Osteomielitis supuratif kronis pada mandibula edentulus Chronic suppurative osteomyelitis on edentulous mandible

Osteomyelitis is an infection of the jaw that extends to the jaw bone, which is the spongy, bone marrow, cortex, andperiosteum. Infection occurs in the calcified bone when fluid in the medullary cavity or under the periosteum interferewith the blood supply. In this case, it was reported an elderly patient with a diagnosis of chronic osteomyelitis ofmandible edentulous dextra. The treatment were sequesterectomy and extraction the radix of tooth 43 by generalanesthesia, and combinating with antibiotics. It was concluded that patient of chronic suppurative osteomyelitis of themandible edentulus could be diagnosed through clinical and radiological examination, and successfully treated withsequesterectomy and extracting the radix under general anesthesia. So the improvement of systemic condition, foodnutrition, vitamin therapy, accelerate the healing process. Treatment of focal infection as soon as possible to avoidmore severe complications.

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Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

The International Journal of Lower Extremity Wounds ◽

10.1177/15347346211029078 ◽

2021 ◽

pp. 153473462110290

Author(s):

Nazira Fatima ◽

Muhammad Saleem

Keyword(s):

Bone Marrow ◽

Wound Healing ◽

Sodium Nitroprusside ◽

Bone Marrow Cells ◽

Healing Process ◽

Wound Healing Process ◽

Inflammatory Infiltration ◽

Acute Wound ◽

High Concentrations ◽

Marrow Cells

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

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The Role of Bone Marrow-Derived Cells During the Bone Healing Process in the GFP Mouse Bone Marrow Transplantation Model

Calcified Tissue International ◽

10.1007/s00223-012-9685-3 ◽

2012 ◽

Vol 92 (3) ◽

pp. 296-306 ◽

Cited By ~ 6

Author(s):

Hidetsugu Tsujigiwa ◽

Yasuhisa Hirata ◽

Naoki Katase ◽

Rosario Rivera Buery ◽

Ryo Tamamura ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Bone Healing ◽

Marrow Transplantation ◽

Healing Process ◽

Mouse Bone Marrow ◽

Bone Marrow Derived Cells ◽

Bone Healing Process ◽

Transplantation Model

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Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats

Bone ◽

10.1016/s8756-3282(03)00053-x ◽

2003 ◽

Vol 32 (5) ◽

pp. 491-501 ◽

Cited By ~ 104

Author(s):

Soshi Uchida ◽

Akinori Sakai ◽

Hideaki Kudo ◽

Hajime Otomo ◽

Makoto Watanuki ◽

...

Keyword(s):

Bone Marrow ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Healing Process ◽

Drill Hole ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Topical Transplantation of Bone Marrow Mesenchymal Stem Cells Made Deeper Skin Wounds Regeneration

Plastic Surgery ◽

10.1177/2292550320967404 ◽

2020 ◽

pp. 229255032096740

Author(s):

Qin Yonghong ◽

Li Aishu ◽

Yazan Al-Ajam ◽

Liao Yuting ◽

Zhang Xuanfeng ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Hair Follicle ◽

Healing Process ◽

Control Group ◽

P Value ◽

Full Thickness ◽

Wound Model ◽

Marrow Mesenchymal Stem Cells

Current wound healing models generally employ full-thickness or irregular split wounds. Consequently, assessing the type of healing at varying wound depths and determining the deepest level at which wounds can regenerate has been a challenge. We describe a wound model that allows assessment of the healing process over a continuous gradient of wound depth, from epidermal to full-thickness dermal loss. Further, we investigate whether green fluorescent protein–labeled bone marrow mesenchymal stem cells (BM-MSCs/GFP) transplantation could regenerate deeper wounds that might otherwise lead to scar formation. A wound gradient was created on the back of 120 Sprague Dawley rats, which were randomized into the BM-MSCs/GFP and control group. These were further subdivided into 6 groups where terminal biopsies of the healing wounds were taken at days 1, 3, 5, 7, 14, and 21 post-operatively. At each observed time point, the experimental animals were anesthetized and photographed, and depending on the group, the animals euthanized and skin taken for rapid freezing, haemotoxylin and eosin staining, and vascular endothelial growth factor (VEGF) immunohistochemistry. We found the deepest layer to regenerate in the control group was at the level of the infundibulum apex, while in the BM-MSCs/GFP group this was deeper, at the opening site of sebaceous duct at hair follicle in which had the appearance of normal skin and less wound contraction than the control group ( P value less than .05). The expression of VEGF in BM-MSCs/GFP group was higher than that in control group ( P value less than .05). The number of vessels increased from 2.5 ± 0.2/phf of control group to 5.0 ± 0.3/phf of BM-MSCs/GFP ( P value less than .05). The progressively deepening wound model we described can identify the type of wound repair at increasing depths. Further, topical transplantation of BM-MSCs/GFP significantly improved regeneration of deeper wounds from infundibulum apex (maximum depth of control group regeneration) to the opening site of sebaceous duct at hair follicle level.

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Chronic osteomyelitis as a factor in focal infection of dental origin

International Journal of Orthodontia Oral Surgery and Radiography ◽

10.1016/s0099-6963(24)90289-4 ◽

1924 ◽

Vol 10 (10) ◽

pp. 656-662

Author(s):

C.W. Lokey

Keyword(s):

Chronic Osteomyelitis ◽

Focal Infection ◽

Dental Origin

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Diagnosis and management of chronic osteomyelitis and cemento-osseous dysplasia of the mandible

Dental Update ◽

10.12968/denu.2019.46.11.1062 ◽

2019 ◽

Vol 46 (11) ◽

pp. 1062-1066

Author(s):

Arifa Akram ◽

Tajinder Lidhar ◽

Katy Marie Valentine ◽

Roger Webb

Keyword(s):

Bone Marrow ◽

General Practitioner ◽

Clinical Relevance ◽

Periodontal Ligament ◽

Chronic Osteomyelitis ◽

Incidental Finding ◽

Signs And Symptoms ◽

Management Options ◽

Osseous Dysplasia ◽

Clinical Considerations

Chronic osteomyelitis is a severe and persistent infection of the bone including the bone marrow. Cemento-osseous dysplasias are a group of conditions arising from the periodontal ligament tissue and are categorized into peri-apical, focal and florid. A case of a patient with buccal and submandibular swelling associated with a discharging sinus between LR45 was presented. History, examination and investigations confirmed a diagnosis of chronic osteomyelitis and an incidental finding of florid cemento-osseous dysplasia of the mandible. The patient's treatment is discussed within the context of important clinical considerations required in managing these patients. CPD/Clinical Relevance: It is pertinent for a general practitioner to be aware of signs and symptoms associated with chronic osteomyelitis and understand the management options.

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Harvesting bone marrow in an outpatient setting using newer anesthetic agents.

Journal of Clinical Oncology ◽

10.1200/jco.1993.11.2.320 ◽

1993 ◽

Vol 11 (2) ◽

pp. 320-323 ◽

Cited By ~ 4

Author(s):

A C Thorne ◽

M Stewart ◽

S C Gulati

Keyword(s):

Bone Marrow ◽

Side Effects ◽

General Anesthesia ◽

Autologous Bone Marrow Transplantation ◽

Autologous Bone Marrow ◽

Pain Medication ◽

Outpatient Setting ◽

Postanesthesia Care Unit ◽

Anesthetic Agents ◽

At Home

PURPOSE To evaluate the results of outpatient bone marrow harvest (BMH). PATIENTS AND METHODS Seventy-two adult patients with various malignancies had 79 BMH procedures performed for future autologous bone marrow transplantation (BMT) in our institution's outpatient surgical facility. All patients were evaluated and educated before the procedure. Newer anesthetic agents specifically developed to have shorter half-lives, more rapid recovery from general anesthesia, and fewer unpleasant side effects were chosen. Propofol was used for induction of anesthesia in 76 patients, the other three were induced with sodium pentothal. The blood volume removed was replaced by colloid (6% hydroxyethyl starch). Also, a new parenteral nonnarcotic pain medication, ketoroloc, was used during the last part of general anesthesia to help with expected postoperative pain in 76 patients. RESULTS BMH took 111 +/- 24 minutes and patients were in postanesthesia care unit (PACU) for 220 +/- 72 minutes before being sent home with a companion and Tylenol with codeine (acetaminophen with codeine; McNeil Pharmaceutical, Spring House, PA). PACU complications were minor and included transient mild dizziness (7.6%), vomiting (3.8%), and fever (2.6%). No life-threatening complication was observed. Only one patient was hospitalized for observation (fever) and then sent home. Seventy-five patients (94.9%) were contacted at home by the hospital nursing staff the day following the procedure. Five (6.7%) complained of nausea or vomiting, and four (5.3%) developed fever at home (temperature, 37.2 to 38.3 degrees C). Only 36% of patients actually took oral narcotic pain medication at home. CONCLUSION Autologous BMH (AuBMH) is a safe outpatient procedure with minimal side effects when newer anesthetic agents are used.

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