COPPER DEFICIENCY COMPLICATING SEVERE CHRONIC INTESTINAL MALABSORPTION

A case of chronic, severe diarrhea and maldigestion beginning in early infancy and possibly due to primary lactase deficiency is presented. By the age of 19 months, this had resulted in marked copper deficiency with anemia, neutropenia, osteoporosis, pathological fractures and probably aggravation of intestinal enzyme activity deficiency. At 6 4/12 years of age copper therapy produced a dramatic improvement in all manifestations, including the maldigestion, and there was a striking growth response.

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Copper metabolism in mottled mouse mutants: copper therapy of brindled (Mobr) mice

Biochemical Journal ◽

10.1042/bj1800605 ◽

1979 ◽

Vol 180 (3) ◽

pp. 605-612 ◽

Cited By ~ 62

Author(s):

J R Mann ◽

J Camakaris ◽

D M Danks ◽

E G Walliczek

Keyword(s):

Growth Response ◽

Copper Deficiency ◽

Lysyl Oxidase ◽

Sebacic Acid ◽

Copper Metabolism ◽

Single Subcutaneous Injection ◽

Mouse Mutants ◽

Brindled Mouse ◽

Copper Therapy ◽

Early Effects

Copper therapy was applied to brindled mouse mutants, which suffer from lethal hypocupraemia, by using cuprous and cupric solutions. The method of treatment was a single subcutaneous injection of 50 microgram of copper at 7 days of age. Early effects of the dose were: prevention of the tremors and spasms seen in untreated mutants, raising to normal and near-normal of caeruloplasmin oxidase and lysyl oxidase activities and pigmentation of skin and fur. Growth of mutants was retarded up to 23 days of age, but thereafter they rapidly gained weight to be nearly normal by 60 days of age. At 3 days after injection, copper concentrations in previously deficient mutant organs apart from liver were at least as much as those of treated normals, which had remained unchanged. Copper in mutant livers had increased only slightly in comparison with the normal control. A state of copper deficiency recurred in mutant tissues by 25 days after injection. A solution of Cu+, retained as such by an alkyl polyether, and sebacic acid resulted in greater growth rates after 23 days than did three other copper treatments. Cu+ may have resulted in an improved growth response owing to it being more readily metabolized than C12+. Delayed release of copper from the site of injection may have played an important role.

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Studies on copper and cobalt therapy of cattle in central coastal Queensland

Australian Journal of Agricultural Research ◽

10.1071/ar9670169 ◽

1967 ◽

Vol 18 (1) ◽

pp. 169 ◽

Cited By ~ 8

Author(s):

GI Alexander ◽

JM Harvey ◽

JH Lee ◽

WC Stubbs

Keyword(s):

Growth Response ◽

Copper Deficiency ◽

Copper Metabolism ◽

Subcutaneous Injections ◽

Liver Copper ◽

Copper Status ◽

Period 2 ◽

Copper Supplementation ◽

Copper Therapy ◽

Effect Of Copper

Four experiments described determined the effect of copper and cobalt therapy on the growth and productivity of cattle on the marine plains of central coastal Queensland. Copper was administered by subcutaneous injections of copper glycinate, and cobalt by dosing per os with heavy cobalt pellets. The growth of weaned cattle was significantly improved by copper, particularly from June to October when limited palatable feed on the high ground forced the animals to forage on the para grass swamps. During the same period, 2-year-old heifers also showed a growth response to copper. Their conception rate increased after 19 months of copper therapy but not after 10.5 months. The growth rate of their calves bas significantly increased by copper supplementation. Liver copper concentrations were always low in untreated cattle. Copper therapy maintained these reserves at higher levels, which varied according to the season and the rate of growth of the animals. Calves born to treated cows had higher initial liver copper reserves than those from untreated cows, but in the absence of copper therapy these reserves declined to low and comparable levels in all calves at weaning. Pasture analyses suggest that the copper deficiency revealed was due to interference with copper metabolism rather than to a low copper status in the diet; this interference did not appear to be due to molybdenum. Weaned cattle appeared to respond to cobalt during 1960 but not subsequently, while the cows and calves showed no response. The vitamin B12 status in liver and serum appeared adequate in both treated and untreated cattle.

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Effects of age, species difference, antibiotics and toxicants on intestinal enzyme activity and genotoxicity

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620120804 ◽

1993 ◽

Vol 12 (8) ◽

pp. 1339-1352 ◽

Cited By ~ 1

Author(s):

R. W. Chadwick ◽

S. E. George ◽

M. J. Kohan ◽

J. C. Allison ◽

J. Chang ◽

...

Keyword(s):

Enzyme Activity ◽

Species Difference ◽

Intestinal Enzyme

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Growth response, digestive enzyme activity and stress enzyme status in early stages of an endangered fish, Notopterus chitala (Hamilton, 1822) fed with live feed and formulated diet

Aquaculture ◽

10.1016/j.aquaculture.2019.05.042 ◽

2019 ◽

Vol 510 ◽

pp. 182-190

Author(s):

Ravindra Sontakke ◽

Chandra Shekhar Chaturvedi ◽

Neelam Saharan ◽

Virendra Kumar Tiwari ◽

Harsha Haridas ◽

...

Keyword(s):

Enzyme Activity ◽

Growth Response ◽

Digestive Enzyme ◽

Digestive Enzyme Activity ◽

Endangered Fish ◽

Early Stages ◽

Live Feed ◽

Formulated Diet

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Changes in the intestinal enzyme activity of lambs during chronic infection with Trichostrongylus vitrinus

Research in Veterinary Science ◽

10.1016/s0034-5288(18)32387-7 ◽

1982 ◽

Vol 32 (3) ◽

pp. 316-323 ◽

Cited By ~ 7

Author(s):

D.G. Jones

Keyword(s):

Enzyme Activity ◽

Chronic Infection ◽

Intestinal Enzyme

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Congenital Copper Deficiency: Copper Therapy and Dopamine-?-Hydroxylase Activity in the Mottled (Brindled) Mouse

Journal of Neurochemistry ◽

10.1111/j.1471-4159.1983.tb00876.x ◽

1983 ◽

Vol 41 (6) ◽

pp. 1648-1652 ◽

Cited By ~ 12

Author(s):

Gary Wenk ◽

Kinuko Suzuki

Keyword(s):

Copper Deficiency ◽

Hydroxylase Activity ◽

Brindled Mouse ◽

Copper Therapy

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Copper deficiency masquerading as myelodysplastic syndrome

Blood ◽

10.1182/blood-2002-01-0256 ◽

2002 ◽

Vol 100 (4) ◽

pp. 1493-1495 ◽

Cited By ~ 125

Author(s):

Xylina T. Gregg ◽

Vishnu Reddy ◽

Josef T. Prchal

Keyword(s):

Myelodysplastic Syndrome ◽

Copper Deficiency ◽

Severe Neutropenia ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Billroth Ii ◽

Morphologic Characteristics ◽

Red Blood Cell Transfusions ◽

Copper Therapy ◽

Stimulating Factor

We describe a woman with severe neutropenia and dependency on red blood cell transfusions who had previously undergone Billroth II surgery and whose bone marrow (BM) showed morphologic characteristics typical of myelodysplastic syndrome (MDS) with ringed sideroblasts. She had transient reversal of anemia and severe neutropenia after therapy with erythropoietin and granulocyte colony-stimulating factor. Because of relapse while receiving growth factors, the patient was referred for allogeneic BM transplantation. A pretransplantation nutritional evaluation revealed severe copper deficiency, and her hematologic abnormalities resolved fully with copper therapy. This case shows that copper deficiency should be an integral part of the differential diagnosis of sideroblastic MDS, even in patients not requiring parenteral nutrition.

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Sex differences in spironolactone induction of rat intestinal and hepatic p-nitrophenol UDP-glucuronyltransferase

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y90-210 ◽

1990 ◽

Vol 68 (10) ◽

pp. 1385-1387 ◽

Cited By ~ 6

Author(s):

Viviana A. Catania ◽

Marcelo G. Luquita ◽

María C. Carrillo ◽

Aldo D. Mottino

Keyword(s):

Enzyme Activity ◽

Sex Differences ◽

Wistar Rats ◽

Female Rats ◽

Intestinal Tissue ◽

Male And Female ◽

Percent Increase ◽

Female Wistar Rats ◽

Related Response ◽

Intestinal Enzyme

In the present study we analyzed the effect of spironolactone administration on hepatic and intestinal p-nitrophenol-UDP-glucuronyltransferase activity. We used microsomal preparations from male and female Wistar rats to establish whether or not this effect was sex dependent. Enzyme activity was measured in the presence of UDP-N-acetylglucosamine, a presumed physiological activator of the enzyme. Female but not male microsomes showed an increase in enzyme activity of both hepatic and intestinal tissue preparations in response to the inducer pretreatment. In addition, the inducer effect observed in female rats showed a tissue-related difference, since percent increase in the intestinal enzyme activity was greater than that in the liver (127 and 52%, respectively). These results suggest that factors regulating enzyme activity or mechanisms involved in the inducer effect of spironolactone could be different in the intestinal mucosa in comparison to the liver. A possible explanation of sex-related response to spironolactone administration was discussed.Key words: p-nitrophenol, UDP-glucuronyltransferase, spironolactone induction, sex differences.

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Dietary pectin and mango pulp effects on small intestinal enzyme activity levels and macronutrient digestion in grower pigs

Food & Function ◽

10.1039/c7fo00602k ◽

2018 ◽

Vol 9 (2) ◽

pp. 991-999 ◽

Cited By ~ 8

Author(s):

Anton M. Pluschke ◽

Barbara A. Williams ◽

Dagong Zhang ◽

Michael J. Gidley

Keyword(s):

Enzyme Activity ◽

Activity Levels ◽

Small Intestinal ◽

Intestinal Enzyme ◽

Mango Pulp ◽

P Addition

Addition of pectin and to a lesser extent mango pulp to pig diets caused either an increase (α-amylase) or decrease (lipase, protease) in small intestinal enzyme activity, which either was (starch, lipid) or was not (protein) associated with residual digesta macronutrient levels.

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