Microcephaly and Congenital Cytomegalovirus Infection: A Combined Prospective and Retrospective Study of a Swedish Infant Population

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1058-1063
Author(s):  
Karin Ahlfors ◽  
Sten-Anders Ivarsson ◽  
Ingrid Bjerre
Keyword(s):  
Head Circumference ◽  
Cytomegalovirus Infection ◽  
Laboratory Data ◽  
Congenital Infection ◽  
Transmitted Infection ◽  
Congenital Rubella ◽  
Primary Cytomegalovirus Infection ◽  
In The Beginning ◽  
The City

Microcephaly and its etiology were studied in an unselected Swedish urban infant population. Virtually, all live-born infants (14,724) born between October 1977 and December 1983 in the city of Malmö, Sweden, were included in the study. Special attention was given to the role of congenital infections, particularly to cytomegalovirus infection. The infant population was studied from two points of view. One part of the study was prospective and based on regular cytomegalovirus isolation in urine within the first week of life. About 80% of the newborns were adequately studied by this test. None of 56 infants shown to be cytomegalovirus excreters (congenitally infected) and followed up were born with or developed microcephaly (head circumference smaller than 3 SD below the mean for age and sex) during the first 1 to 7 years of life. However, two of the 56 infants had a head circumference of –2 SD. In the beginning of 1985, an inventory was made of the presence of symptomatic microcephaly in the abovementioned population still living in the city or deceased there. Of about 10,000 such children, 12 were found to have symptomatic microcephaly. By studies of personal, clinical, and laboratory data and by retrospective serologic studies of frozen pre- and postconceptional maternal sera, a possible explanation or a recognized syndrome was obtained in ten of the 12 cases. In one of them, the mother had a primary cytomegalovirus infection, possibly in early pregnancy. Although the infant had symptoms compatible with a congenital infection, no laboratory evidence of transmitted infection was found. In no case were congenital rubella virus or Toxoplasma gondii infections suspected.

scholarly journals Transient Antiphospholipid Syndrome Associated with Primary Cytomegalovirus Infection: A Case Report and Literature Review

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tsuyoshi Nakayama ◽  
Mitsuteru Akahoshi ◽  
Kensuke Irino ◽  
Yasutaka Kimoto ◽  
Yojiro Arinobu ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Case Report ◽  
Literature Review ◽  
Antiphospholipid Antibodies ◽  
Cytomegalovirus Infection ◽  
Cmv Infection ◽  
Primary Cytomegalovirus Infection ◽  
First Time ◽  
Acute Cytomegalovirus

Viral infection is known to induce transient autoimmunity in humans. Acute cytomegalovirus (CMV) infection is implicated in occasional thrombosis formation. We here, for the first time, report a 19-year-old female who had an acute CMV infection, leading to a deep venous thrombosis and a pulmonary embolism along with transient appearance of lupus anticoagulant. The pathological role of antiphospholipid antibodies in CMV-mediated thrombosis is discussed.

scholarly journals Cytomegalovirus congenital infection – cause of neurosensorial hearing loss

2016 ◽  
Vol 19 (2) ◽  
pp. 50-53
Author(s):  
Dana-Teodora Anton-Păduraru ◽  
◽  
Ana Simona Drochioi ◽  
Delia Bizim ◽  
Angelica-Cristina Marin ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cytomegalovirus Infection ◽  
Strong Predictor ◽  
Public Health Problem ◽  
Congenital Infection ◽  
Major Public Health Problem ◽  
Seroprevalence Rate ◽  
Specific Symptoms ◽  
The Relationship

Cytomegalovirus infection is a major public health problem, because annually there are born increasingly more children with this infection. Numerous studies have shown that cytomegalovirus infection is an important cause of hearing loss. Cytomegalovirus infection specific symptoms present at birth are a strong predictor for hearing loss, even in populations with low maternal seroprevalence rate. The severity of deafness due to cytomegalovirus infection is variable. Pathophysiology of deafness caused by cytomegalovirus infection is not well known, the mechanisms possible involved being impaired endolymphatic structures, cytopathic effect of the virus and the host response to the inner ear structures. The relationship between viral load and increased likelihood of deafness in infants supports the role of antiviral therapy in decreasing the incidence and the severity of deafness caused by cytomegalovirus. We consider that monitoring children with congenital cytomegalovirus infection should include also hearing monitoring.

scholarly journals Is low birth weight a risk indicator for congenital cytomegalovirus infection?

2009 ◽  
Vol 4 (01) ◽  
pp. 044-047 ◽  
Author(s):  
Zakyieh Al-Hareth ◽  
Fawza Monem ◽  
Nagwa Abdel Megiud
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Head Circumference ◽  
Cytomegalovirus Infection ◽  
Congenital Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Background: Congenital cytomegalovirus infection is currently the leading cause of congenital infection in 0.2-2.2% of live births worldwide leading to variable serious sequalae. The aim of the study was to determine if low birth weight is an indicator of CMV congenital infection evidenced by detecting CMV-DNA in umbilical cord blood at the time of delivery. Methodology: CMV-IgG and IgM antibodies and CMV-DNAemia were assessed in umbilical cord blood of two hundreds newborns, one hundred of whom had birth weight ≤ 2700 gram and/or head circumference ≤ 32 cm. Results: CMV-IgM was not detected, while CMV-IgG was positive in 80-90% of the two hundreds tested newborns. CMV-DNA was detected in four out of the 200 newborns. One of them was over the adopted weight limit (> 2700 gram). Conclusions: CMV-IgM and IgG antibodies assessment was not a potential discriminative test to identify congenitally infected newborns. In addition, low birth weight and small head circumference at birth failed to predict congenital CMV infection. CMV-DNA detection in umbilical cord blood at the time of delivery using real-time PCR of all newborns is recommended as decisive, rapid and non-invasive test.

scholarly journals The role of socioeconomic status, environment, and temperature in the spatio-temporal distribution of the first Chikungunya epidemic in the city of Rio de Janeiro, Brazil

2020 ◽  
Author(s):  
Laís Picinini Freitas ◽  
Alexandra M. Schmidt ◽  
William Cossich ◽  
Oswaldo Gonçalves Cruz ◽  
Marilia Sá Carvalho
Keyword(s):  
Rio De Janeiro ◽  
Temporal Dynamics ◽  
Spatial Models ◽  
Temporal Distribution ◽  
Green Area ◽  
Arboviral Diseases ◽  
Spatio Temporal ◽  
In The Beginning ◽  
The City

AbstractChikungunya is an Aedes-borne disease therefore its dynamics are impacted by the vector’s ecology. We analysed the spatio-temporal distribution of the first chikungunya epidemic in Rio de Janeiro, estimating the effect of the socioeconomic and environmental factors as proxies of mosquitoes abundance. We fitted spatial models using notified cases counts by neighbourhood and week. To estimate the instantaneous and the memory effect of the temperature we used a transfer function. There were 13627 chikungunya cases in the study period. The sociodevelopment index, especially in the beginning of the epidemic, was inversely associated with the risk of cases, whereas the green area proportion effect was null for most weeks. The temperature increased the risk of chikungunya in most areas and this effect propagated for longer where the epidemic was concentrated. Factors related to the Aedes mosquitoes contribute to understanding the spatio-temporal dynamics of urban arboviral diseases.

The role of the virological tests in the diagnosis of the cytomegalovirus infection during pregnancy

2014 ◽  
Vol 155 (41) ◽  
pp. 1632-1642
Author(s):  
Ilona Mihály ◽  
Zsuzsanna Arányi ◽  
Gyula Prinz ◽  
Adrienne Lukács ◽  
Tímea Kolozsi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Congenital Infection ◽  
Diagnostic Tools ◽  
Test Results ◽  
Cytomegalovirus Disease ◽  
Fetal Ultrasound ◽  
Recent Infection ◽  
Medical Specialties

Introduction: The most harmful and most frequent foetal agent is cytomegalovirus. The progress in diagnostic tools and therapeutic opportunities opened new perspectives in the diagnosis and management of foetal cytomegalovirus infection. Aim: Evaluation of cytomegalovirus virological test results performed during pregnancy between 2007 and 2012. Method: Clinical and virology data were retrospectively analysed. Results: 64.5% of the 956 tested women were serologically protected and 33.3% were susceptible to cytomegalovirus. Recent infection was confirmed in 10 pregnant women, while the infection could not be confirmed or excluded in 3 pregnant women. Six pregnant women were asymptomatic, 5 had typical disease, and 2 had abnormal fetal ultrasound. One fetus aborted, congenital infection was confirmed in 2, and was excluded in one of the four newborns tested. Conclusions: The immunity of women to cytomegalovirus reflects high socioeconomic circumstances. Confimatory tests must be done both in women who have cytomegalovirus disease and those who have IgM positive result detected by enzyme (linked) immunoassay. Screening must be done prior to pregnancy. Strict collaboration between professionals of different medical specialties is necessary. Orv. Hetil., 2014, 155(41), 1632–1642.

The Great Reform and the Fate of Capitalism in Russia (On the 150th Anniversary of the Emancipation Reform)

2011 ◽  
pp. 119-136
Author(s):  
M. Voeikov
Keyword(s):  
20Th Century ◽  
Historical Research ◽  
150Th Anniversary ◽  
In The Beginning

The paper deals with the problem of the establishment of capitalism in Russia in the late 19 - early 20th centuries. Using a wide array of historical research and documents the author argues that the thesis on the advanced state of capitalism in Russia in the beginning of the 20th century does not stand up to historical scrutiny, and the role of the famous Emancipation reform of 1861 appears to be of limited importance.

PROBLEMS OF STRAY ANIMALS IN NOVOSIBIRSK

2020 ◽  
Vol 4 (2) ◽  
pp. 85-91
Author(s):  
Elena E. Rinchinova ◽  
Diyara A. Takumova ◽  
Irina I. Bochkareva
Keyword(s):  
Urban Population ◽  
Domestic Animals ◽  
Legal Documents ◽  
Quantitative Indicators ◽  
The City

The article discusses main issues of organizing activities for the treatment of stray and street animals in the city of Novosibirsk. The important role of successful solving the problem of stray animals in ensuring environmental comfort and safety of the urban population is noted. Definitions of the concepts “stray animals” and “street animals” are given, the differences between them are emphasized. The main regulatory and legal documents governing the handling of stray and street animals are listed. The ways in which domestic animals get into a stray state are described briefly. The results of the collection and analysis of information on the activities of shelters for stray animals in Novosibirsk are described. The information on the quantitative indicators of the shelters are given. Conclusions on how to solve the problem of stray animals, relying on the latest regulations are drawn.

Crossing the Pomerium

2020 ◽  
Author(s):  
Michael Koortbojian
Keyword(s):  
Social Practices ◽  
Civic Life ◽  
Public Monuments ◽  
Religion And Law ◽  
Mediterranean World ◽  
The Mediterranean ◽  
The Military ◽  
The City

The ancient Romans famously distinguished between civic life in Rome and military matters outside the city—a division marked by the pomerium, an abstract religious and legal boundary that was central to the myth of the city's foundation. This book explores, by means of images and texts, how the Romans used social practices and public monuments to assert their capital's distinction from its growing empire, to delimit the proper realms of religion and law from those of war and conquest, and to establish and disseminate so many fundamental Roman institutions across three centuries of imperial rule. The book probes such topics as the appearance in the city of Romans in armor, whether in representation or in life, the role of religious rites on the battlefield, and the military image of Constantine on the arch built in his name. Throughout, the book reveals how, in these instances and others, the ancient ideology of crossing the pomerium reflects the efforts of Romans not only to live up to the ideals they had inherited, but also to reconceive their past and to validate contemporary practices during a time when Rome enjoyed growing dominance in the Mediterranean world. The book explores a problem faced by generations of Romans—how to leave and return to hallowed city ground in the course of building an empire.

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