Epidemiological Features and Associated Factors of Pulmonary Tuberculosis with Positive Microscopy in the Infectious Diseases Unit at the CHU of Brazzaville

We present an analysis of 28 leptospirosis cases, associated with abroad traveling, and registered from 2011 to 2017 years. The relative ratio of leptospirosis with other imported infectious diseases is shown, and clinical and epidemiological features of imported leptospirosis cases were described

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Anti- cyclic citrullinated peptide antibodies in tuberculosis and human immunodeficiency virus

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201615 ◽

2020 ◽

Vol 7 (5) ◽

pp. 804

Author(s):

Rakesh K. Yadav ◽

Raj K. ◽

Kachnar V. ◽

Manoj K. Mathur ◽

Amitabh D. Shukla

Keyword(s):

Rheumatoid Arthritis ◽

Human Immunodeficiency Virus ◽

Virus Infection ◽

Pulmonary Tuberculosis ◽

Infectious Diseases ◽

Human Immunodeficiency Virus Infection ◽

Extra Pulmonary Tuberculosis ◽

Immunodeficiency Virus ◽

Extra Pulmonary ◽

Citrullinated Peptide

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like tuberculosis, human immunodeficiency virus infection, etc.Methods: Eighty patients of tuberculosis both pulmonary and extra-pulmonary tuberculosis and thirty patients of human immunodeficiency virus were enrolled in this study from inpatient and outpatient departments from September 2018 to August 2019. Anti-CCP antibody test was done in all the patient by enzyme linked immunosorbent assay.Results: Fifty-three patients were of pulmonary tuberculosis, 27 patients were extra-pulmonary tuberculosis and 30 patients were human immunodeficiency virus infection. Of the 53 cases of pulmonary tuberculosis, 21 (39.6%) cases were positive for anti-CCP antibodies and 32 (60.4%) cases were negative for the same. Of the 27 cases of extra-pulmonary tuberculosis, 3(11.1%) cases were positive for anti-CCP antibodies and 24 (88.9%) cases were negative. Of the 53 patients of pulmonary tuberculosis, 16 were sputum positive and 37 were sputum negative. Of those withsputum positive 9 (56.2%) cases were positive for anti-CCP antibodies and those with sputum negative, 12 (32.4%) cases were positive for anti-CCP antibodies. Of the 30 cases of human immunodeficiency virus, 5 (16.7%) cases were positive for anti-CCP antibodies and 25 (83.3%) cases were negative.Conclusions: Anti-CCP can be positive in cases of infectious diseases like tuberculosis and human immunodeficiency virus. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary tuberculosis. Anti-CCP, thus is not very specific for rheumatoid arthritis.

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Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia

Infection and Drug Resistance ◽

10.2147/idr.s326798 ◽

2021 ◽

Vol Volume 14 ◽

pp. 4493-4500

Author(s):

Ziad Amin ◽

Habtamu Mitiku ◽

Dadi Marami ◽

Tadesse Shume ◽

Fitsum Weldegebreal

Keyword(s):

Multidrug Resistance ◽

Pulmonary Tuberculosis ◽

Associated Factors ◽

Eastern Ethiopia

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Delay for First Consultation and Its Associated Factors among New Pulmonary Tuberculosis Patients of Central Nepal

Tuberculosis Research and Treatment ◽

10.1155/2016/4583871 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Wongsa Laohasiriwong ◽

Roshan Kumar Mahato ◽

Rajendra Koju ◽

Kriangsak Vaeteewootacharn

Keyword(s):

Pulmonary Tuberculosis ◽

Associated Factors ◽

Cross Sectional Study ◽

Patient Delay ◽

Cross Sectional ◽

Tuberculosis Patients ◽

Central Nepal ◽

Delay Duration ◽

Development Region ◽

Public Health Challenge

Tuberculosis (TB) is still a major public health challenge in Nepal and worldwide. Most transmissions occur between the onset of symptoms and the consultation with formal health care centers. This study aimed to determine the duration of delay for the first consultation and its associated factors with unacceptable delay among the new sputum pulmonary tuberculosis cases in the central development region of Nepal. An analytical cross-sectional study was conducted in the central development region of Nepal between January and May 2015. New pulmonary sputum positive tuberculosis patients were interviewed by using a structured questionnaire and their medical records were reviewed. Among a total of 374 patients, the magnitude of patient delay was 53.21% (95% CI: 48.12–58.28%) with a median delay of 32 days and an interquartile range of 11–70 days. The factors associated with unacceptable patient delay (duration ≥ 30 days) were residence in the rural area (adj. OR = 3.10, 95% CI: 1.10–8.72;pvalue = 0.032) and DOTS center located more than 5 km away from their residences (adj. OR = 5.53, 95% CI: 2.18–13.99;pvalue < 0.001). Unemployed patients were more likely to have patient delay (adj. OR = 7.79, 95% CI: 1.64–37.00;pvalue = 0.010) when controlled for other variables.

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772. Factors Associated With Healthcare Delay of Active Pulmonary Tuberculosis After Hospitalization

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.779 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S276-S277

Author(s):

Jaijun Han ◽

Se Yoon Park ◽

Jebyung Park ◽

So Young Lee ◽

Gil Eun Kim ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Infectious Diseases ◽

Early Recognition ◽

Multivariate Logistic Regression Analysis ◽

Hospitalized Patients ◽

Pulmonary Tb ◽

Active Pulmonary Tuberculosis ◽

Factors Associated ◽

Delayed Recognition ◽

Significant Factors

Abstract Background Hospitals are undesirable reservoirs for a respiratory outbreak. Active pulmonary tuberculosis (TB) can be readily transmitted among hospitalized patients. Early recognition of pulmonary TB is an essential priority against transmission. The aim of this study was to evaluate factors associated with delayed identification of pulmonary TB in hospital settings. Methods Medical records of newly diagnosed TB patients admitted to a referral hospital from January 2015 through December 2017 were reviewed. Delayed recognition of pulmonary TB was defined as failure to initiate airborne isolation within the first 3 days after admission. We analyzed clinical, microbiological, radiological, and healthcare factors associated with delayed recognition of pulmonary TB. Patients who were not suspected of having active pulmonary TB had no remarks about TB on their initial chest radiograph interpretation by radiologists. Multivariate logistic regression analysis was performed with significant factors included. Results A total of 136 patients were analyzed who had positive sputum acid-fast bacilli (AFB) cultures. Of these, 45 (33%) patients were isolated 3 days after admission and had longer days of exposure before isolation (median 9, interquartile range [IQR] 6–14, P < 0.001) in comparison to others (median 0, IQR 0–1). Patients with older age (odds ratio [OR] = 1.04, 95% confidence interval [CI] 1.01–1.08, P = 0.01), patients who were admitted to departments other than infectious diseases or pulmonology (OR = 6.23, 95% CI 2.17–17.89, P = 0.001) and patients who were not suspected of having active pulmonary TB by radiologists (OR = 11.36, 95% CI 4.11–31.39, P < 0.001) were more likely to have delayed recognition of pulmonary TB. Conclusion In a country with intermediate TB prevalence, better awareness for pulmonary TB is required for all hospitalized patients who are admitted to departments other than infectious diseases or pulmonology. Although active pulmonary TB is not suspected by a radiologist, sputum AFB smear, and culture are necessary when new lesions are present in chest radiographs. Disclosures All authors: No reported disclosures.

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