FROM FANCY TO FACT

PEDIATRICS ◽  
1972 ◽  
Vol 50 (5) ◽  
pp. 685-687
Author(s):  
Robert E. Greenberg
Keyword(s):  
Human Physiology ◽  
Laboratory Finding ◽  
Effective Therapy ◽  
Cellular Mechanisms ◽  
Main Route ◽  
Abnormal Laboratory ◽  
Abnormal Laboratory Finding ◽  
Discrete Map

Recognition of a given symptom, sign, or abnormal laboratory finding represents the start of a long, often tortuous path. The trail soon broadens, as combinations of findings coalesce into syndromes. Blind alleys, thick forests, and divergent roads beguile and confuse the traveler. One may stumble onto the main route by application of rational, physiologic patterns of thought. Charting a discrete map to finite understanding and effective therapy is dependent upon delineation of underlying cellular mechanisms. Similar parables have often been utilized to indicate the applicability and essentiality of studies of cellular and intercellular processes in relation to human physiology and disease.

scholarly journals Albinism Associated with Hemorrhagic Diathesis and Unusual Pigmented Reticular Cells in the Bone Marrow: Report of Two Cases with Histochemical Studies

Blood ◽  
1959 ◽  
Vol 14 (2) ◽  
pp. 162-169 ◽  
Author(s):  
F. HERMANSKY ◽  
P. PUDLAK
Keyword(s):  
Bone Marrow ◽  
Bleeding Time ◽  
Congenital Abnormalities ◽  
Histochemical Study ◽  
Laboratory Finding ◽  
Hemorrhagic Diathesis ◽  
Abnormal Laboratory ◽  
Prolonged Bleeding Time ◽  
Abnormal Laboratory Finding ◽  
Reticular Cells

Abstract 1. A description is given of two unrelated albinos with hemorrhagic diathesis and peculiar, pigmented reticular cells in the bone marrow. 2. On examining hemostasis, the only consistent abnormal laboratory finding was a prolonged bleeding time, so that the hemorrhagic disorder fell into the group of so-called pseudohemophilias. 3. Unusual reticuloendothelial cells in the bone marrow were packed with blackish or greenish blue granules or particles. According to the histochemical study, the substance in the cytoplasm was probably of a lipid nature. These cells could not be identified with similar cells of this kind which have so far been described. 4. The combination of the above described congenital abnormalities (albinism, pseudohemophilia and unusual pigmented macrophages in the bone marrow) in two unrelated patients suggests that a common syndrome is present.

scholarly journals Spontaneous Pneumomediastinum an Unusual Complication of Covid-19 Infection in a Non-intubated Patient With Diffuse Bilateral Ground-glass Opacity: A Case Report of Progression of Disease During Self-isolation

2021 ◽  
Vol 11 (2) ◽  
pp. 32679-32679
Author(s):  
Khosrow Agin ◽  
◽  
Tahereh Naghiloo ◽  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Bacterial Infections ◽  
Laboratory Finding ◽  
Ground Glass Opacity ◽  
Positive Pressure ◽  
Unusual Complication ◽  
Spontaneous Pneumomediastinum ◽  
Abnormal Laboratory Finding ◽  
Progression Of Disease

Background: Spontaneous pneumomediastinum or mediastinal emphysema is relatively a rare disease that occurs in viral and bacterial infections with the benign entity. Case: The patient was a 57-year-old man who, after a week of self-isolation at home, coming to the COVID-19 triage center of the hospital with severe shortness of breath. He was admitted to the Intensive Care Unit (ICU) due to acute respiratory failure. The patient was treated as the protocol designed and respiratory support with high flow nasal oxygen and Non-Invasive Positive Pressure Ventilation (NIPPV). Spontaneous pneumomediastinum was developed during viral pneumonia infection. The known risk factors included age, male sex, and abnormal laboratory finding. All the biochemical and hematological findings such as lymphopenia, thrombocytopenia, raised CRP, LDH, and ferritin were detected in our cases. They indicate a possible prognosis for the development of acute respiratory failure and adverse clinical outcomes. Conclusion: Spontaneous pneumomediastinum has usually a benign outcome in COVID-19 Pneumonia and its prognosis is related to background conditions in patients.

Thrombophilia: What's a Practitioner to Do?

Hematology ◽  
2001 ◽  
Vol 2001 (1) ◽  
pp. 322-338
Author(s):  
B. Gail Macik ◽  
Jacob H. Rand ◽  
Barbara A. Konkle
Keyword(s):  
Hormonal Therapy ◽  
Oral Anticoagulant Therapy ◽  
Laboratory Finding ◽  
Treatment Strategies ◽  
Self Management ◽  
New Approach ◽  
Self Testing ◽  
Abnormal Laboratory Finding ◽  
History Of ◽  
Management Issues

Abstract Management of thrombophilia is an ever-changing field as new disorders are described and additional clinical experience accrues. This paper addresses three common management issues in the care of patients with thrombophilia. The first two topics are updates for common but perplexing hypercoagulable states and the last topic introduces a new option for optimal management of oral anticoagulant therapy. Dr. Jacob Rand updates and organizes the approach to patients with antiphospholipid syndrome. This syndrome is a common acquired thrombophilic state, but the diagnosis and treatment of patients remains a challenge. Dr. Rand outlines his diagnostic and treatment strategies based on the current understanding of this complicated syndrome. Dr. Barbara Konkle addresses the special concerns of managing women with thrombophilia. Hematologists are often asked to advise on the risks of hormonal therapy or pregnancy in a woman with a personal or family history of thrombosis or with an abnormal laboratory finding. Dr. Konkle reviews the available data on the risks of hormonal therapy and pregnancy in women with and without known underlying thrombophilic risk factors. In Section III, Dr. Gail Macik will discuss a new approach to warfarin management. Several instruments are now available for home prothrombin time (PT) monitoring. Self-testing and self management of warfarin are slowly emerging as reliable alternatives to traditional provider-based care and Dr. Macik reviews the instruments available and the results of studies that support this new management option.

Thrombophilia: What's a Practitioner to Do?

Hematology ◽  
2001 ◽  
Vol 2001 (1) ◽  
pp. 322-338 ◽  
Author(s):  
B. Gail Macik ◽  
Jacob H. Rand ◽  
Barbara A. Konkle
Keyword(s):  
Hormonal Therapy ◽  
Oral Anticoagulant Therapy ◽  
Laboratory Finding ◽  
Treatment Strategies ◽  
Self Management ◽  
New Approach ◽  
Self Testing ◽  
Abnormal Laboratory Finding ◽  
History Of ◽  
Management Issues

Management of thrombophilia is an ever-changing field as new disorders are described and additional clinical experience accrues. This paper addresses three common management issues in the care of patients with thrombophilia. The first two topics are updates for common but perplexing hypercoagulable states and the last topic introduces a new option for optimal management of oral anticoagulant therapy. Dr. Jacob Rand updates and organizes the approach to patients with antiphospholipid syndrome. This syndrome is a common acquired thrombophilic state, but the diagnosis and treatment of patients remains a challenge. Dr. Rand outlines his diagnostic and treatment strategies based on the current understanding of this complicated syndrome. Dr. Barbara Konkle addresses the special concerns of managing women with thrombophilia. Hematologists are often asked to advise on the risks of hormonal therapy or pregnancy in a woman with a personal or family history of thrombosis or with an abnormal laboratory finding. Dr. Konkle reviews the available data on the risks of hormonal therapy and pregnancy in women with and without known underlying thrombophilic risk factors. In Section III, Dr. Gail Macik will discuss a new approach to warfarin management. Several instruments are now available for home prothrombin time (PT) monitoring. Self-testing and self management of warfarin are slowly emerging as reliable alternatives to traditional provider-based care and Dr. Macik reviews the instruments available and the results of studies that support this new management option.

scholarly journals Cutaneous manifestations and systemic correlation in patients with lupus erythematosus and its subsets: a study of 40 cases

2018 ◽  
Vol 4 (4) ◽  
pp. 479
Author(s):  
Rashmi Mahajan ◽  
Kishan Ninama ◽  
Ishan Pandya ◽  
Rajvee Patel ◽  
F. E. Bilimoria
Keyword(s):  
Hair Loss ◽  
Lupus Erythematosus ◽  
Laboratory Finding ◽  
Tertiary Care ◽  
Discoid Lupus Erythematosus ◽  
Care Hospital ◽  
Cutaneous Manifestations ◽  
Malar Rash ◽  
Abnormal Laboratory ◽  
Rowell’S Syndrome

<p class="abstract"><strong>Background:</strong> The objective was to study various dermatological manifestations and clinical and laboratory features in patients of lupus erythematosus (LE) and its subsets.</p><p class="abstract"><strong>Methods:</strong> This is a cross sectional observational study done in a tertiary care hospital in a rural setup in Piparia, Ta. Waghodiya, Dist. Vadodara, Gujarat. All the patients with clinical features of LE and its subsets were included in the study over a period of 16 months and were subjected to detailed history taking, complete cutaneous and general examination and laboratory investigations.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of the 40 cases, 22 cases were systemic lupus erythematosus (SLE), 13 cases were discoid lupus erythematosus (DLE), four cases were of Rowell’s syndrome and one case was of mixed connective tissue disorder (MCTD). 97.5% of cases had cutaneous involvement, i.e. photosensitivity (77.5%), oral ulcers, hair loss and malar rash. Systemic symptoms and abnormal laboratory parameters were present in the cases of SLE, Rowell’s syndrome and MCTD, with hematological involvement being the most common in both SLE (77%) and Rowell’s syndrome (100%) and positive anti-nuclear antibody (ANA) titer being the most common abnormal laboratory finding in both SLE (95.4%) and Rowell’s syndrome (100%). The most commonly found antibody was anti-dsDNA (64.3%) in SLE and anti SS-A (100%) in Rowell’s syndrome.</p><p class="abstract"><strong>Conclusions:</strong> Cutaneous features though occasionally subtle, are pointers to a diagnosis of SLE. Hair loss, malar rash and photosensitivity alone or in association with altered hematologic/ANA profile are the key markers of the disease activity.</p><p> </p>

scholarly journals A case report of COVID-19 infection and management during pregnancy

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110158
Author(s):  
Ifeoma Ogamba ◽  
Linus Chuang ◽  
Erin Panarelli ◽  
Dimitry Zilberman
Keyword(s):  
Clinical Symptoms ◽  
Laboratory Finding ◽  
Case Series ◽  
The United States ◽  
Limited Data ◽  
X Ray ◽  
Cough Headache ◽  
Abnormal Laboratory Finding ◽  
Chest X Ray ◽  
In Pregnancy

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which started in Wuhan, Hubei Province, China, and progressed to a pandemic affecting over 210 countries and territories including the United States. The severity of symptoms range from mild to critical disease involving multi-organ failure; however, many pregnant COVID-19 patients have mild symptoms. The understanding of COVID-19 is evolving and there is limited data about its effects in pregnancy. This case series features two pregnant patients with COVID-19 with a range of symptoms, including fever, non-productive cough, headache, and worsening dyspnea. Both patients had chest x-ray findings notable for lung opacities, and lymphopenia was a consistent abnormal laboratory finding. Both of the patients had hypoxia which was treated with hydroxychloroquine and lopinavir-ritonavir with significant improvement in clinical symptoms and prolongation of pregnancy.

Surveillance of Adverse Events Following Immunization (AEFI) - Post COVID 19 vaccination

2021 ◽  
Vol 6 (3) ◽  
pp. 178-182
Author(s):  
Priyanka Suhagiya ◽  
Jumana Hakim ◽  
Dhanyata Athmakuri ◽  
Mounika Kuracha ◽  
Thrilok Chander
Keyword(s):  
Adverse Events ◽  
Healthcare Workers ◽  
Laboratory Finding ◽  
Local Population ◽  
Surveillance Studies ◽  
The Public ◽  
Medical College ◽  
Untoward Medical Occurrence ◽  
Abnormal Laboratory Finding ◽  
Gandhi Medical College

Vaccination is a safe and effective way to prevent disease and save lives, but they may also produce some undesirable side effects which may affect the healthy individuals. Therefore, the monitoring of adverse events following immunization is necessary. Any untoward medical occurrence which follows immunization, and which does not necessarily have a causal relationship with the use of the vaccine. The adverse event may be any unfavorable or unintended sign, an abnormal laboratory finding a symptom or a disease. AEFI surveillance studies helps to detect to identify a specific risk among the local population. In this study, we included 20 healthcare workers who were admitted in Gandhi medical college and hospital following immunization by Covid vaccination drive. No major AEFI was reported following vaccination. Our study concludes that proper counselling about the need for covid vaccination and the possible adverse events following vaccination would create an awareness among the public would prevent them from apprehension of second dose after developing AEFI following first dose.

scholarly journals X-Linked Agammaglobulinemia Presenting as Neutropenia: Case Report and an Overview of Literature

2021 ◽  
Vol 9 ◽  
Author(s):  
Mosopefoluwa Lanlokun ◽  
Amanda Borden ◽  
Daime Nieves ◽  
Jolan E. Walter ◽  
Deborah Albright
Keyword(s):  
Laboratory Finding ◽  
Young Male ◽  
Healthy Male ◽  
Humoral Immune ◽  
Bruton Tyrosine Kinase ◽  
Abnormal Laboratory Finding ◽  
Inherited Immunodeficiency ◽  
Immune Deficiencies ◽  
Neutropenic Patients ◽  
Male Patients

X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency caused by mutations in the Bruton Tyrosine Kinase (BTK) gene. Marked neutropenia can be the initial abnormal laboratory finding in patients with XLA who are presenting with their first illness. The two cases presented herein support early consideration of evaluation for primary humoral immune deficiency in previously healthy male patients under the age of 12 months who present with neutropenia in the setting of infection shortly after passively acquired maternal antibody has sufficiently waned. Initial consideration of XLA (or other humoral immune deficiencies) in this particular population of young male neutropenic patients may afford the opportunity to avoid bone marrow biopsy in otherwise stable cases with similar presentations.

Sign in / Sign up

Export Citation Format

Share Document