality over previous benchmarks. Despite improvements, lung cancer patients who had surgery received less frequent and less timely pre-treatment evaluation than those without surgery. Implementing a standardized cancer care pathway from diagnosis to surgery could help to reduce variations in optimal care delivery.[Table: see text]


2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Alexander Parker ◽  
Andrea Tavlarides ◽  
Rebecca McNeil ◽  
Krisitin Green ◽  
Steven Ames ◽  
...  

2019 ◽  
pp. 35-41
Author(s):  
Adrian Maj ◽  
Aida Kusiak ◽  
Katarzyna Garbacz ◽  
Marta Ziółkowska-Klinkosz

Introduction. Photodynamic therapy is supportive method of non-surgical treatment of periodontitis. The aim of the study was the assessment of photodynamic therapy impact on periodontal disease clinical parameters with a particular emphasis on microbiological aspects during periodontal treatment. Material and methods. The research was conducted on seven healthy patients aged 26- 55 years. All the patients were treated with a non-surgical (SRP) periodontal treatment. Then, the assisted photodynamic therapy was applied in selected pockets. Samples of the material obtained from periodontal pockets before and after the treatment were cultured in a microbiological laboratory. Results. After the introduced therapy the clinical improvement of periodontal disease was observed in the majority (6/7) of patients taking part in the study. There obtained the elimination of inflammation to 85.7% of the patients. Periodontal pocket depths have deteriorated from 0.5 to 3.0 mm in comparison to the pre-treatment values. The overall number of bacteria compared to the pre-treatment value was reduced. In addition, there was noticed a decrease in the number of periopathogens. Control samples showed a vivid dominance of the physiological flora. Conclusions. The non-surgical treatment of periodontitis in combination with the supportive action of photodynamic therapy has promising therapeutic effects by reducing the inflammation and decreasing the depth of periodontal pockets. The change in the ratio of periopathogens to physiological flora may indicate the restoration and maintenance of the state balance in periodontal pockets for patients with periodontitis.


2018 ◽  
Vol 11 (2) ◽  
pp. 985-991
Author(s):  
Ahmad Fauzi ◽  
Asrafi Rizky Gatham ◽  
S. Dohar Al-Tobing ◽  
Luthfi Gatham

There are several options of surgical treatment of Hernia Nucleous Pulposus (HNP) such as discectomy and micro-endodiscectomy (MED). The fundamental differences between these procedures are the size of the incision, the discectomy procedure and the volume of disc taken. However, until now, there has not been any class 1 evidences explaining the efficacy of these procedures, and there is only a few studies about its safety and factors influencing its efficacy in treating HNP, especially in Indonesia. This study is aimed to assess clinical outcomes and safety of MED in HNP patients who underwent this procedure. Patient with HNP who underwent MED were followed prospectively in a period of January 2015 until December 2016. Clinical outcomes were evaluated by using Visual Analog Score (VAS) for assessing back pain and leg, and Oswestry Disability Index (ODI). The mean of pre-treatment score was compared with the mean of post-surgical treatment score by using paired t-test. Sampel were 78 HNP patients treated surgery. The average surgery duration (± SD) was 60 ± 17.1 minutes. The pretreatment score mean on VAS and ODI were 4.88 ± 1.10 and 35.21 ± 8.24. After surgical treatment, the VAS and ODI score obtained were significantly reduced to 1.53 ± 1.14 and 5.16 ± 5.52, respectively (p<0,001). A type of complication was observed, which was 5 (6.4%) cases of dural tear; no deficit in ankle dorsiflexion nor foot paresis were found. MED has been shown to be able to treat HNP with clinical outcomes similar to conventional open discectomy but with better levels of safety and effectiveness. However, this procedure still requires high quality randomized controlled trials studying about its efficacy and cost effectiveness in HNP treatment.


2006 ◽  
Vol 54 (4) ◽  
pp. 349 ◽  
Author(s):  
Anne Cochrane ◽  
Robin Probert

This paper describes the effects of temperature and simple or multiple dormancy-breaking treatments (potassium nitrate, surgical treatment, gibberellic acid (GA3), after-ripening at 45°C and nitrogen dioxide gas) on germination of five endemic and geographically restricted herbaceous perennials (Apium prostratum Vent. subsp. phillipii Keighery ms, Goodenia stenophylla F.Muell., Marianthus granulatus (Turcz.) Benth, Myriocephalus suffruticosus Benth. and Velleia foliosa (Benth.) K.Krause) from the species-rich south-west of Western Australia. Except for seeds of A. prostratum that were non-dormant, seeds were partially dormant or fully dormant when incubated without pre-treatment at three temperatures (15, 20 and 25/10°C). Low germination (≤52%) was detected in M. granulatus under the best identified conditions, and seeds of G. stenophylla showed little to no response to any germination cue. In M. granulatus, M. suffruticosus and V. foliosa combinations of treatments were found that led to enhanced germination and in the case of V. foliosa, germination was not significantly different from a tetrazolium test of viability when seeds were surgically treated and then incubated with KNO3. Although none of the species studied exhibited physical dormancy, surgical excision of the seed coat in the vicinity of the embryo featured in the most successful combination of treatments in every case. Whilst seeds of M. granulatus responded positively to surgical treatment, after-ripening of seeds at 45°C for 2, 4 or 6 weeks did not increase either speed or final germination compared with other treatments. The mean time to germinate (MTG) ranged from 12.6 days (A. prostratum ssp. phillipii) to 46.5 days (G. stenophylla) under the best treatment conditions for each species.


2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Stefano Frara ◽  
Marco Losa ◽  
Erika Pedone ◽  
Eugenia Resmini ◽  
Francesco Tecilazich ◽  
...  

Abstract Introduction: somatostatin receptor ligands (SRL) represent the first-line medical therapy in acromegaly patients who were not cured by surgery and in those where surgical remission is unlikely. It is well known that SRL may negatively act on insulin secretion, with consequent hyperglycemia and diabetes mellitus (DM). Purpose: To evaluate whether the degree of response to surgical pre-treatment with SRL predicts alterations in blood glucose levels.Patients and Methods: We retrospectively studied 181 patients attending the Unit of Neurosurgery of our Hospital prior to transsphenoidal surgery. All patients had a biochemical and radiological diagnosis of acromegaly (nadir GH during OGTT &gt;0.4 ng/mL; IGF-I above age-standardized UNL and pituitary adenoma at MRI scans); diagnosis of DM and impaired fasting glucose (IFG) was performed on fasting blood glucose (FBG) according to the American Diabetes Association guidelines; all parameters of the pituitary axes were determined. The response to SRL treatment was determined as percent change of GH levels. Data are presented as mean±SD; Continuous data normally distributed were analyzed using a two-tailed Student’s t-test to compare two groups, and one-way ANOVA to compare several groups, followed by the Bonferroni post-hoc procedure for pairwise comparison of groups after the null hypothesis was rejected (p&lt;0.05); categorical data were analyzed by chi-squared test.Results: 97 (54%) patients with acromegaly underwent pre-surgical treatment with SRL; we found no difference in age (53±11 vs. 51±12 years; p=NS) and sex (M/F: 51/46 vs. 43/41; p=NS) between SRL treated and non-treated patients. We found no difference in FBG between SRL treated vs. non-treated patients. In contrast, we found increased proportions of IFG and DM patients in SRL treated when compared to non-treated patients (euglycemic: 45%, IFG: 42%, DM: 13% vs. euglycemic: 70%, IFG: 22%, DM: 8%, respectively; p=0.006). In addition, SRL treatment increased the odds ratio of IFG and DM (OR 4.7; 95%CI 2.1-10.3). When considering the degree of response to SRL pre-surgical treatment, we found that poor responders displayed at the time of surgery glycemias diagnostic of DM; whereas, good responders displayed glycemias in the range of IFG (percent change in GH levels 50±35% vs 79±22%, respectively; p&lt;0.05).Conclusions: Our findings show that the proportion of patients with acromegaly undergoing surgery with glycemic levels diagnostic of DM, is modest. Interestingly, pre-treatment with SRL represents an independent risk factor for high glucose levels. Moreover, among patients on SRL pre-treatment, the ones that respond poorly are the ones that at the time of surgery display glycemias diagnostic of DM. Our findings suggest that SRL pre-treatment may predispose to worsened glucose metabolism but selectively affecting those patients in whom biochemical control is not reached.


Author(s):  
Anja Quast ◽  
Petra Santander ◽  
Johanna Leding ◽  
Daniela Klenke ◽  
Norman Moser ◽  
...  

Abstract Objectives Sufficient dental decompensation is crucial for treatment success in combined orthodontic-surgical treatment. The study’s objective was to determine the treatment success and efficiency in sagittal, vertical, and transversal decompensation. Methods This longitudinal, observational study enrolled 52 adult patients, who underwent orthodontic-surgical treatment. Incisor inclinations and positions as well as skeletal changes were assessed pre-treatment (T1), pre-surgical (T2), and post-surgical (T3) by lateral cephalograms and CBCT scans. Results Incisor decompensation was insufficient in all three dimensions. Sagittal: treatment efficiency did not differ between class II and III patients. Vertical: patients with open bite demonstrated pre-surgical bite deepening and insufficient surgical reduction of the maxillomandibular plane angle. Transversal: Dental midline deviations were not adapted to the skeletal asymmetry so that menton deviations were not properly corrected. Conclusions Incisor decompensation was not as successful as requested in all three dimensions and the treatment ideal was seldom achieved. Clinical relevance To improve the skeletal outcome, the orthodontist has to treat the patient with the desired surgical movements in mind and should critically evaluate the pre-surgical incisor decompensation before referral to the surgical team.


2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e16014-e16014
Author(s):  
Steven Bennett Chinn ◽  
Mathew E Spector ◽  
Emily Light ◽  
Tasha Lotus Lin ◽  
Theodoros Nicholas Teknos ◽  
...  

e16014 Background: The objective of the study is to evaluate the outcomes of an induction selection (IS) concurrent chemotherapy protocol versus primary surgical extirpation in advanced OCSCC. Methods: Retrospective quasi-experimental comparison of patients treated by IS versus surgery. The cohorts were matched based on pretreatment characteristics and compared in an intent-to-treat model.19 patients were accrued with resectable stage III/IV OCSCC without bone involvement between 2000-2002 into a phase II IS trial using 1 cycle of IS to select patients for definitive chemoradiation (CRT). Tumor response was evaluated 3-weeks post-infusion. Patients with >50% response underwent concurrent CRT (70Gy; 35 fractions with concurrent cisplatin 100mg/m2 or carboplatin (AUC 6) every 3-weeks for 3 cycles). Those with <50% underwent surgical treatment and radiation therapy. A comparison cohort of patients with primary surgical extirpation was selected from an OCSCC database from 1998-2009. The surgical cohort of 53 patients was identified based on comparable pretreatment variables to the IS cohort. There was no difference in age, gender, pre-treatment AJCC stage, T-class, N-class, smoking status, alcohol status, or subsite between the two cohorts. Results: Kaplan-Meier estimates demonstrated overall survival (OS) at 5-years was 32% in the IS group and 64% in the surgical cohort. Disease-specific survival (DSS) at 5-years was 46% in the IS group and 76% in the surgical cohort. Local-regional control (LRC) at 5-years was 26% in the IS cohort and 72% in the surgical cohort. Multivariable analysis demonstrated significantly better OS, DSS and LRC (p=0.03, p=0.001 and p=0.0002 respectively) in the surgical cohort compared to the IS cohort. Conclusions: Primary surgical treatment showed significantly better OS, DSS and LRC compared to IS in this quasi-experimental designed comparison. These findings support surgery as the principal treatment for OCSCC.


2017 ◽  
Vol 2 (2) ◽  

Purpose: Representing the algorithm of periorbital area rejuvenation Materials: As part of the research, 1216 eyes of 608 patients were included. According to patients’ complaints and evaluating their situation, treatments were carried out as medical and surgical. Treatment was not applied to 75 patients that their request and the cure were not compromise. Patients were followed approximately 11,3 months (1-32 months). The study is evaluated according to patients’ reason of request, their general characteristics and the treatments that are applied. Findings: Age average of 608 patients who are applied to my clinic with the intent of periorbital area rejuvenation and enhancing eyelid deformity between the dates of March 2014-January 2017 is 38. 81,25% patients were female and 18,75% was male. 538 patients (88,5%) were applied medical treatment. 260 patients (42,8%) got surgical treatment and to 31,3% patients, combined treatment was applied. The treatment that I applied and the complaints of 89% patients harmonized with each other. 11% of patients were not treated since their complaints and their treatment request were not corresponded to each other. Result: The most important phase is pre-treatment to become successful in the treatment. First thing to do is listening and understanding the patient carefully, because the problem we observe and patient’s complaint may not be the same. In this case, no matter how successful the treatment is, we can not satisfy the patient. Sometimes, patient has unrealistic expectations. When such a patient like this is encountered, it must be kept away from him or her and the treatment should not be applied.


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