scholarly journals A Descriptive Report of Combination Therapy (Custom Face Mask for CPAP Integrated With a Mandibular Advancement Splint) for Long-Term Treatment of OSA With Literature Review

2017 ◽  
Vol 04 (02) ◽  
pp. 29-36
Author(s):  
Ronald S. Prehn ◽  
Todd Swick
Keyword(s):  
Literature Review ◽  
Combination Therapy ◽  
Face Mask ◽  
Term Treatment ◽  
Mandibular Advancement ◽  
Mandibular Advancement Splint ◽  
Long Term Treatment

Aspects of Long-Term Treatment with Neuroleptics Historical and Literature Review—Personal Experience with Fluspirilene and Penfluridol

1975 ◽  
Vol 3 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Lucian Floru
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Personal Experience ◽  
Term Treatment ◽  
Term Therapy ◽  
Tabular Form ◽  
Long Term Effects ◽  
Long Term Treatment ◽  
Long Term Therapy

The literature on neuroleptics with substance-specific long-term effects (fluspirilene, penfluridol) is reviewed in tabular form. This is followed by a report of personal investigations on 76 schizophrenics who were treated with fluspirilene initially within the hospital and later on an out-patient basis, on 86 patients who were treated with it exclusively at the out-patients' department, as well as on 123 schizophrenic psychoses treated with penfluridol in the out-patients' department. The side-effects caused by the two substances are compared. Pre-requisites for effective long-term therapy with a few complications are discussed.

scholarly journals Defining phenotypes of long-term lithium and valproate response, including combination therapy: a modified application of the Alda scale in patients with bipolar disorders

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Jinyoung Lee ◽  
Ji Hyun Baek ◽  
Dongbin Lee ◽  
Sung Woo Ahn ◽  
So-Yung Yang ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Treatment Response ◽  
Mood Stabilizer ◽  
Term Treatment ◽  
Mood Stabilizers ◽  
Combination Group ◽  
Monotherapy Group ◽  
Clinical Correlates ◽  
Long Term Treatment

Abstract Background When evaluating the long-term treatment response to mood stabilizers using the Alda scale, mood stabilizer combination therapy is typically considered a confounding factor, and patients receiving combination therapy are excluded from the analysis. However, this may result in bias if those under combination therapy are worse treatment responders. This study aims to explore whether the Alda scale is applicable to patients taking lithium and valproate combination therapy. We compared long-term treatment response in patients receiving monotherapy and combination therapy of the two drugs, and investigated clinical correlates of the responses to each drug. Methods The study subjects consisted of 102 patients with bipolar I (BD-I) or bipolar II (BD-II) disorder who had been undergoing maintenance treatment with lithium and/or valproate for more than 2 years at a single specialized bipolar disorder clinic. Long-term treatment response was measured using the Alda scale and compared among the lithium monotherapy group, the valproate monotherapy group, and the mood stabilizer combination group. Clinical correlates of long-term treatment response were evaluated in lithium users and valproate users separately. Results There were no significant differences in terms of baseline illness characteristics among groups. The combination group showed the worst treatment response for all the response measurements applied. This group also had the higher rate of ‘poor responder’ with a statistically significant difference compared to valproate group. Older age at onset and (hypo)manic episode at onset showed significant positive associations with total Alda score in lithium users, while comorbid anxiety disorders, obsessive–compulsive disorder and mixed episode showed significant negative associations in valproate users. Conclusions The combination group had poorer long-term treatment response but did not show distinct clinical characteristics compared to the monotherapy groups. When exploring the long-term effects of mood stabilizers, excluding patients undergoing combination treatment could result in bias because they may represent a poor response group. The long-term treatment responses of lithium and valproate had different clinical correlates.

scholarly journals The importance of psychological and nutritional follow-up after bariatric surgery: Literature review

2021 ◽  
pp. 20-44
Author(s):  
Carla Viana Dendasck ◽  
Rogério Bongestab dos Santos ◽  
Vitor Maia Santos ◽  
Tadeu Uggere de Andrade ◽  
Adriano Ribeiro Meyer Pflug
Keyword(s):  
Bariatric Surgery ◽  
Literature Review ◽  
Postoperative Period ◽  
Term Treatment ◽  
Psychological Status ◽  
Postoperative Treatment ◽  
Long Term Treatment ◽  
The Individual

Obesity is a multifactorial chronic disease. The patient may present several clinical conditions associated with it. The clinical picture is complex, which can hinder the use of conventional treatments and methods. Bariatric surgery is an effective long-term treatment for this condition. Based on a literature review, the article aims to discuss the importance of post-bariatric psychological and nutritional follow-up. The fundamental question that underpits this study is: how can typical strategies in the postoperative period contribute to the individual undergoing surgery to give greater importance to his diet and mental health? The most effective treatment strategy has been bariatric surgery, however, the multidisciplinary evaluation that scores the patient’s biological, social and psychological status is fundamental, since psychopathological changes are common to obese individuals. Although bariatric surgery contributes to the improvement in the quality of life of patients, there needs to be greater attention to postoperative treatment. These individuals should be encouraged to continue with nutritional and psychological follow-up in the postoperative period, so that it is possible to prevent possible complications in the medium and long term.

scholarly journals Momordica charantia (Bitter melon) in Combination with Metformin Potentiates Hypoglycemic and Hypolipidemic Effects in Alloxan-induced Diabetic Rats

2018 ◽  
Vol 21 (2) ◽  
pp. 109-117
Author(s):  
Monirul Islam ◽  
Md Saiful Islam ◽  
Shaheda Zannah ◽  
Golam Sadik ◽  
Mamunur Rashid
Keyword(s):  
Combination Therapy ◽  
Treatment Protocol ◽  
Liver Glycogen ◽  
Term Treatment ◽  
Fixed Dose ◽  
Control Group ◽  
Bitter Melon ◽  
Short Term ◽  
Long Term Treatment

The present study was designed to investigate the effects of bitter melon (Momordica charantia) in combination with a standard oral hypoglycemic agent metformin on alloxan induced diabetic rats (AIDRs). Both the plant extract and the drug, individually and in combination, were subjected in vivo for two weeks (short term) and four weeks (long term) treatment protocol to determine blood glucose level, lipid profile and liver glycogen level using Swiss Albino rats. In short term treatment protocol, bitter melon extract (BME) at a dose of 75, 150 and 300 mg/ kg body weight (bw) were administered in AIDRs by using oral gavages once daily and dose-dependent antihyperglycemic and antidyslipidemic effects were investigated. This short term study revealed that the most effective dose of BME was found as 300 mg/kg bw among the three doses. In long term treatment protocol, AIDRs in different groups received fixed dose monotherapy of BME (300 mg/kg bw) and metformin (15 mg/kg bw) and fixed dose BME (150 mg/kg bw) and metformin (7.5 mg/kg bw) combination therapy. The study showed that combination therapy significantly decreased the blood glucose level from 18.42 ± 0.95 to 6.80 ± 0.39 mmol/l in comparison to the control group after daily treatment for four weeks. In case of antidyslipidemic effect, combination therapy reduced total cholesterol (34.25%), triglycerides (11.92%) and LDL-cholesterol (57.73%) levels and increased HDL-cholesterol level (55.48%) in comparison with their respective control groups. Metformin, BME and their combination preserved the liver glycogen level by 35.21%, 22.54% and 49.01%, respectively in comparison to diabetic control group. These changes were significantly better than those of BME and metformin monotherapy. The results suggested that treatment with combination therapy was more effective than mono-therapy for preventing diabetes as bitter melon extract potentiates the effects of metformin on long term alloxan-induced diabetic rats.Bangladesh Pharmaceutical Journal 21(2): 109-117, 2018

Evaluation of long-term treatment with glycyrrhizin and of combination therapy with glycyrrhizin and AZT or DDI on HIV-1 carriers

1996 ◽  
Vol 30 (1) ◽  
pp. A33 ◽  
Author(s):  
N. Ikegami ◽  
S. Kinoshita ◽  
T. Kanesaki ◽  
K. Uno ◽  
K. Akatani ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Hiv 1
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