Hirsutism and Menstrual Irregularity in a 16-year-old Girl

US state legislatures have proposed laws to prohibit abortion once the earliest embryonic electrical activity is detectable (fetal “heartbeat”). On average, this occurs roughly 6 wk after the last menstrual period. To be eligible for abortion, people must recognize pregnancy very early in gestation. The earliest symptom of pregnancy is a missed period, and irregular menstrual cycles—which occur frequently—can delay pregnancy detection past the point of fetal cardiac activity. In our analysis of 1.6 million prospectively recorded menstrual cycles, cycle irregularity was more common among young women, Hispanic women, and women with common health conditions, such as diabetes and polycystic ovary syndrome. These groups face physiological limitations in detecting pregnancy before fetal cardiac activity. Restriction of abortion this early in gestation differentially affects specific population subgroups, for reasons outside of individual control.

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Long-Term Health Outcomes of Korean Adults With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

Frontiers in Endocrinology ◽

10.3389/fendo.2021.761258 ◽

2021 ◽

Vol 12 ◽

Author(s):

Seung Gyun Lim ◽

Young Ah Lee ◽

Han Na Jang ◽

Sung Hye Kong ◽

Chang Ho Ahn ◽

...

Keyword(s):

Dehydroepiandrosterone Sulfate ◽

Metabolic Risk ◽

Menstrual Irregularity ◽

Adrenal Hyperplasia ◽

Hydroxylase Deficiency ◽

Classic Congenital Adrenal Hyperplasia ◽

Increased Risk ◽

21 Hydroxylase Deficiency ◽

Age And Sex

There is a lack of studies regarding the long-term outcomes of Asian adults with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. We hypothesized that adults with CAH are at higher metabolic risk than their age-, and sex-matched controls. We further investigated the long-term health outcome-related factors in adults with CAH. We compared metabolic risk between adults with CAH (71 men, 93 women) and age-, and sex-matched controls (190 men, 261 women) from the Korean National Health and Nutrition Examination Survey data. The presence of obesity, testicular adrenal rest tumors (TARTs), and menstrual irregularity was assessed. Hormone status and treatment regimens were compared according to the presence of adverse outcomes. The median age was 27.0 y and 28.0 y for men and women, respectively. Adults with CAH had a higher waist circumference (88.0 vs. 82.3 cm in men, and 83.5 vs. 72.3 cm in women), and blood pressure (125.0 vs. 113.0 mmHg in men, and 120.0 vs. 104.0 mmHg in women) than age- and sex-matched controls (P<0.05 for all). The 2.7-fold increased risk for hypertension (men) and 2.0-fold increased risk for obesity (women) was significant in patients with CAH (P<0.05 for both). Obese adults with CAH showed significantly higher adrenal limb thicknesses (men) and 17-hydroxyprogesterone and dehydroepiandrosterone sulfate levels (women) (P<0.05 for both). TARTs occurred in 58.1% of men and did not differ by hormone or treatment regimen. Irregular menstruation was observed in 57.1% of women, with higher dehydroepiandrosterone sulfate levels in those with irregular periods. Adults with CAH had a higher metabolic risk than the general population. Poor disease control may increase their risk of metabolic morbidity and menstrual irregularity.

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Impacts of Air Pollution on Gynecologic Disease: Infertility, Menstrual Irregularity, Uterine Fibroids, and Endometriosis: a Systematic Review and Commentary

Current Epidemiology Reports ◽

10.1007/s40471-018-0157-9 ◽

2018 ◽

Vol 5 (3) ◽

pp. 197-204 ◽

Cited By ~ 1

Author(s):

Shruthi Mahalingaiah ◽

Kevin J. Lane ◽

Chanmin Kim ◽

J. Jojo Cheng ◽

Jaime E. Hart

Keyword(s):

Systematic Review ◽

Air Pollution ◽

Uterine Fibroids ◽

Menstrual Irregularity

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The oracle study – fibromyalgia, prevalence and severity in the hospital setting

Journal of the Pakistan Medical Association ◽

10.47391/jpma.1000 ◽

2021 ◽

pp. 1-7

Author(s):

Mohammad Ali Arif ◽

Fibhaa Syed ◽

Rauf Niazi ◽

Saba Ali Arif ◽

Umme e Laila Hashmi ◽

...

Keyword(s):

Economic Status ◽

Demographic Data ◽

Fibromyalgia Impact Questionnaire ◽

Hospital Setting ◽

Menstrual Irregularity ◽

Medical Sciences ◽

American College Of Rheumatology ◽

Previous Medication ◽

Age Of Menarche

Abstract Objective: The aim of the present study was to assess the prevalence and severity of Fibromyalgia in hospital visiting patients. Methods: A total of 750 patients aged 18 to 75 years were enrolled at the Pakistan Institute of Medical Sciences, Islamabad from July 2018 – January 2019. Demographic data, the presence of comorbidities and previous medication, were recorded for each patient and the 2010/2011 modified ACR (American College of Rheumatology) preliminary diagnostic criteria for fibromyalgia was applied. If fibromyalgia was diagnosed, the FIQR (Fibromyalgia impact questionnaire) was administered to assess the severity of FM. Results: The prevalence of fibromyalgia in hospital visiting patients was found to be 33.3% (n=250), with a female preponderance of 76% (n=190) in the diagnosed subset. Females were more than twice as likely to have fibromyalgia as their age matched male counterparts (OR 2.87, 95% CI 2.05 – 4.04, p<0.0001). The presence of diabetes, anxiety and rheumatoid arthritis but not other comorbidities (p<0.0001), advancing age (p=0.002) and increased BMI (p=0.004) were found to be significantly associated with FM. In patients diagnosed with FM, over 70% (n=180) had been previously diagnosed as having musculoskeletal pain with 66% (n=165) being on long term NSAID therapy. Multiple regression analysis showed FM severity was not influenced by comorbidities, marital status, education or economic status. A unique finding was a later age of menarche (R2=0.194, p=0.009) and menstrual irregularity (R2=0.229, p=0.003) being associated with more severe fibromyalgia symptoms. Continuous....

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The Association between Serum Ferritin and Menstrual Irregularity in Female Adults in Korea

Korean Journal of Family Practice ◽

10.21215/kjfp.2018.8.4.530 ◽

2018 ◽

Vol 8 (4) ◽

pp. 530-534

Author(s):

Dong-Won Kim ◽

Do-Hoon Kim ◽

Seung-Hyun Lee ◽

Chung-Woo Lee ◽

Hyonchong Kim ◽

...

Keyword(s):

Serum Ferritin ◽

Menstrual Irregularity

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Polycystic Ovary Syndrome in the Adolescent

10.2310/obg.19115 ◽

2019 ◽

Author(s):

Tara A. Singh ◽

Kathleen F. Harney

Keyword(s):

Young Women ◽

Early Recognition ◽

Polycystic Ovary ◽

Poor Quality ◽

Lifestyle Changes ◽

Hormonal Contraceptives ◽

Menstrual Irregularity ◽

Oral Contraceptive Pills ◽

Adolescent Women ◽

First Line Therapy

The typical PCOS phenotype of anovulation, androgen excess, and polycystic ovarian morphology can overlap with normal adolescence, thus making the diagnosis more difficult. Early recognition of adolescents at a risk for PCOS allows for earlier intervention with the potential for improved cardiovascular and metabolic health. Mental health issues and poor quality of life are frequently associated with PCOS in adolescent women and, therefore, should be identified and addressed. As with many issues confronting the adolescent, peer and family support should be encouraged. Lifestyle changes and weight loss should be thought of as first-line therapy for young women with PCOS. Combined hormonal contraceptives remain the medical therapy of choice for the treatment of menstrual irregularity, hirsutism, acne, and contraception. Metformin and spironolactone may be considered, with metformin particularly beneficial in young women with metabolic abnormalities. This review contains 2 tables and 50 references. Key Words: antiandrogens, antimüllerian hormone, hirsutism, hyperandrogenism, hyperinsulinemia, insulin resistance, menstrual irregularity, obesity, oral contraceptive pills, polycystic ovary

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