Hematuria

2020 ◽  
Keyword(s):  
Microscopic Hematuria ◽  
Renal Ultrasonography ◽  
Macroscopic Hematuria ◽  
Common Cause ◽  
School Aged Children ◽  
Key Points ◽  
Urologic Disease ◽  
Common Sign ◽  
Isolated Microscopic Hematuria ◽  
Work Up

Key Points The most common cause of hematuria overall is UTI. The most common cause of asymptomatic isolated microscopic hematuria is benign transient hematuria. Before further evaluation, repeating the urinalysis at least once is prudent, and asymptomatic school-aged children may be followed for 2 or more years before further work-up. Macroscopic hematuria is a common sign of glomerular or urologic disease, warranting renal ultrasonography and further evaluation as indicated.

scholarly journals Histo-Pathological Study of Endometrial Biopsies in Patients With Abnormal Uterine Bleeding

2017 ◽  
Vol 15 (2) ◽  
pp. 26-31
Author(s):  
Sharmila Parajuli ◽  
Binita Thapa
Keyword(s):  
Endometrial Carcinoma ◽  
Postmenopausal Women ◽  
Abnormal Uterine Bleeding ◽  
The Elderly ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Common Cause ◽  
Histopathological Findings ◽  
Common Sign ◽  
Work Up

Introduction: Abnormal uterine bleeding is a common sign of a number of different uterine disorders ranging from dysfunctional (non organic) abnormalities or complications of pregnancy to organic lesions such as polyps, hyperplasia or carcinoma. Methods: This is a retrospective study conducted at Hospital of 2nd author during a period of 5 years (Jan 2008-Dec 2013).  Histopathology records were retrieved and searched for cases of abnormal uterine bleeding. Relevant histopathological findings and clinical data were recorded and analyzed. The aim of the study was to determine the causes for abnormal uterine bleeding in women presenting to the hospital and to compare the histopathological findings at various age groups.Results: The age of patients ranged from 17 to 71 years with an average of 43 years. The most common cause of uterine bleeding was found to be proliferative phase endometrium; that were 649 cases (56.43%). Out of the pathological causes, the most common cause was found to be endometrial hyperplasia- 44 cases (3.82%). Endometrial carcinoma was found to be more common in the elderly postmenopausal women. A total of 6 cases (0.5%) of endometrial carcinoma were present.Conclusion: Endometrial hyperplasias and malignancies are common in increasing age group, especially in perimenopausal and postmenopausal women. So, a thorough work-up and diagnostic endometrial biopsy is therefore mandatory without delay in these patients to rule out malignancies. 

Vaginal Bleeding

2020 ◽  
Keyword(s):  
Menstrual Cycle ◽  
Vaginal Bleeding ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Common Cause ◽  
Key Points ◽  
Normal Menstrual Cycle

Key Points Abnormal uterine bleeding refers to bleeding that is excessive or occurs outside normal cyclic menstruationAnovulatory uterine bleeding is the most common cause of abnormal uterine bleeding adolescents within 1–2 years of menarche.It is important to exclude pregnancy and infections prior to initiating treatment for anovulatory bleedingGoals of management for abnormal uterine bleeding include return to pattern of normal menstrual cycle and prevention of anemia.

scholarly journals Indian scenario of IgA nephropathy: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
pp. 159-65
Author(s):  
Anju Khairwa
Keyword(s):  
Systematic Review ◽  
Iga Nephropathy ◽  
Clinical Features ◽  
Meta Analysis ◽  
Microscopic Hematuria ◽  
Macroscopic Hematuria ◽  
Female Ratio ◽  
Cochrane Database ◽  
Male Female Ratio ◽  
Indian Scenario

Background: IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of IgAN and its clinical features in different studies from India. Aim: To summarize overall scenario of IgAN in India. Methods: In this systematic review, studies related to IgAN and related renal disease were included. Data searched were PubMed, EMBASE, Google scholar, and Cochrane Database from inception to 31st January 2019. Results: Total 49 studies (N=2480) were included: 21studies (N=2309) of primary IgAN; 19 studies (N=21) of Secondary IgAN; four studies (N=133) of IgA vasculitis nephropathy (IgAVN); and five studies (N=17) of IgA dominant nephropathy (IgADN). Prevalence of IgAN was 16.5% in India. Age of affected persons was ranging from 27.2±16.7 to 48.6±21.3 years . Male female ratio was 1.8:1. Clinical features of Primary IgAN, IgAVN, IgADN & Secondary IgAN were microscopic hematuria (49.6%, 44.4%, 15.6% & 59.5%), macroscopic hematuria (5.1%, 0.4%,40.9%,& 35.7%), Subnephrotic proteinuria (42.1%, 29.4%, 23.2%, & 52.3%), nephrotic proteinuria (16.0%, 4.4%, 76.8%,& 47.6%), and hypertension (25.8%,18.3%, 35.5%,& 47.6%).. The 24 hours proteinuria was ranging from 2.6±1.5 to 4.7±2.3 gm/day and serum creatinine (mg/dl) was ranging from 0.9±0 to 3.5±3.9 mg/dl. Histolomorphologically, all type of IgAN showed mesangial hypercellularity and Immunofluorescence revealed IgA deposition. Conclusion: The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic hematuria were common clinical features. Keywords: IgA Nephropathy; histomorphology; prevalence; India.

scholarly journals The spectrum of paroxysmal dyskinesias

2019 ◽  
Vol 14 (3) ◽  
pp. FNL26 ◽  
Author(s):  
Raquel Manso-Calderón
Keyword(s):  
Differential Diagnosis ◽  
Loss Of Consciousness ◽  
Paroxysmal Kinesigenic Dyskinesia ◽  
Appropriate Treatment ◽  
Key Points ◽  
Paroxysmal Disorders ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Paroxysmal dyskinesias (PxD) comprise a group of heterogeneous syndromes characterized by recurrent attacks of mainly dystonia and/or chorea, without loss of consciousness. PxD have been classified according to their triggers and duration as paroxysmal kinesigenic dyskinesia, paroxysmal nonkinesigenic dyskinesia and paroxysmal exertion-induced dyskinesia. Of note, the spectrum of genetic and nongenetic conditions underlying PxD is continuously increasing, but not always a phenotype–etiology correlation exists. This creates a challenge in the diagnostic work-up, increased by the fact that most of these episodes are unwitnessed. Furthermore, other paroxysmal disorders, included those of psychogenic origin, should be considered in the differential diagnosis. In this review, some key points for the diagnosis are provided, as well as the appropriate treatment and future approaches discussed.

Prevalence of Urologic Disease Among Patients Investigated for Hematuria With CT Urography

2020 ◽  
pp. 084653712090213
Author(s):  
Andrew K. C. Fenwick ◽  
Eric Sala ◽  
Donaldo D. Canales
Keyword(s):  
Urinary Tract ◽  
Odds Ratio ◽  
Upper Urinary Tract ◽  
Microscopic Hematuria ◽  
Ct Urography ◽  
Gross Hematuria ◽  
Radiology Reports ◽  
Patient Morbidity ◽  
Urologic Disease ◽  
Care Costs

Purpose: The current study evaluated the prevalence of urologic disease among patients with hematuria referred for computerized tomography (CT) urography to determine which patients require investigation with CT urography. Methods: We retrospectively reviewed radiology reports of 1046 CT urograms performed for the indication of microscopic (43.7%) or gross hematuria (56.3%). Urological findings were categorized as negative, benign, or suspicious (pathologically confirmed) for malignancy. Results: Of 1046 CT urograms performed, 53.5% were negative, 36.4% were benign, and 10% were suspicious for malignancy. The most common benign finding was urolithiasis (22.3%). Overall, urinary tract malignancies were present in 3.6% of patients, and the rate was significantly higher ( P < .001) for gross (5.8%) than microscopic hematuria (0.9%). CT urography identified 0.6% patients with upper urinary tract malignancies; the malignancy rate was significantly higher ( P = .038) for gross (1%) than microscopic hematuria (0%), and no significant sex ( P = 1.00; male = 0.6%, female = 0.6%) or age ( P = .600; < 50 years = 0%, ≥ 50 years = 0.7%) differences were observed. Logistic regression revealed that being male was associated with gross hematuria (odds ratio [OR] = 2.92), and that both age and gross hematuria (ORs = 1.06 and 5.13, respectively) were associated with malignancy. Conclusions: CT urography found no upper urinary tract malignancies in 99.4% of patients presenting with hematuria, including all patients with microscopic hematuria and those with gross hematuria <50 years old. Investigating these subgroups with CT urography may be unnecessary and result in increased patient morbidity and health-care costs.

scholarly journals Adult-Onset Severe Hypocalcemia Due Defect in Parathyroid Calcium-Sensing Receptors

2020 ◽  
Vol 5 (07) ◽  
pp. 250-251
Author(s):  
Kamel El-Reshaid ◽  
Shaikha Al-Bader
Keyword(s):  
Case Report ◽  
Adult Onset ◽  
Common Cause ◽  
Autoimmune Polyglandular Syndrome ◽  
Calcium Sensing ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Parathyroidectomy, of the 4 glands, with/without thyroidectomy is the most common cause of hypoparathyroidism. Autoimmunity is a rare etiology, either as an isolated endocrinopathy or as a component of autoimmune polyglandular syndrome 1 (APS 1). In this case report; we describe a patient with an adult-onset hypoparathyroidism and discuss its pathophysiology in relation to calcium-sensing receptors in addition to its diagnostic work up and management.

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