Symptoms of Overdosage of Amoxapine
Amoxapine is a popular antidepressant that has been marketed in the United States since 1980. It is a tricyclic dibenzoxapine that is reported to have a rapid antidepressant effect and limited toxicity as compared with other tricyclic antidepressants. In a review of the outcome of 479 cyclic antidepressant overdoses that were reported to two poison control centers during an 18-month period, the mortality rate associated with overdoses was 23 times greater than the mortality associated with overdoses of the other cyclic antidepressants (15.2% v 0.77%). Persistent and poorly controllable seizures, which occurred eight times more frequently than with other antidepressants, were the most profound toxic effect (36.4%). Hyperthermia was reported in several cases (9.1%) due to status epilepticus.