scholarly journals Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats

2013 ◽  
Vol 218 (3) ◽  
pp. 255-262 ◽  
Author(s):  
C Y Shan ◽  
J H Yang ◽  
Y Kong ◽  
X Y Wang ◽  
M Y Zheng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Intestinal Barrier ◽  
Resistance Index ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Sprague Dawley ◽  
Type 2 Diabetic Patients ◽  
Junction Protein ◽  
Type 2 Diabetic

For centuries, Berberine has been used in the treatment of enteritis in China, and it is also known to have anti-hyperglycemic effects in type 2 diabetic patients. However, as Berberine is insoluble and rarely absorbed in gastrointestinal tract, the mechanism by which it works is unclear. We hypothesized that it may act locally by ameliorating intestinal barrier abnormalities and endotoxemia. A high-fat diet combined with low-dose streptozotocin was used to induce type 2 diabetes in male Sprague Dawley rats. Berberine (100 mg/kg) was administered by lavage to diabetic rats for 2 weeks and saline was given to controls. Hyperinsulinemia and insulin resistance improved in the Berberine group, although there was no significant decrease in blood glucose. Berberine treatment also led to a notable restoration of intestinal villi/mucosa structure and less infiltration of inflammatory cells, along with a decrease in plasma lipopolysaccharide (LPS) level. Tight junction protein zonula occludens 1 (ZO1) was also decreased in diabetic rats but was restored by Berberine treatment. Glutamine-induced glucagon-like peptide 2 (GLP2) secretion from ileal tissue decreased dramatically in the diabetic group but was restored by Berberine treatment. Fasting insulin, insulin resistance index, plasma LPS level, and ZO1 expression were significantly correlated with GLP2 level. In type 2 diabetic rats, Berberine treatment not only augments GLP2 secretion and improves diabetes but is also effective in repairing the damaged intestinal mucosa, restoring intestinal permeability, and improving endotoxemia. Whether these effects are mechanistically related will require further studies, but they certainly support the hypothesis that Berberine acts via modulation of intestinal function.

The effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients

2012 ◽  
Vol 51 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Kyeong Hye Park ◽  
Kwang Joon Kim ◽  
Byung-Wan Lee ◽  
Eun Seok Kang ◽  
Bong Soo Cha ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Postprandial Triglycerides ◽  
Korean Type ◽  
Type 2 Diabetic

A study of the relation between insulin resistance, insulin-like growth factor-1, and malignancy in type 2 diabetic patients

2015 ◽  
Vol 28 (2) ◽  
pp. 494
Author(s):  
DoaaS Elgendy ◽  
NabilA El Kafrawy ◽  
AliZ Glal ◽  
MonaA Kandil ◽  
AlaaA Eldin Dawood ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Diabetic Patients ◽  
Insulin Like Growth Factor ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals SUN-656 Hypoglycemic Effect of Oral Administered Superoxide Dismutase

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shutao Liu ◽  
Hangqi Liu
Keyword(s):  
Insulin Resistance ◽  
Superoxide Dismutase ◽  
Resistance Index ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Model Group ◽  
Curative Effect ◽  
Insulin Resistance Index ◽  
Type 2 Diabetic

Abstract Hypoglycemic Effect of Oral Administered Superoxide Dismutase on Type 2 Diabetes via reduction of glucogan and insulin resistance Background & Objective: Superoxide dismutase (SOD) is carefully used in food industry for the concern of its easy degradation and difficult adsorption in digestive tract, although it plays central role in antioxidant system. It is previous reported that orally administered SOD was effective in alleviating hyperglycemia, cerebral ischemia-reperfusion and chronic hepatitis. This work aimed to investigate in-depth the hypoglycaemic effect and possible mechanism of orally administered SOD in the model of type 2 diabetic rats. Methods:The model of type 2 diabetic rats were divided into 6 groups and orally administered with different Cu/Zn-SOD (abbreviated as SOD) samples and negative or positive controls. The 6 groups included SOD, SOD hydrolysate (pepsin-treated SOD), L-SOD (liposome-embedded SOD), model group and metformin positive groups, as well as normal group. Results of the body weight, serum indexes (including blood glucose, glycated albumin, insulin, glucagon, AMPK, MDA), SOD enzymatic activity in organs (liver, heart, kidney, skeletal muscle, spleen, and pancreas) as well as intestinal density and HE staining were measured to evaluate the hypoglycemic effect and possible mechanism. Results: SOD showed substantial hypoglycemic effect and improved serum indicators. Moreover, L-SOD group exhibited better effect than SOD group, though the effect of SOD hydrolysate was not obvious. Colon density and HE staining showed obvious intestinal injury in the model group, and SOD was beneficial to repair intestinal structural integrity. Furthermore, the reparative effect of SOD was much better than that of the SOD hydrolysate, but not as good as that of the L-SOD. The SOD enzymatic activity of tissues was positively correlated with the curative effect of three kinds of SOD samples. The contents of serum MDA were negatively correlated with the curative effect. Compared with the model group, the insulin resistance index of SOD group, L-SOD group and positive group were significantly reduced; and glucagon significantly decreased by 68.38, 77.50 and 65.01%, respectively. Conclusion: Oral SOD showed obvious hypoglycemic effect on type 2 diabetic rats, and liposome could improve this effect. The mechanism may be that SOD effectively reduces intestinal injury, so as to reduce glucongen and insulin resistance index.

Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke

Diabetes Care ◽  
1999 ◽  
Vol 22 (7) ◽  
pp. 1191-1195 ◽  
Author(s):  
K. Matsumoto ◽  
S. Miyake ◽  
M. Yano ◽  
Y. Ueki ◽  
A. Miyazaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Ischemic Stroke ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
Sign in / Sign up

Export Citation Format

Share Document