scholarly journals Sperm count and future challenges for cancer patients

2020 ◽  
Vol 11 (3) ◽  
pp. 179-183
Author(s):  
Murid Javed
Keyword(s):  
Quality Of Life ◽  
Fertility Preservation ◽  
Sperm Count ◽  
Testicular Tissue ◽  
Chemotherapeutic Agents ◽  
Sexual Life ◽  
Malignant Neoplasms ◽  
Minimum Requirement

Cancer has significantly harmful effects on sperm count, motility and sexual life of the survivor, thereby adversely affecting the fertility and post cancer quality of life. Use of safer chemotherapeutic agents, protection from radiation damage, cryopreservation of sperm and testicular tissue and use of protective drugs to reduce testicular damage is recommended. More research is needed to safeguard fertility of cancer affected children as testicular tissue cryopreservation is the only fertility preservation option. Advanced understanding of in vitro sperm production is needed. In this era of advanced assisted reproduction, the minimum requirement for fertilization is one healthy sperm for one oocyte. Children born after chemotherapy do not have statistically significant increase in malignant neoplasms. Proper cancer counseling and referral for fertility preservation are of high importance to protect fertility. The focus of this review is to share knowledge of sperm formation, importance of sperm count, nature of damage to male fertility, remedies to overcome damage and to improve post cancer quality of life of male cancer survivors.

Does Infliximab Short Infusion have a Beneficial Impact on the Quality of Life in Patients with Inflammatory Bowel Diseases? A Single Centre Prospective Evaluation

2015 ◽  
Vol 24 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Mariabeatrice Principi ◽  
Giuseppe Losurdo ◽  
Rosa Federica La Fortezza ◽  
Pasquale Lopolito ◽  
Rosa Lovero ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Diseases ◽  
Adverse Reactions ◽  
Severe Disease ◽  
Sexual Life ◽  
Necrosis Factor Alpha ◽  
Short Infusion ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Background & Aims: Infliximab (IFX) is an anti-tumor necrosis factor alpha agent used in inflammatory bowel diseases (IBD) therapy. Usually, it is administered over a 2-hour intravenous infusion. However, shortening the infusion duration to 1 hour has proved to be feasible and safe. In the present study we evaluated whether shortening the IFX infusion could affect the patients' quality of life (QoL) compared to the standard protocol.Methods: Subjects affected by IBD receiving IFX were prospectively recruited. The main criterion to shorten the infusion was the absence of IFX-related adverse reactions during the previous three 2-h infusions. For each patient, demographic, clinical and anthropometric data were collected. A questionnaire investigating their overall/job/social/sexual QoL was administered. Ordinal regression was performed with odds ratios (OR) for significant independent variables.Results: Eighty-one patients were included (46 with ulcerative colitis - UC, 35 with Crohn's disease - CD). Sixteen received the 2-h infusion due to previous adverse reactions, and the remaining 65 underwent the 1-h schedule. Shortening the infusion to 1 hour determined a better QoL (OR=0.626). However, the QoL was negatively influenced by age (OR=1.023), female sex (OR=2.04) and severe disease activity (OR=7.242). One-hour IFX infusion induced a better outcome on work (OR=0.588) and social (OR=0.643) QoL. Long-standing disease was correlated with a slightly better sexual QoL (OR=0.93). Conversely, older age (OR=1.046), severe clinical score (OR=15.579), use of other immunomodulators (OR=3.693) and perianal CD (OR=3.265) were related to an unsatisfactory sexual life. The total number of infusions (OR=0.891), proctitis (OR=0.062) or pancolitis (OR=0.1) minimized the perception of infusion-related side effects.Conclusion: The 1-h short infusion improves overall, social and job QoL, so that, when indicated, it should be recommended.

Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

2019 ◽  
Vol 26 (7) ◽  
pp. 512-522
Author(s):  
Xian Li ◽  
Long Xia ◽  
Xiaohui Ouyang ◽  
Qimuge Suyila ◽  
Liya Su ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Nude Mice ◽  
Low Dose ◽  
Bioactive Peptides ◽  
Human Colorectal Cancer ◽  
Short Term ◽  
Hct 116

<P>Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. </P><P> Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. </P><P> Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. </P><P> Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. </P><P> Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.</P>

Sexual Function and Fertility Quality of Life in Women Using In Vitro Fertilization

2015 ◽  
Vol 12 (4) ◽  
pp. 985-993 ◽  
Author(s):  
Nicole K. Smith ◽  
Jody Madeira ◽  
Heather R. Millard
Keyword(s):  
Quality Of Life ◽  
In Vitro Fertilization ◽  
Sexual Function ◽  
Vitro Fertilization

Changes in weight and weight-related quality of life in a multicentre, randomized trial of aripiprazole versus standard of care

2008 ◽  
Vol 23 (8) ◽  
pp. 561-566 ◽  
Author(s):  
Ronette L. Kolotkin ◽  
Patricia K. Corey-Lisle ◽  
Ross D. Crosby ◽  
Hong J. Kan ◽  
Robert D. McQuade
Keyword(s):  
Quality Of Life ◽  
Clinical Symptoms ◽  
Clinical Trial Data ◽  
Standard Of Care ◽  
Random Regression ◽  
Sexual Life ◽  
Baseline Body Mass Index ◽  
Meaningful Change ◽  
Related Quality

AbstractBackgroundThis is a secondary analysis of clinical trial data collected in 12 European countries. We examined changes in weight and weight-related quality of life among community patients with schizophrenia treated with aripiprazole (ARI) versus standard of care (SOC), consisting of other marketed atypical antipsychotics (olanzapine, quetiapine, and risperidone).MethodFive-hundred and fifty-five patients whose clinical symptoms were not optimally controlled and/or experienced tolerability problems with current medication were randomized to ARI (10–30 mg/day) or SOC. Weight and weight-related quality of life (using the IWQOL-Lite) were assessed at baseline, and weeks 8, 18 and 26. Random regression analysis across all time points using all available data was used to compare groups on changes in weight and IWQOL-Lite. Meaningful change from baseline was also assessed.ResultsParticipants were 59.7% male, with a mean age of 38.5 years (SD 10.9) and mean baseline body mass index of 27.2 (SD 5.1). ARI participants lost an average of 1.7% of baseline weight in comparison to a gain of 2.1% by SOC participants (p < 0.0001) at 26 weeks. ARI participants experienced significantly greater increases in physical function, self-esteem, sexual life, and IWQOL-Lite total score. At 26 weeks, 20.7% of ARI participants experienced meaningful improvements in IWQOL-Lite score, versus 13.5% of SOC participants. A clinically meaningful change in weight was also associated with a meaningful change in quality of life (p < 0.001). A potential limitation of this study was its funding by a pharmaceutical company.ConclusionsCompared to standard of care, patients with schizophrenia treated with aripiprazole experienced decreased weight and improved weight-related quality of life over 26 weeks. These changes were both statistically and clinically significant.

Quality of Life in People Living With HIV: An Exploratory Cross-Sectional Survey in Belgium

2021 ◽  
Vol 33 (3) ◽  
pp. 249-264
Author(s):  
Gert Scheerder ◽  
Sandra Van den Eynde ◽  
Patrick Reyntiens ◽  
Ria Koeck ◽  
Jessika Deblonde ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Sexual Life ◽  
People Living With Hiv ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Related Stigma ◽  
Living With Hiv ◽  
The Impact

This cross-sectional survey explored the quality of life in 505 people living with HIV in Belgium. Several domains of quality of life were impaired: 26% had been diagnosed with depression and 43% had weak social support. HIV-related stigma is still widespread, with 49% believing most people with HIV are rejected and 65% having experienced discrimination due to HIV. The impact of HIV was limited on professional life, but 40% experienced a negative impact on life satisfaction and 41% a negative impact on sexual life. For several domains, people with a recent diagnosis of HIV and long-term survivors had significantly worse scores. This survey also uncovered strengths of people living with HIV, such as positive coping and HIV self-image. Expanding the scope of quality of life in people living with HIV may provide a more complete picture of relevant life domains that may be impacted by living with HIV, but this needs further validation.

scholarly journals PENGARUH SINDROMA DEPRESI TERHADAP DISFUNGSI EREKSI

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Andre Hutagalung ◽  
Christoffel Elim ◽  
Herdy Munayang
Keyword(s):  
Quality Of Life ◽  
Erectile Dysfunction ◽  
Sexual Function ◽  
Key Words ◽  
Sexual Intercourse ◽  
Social Process ◽  
Sexual Life ◽  
Sexual Stimulus ◽  
Physical Diseases

Abstract: Normal sexual function is a bio-psycho-social process which is significantly related to the quality of life (QOL). Any disturbance in one of the components can be a disaster in sexual life.  Erectile dysfunction is a disability to get an erection or to maintain the erection well enough for a sexual intercourse, which persists or recurs at least three months conse-cutively due to either psychogenic or organic disturbances, or both. Some psychogenic dis-turbances especially depression, anxiety, and relational distress, play some important roles in ED. Besides that, aging, low testoteron level, physical diseases, and some certain medicines have to be included. Key words: erection, erectile dysfunction, sexual stimulus, depression.     Abstract: Fungsi seksual yang normal merupakan suatu proses biopsikososial yang berkaitan langsung dengan kualitas hidup. Adanya gangguan pada salah satu komponen dapat menjadi malapetaka bagi kehidupan seksual. Disfungsi ereksi dapat dedefinisikan sebagai suatu keti-dakmampuan untuk ereksi atau mempertahankan ereksi yang cukup untuk melakukan hu-bungan seksual yang memuaskan, yang menetap atau berulang paling tidak selama tiga bulan berturut-turut. Gangguan psikogenik khususnya sindroma depresi, ankietas, dan distres relasional berperan penting dalam hal terjadinya disfungsi ereksi. Disamping itu usia lanjut, rendahnya kadar testoteron, penyakit fisik, dan beberapa jenis obat perlu diperhitungkan. Kata kunci: fisiologi ereksi, disfungsi ereksi, stimulus seksual, depresi.

scholarly journals PROFILE OF MALIGNANT IN CHILDREN OF VINNITSIA REGION, CLINICAL EXPERIENCE

2021 ◽  
Vol 11 (2(40)) ◽  
pp. 5-11
Author(s):  
O. Rubina ◽  
J. Kulik ◽  
О. Моravska ◽  
К. Bеrtsun ◽  
R. Homon
Keyword(s):  
Quality Of Life ◽  
Computed Tomography ◽  
Contrast Enhancement ◽  
Clinical Experience ◽  
Cancer Incidence ◽  
Age Groups ◽  
Malignant Neoplasms ◽  
Embryonic Origin

Introduction. The structure of cancer incidence inchildren has its own characteristics. The majority of tumorsthat appear in childhood are of embryonic origin. Malignantneoplasms (MN) remain one of the most serious diseases ofchildhood. At present, it is obvious that it is impossible totake measures aimed at reducing morbidity and mortalityfrom MN and to improve the quality of life of cancerpatients without proper accounting and registration of thispatients’ group. The structure of oncopathology in childrenof different age groups of Vinnitsia region is given.The purpose of the study is to provide medical andstatistical assessment of malignant neoplasms in children ofVinnitsia region and to highlight the experience of treatmentof a newborn with giant teratoblastoma of external-internallocalization and teratoma of internal localization.Results. The profile of malignant neoplasms in childrenof Vinnitsia region has been presented and the clinical caseof giant teratoblastoma of external-internal localizationand teratoma of internal localization has been described.Conclusions. The most informative diagnostic methodis computed tomography with contrast enhancement, whichallows you to clearly determine the topographic location ofthe tumor and its relationship to the surrounding anatomicalstructures, considering the complexity of the anatomicallocation of sacrococcygeal teratoblastoma (SCT). Earlysurgical treatment of SCT, namely removal of the tumorwith the coccyx, is the only correct and justified treatmenttactic.

scholarly journals Justification for use of selenium-modified mineral water in medical rehabilitation of patients who underwent colon surgery due to malignant tumor (overview)

2019 ◽  
Vol 18 (6) ◽  
pp. 396-400
Author(s):  
Marat B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Large Intestine ◽  
Malignant Tumor ◽  
Mineral Water ◽  
Immune Status ◽  
Colon Surgery ◽  
Medical Rehabilitation ◽  
Malignant Neoplasms ◽  
Malignant Diseases

The article presents the justification for the use of selenium-modified low-mineralized mineral water of Chapaevsk deposit (the Karachay-Cherkess Republic), modified by selenium. It describes its effect on the state of hormonal and immune status, antioxidant system in malignant diseases of digestive organs, prevention of complications, reduction of dose of used medicines, improvement of quality of life of this category of patients. Conclusion. It is noted that the use of selenium-modified low-mineralized mineral water expands and complements the possibilities of rehabilitation and rehabilitation assistance to patients who have undergone operations on the large intestine in case of malignant neoplasms.

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