In Reply: White Blood Cell Transfusions

PEDIATRICS ◽  
1985 ◽  
Vol 75 (6) ◽  
pp. 1170-1171
Author(s):  
MITCHELL S. CAIRO
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
White Blood Cell ◽  
Neonatal Sepsis ◽  
Clinical Criteria ◽  
Children's Hospital ◽  
Obstetrical Unit ◽  
Children’S Hospital

The first question concerning the ratio of suspected to proven neonatal sepsis is a good one. Our ratio was so low because of the strict clinical criteria that we adhered to for patient entry into study. Because we are a tertiary children's hospital and do not have an obstetrical unit attached to our institution, most patients referred to our institution are very critically ill. In our area, the vast majority of neonates for whom sepsis is ruled out are being taken care of at intermediate centers, and I agree that most of the ratios of suspected to proven neonatal sepsis are probably quite high in those centers.

Evaluation and use of the white blood cell differential provided by the Coulter® STKS in a children's hospital

2008 ◽  
Vol 16 (1) ◽  
pp. 33-42 ◽  
Author(s):  
M. FOURNIER ◽  
C. ADENIS ◽  
H. FONTAINE ◽  
B. CARNAILLE ◽  
J. GOUDEMAND
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Children's Hospital ◽  
Children’S Hospital

Neutropenia Associated with Cefotaxime

1983 ◽  
Vol 17 (10) ◽  
pp. 739-741 ◽  
Author(s):  
Tomoji Ohsawa ◽  
Fumitaka Furukawa
Keyword(s):  
Bone Marrow ◽  
Blood Cell ◽  
White Blood Cell ◽  
Case Reports ◽  
The Other ◽  
Cell Analysis ◽  
Bone Marrow Depression ◽  
Children's Hospital ◽  
Children’S Hospital

Neutropenia is rarely associated with cephalosporins. We report a case of neutropenia associated with cefotaxime. A seven-year-old boy was admitted to the Chidoribashi Hospital with suspected septicemia. Cefotaxime 2 g/d was started. On day 18, neutropenia associated with cefotaxime was suspected. On day 22, the patient was transferred to Fukuoka Children's Hospital because of continuing neutropenia and eosinophilia. In Fukuoka Children's Hospital, bone marrow puncture revealed severe bone marrow depression. After one month, the patient was discharged. When we considered case reports of granulocytopenia, leukopenia, and agranulocytosis associated with cephalosporins, we found two types of leukopenia. One is the granulocytopenic type and the other is the neutropenic type. In diagnosing leukopenia due to cephalosporins, an increased percentage of eosinophils in white-blood-cell analysis is significant.

scholarly journals Diagnostic Significance of White Blood Cell Count and C-Reactive Protein in Neonatal Sepsis; Asella Referral Hospital, South East Ethiopia

2018 ◽  
Vol 12 (1) ◽  
pp. 209-217
Author(s):  
Abebe Sorsa
Keyword(s):  
Blood Culture ◽  
Blood Cell ◽  
White Blood Cell ◽  
Neonatal Sepsis ◽  
C Reactive Protein ◽  
Diagnostic Significance ◽  
Gram Negative ◽  
Reactive Protein ◽  
Wbc Count ◽  
Sensitivity Specificity

Introduction:Nowadays various biochemical markers, such as C-Reactive Protein (CRP), Procalcitonin and tumor necrosis factor alpha, have been proposed as a potential marker for screening neonatal sepsis. In the current study, we tried to see the diagnostic significance of White Blood Cell (WBC) count and CRP in diagnostic screening of neonatal sepsis.Methods:A prospective cross-sectional study was conducted from May 2016 to April 2017 in Asella Teaching and Referral Hospital. Data were entered into EPI-INFO version 3.5.1 for cleanup and then exported to SPSS version 17 for further analysis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV) were used to assess the accuracy of CRP and WBC count taking blood culture as gold standard.Results:Data of 303 neonates with clinical sepsis were analyzed. Positive CRP and abnormal WBC were reported in 136(45%) and 99(32.7%) of study subjects respectively. Blood culture turned to be positive in 88(29.4%) of study subjects. The Sensitivity, Specificity, PPV and NPV of WBC count were 59.5 %, 79.6%, 52%, 64.5% respectively while the sensitivity, specificity, PPV and NPV of CRP were 65.6%, 78%, 42% and 91% respectively. By combining both WBC and CRP, the sensitivity, specificity, PPV and NPV improve to 78.5%, 83%, 60% and 93% respectively. CRP positivity rate was comparable across gram positive and gram negative bacteria while high WBC count were more reported among gram positive sepsis than gram negative ( OR 4.8, (95% CI 1.45-15.87, P 0.01)Conclusion:Based on this study’s finding, it can be concluded that CRP alone or in combination with WBC count showed better diagnostic accuracy in neonatal sepsis.

A New Study of Intraosseous Blood for Laboratory Analysis

2010 ◽  
Vol 134 (9) ◽  
pp. 1253-1260 ◽  
Author(s):  
Larry J. Miller ◽  
Thomas E. Philbeck ◽  
Diana Montez ◽  
Cathy J. Spadaccini
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
White Blood Cell ◽  
Critically Ill Patients ◽  
Blood Chemistry ◽  
Laboratory Analysis ◽  
Blood Samples ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

Abstract Context.—Intraosseous (IO) blood is frequently used to establish a blood chemistry profile in critically ill patients. Questions remain regarding the reliability of IO blood for laboratory analysis and established criteria regarding the amount of marrow/blood to waste before taking an IO sample are not available. Objectives.—To evaluate IO-derived blood for routine laboratory blood tests needed in the care of critically ill patients and to determine the amount of marrow/blood to waste before drawing blood from the IO space for laboratory analysis. Design.—Blood samples were drawn from peripheral veins of 10 volunteers. Within 5 minutes, 2 IO blood samples were obtained; one following 2 mL of waste and another following 6 mL of waste. Samples were analyzed for complete blood count and chemistry profile. Values were analyzed using Pearson correlation coefficients. Levels of significance were determined using the t distribution. Mean values for the draws were calculated and compared, with the intravenous blood sample serving as a control for the IO samples. Results.—There was a significant correlation between intravenous and IO samples for red blood cell counts and hemoglobin and hematocrit levels but not for white blood cell counts and platelet counts. There was a significant correlation between intravenous and IO samples for glucose, blood urea nitrogen, creatinine, chloride, total protein, and albumin concentrations but not for sodium, potassium, CO2, and calcium levels. Conclusions.—When venous blood cannot be accessed, IO blood aspirate may serve as a reliable alternate, especially for hemoglobin and hematocrit levels and most analytes in a basic blood chemistry profile. Exceptions are CO2 levels and platelet counts, which may be lower, and white blood cell counts, which may appear elevated.

Sign in / Sign up

Export Citation Format

Share Document