Diuretic activities of hydro-alcoholic extract and solvent fractions of the roots of Withania somnifera L. (Solanacaea) in rats

Abstract: The present reaearch has been undertaken with the aim to fomulate and evaluate the herble gel containng alcoholic extract of Hollarrhena pubences(kurchi), Withania somnifera(ashwagandha), curcuma longa(turmeric)Azadiracht indica(neem). The gel formulation prepared by using various polymer bases(methyl cellulose) . The stability study have carried as perICH guideline. The result show that the gel formulation containing kurchi, ashwagandha, turmeric, neem has better stability than other. All formulation studied on animal model(rat).The present work justifies the use oh herbal gel containing ashwagandha, turmeric, neem, kurchi for wound healing. Keywords: wound healing; Hollarrhena pubences, withania somnifera, curcuma longa, azadirachta indica; topicle gel.

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New withanolides from a cross of a South African chemotype by chemotype II (Israel) in Withania somnifera

Phytochemistry ◽

10.1016/s0031-9422(00)82110-x ◽

1980 ◽

Vol 19 (5) ◽

pp. 1503-1507 ◽

Cited By ~ 2

Author(s):

F Eastwood

Keyword(s):

South African ◽

Withania Somnifera

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Antiplasmin Deficiency in Polycythaemia: a Form of Thrombopathy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654576 ◽

1961 ◽

Vol 06 (03) ◽

pp. 445-461 ◽

Cited By ~ 3

Author(s):

S. I de Vries ◽

M. A. J Braat-van Straaten ◽

E Müller ◽

M Wettermark

Keyword(s):

Fibrinolytic Activity ◽

Alcoholic Extract ◽

Surgical Interventions ◽

Fallot's Tetralogy ◽

Naturally Occurring ◽

Fallot’S Tetralogy

SummaryA marked fibrinolytic activity could be demonstrated in the blood of 10 patients with polycythaemia. In these cases fibrinolysis was considered the result of a deficiency an antiplasmin. It could be demonstrated that this naturally occurring inhibitor of fibrinolysis is present in normal platelets but is lacking in the patient’s own thrombocytes. This factor is probably attached to the surface of the thrombocytes. It could be removed by repeatedly washing. Lack of antiplasmin is a dysfunction of platelets and a form of thrombopathy. It does not respond on treatment with ACA or prednisone. In primary polycythaemia busulfan (Myleran) was considered to be the treatment of choice, whereas in 1 case of secundary erythrocytosis (Fallot’s tetralogy) the reaction on unroasted peanuts was unmistakable. In 4 more patients an alcoholic extract of peanuts was given, and promising results were obtained in 3 of them. The importance of this “thrombopathic type’ of fibrinolysis has been pointed out especially in view of surgical interventions.

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Therapeutic efficacy of some extracts of hot pepper fruits (Capsicum annuum) and Sumac seeds (Rhus coriaria) on the growth of some isolated dermatophytes species

International Journal of Medical Sciences ◽

10.32441/ijms.v1i3.102 ◽

2018 ◽

Vol 1 (3) ◽

pp. 52-62

Author(s):

Sara Omran ◽

Abdulghani Alsamarai ◽

Firas Razzzaq

Keyword(s):

Antifungal Activity ◽

Fungal Infection ◽

Aqueous Extract ◽

Plant Extracts ◽

Therapeutic Efficacy ◽

Diffusion Method ◽

Quantitative Detection ◽

Hot Pepper ◽

Alcoholic Extract ◽

Dermatology Clinic

Background: Fungal infections are one of the common skin diseases with difficulty in their treatment approach. The present efficient drugs for fungal infection are limited. Aim: To determine the therapeutic efficacy of plant extracts as alternative antifungal agents. Materials and methods: 100 clinical samples [68 from female and 32 from male] were collected during the period from March to July 2017 from subjects attending Dermatology Clinic in Salah Uldean General Hospital. Fungal infection was diagnosed with using KOH wet preparation. Fungal species identified by using conventional approach. The active ingredients existing in the plant extracts were detected and analyzed through qualitative and quantitative detection technique of chemical compounds using a high performance liquid chromatographic device (HPLC). Agar diffusion method was used to determine antifungal activity of plant extracts. Results: Direct microscopic examination showed that there were (75%) positive samples, while culture shows (67%) positive samples. The isolated dermatophytes belong to Epidermophyoton, Microsporum, and Trichophyton genus. The predominant dermatophytes were T. rubrum (25%) species. The highest frequency of infection was in the age group of 11-20 years. The sensitivity of the tested fungi to the aqueous and alcoholic plant extracts varies. Alcoholic extract of the hot pepper plant was more effective as antifungal than the aqueous extract of the same plant. However, aqueous hot pepper extracts was more effective against T. mentagrophyte than that of alcoholic extract. Additionally, alcoholic Sumac extract shows higher efficacy that aqueous extract. Conclusion: Hot pepper and Sumac extracts show antifungal activity against Microsporum canis, Trichophyton rubrum and T. mentagrophyte.

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