scholarly journals Revisiting Prostate Biopsy with 2014 ISUP Modified Gleason Score and Gleason Grade – A Cross Section Study

2018 ◽  
Vol 5 (12) ◽  
pp. 2918-2925
Author(s):  
Manan B Shah ◽  
Kalyani Raju ◽  
Harish Kumar G
Keyword(s):  
Risk Stratification ◽  
Cross Section ◽  
Gleason Score ◽  
Prostatic Carcinoma ◽  
Marked Decrease ◽  
Gleason Grade ◽  
Gleason Grading ◽  
The World ◽  
The Impact ◽  
New Criteria

Background: Prostatic carcinoma is one of the most common carcinomas among men throughout the world. Gleason score (GS) system is used in reporting and assessing the prognosis of prostatic carcinoma. The GS has undergone modifications. The objective of this study is to evaluate the impact of the new 2014 ISUP Modified Gleason System and Gleason grading (GG) on reporting of prostatic carcinoma. Methodology: This is a retrospective Study. All cases reported as adenocarcinoma prostate from January 2013 to July 2018 were included in the study. The GS done previously as per 2005 criteria was noted. The GS system and GG were done on the microslides retrieved as per 2015 criteria and compared with that of GS already recorded and also with old risk stratification. Results: Comparing the GS of 2005 and 2015 criteria, there was a marked decrease (80%) in Gleason score 6; among these cases, 80% cases were graded as score 7, and 20% cases were graded as score 8. There is also a 28.57% decrease in Gleason score 8 and 60% increase in Gleason score 9 due to the new criteria for pattern 4. The GG 1,2,3,4 and 5 constituted 3.03%, 18.18%, 15.15%, 15.15%, and 48.49% of cases respectively. Conclusion: The new GS and GG has more impact on prognosis of adenocarcinoma prostate as GS 6 has better prognosis and GG gives better risk stratification compared to the previous risk stratification.  

SU-FF-T-53: The Impact of Primary Gleason Grade On Biochemical Outcome Following Brachytherapy for Hormone Naïve Gleason Score 7 Prostate Cancer

2005 ◽  
Vol 32 (6Part7) ◽  
pp. 1961-1961
Author(s):  
G Merrick ◽  
W Butler ◽  
R Galbreath ◽  
Z Allen ◽  
E Adamovich
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Gleason Grade ◽  
The Impact

The Impact of Primary Gleason Grade on Biochemical Outcome Following Brachytherapy for Hormone-Naive Gleason Score 7 Prostate Cancer

2005 ◽  
Vol 11 (3) ◽  
pp. 234-240 ◽  
Author(s):  
Gregory S. Merrick ◽  
Wayne M. Butler ◽  
Kent E. Wallner ◽  
Robert W. Galbreath ◽  
Zachariah A. Allen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Gleason Grade ◽  
The Impact

scholarly journals ADC mapping with 12 b values: an improved technique for image quality in diffusion prostate MRI

2019 ◽  
Author(s):  
Lucas Scatigno Saad ◽  
George de Queiroz Rosas ◽  
Homero José de Farias e Melo ◽  
Henrique Armando Azevedo Gabriele ◽  
Jacob Szejnfeld
Keyword(s):  
Gleason Score ◽  
Gleason Grade ◽  
Resonance Imaging ◽  
Gleason Grading ◽  
Apparent Diffusion ◽  
Adc Mapping ◽  
Normal Area ◽  
Magnetic Resonance Imaging Mri ◽  
Improved Technique

AbstractPurposeTo compare diffusion images and coefficients obtained with 4 b-value versus 12 b-value apparent diffusion coefficient (ADC) mapping for characterization of prostate lesions and how these coefficients relate and compare to the PI-RADS™ classification and Gleason grading system.MethodsPatients with indications for prostate cancer testing (n=158) underwent multiparametric 3T magnetic resonance imaging (MRI). Two diffusion sequences were acquired, one with 4 b values and one with 12 b values. ADC maps were calculated for each (ADC4 and ADC12) and the respective coefficients were tested for correlation with PI-RADS™ classification and Gleason score.ResultsThe ADC12 sequence produced images of superior quality and sharpness than ADC4. Normal-area means (ADC4, 1793.3×10−6mm2/s; ADC12, 1100×10−6mm2/s) were significantly lower than those of lesion areas (ADC4, 1105.9×10−6mm2/s; ADC12, 689.4×10−6mm2/s) (p<0.001). Both techniques behaved similarly and correlated well with PI-RADS™ classification, distinguishing scores 3, 4, and 5 and with means tending to decline with increasing Gleason grade. ADC12 mapping yielded higher specificity than ADC4 (82.6% vs. 72.3%).ConclusionsDiffusion with 12 values is a viable technique for examination of the prostate. It produced higher-quality images than current techniques and correlates well with PI-RADS™ classification and Gleason score.

The impact of primary Gleason grade on biochemical outcome following brachytherapy for Gleason score 7 prostate cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 4699-4699
Author(s):  
W. Butler ◽  
G. Merrick ◽  
K. Wallner ◽  
R. Galbreath ◽  
Z. Allen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gleason Score ◽  
Gleason Grade ◽  
The Impact

scholarly journals Understanding the gleason grading system and its changes

2019 ◽  
Vol 9 (2) ◽  
pp. 1580-1585
Author(s):  
Sujata Pudasaini ◽  
Neeraj Subedi
Keyword(s):  
Prostatic Carcinoma ◽  
World Health ◽  
Grading System ◽  
Pathology Report ◽  
Gleason Grade ◽  
High Grade ◽  
Grade Group ◽  
Gleason Grading ◽  
Gleason Pattern ◽  
Health Organization

Gleason Grading System is the most widely used grading system used for prostatic carcinoma. The five basic grade patterns are used to generate a histologic score, which can range from 2 to 10 (including primary and secondary patterns). The original Gleason Grading System was used to grade acinar adenocarcinoma based on architectural features and it has been correlated with excellent clinical outcomes. Since 1960s, after the discovery of the original Gleason Grading System, a modified version of the Gleason Grading System was introduced in the International Society of Urological Pathology 2005 which came up with many changes including elimination of Gleason pattern 1. The ISUP 2005 was further updated in 2014 to provide more accurate stratification of prostatic carcinoma. The new Gleason Grade Group 1 to 5 has been introduced and it has little resemblance to the original Gleason system. This Gleason Grade Group has been accepted by the 2016 World Health Organization classification of tumors of the prostate. For a needle biopsy, high grade component of any quantity should be included in the Gleason score as it indicates a high probability of finding significant high grade tumor in the prostate. By understanding the principles and practice of this grading system, the pathology report has to clearly indicate which system is adopted in the reporting. This review discusses GGS and its recent development focusing on major changes over the years that led to the new Grade Group system proposed by the 2014 ISUP consensus.

scholarly journals Retracted: Histopathological Correlation Between Prostatic Adenocarcinoma in Transrectal Ultrasound Guided Biopsies and Radical Prostatectomy Specimens

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammad Faisal ◽  
Hina Tariq
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
National Level ◽  
Transrectal Ultrasound ◽  
Gleason Grade ◽  
Local Data ◽  
Grade Group ◽  
Regional Lymph Nodes ◽  
Gleason Grading ◽  
Bilateral Involvement

Introduction: Differences in Gleason grade in transrectal ultrasonography (TRUS) biopsies and radical prostatectomy (RP) specimens are well documented in literature. Keeping in view the limitations of Gleason grading system, Epstein JI grade group system was introduced. Various other parameters also have a significant role in predicting the pathological stage, extraprostatic extension, status of surgical margins and metastatic disease in regional lymph nodes. RP is performed at limited centres in Pakistan. Till date, no comparison of the histopathological findings in 12-core TRUS and RP specimens had been performed at the national level. Our study is aimed at generating local data in this context. Materials and Methods: This was a crosssectional study and non-probability consecutive sampling was performed. It was conducted at Histopathology Department, Shifa International Hospital, Islamabad, from January 2008 to December 2014. Gleason scores of 20 RP specimens were compared to Gleason scores of TRUS biopsies of same patients. Concordance in Gleason score and grade groups with laterality, perineural invasion was also studied. Results: Out of 20 RP cases, 40% (n = 8) had a Gleason score of 6, 30% (n = 6) had score 7, 20% (n = 4) had score 8 and 15% (n = 3) had score 9. Compared to the TRUS biopsy, RP Gleason score was concordant in 11 cases (55%), higher in 7 cases (35%) and lower in 2 cases (10%). TRUS involvement was unilateral in 10 cases (50%) and bilateral in 10 cases (50%). However, bilateral involvement of RP specimen was seen in 14 cases (70%) and unilateral in 6 cases (30%). Thus, better tumour yield was observed in RP specimens i.e., bilateral involvement in RP specimens was found in additional 5 cases (25%). Perineural involvement was higher in RP specimen i.e., 12 cases (60%), compared to 5 cases (25%) in TRUS biopsies. Its concordance was significantly higher in those with Gleason score of equal to or more than 7 (83%) and low in score less than score 7 (17%). Conclusion: When comparing RP to initial TRUS biopsies, Gleason score was upgraded in 35% and downgraded in 10% of cases. Bilateral involvement in 25% of cases of RP specimens was underestimated as unilateral involvement in TRUS biopsies. Perineural involvement with high Gleason score was also seen. 

World fintech: main trends

2021 ◽  
pp. 14-26
Author(s):  
Yuliya Viktorovna Evdokimova ◽  
Olga Vladimirovna Shinkareva
Keyword(s):  
Mergers And Acquisitions ◽  
Banking Industry ◽  
Digital Technologies ◽  
Digital Transformation ◽  
The World ◽  
The Subject ◽  
Coronavirus Infection ◽  
Basic Characteristics ◽  
The Impact ◽  
New Criteria

Recently, digital technologies in the fi nancial sector have been actively developing. The pandemic of a new coronavirus infection COVID-19 only spurred this process. The result of these events was the structural transformation of the global fi nancial services market, which is the object of this study. The subject of the study is the processes taking place in this market as a result of its digital transformation and the development of fi nancial technologies. Analysis, synthesis, induction, deduction were used as research methods. The multidisciplinary nature of the study should be noted due to the interconnection of sectors such as information technology, fi nancial technology, economic aspects. The study examines the basic characteristics of fi ntech solutions introduced into the practice of the world business, an ecosystem of fi nancial services, reveals the features of such models of the development of fi nancial innovations as USChinese, European and Russian. The impact of the pandemic of a new coronavirus infection of COVID-19 on the fi nancial services market was analyzed, it was noted that fi nancial and technological leaders of this sector of the economy can benefi t from the current situation. New criteria for the optimality of fi nancial services are highlighted, in particular, international nature, round-the-clock access, instant conversion with minimal costs and the presence of both fi at money and cryptocurrency. The volume of the global fi ntech market was analyzed, as well as forecasts regarding its development in the future, the volume of global investments in fi ntech in the fi eld of mergers and acquisitions was considered. The main directions of the fi ntech segment development according to the results of the 2019 study were considered and the countries in which this segment is developing most actively were highlighted. The evolution of traditional banks and revealed fi ntech trends in the banking industry in 2020.

Impact of Primary Gleason Grade on Risk Stratification for Gleason Score 7 Prostate Cancers

2012 ◽  
Vol 82 (1) ◽  
pp. 200-203 ◽  
Author(s):  
Bridget F. Koontz ◽  
Matvey Tsivian ◽  
Vladimir Mouraviev ◽  
Leon Sun ◽  
Zeljko Vujaskovic ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Gleason Score ◽  
Gleason Grade ◽  
Prostate Cancers

Prostate image-guided transperineal elastic-registration biopsy, a new diagnostic tool to refine the risk-stratification of prostate cancer and improve therapeutic decisions.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e16595-e16595
Author(s):  
Pierre Graff-Cailleaud ◽  
Bertrand Covin ◽  
Daniel Portalez ◽  
Richard Aziza ◽  
Jonathan Khalifa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Stratification ◽  
Active Surveillance ◽  
Gleason Score ◽  
Risk Groups ◽  
Gleason Grade ◽  
Curative Intent ◽  
Elastic Registration ◽  
Image Guided ◽  
Therapeutic Decisions

e16595 Background: To evaluate image-guided Transperineal Elastic-Registration biopsy (TPER-B) in the risk-stratification of low-to-intermediate risk prostate cancer detected by Transrectal-ultrasound biopsy (TRUS-B) when estimates of cancer grade and volume discorded with multiparametric Magnetic Resonance Imaging (MRI). Methods: All patients referred for active surveillance or organ-conservative management were collegially reviewed for consistency between TRUS-B results and MRI. Image-guided TPER-B of the index target (IT) defined as the largest Prostate Imaging-Reporting Data System-v2 ≥3 abnormality were organized for discordant cases. Pathology reported Gleason grade, maximum cancer core length (MCCL) and total CCL (TCCL). Results: Of 237 prostate cancer patients (1-7/2018), 42 required TPER-B for risk-stratification. Eight cores were obtained [Median&IQR: 8 (6-10)] including five (IQR: 4-6) in the IT. TPER-B of the IT yielded longer MCCL [Mean&(95%CI): 5.4(3.9-6.9) vs. 2.5mm(1.9-3.1), p = 0.002] and TCCL [16.7(10.6-22.8) vs. 3.9mm(3.1-4.8), p = 0.0001] than TRUS-B of the gland. On TPER-B cores, longer TCCL [Mean&(95%CI): 28.9mm(19.1-38.7) vs. 12.3mm(4.8-19.7), p = 0.02] were measured in Gleason score-7 than score-6 cancers (no cancers detected on IT TPER-B in 11 patients, all but one score 6 < 4mm on TRUS-B). TPER-B cores of the IT upgraded 16/42(38.1%) patients. 21/42(50.0%) met University College London-definition 1 (Gleason score≥4+3 and/or MCL≥6mm) and 27/42(64.3%) definition 2 (Gleason score≥3+4 and/or MCL≥4mm), which correlate to clinically significant cancers > 0.5mL and > 0.2mL, respectively. Allocation to higher risk groups than anticipated from TRUS-B spurred adaptation of treatment protocols (active surveillance n = 15, prostatectomy n = 11, ionizing radiation n = 13, pending n = 3). Conclusions: Image-guided TPER-B of the index target provided more cancer material for pathology. Subsequent re-evaluation of cancer volume and grade switched a majority of patients towards higher risk groups and treatments with curative intent.

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