The relationship between forced expiratory volume 1 (FEV 1) with 25(OH) vitamin D level and hs-CRP in COPD in H. Adam Malik General Hospital Medan

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relationship between biochemical markers of vitamin D status and androgens in women with PCOS. This cross-sectional study used bio-banked samples from 46 pre-menopausal women with PCOS (mean ± SD: age 30 ± 6 years; BMI 29 ± 6 kg/m2). We measured 25-hydroxyvitamin D (25[OH]D), vitamin D-binding protein (DBP), total testosterone, sex hormone-binding globulin (SHBG), and calculated the free androgen index (FAI) and bioavailable and free 25(OH)D. Fasting glucose and insulin were used to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) and body fat percentage was determined via dual energy x-ray absorptiometry. High-sensitivity C-reactive protein (hs-CRP) was measured as a marker of inflammation. DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. There were no associations between vitamin D metabolites and total testosterone, SHBG or FAI, even after adjusting for age, body fat percentage, HOMA-IR and hs-CRP. We found no associations between vitamin D metabolites and androgens in women with PCOS. Studies that have identified a vitamin D–androgen link have largely relied on methodology with numerous pitfalls; future studies should exclusively use gold-standard measures to confirm these findings in this population.

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Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients

Progress in Transplantation ◽

10.1177/1526924816664086 ◽

2016 ◽

Vol 26 (4) ◽

pp. 335-339 ◽

Cited By ~ 5

Author(s):

Omer Atis ◽

Mustafa Keles ◽

Erdem Cankaya ◽

Hasan Dogan ◽

Hulya Aksoy ◽

...

Keyword(s):

Vitamin D ◽

Endothelial Dysfunction ◽

Renal Transplant ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Transplant Patients ◽

Vitamin D Levels ◽

Hs Crp ◽

25 Oh Vitamin D

Context: Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer. Objective: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. Design: Prospective. Setting: Nephrology clinic. Patients: Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months. Intervention: One-time oral dose of 300 000 IU vitamin D3. Main Outcome Measures: Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured. Results: Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = −.36, P = .02). Conclusion: This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.

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Vitamin D and Chronic Pain in Immigrant and Ethnic Minority Patients—Investigation of the Relationship and Comparison with Native Western Populations

International Journal of Endocrinology ◽

10.1155/2010/753075 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 12

Author(s):

Sebastian Straube ◽

R. Andrew Moore ◽

Sheena Derry ◽

Ernst Hallier ◽

Henry J. McQuay

Keyword(s):

Vitamin D ◽

Chronic Pain ◽

Ethnic Minority ◽

Minority Populations ◽

Insufficient Evidence ◽

Vitamin D Levels ◽

Ethnic Minority Populations ◽

25 Oh Vitamin D ◽

The Relationship ◽

Lower Vitamin

Vitamin D deficiency has been implicated in chronic pain. Immigrant and ethnic minority populations have been shown to have lower vitamin D levels than native Western populations and often to be vitamin D deficient. This systematic review investigates the relationship between vitamin D and chronic pain in immigrant and ethnic minority populations. Included were studies reporting on 25-OH vitamin D levels in immigrant/ethnic minority populations affected by chronic pain, and/or reporting on the treatment of chronic pain with vitamin D preparations in such populations. We found that 25-OH vitamin D levels were low and often deficient in immigrant/ethnic minority populations. Vitamin D levels depended on the latitude of the study location and hence sunlight exposure. There was insufficient evidence to reach a verdict on the value of treating chronic pain in immigrant/ethnic minority patients with vitamin D preparations because the studies were few, small, and of low quality.

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The Relationship Between 25 (OH) Vitamin D Level and the Severity of Disease and Sleep Quality in Restless Legs Syndrome

Turkish Journal Of Neurology ◽

10.4274/tnd.galenos.2019.25478 ◽

2019 ◽

Vol 25 (2) ◽

pp. 87-91

Author(s):

Arife Çimen Atalar

Keyword(s):

Vitamin D ◽

Sleep Quality ◽

Restless Legs Syndrome ◽

Restless Legs ◽

Severity Of Disease ◽

25 Oh Vitamin D ◽

The Relationship

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092 A STUDY ON THE PREVALENCE OF SERUM 25(OH)-VITAMIN D DEFICIENCY IN PATIENTS ON MAINTENANCE HEMODIALYSIS AND PERITONEAL DIALYSIS IN SARAWAK GENERAL HOSPITAL

Kidney International Reports ◽

10.1016/j.ekir.2017.06.102 ◽

2017 ◽

Vol 2 (4) ◽

pp. S31 ◽

Cited By ~ 1

Author(s):

K.H. Lai ◽

H.S. Florence Tan ◽

V.E. Phui ◽

K.F. Chew ◽

W.S. Lawrence Hii ◽

...

Keyword(s):

Vitamin D ◽

Peritoneal Dialysis ◽

Vitamin D Deficiency ◽

General Hospital ◽

Maintenance Hemodialysis ◽

25 Oh Vitamin D

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The Relationship Between 25 (OH) Vitamin D Level and the Severity of Disease and Sleep Quality in Restless Legs Syndrome

Turkish Journal Of Neurology ◽

10.4274/tnd.2019.25478 ◽

2019 ◽

Vol 25 (2) ◽

pp. 87-91

Author(s):

Arife Çimen Atalar

Keyword(s):

Vitamin D ◽

Sleep Quality ◽

Restless Legs Syndrome ◽

Restless Legs ◽

Severity Of Disease ◽

25 Oh Vitamin D ◽

The Relationship

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Therapeutic Value of Vitamin D as an Adjuvant Therapy in Neonates with Sepsis

Infectious Disorders - Drug Targets ◽

10.2174/1871526519666190626141859 ◽

2020 ◽

Vol 20 (4) ◽

pp. 440-447 ◽

Cited By ~ 2

Author(s):

Adel A. Hagag ◽

Mohamed S. El Frargy ◽

Hoassam A. Houdeeb

Keyword(s):

Vitamin D ◽

Neonatal Sepsis ◽

P Value ◽

Group I ◽

Therapeutic Value ◽

Significant Difference ◽

Sepsis Score ◽

Group Ii ◽

Hs Crp ◽

25 Oh Vitamin D

: Sepsis is unusual systemic reaction to an ordinary infection, and it probably represents a pattern of response by the immune system to the injury. Vitamin D is a fat-soluble steroid hormone that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization. Vitamin D has an important role in the regulation of both innate and adaptive immune systems. Aim of the Work: The current study aimed to evaluate the therapeutic value of vitamin D supplementation as an adjuvant therapy in neonates with sepsis. Subjects and Method: This study included 60 neonates with sepsis who were randomly divided into 2 equal groups; group I: 30 neonates with sepsis who received antibiotic only, Group II: 30 neonates with sepsis who received antibiotic therapy and vitamin D. This study also included 30 healthy neonates as a control group. For all patients and controls, serum level of 25 (OH) vitamin D and highly sensitive C reactive protein (hs-CRP) were immunoassayed. Results: There is no significant difference between groups I, II and controls regarding weight, gestational age, sex and mode of delivery. There were significant differences between groups I and II in sepsis score and hs-CRP after 3, 7, 10 days of treatment (p values for sepsis score were 0.009, 0.006, 0.004 respectively and for hs-CRP were 0.015, 0.001, 0.001 respectively). There was a significant difference in immature /total (I/T) ratio after 7, and 10 days of treatment (p value= 0.045, 0.025, respectively,) while there was no significant difference in immature /total (I/T) ratio after 3 days of treatment (p value = 0.624).Serum 25(OH) vitamin D levels were significantly lower in neonates with sepsis (group I and II) than the controls (p value < 0.05, while there were no significant differences between the three groups considering serum calcium and phosphorus levels (P =1.000, 1.000, respectively). Isolated organisms from blood culture in neonates with sepsis (group I and group II) were most commonly B- hemolytic streptococci, E-coli, hemophilus influenza and staphylococcus aurous. There was a significant negative correlation between hs-CRP and serum 25 (OH) vitamin in group II on entry (r = - 0.832 and P value = 0.001) and after 2 weeks (r = - 0.590 and P value = 0.021). ROC curve of specificity and sensitivity of 25 (OH) vitamin D level in prediction of early-onset neonatal sepsis showed that cutoff value of vitamin D was ≤20 ng/ml, sensitivity was 100%, specificity was 73%, positive predictive value was 73%, negative predictive value was 100% and accuracy was 87. Conclusion and Recommendation: Serum 25 (OH) vitamin D levels of neonates with the early onset neonatal sepsis were significantly lower than the healthy controls. Vitamin D supplementation improved sepsis score and decrease high levels of hs-CRP; this reflects the role of vitamin D as a target therapy for neonatal sepsis. Further studies are warranted to confirm the therapeutic value of vitamin D in neonatal sepsis.

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