scholarly journals Ethanol and Stem Cells

2017 ◽  
Vol 3 ◽  
pp. 58
Author(s):  
Afsaneh Farokhi ◽  
Fatemeh Koohpeima ◽  
Mohammad Javad Mokhtari
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
High Risk ◽  
Dental Pulp ◽  
Embryonic Stem ◽  
Ethanol Exposure ◽  
Tooth Decay ◽  
The Central Nervous System

Many studies have showed disadvantageous effect of ethanol exposure on stem cells. Ethanol exposure during development leads injury to various types of stem cells including neural stem cells (NSCs), dental pulp stem cells, mesenchymal stem cells, embryonic stem cells and etc. Because NSCs play a basic role in the development and maturation of the central nervous system, it is vital to understand the effect of ethanol on NSCs differentiation. Additionally, alcohol misusage appears lead to periodontal disease, tooth decay and mouth wounds that are potentially precancerous. Individuals who abuse alcohol are at high risk of having seriously destroyed teeth, gums and compromised oral health in general. Some of these adverse situations maybe are because of ethanol effects on stem cells. Therefore, here, ethanol effects on the various types of stem cells were reviewed.

Ablation of Tumor-Derived Stem Cells Transplanted to the Central Nervous System by Genetic Modification of Embryonic Stem Cells with a Suicide Gene

2007 ◽  
Vol 18 (12) ◽  
pp. 1182-1192 ◽  
Author(s):  
Juyeon Jung ◽  
Neil R. Hackett ◽  
Robert G. Pergolizzi ◽  
Lorraine Pierre-Destine ◽  
Anja Krause ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Embryonic Stem Cells ◽  
Genetic Modification ◽  
Embryonic Stem ◽  
Suicide Gene ◽  
The Central Nervous System

Human Endometrial-Derived Mesenchymal Stem Cells Suppress Inflammation in the Central Nervous System of EAE Mice

2011 ◽  
Vol 8 (3) ◽  
pp. 940-952 ◽  
Author(s):  
J. P. S. Peron ◽  
T. Jazedje ◽  
W. N. Brandão ◽  
P. M. Perin ◽  
M. Maluf ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
The Central Nervous System

Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis

2009 ◽  
Vol 15 (5) ◽  
pp. 644-646 ◽  
Author(s):  
J Liang ◽  
H Zhang ◽  
B Hua ◽  
H Wang ◽  
J Wang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
Autoimmune Disorder ◽  
Disease Course ◽  
The Central Nervous System ◽  
Stem Cells Transplantation

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

scholarly journals Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways

2019 ◽  
Vol 20 (23) ◽  
pp. 6039 ◽  
Author(s):  
Luigi Chiricosta ◽  
Serena Silvestro ◽  
Jacopo Pizzicannella ◽  
Francesca Diomede ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
Tnf Α ◽  
The Central Nervous System ◽  
Anti Inflammatory ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Stat Pathway

Inflammation is a common feature of many neurodegenerative diseases. The treatment of stem cells as a therapeutic approach to repair damage in the central nervous system represents a valid alternative. In this study, using Next-Generation Sequencing (NGS) technology, we analyzed the transcriptomic profile of human Gingival Mesenchymal Stem Cells (hGMSCs) treated with Moringin [4-(α-l-ramanosyloxy)-benzyl isothiocyanate] (hGMSCs-MOR) or with Cannabidiol (hGMSCs-CBD) at dose of 0.5 or 5 µM, respectively. Moreover, we compared their transcriptomic profiles in order to evaluate analogies and differences in pro- and anti-inflammatory pathways. The hGMSCs-MOR selectively downregulate TNF-α signaling from the beginning, reducing the expression of TNF-α receptor while hGMSCs-CBD limit its activity after the process started. The treatment with CBD downregulates the pro-inflammatory pathway mediated by the IL-1 family, including its receptor while MOR is less efficient. Furthermore, both the treatments are efficient in the IL-6 signaling. In particular, CBD reduces the effect of the pro-inflammatory JAK/STAT pathway while MOR enhances the pro-survival PI3K/AKT/mTOR. In addition, both hGMSCs-MOR and hGMSCs-CBD improve the anti-inflammatory activity enhancing the TGF-β pathway.

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