Association between Thyroid Hormone and Risk Factors of Metabolic Syndrome in Adult Men of Normal Thyroid Function

Abstract Background: The objective of this study is to retrospectively analyze the correlation between the thyroid hormones and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function. Methods: Totally 586 T2DM patients with normal thyroid function participated in this research and were divided into T2DM without NAFLD (240 cases) group and T2DM with NAFLD (346 cases) group. The NAFLD fibrosis score (NFS) >0.676 was defined as progressive liver fibrosis and used to categorize the patients into T2DM without progressive liver fibrosis group (493 cases) and T2DM with progressive liver fibrosis group (93 cases). Results: The results indicated that the levels of free triiodothyronine (FT3) and total triiodomethylamine (TT3) were significantly higher while the free thyroxine (FT4) level was lower in T2DM with NAFLD group than that in T2DM2 without NAFLD group (p<0.05). The levels of FT3, FT4 and TT3 in patients with progressive liver fibrosis were significantly lower in patients with progressive liver fibrosis than that in patients without progressive liver fibrosis (p<0.05). Logistic regression analysis showed a negative relationship between FT4 level and NAFLD (p=0.026), between the levels of FT4,TT3 and total thyroxine (TT4) and the risk of progressive hepatic fibrosis (p=0.022, p=0.007,p=0.046).Conclusion: There is a certain correlation between thyroid hormone levels and NAFLD in T2DM patients, suggesting that the assessment of thyroid hormone levels in T2DM patients with normal thyroid function is of great significance in the prevention and treatment of NAFLD.

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Low normal thyroid function attenuates serum alanine aminotransferase elevations in the context of metabolic syndrome and insulin resistance in white people

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2014.04.016 ◽

2014 ◽

Vol 47 (12) ◽

pp. 1028-1032 ◽

Cited By ~ 8

Author(s):

Robin P.F. Dullaart ◽

Eline H. van den Berg ◽

Melanie M. van der Klauw ◽

Hans Blokzijl

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Thyroid Function ◽

Alanine Aminotransferase ◽

White People ◽

Normal Thyroid ◽

Serum Alanine Aminotransferase ◽

Normal Thyroid Function

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The Recovery of Thyroid Function in Low-Risk Papillary Thyroid Cancer After Lobectomy: A 3-Year Follow-Up Study

Frontiers in Endocrinology ◽

10.3389/fendo.2020.619841 ◽

2021 ◽

Vol 11 ◽

Author(s):

Yi Dou ◽

Yingji Chen ◽

Daixing Hu ◽

Xinliang Su

Keyword(s):

Risk Factors ◽

Thyroid Function ◽

Hashimoto’S Thyroiditis ◽

Low Risk ◽

Hashimoto's Thyroiditis ◽

First Year ◽

Papillary Thyroid ◽

Normal Thyroid ◽

Normal Thyroid Function

PurposeManagement strategies after lobectomy for low-risk papillary thyroid carcinoma (PTC) are controversial. This study aimed to identify the proportion of patients among low-risk PTC patients who do not require hormone replacement therapy and to evaluate the risk factors for postoperative hypothyroidism after lobectomy.Patients and MethodsThe records of 190 PTC patients who underwent thyroid lobectomy from January 2017 to December 2018 were retrospectively reviewed. Clinicopathological characteristics and follow-up data were collected. Univariate and multivariate analyses were performed to identify the risk factors associated with postoperative hypothyroidism and the recovery of thyroid function.ResultsIn summary, 74.21% of patients (141/190) had normal thyroid function without levothyroxine supplementation, while 40.53% (77/190) developed temporary or permanent hypothyroidism. Multivariate analysis indicated that higher preoperative thyroid-stimulating hormone (TSH) levels (>2.62 mIU/L), Hashimoto’s thyroiditis (HT), and right lobectomy were associated with hypothyroidism (all P<0.05). The Area Under Curve (AUC) by logistic analysis was 0.829. Twenty-eight (28/77, 36.4%) patients recovered to the euthyroid state in the first year after surgery, and this recovery was significantly associated with preoperative TSH level. Forty-nine (49/77, 63.6%) patients developed persistent hypothyroidism. The thyroid function of most patients (11/28, 39.3%) recovered in the third month after surgery.ConclusionPatients with a lower level of preoperative TSH, with left lobectomy and without Hashimoto’s thyroiditis had a higher chance of normal thyroid function within the first year after lobectomy. The recovery of thyroid function was associated with the level of preoperative TSH.

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Thyroid hormone alterations in critically and non-critically ill patients with SARS-CoV-2 infection

Endocrine Connections ◽

10.1530/ec-21-0029 ◽

2021 ◽

Author(s):

Dimitra Argyro Vassiliadi ◽

Ioannis Ilias ◽

Maria Pratikaki ◽

Edison Jahaj ◽

Alice G Vassiliou ◽

...

Keyword(s):

Thyroid Hormone ◽

Critically Ill ◽

Thyroid Function ◽

Critically Ill Patients ◽

Icu Patients ◽

Similar Frequency ◽

Normal Thyroid ◽

Severity Of Disease ◽

Normal Thyroid Function ◽

High Prevalence

Objective: Following evolution of COVID-19 pandemic, reports pointed on a high prevalence of thyroiditis related thyrotoxicosis. Interpretation of thyroid tests during illness, however, is hampered by changes occurring in the context of non-thyroidal illness syndrome (NTIS). In order to elucidate these findings, we studied thyroid function in carefully selected cohorts of COVID-19 positive and negative patients. Design: Cohort observational study. Methods: We measured TSH, FT4, T3 within 24hours of admission in 196 patients without thyroid disease and/or confounding medications. 102 patients were SARS-CoV-2 positive; 41 admitted in the ICU, 46 in the ward and 15 outpatients. Controls consisted of 94 SARS-CoV-2 negative patients; 39 in the ICU and 55 in the ward. We designated the thyroid hormone patterns as consistent with NTIS, thyrotoxicosis and hypothyroidism. Results: A NTIS pattern was encountered in 60% of ICU and 36% of ward patients, with similar frequencies between SARS-CoV-2 positive and negative patients (46.0% vs 46.8%, p=NS). A thyrotoxicosis pattern was observed in 14.6% SARS-CoV-2 ICU patients vs. 7.7% in ICU negative (p=NS) and, overall in 8.8% of SARS-CoV-2 positive vs. 7.4% of negative patients. In these patients thyroglobulin levels were similar to those with normal thyroid function or NTIS. The hypothyroidism pattern was rare. Conclusions: NTIS pattern is common and relates to the severity of disease rather than SARS-CoV-2 infection. A thyrotoxicosis pattern is less frequently observed with similar frequency between patients with and without COVID-19. It is suggested that thyroid hormone monitoring in COVID-19 should not differ from other critically ill patients.

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Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Lipids in Health and Disease ◽

10.1186/s12944-016-0403-4 ◽

2017 ◽

Vol 16 (1) ◽

Cited By ~ 3

Author(s):

Lynnda J. N. van Tienhoven-Wind ◽

Robin P. F. Dullaart

Keyword(s):

Metabolic Syndrome ◽

Thyroid Function ◽

Normal Thyroid ◽

Normal Thyroid Function

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Relationship between thyroid hormones and metabolic syndrome in a normal thyroid function population in Western China

Chinese Medical Journal ◽

10.1097/cm9.0000000000001553 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Sheng-Ru Liang ◽

Jing Cai ◽

Yang Yang ◽

Lei Zhang ◽

Peter Taylor ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Hormones ◽

Thyroid Function ◽

Western China ◽

Normal Thyroid ◽

Normal Thyroid Function

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Lower Normal Thyroid Function is Associated With a Higher Risk of Metabolic Syndrome: A Retrospective Cohort on Chinese Population

10.21203/rs.3.rs-91686/v1 ◽

2020 ◽

Author(s):

Xi Ding ◽

Chunying Zhu ◽

Rui Li ◽

Liping Wu ◽

Yue Wang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Function ◽

Heart Association ◽

Health Examination ◽

Reference Ranges ◽

Free Triiodothyronine ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Cutoff Values ◽

Significant Difference

Abstract BackgroundRecently, the relationship between thyroid hormones (THs) across the euthyroid ranges and metabolic syndrome (MetS) has been widely discussed. This study aimed to present specific cutoff values of THs to assess the association between THs and MetS in a euthyroid cohort.MethodsData of 2694 subjects, aged 18-80 years, who attended health examination in Xi’an Electric Power Central Hospital from April 2011 to December 2015 were collected and analyzed. The basic cohort enrolled 929 participants (followed up by 2221 person-years totally) to assess correlations between serum thyrotropin (TSH), triiodothyronine (T3), thyroxine (T4) levels and MetS. The second cohort included 698 participants (followed up by 1709 person-years totally) to evaluate relationships between serum free triiodothyronine (FT3), free thyroxine (FT4) levels and MetS. MetS was defined according to the criteria of the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) scientific statements of 2009. Euthyroidism was defined as serum TSH, FT3 and FT4 levels within the reference ranges without taking any thyroid medication.ResultsThe cutoff values for TSH, T3, T4, FT3 and FT4 were 2.0mIU/L, 1.9nmol/L, 117nmol/L, 4.3pmol/L and 16pmol/L, respectively. Participants were categorized into two groups according to cutoff values: the lower-THs group and the higher-THs group. There was no significant difference in the risk of MetS between two groups in TSH, T3, T4 and FT3. The incidence of MetS was significantly higher in lower-FT4 group than higher-FT4 group (1.00 vs 0.622 (0.458, 0.846), P=0.002). The lower-FT4/higher-TSH group had the highest hazard ratios of MetS. (2.131vs 1.0 (1.380,3.291), P=0.006)ConclusionsLower normal FT4 (FT4≤16.0 pmol/L) is an independent risk factor for MetS, and lower normal thyroid function (TSH>2.0 mIU/L and FT4≤16.0 pmol/L) is associated with a higher risk of developing MetS.

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Retrospective Analysis of the Correlation between Uric Acid and Thyroid Hormone in People with Normal Thyroid Function

Journal of Diabetes Research ◽

10.1155/2019/5904264 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Guanqun Chao ◽

Yue Zhu ◽

Lizheng Fang

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Thyroid Hormone ◽

Physical Examination ◽

Retrospective Analysis ◽

Thyroid Function ◽

General Information ◽

Normal Thyroid ◽

Medical College ◽

Normal Thyroid Function

Objective. This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone. Methods. The subjects of the study were healthy subjects who underwent physical examination at the Sir Run Run Shaw Hospital affiliated to the Medical College of Zhejiang University from January 2016 to December 2018. Demographic information and medical history of all subjects were recorded through an electronic health system. Serum uric acid (SUA) was grouped by quartiles. Statistical analyses were performed with R version 3.5.1. Results. A total of 48,526 subjects were included in the analysis. Gender ratio, age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, FBG, HbA1c, TG, HDL-C, ALT, AST, FT3, FT4, and TSH were significantly different among the uric acid groups. The regression coefficients of SUA in the TSH, FT3, and FT4 regression models were B=1.000 (95% CI 1.000-1.000, p=0.009), B=0.999 (95% CI 0.999-0.999, p<0.001), and B=1.001 (95% CI 1.001-1.001, p<0.001), respectively. There was a significant dose-dependent relationship between FT4, FT3, and SUA gradient. Conclusions. Under normal thyroid function, there were significant differences in TSH, FT3, and FT4 between groups with different uric acid levels. Uric acid levels were linearly correlated with FT3 and FT4, but not with TSH.

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