scholarly journals Protective effects of Vitamin E on CCl4-induced testicular toxicity in male rats

2016 ◽  
Vol 103 (2) ◽  
pp. 157-168 ◽  
Author(s):  
AA El-Faras ◽  
IA Sadek ◽  
YE Ali ◽  
MIM Khalil ◽  
EB Mussa
Keyword(s):  
Vitamin E ◽  
Male Rats ◽  
Testicular Toxicity ◽  
Protective Effects

scholarly journals Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Izadpanah Gheitasi ◽  
Arsalan Azizi ◽  
Navid Omidifar ◽  
Amir Hossein Doustimotlagh
Keyword(s):  
Vitamin E ◽  
Histopathological Examination ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Protein Carbonyl ◽  
Male Rats ◽  
Protective Effects ◽  
Antioxidant Power ◽  
Antioxidant Parameters ◽  
Origanum Majorana

Background. The most important cause of acute renal failure in normal kidneys is ischemia-reperfusion (I/R) injury. The aim of the current study was to investigate the protective effects of Origanum majorana (OM) methanolic extract, carvacrol, and vitamin E on I/R-induced kidney injury in male rats. Material and Method. Thirty Wistar male rats were randomly allocated into 5 groups; sham, I/R, I/R + OM (300 mg/kg), I/R + carvacrol (75 mg/kg), and I/R + vitamin E (100 mg/kg). Renal function markers, oxidant-antioxidant parameters, and histopathological examination were evaluated. Results. It was exhibited that the urea, creatinine, protein carbonyl, glomerular filtration rate, total thiol, ferric reducing antioxidant power, and histopathological changes markedly reversed in the treatment groups with OM or carvacrol in comparison to the I/R merely group. Conclusion. We conclude that OM extract or its ingredient, carvacrol, exerts renoprotective impacts in I/R-induced kidney injury possibly by scavenging free radicals and increasing antioxidant power.

scholarly journals Study the Effect of Vitamins (C and E) on Oxidative Stress and Antioxidants Changes Induced by VCM in Male Rats

2020 ◽  
Vol 11 (03) ◽  
pp. 430-434
Author(s):  
Shaymaa J. Shamran ◽  
Haider S. Jaffat
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Vitamin C ◽  
Male Rats ◽  
Control Group ◽  
Protective Effects ◽  
Vancomycin Group ◽  
Animal House ◽  
Antioxidant Effects ◽  
Oxidative Effect

The current study was designed to determine the antioxidant effects of vitamin C and vitamin E against oxidative stress induced by vancomycin in some antioxidants changes in the male rats. The study was conducted in the animal house of the Faculty of Science/University of Kufa for the period from April, 2018 to May, 2018 on 119 animals of male rats aged 2.5–3 months and the weight of 150-200 gm. Two experiments designed in this study addressed the first and two experiments to study the oxidative effect of vancomycin in addition to the protective effects of vitamin C and vitamin E to reduce these effects in the treatment of animals for one week and three weeks with vancomycin and vancomycin plus vitamins. The results indicated a significant increase (p less than 0.05) in the MDA, CAT, and significant decrease (p less than 0.05) in SOD, and GPX. In the animals treated with vancomycin 40,60 mg/kg only compared to the control group for the two periods of administration at the same time occur a significant decrease(p less than 0.05) in the MDA, CAT and a significant increase (p less than 0.05) in the SOD and GPX after treated animals with vancomycin 40,60 mg/kg with vitamin C and vitamin E for a period of one and three weeks compared with vancomycin group.

scholarly journals Comparison of the protective effects of Scrophularia striata extract with vitamin E on cognitive function, anxiety and pain sensitivity in diazinon-exposed male rats

2020 ◽  
Vol 25 (1) ◽  
pp. 47-56
Author(s):  
Ali Abedi ◽  
◽  
Khayam Bamdad ◽  
Hilda Yaghoubi Shahir ◽  
Raziyeh Dehghany ◽  
...  
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Cognitive Function ◽  
Pain Sensitivity ◽  
Male Rats ◽  
Thermal Stimulus ◽  
Protective Effects ◽  
Hot Plate ◽  
Neuroprotective Effects ◽  
Scrophularia Striata

Introduction: Scrophularia striata is used in traditional medicine to treat various disorders and has neuroprotective effects. There are no studies about the effects of S. striata on cognitive functions in diazinon (DZN)- exposed rats. According to the results of previous studies, vitamin E (Vit. E) can also act as a protective agent against cognitive impairments. Therefore, the present study was designed to compare the effects of Vit. E and S. striata on DZN-induced behavioral impairments in male rats. Methods: Neuroprotective effects of S. striata (30mg/kg, 5 days/week for 8 weeks) and Vit. E (200mg/kg, 5 days/week for 8 weeks, IP) were assessed through changes in memory, anxiety-like behaviors and pain threshold following DZN exposure. Open field, shuttle box and hot plate were used to examine anxiety-like behaviors, passive avoidance learning and memory as well as pain sensitivity, respectively. Results: Our findings indicated that exposure to DZN caused a significant decrease in memory retention and an increase in anxiety-like behaviors. S. striata and Vit. E administration compensated memory and emotional impairments induced by DZN. As well as, S. striata alone decreased reaction time against thermal stimulus in the hot plate test. The findings of the present study also indicated that exposure to DZN significantly decreased body weight, while S. striata and Vit. E consumption restored it. Conclusion: Results of our study indicated the protective effects of S. striata consumption like Vit. E against DZN-induced disruptions in anxiety, cognitive function and body weight loss.

scholarly journals Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

2016 ◽  
Vol 50 (4) ◽  
pp. 194-206 ◽  
Author(s):  
H Bahadoran ◽  
MR Naghii ◽  
M Mofid ◽  
MH Asadi ◽  
K Ahmadi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ethylene Glycol ◽  
Stone Disease ◽  
Male Rats ◽  
Calcium Deposition ◽  
Control Group ◽  
Renal Tubules ◽  
Protective Effects ◽  
Group 5 ◽  
Group 2

AbstractObjectives. Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation.Methods. Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75% ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the first day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group).Results. Kidney sections showed that crystals in the EG group increased significantly in comparison with the control group. Crystal calcium deposition score in groups of EG+B (160), EG+Vit E, and EG+B+Vit E showed a significant decrease compared to EG group. Measurement of the renal tubules area and renal tubular epithelial histological score showed the highest significant dilation in the EG group. Tubular dilation in the EG+B+Vit E group decreased compared to the EG+B and EG+Vit E groups.Conclusions. Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.

Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

Andrologia ◽  
2013 ◽  
Vol 46 (4) ◽  
pp. 437-446 ◽  
Author(s):  
M. Dorostghoal ◽  
S. M. Seyyednejad ◽  
A. Jabari
Keyword(s):  
Male Rats ◽  
Testicular Toxicity ◽  
Protective Effects
Sign in / Sign up

Export Citation Format

Share Document