REVIEW ARTICLE

PEDIATRICS ◽  
1956 ◽  
Vol 17 (6) ◽  
pp. 897-924
Author(s):  
Lytt I. Gardner

THE IDENTIFICATION and measurement of adrenocortical steroids in body fluids over the past 2 decades have made possible an extensive exploration of adrenal function. This review is restricted to adrenocortical metabolism in the fetus, infant and child. No attempt will be made to cover all of this rapidly developing area of endeavor. Certain aspects have been treated in other review articles, to which the reader is referred. The reviews by Moore on fetal endorinology, Klein on neonatal adrenal physiology, Lieberman and Teich and Roberts and Szego on steroid biochemistry, White and Wettstein and Anner on adrenal cortical hormones, Ingle on cortisone and Gaunt, Renzi and Chart on aldosterone are especially useful. The books by Wilkins and by Talbot and colleagues contain helpful treatments of this area. Due to the prolific nature of even the review literature, it is necessary to make a rather arbitrary selection of material. NEWER METHODOLOGY Within recent years a number of methods have been developed for the estimation of hormones in urine and plasma. Several techniques for the chromatographic separation of the 17-ketosteroids in urine have been described. Of particular value in the diagnosis of virilizing adrenal tumor has been the development of colorimetric methods for the estimation of dehydroepiandrosterone in urine. Some progress has been made in the estimation of corticosteroids in the urine. Techniques for the measurement of 11-oxygenated neutral 17-ketosteroids, pregnanetriol and pregnanediol in the urine of patients with congenital adrenal hyperplasia have been described. There has been a blossoming of methods for estimating steroids in plasma. Several varieties of techniques are now available for the measurement of corticosteroids and 17-ketosteroids in plasma.

Author(s):  
John Hunsley ◽  
Eric J. Mash

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.


2017 ◽  
Vol 145 (13) ◽  
pp. 2640-2655 ◽  
Author(s):  
S. TOWERS

SUMMARYSince 1978, a series of papers in the literature have claimed to find a significant association between sunspot activity and the timing of influenza pandemics. This paper examines these analyses, and attempts to recreate the three most recent statistical analyses by Ertel (1994), Tappinget al.(2001), and Yeung (2006), which all have purported to find a significant relationship between sunspot numbers and pandemic influenza. As will be discussed, each analysis had errors in the data. In addition, in each analysis arbitrary selections or assumptions were also made, and the authors did not assess the robustness of their analyses to changes in those arbitrary assumptions. Varying the arbitrary assumptions to other, equally valid, assumptions negates the claims of significance. Indeed, an arbitrary selection made in one of the analyses appears to have resulted in almost maximal apparent significance; changing it only slightly yields a null result. This analysis applies statistically rigorous methodology to examine the purported sunspot/pandemic link, using more statistically powerful un-binned analysis methods, rather than relying on arbitrarily binned data. The analyses are repeated using both the Wolf and Group sunspot numbers. In all cases, no statistically significant evidence of any association was found. However, while the focus in this particular analysis was on the purported relationship of influenza pandemics to sunspot activity, the faults found in the past analyses are common pitfalls; inattention to analysis reproducibility and robustness assessment are common problems in the sciences, that are unfortunately not noted often enough in review.


1950 ◽  
Vol 2 (3) ◽  
pp. 124-131 ◽  
Author(s):  
R. G. Hopkinson

A technique is described by which, the quantitative connection between physical aspects of a stimulus situation and subjective aspects of the perceptual response may be conveniently and reliably determined. The subject is given control of one of the significant physical variables such, for instance, as brightness, and is asked to set this variable to correspond In turn with a limited number of defined criteria relating to a subjective variable such as glare-discomfort It is found that each criterion acts as a check upon judgments made in terms of the others, so that the scatter of the control settings Is less than when a single criterion is used The functional relationship between the physical and the subjective variable can be estimated, and provided care Is taken in the design of the experiment and In the selection of observers, consistent results are obtained. This technique has been applied during the past ten years to a wide range of visual problems which Include those of the visibility of radar echoes, the visibility of street-lighting from the air, discomfort-glare and ease of reading. It Is thought that It might find wide application not only in applied Psychological work but in the investigation of problems of theoretical import.


Synthesis ◽  
2021 ◽  
Author(s):  
Claire Empel ◽  
Sripati Jana ◽  
Rene M. Koenigs

This review article summarizes progress made in [1,2]-sigmatropic rearrangements using carbenes in the ylide formation step. While other rearrangements, such as the [2,3]-sigmatropic, Doyle-Kirmse, or Sommelet-Hauser rearrangements, have been studied in detail over the past decades, studies on [1,2]-sigmatropic rearrangements are still limited. Based on the application of diazoalkanes as carbene precursors, research on diazoalkanes in ylide formation reactions started flourishing in the 1990s. This review covers milestones from the beginning of [1,2]-sigmatropic rearrangements using carbenes to generate ammonium, oxonium and other ylide species and should serve as an overview to further promote research in this area.


Author(s):  
John Hunsley ◽  
Eric J. Mash

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sophia Dege-Müller ◽  
Jonas Karlsson

In 1986, a Franco-Israeli team of scholars set out to document the liturgy of the Beta ʾƎsrāʾel, a group of Ethiopian Jews which at the time was in the process of making aliyah under dramatic circumstances. The scholars gathered a group of priests in Israel and produced an impressive corpus of recordings, covering important parts of the liturgical tradition. Over the past decades, the team has been publishing their results in a number of articles and monographs, and in 2019 presented a selection of recordings in the form of a CD box. The box contains three CDs plus a bilingual booklet with information about the liturgical tradition of the Beta ʾƎsrāʾel: their music, prayers, and ritual practices. In this review article, the research results presented in the booklet are evaluated, with special attention paid to the effects that migration has had on the Beta ʾƎsrāʾel liturgical tradition. 


2020 ◽  
pp. 133-139
Author(s):  
Sanatan Ratna ◽  
B Kumar

In the past few decades, there has been lot of focus on the issue of sustainability. This has occurred due to the growing concerns related to climate change and the growing awareness about environmental concerns. Also, the competition at global level has led to the search for the most sustainable route in the industries. The current research work deals with the selection of green supplier in a Nickle coating industry based on certain weighted green attributes. For this purpose, a hybrid tool comprising of Fuzzy AHP (Fuzzy Analytical Hierarchy) and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) is used. The Fuzzy AHP is used for assigning proper weights to the selected criteria for supplier evaluation, while VIKOR is used for final supplier selection based on the weighted criteria. The three criterions for green supplier selection are, Ecological packaging, Corporate socio-environmental responsibility and Staff Training. The outcome of the integrated model may serve as a steppingstone to other SMEs in different sectors for selecting the most suitable supplier for addressing the sustainability issue.


Author(s):  
I.V. TORBINA ◽  
◽  
I.R. FARDEYEVA ◽  

The paper assesses the promising varieties of winter wheat in a competitive variety test by the main economic and biological characteristics that determine the suitability of the variety for commercial use. The object of research was the authors’ own breeding material. The experiments on the selection of winter wheat were made in the experimental crop rotation pattern of the Institute.


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