Novel Collagen Based Material for Local Drug Delivery Systems

2007 ◽  
Vol 1008 ◽  
Author(s):  
Luciano Castaneda ◽  
Suzanne Pluskat ◽  
Darline Ky ◽  
Earry Te ◽  
Katarzyna Slowinska

AbstractIn a search for new drug delivery matrix, the synthesis of a novel collagen material based on tiopronin protected gold clusters (MPC) as a crosslinking agent is proposed. The structure of collagen matrix modified with MPC is studied using transmission electron microscope. The thermal properties are examined with differential scanning calorimetry. To assess the biocompatibility of the matrix, the cytotoxicity assays are conducted.

2015 ◽  
Vol 51 (2) ◽  
pp. 255-263
Author(s):  
Rupali Nanasaheb Kadam ◽  
Raosaheb Sopanrao Shendge ◽  
Vishal Vijay Pande

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>


2021 ◽  
Author(s):  
Saikat Das ◽  
R. Govinda Rao ◽  
Prasanta Kumar Rout

Abstract In the present work, the artificial aging kinetics of SiCp particles reinforced AA7075-SiCp composite fabricated by stir casting method was investigated. The aging behavior of AA7075-SiCp composite was investigated by Rockwell hardness tests and differential scanning calorimetry (DSC). Results show there are no changes in the sequences of formation and dissolution of precipitate. Reinforced particles are uniformly distributed throughout the matrix. The hardness profile shows increase in hardness with the comparison of AA7075 base alloy. In addition to SiCp in the matrix, precipitation kinetics has changed compared with base alloy since higher dislocations present in composite, hence requires lower activation energy to form ή precipitate and takes less time to reach the maximum hardness. In contrast, the addition of SiCp at low volume percent also showing accelerated aging phenomena in the composite during the aging process. High-resolution transmission electron microscope (HRTEM) micrograph of peak age (T6) condition divulges that enormous fine and plate-like ή (MgZn2) precipitates are uniformly distributed in the composite.


Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve

Background: Polymers are the backbone of modern pharmaceutical formulations and drug delivery technologies. Polymers that may be natural, synthetic, or semisynthetic are used to control the release of drugs in a pre-programmed fashion. The drug delivery systems are mainly prepared to enhance the bioavailability, site-specific release, sustained release, controlled release, i.e., to modify the release of drug from dosage form may be a tablet, capsule, etc. Objective: The objective of the present study is to overview the recent patents concerning the application of eudragit in the prevention of cancer and other ailments. Eudragit polymers are polymethacrylates and may be anionic, cationic, or non-ionic polymers of methacrylic acid, dimethyl-aminoethyl methacrylates, and methacrylic acid esters in varying ratios. Eudragit is available in various grades with solubilities at different pH, thus helping the formulators design the preparation to have a well-defined release pattern. Method: In this review, patent applications of eudragit in various drug delivery systems employed to cure mainly cancer are covered. Results : Eudragit has proved its potential as a polymer to control the release of drugs as coating polymer and formation of the matrix in various delivery systems. It can increase the bioavailability of the drug by site-specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs. Conclusion: The potential of eudragit to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.


Author(s):  
Joana Vieira Costa ◽  
Jaime Portugal ◽  
Cristina Bettencourt Neves ◽  
Ana F. Bettencourt

2010 ◽  
Vol 17 (02) ◽  
pp. 165-172 ◽  
Author(s):  
SEUNG-CHUL LEE ◽  
SANG-WHA LEE ◽  
IK-JOONG KANG

Chitosan–gold nanocomposites were fabricated via a seed-mediated goldshell growth over chitosan–gold nanocomplex and examined as a potential biomedical agent for drug delivery. Chitosan–gold nanocomplex was formed by the electrostatic interaction between of cationic chitosan nanoparticles (ca. 50 nm) and anionic gold colloids (ca. 1–3 nm) and the subsequent reduction of gold salts was conducted to form the gold clusters over the chitosan nanoparticles in the presence of reducing ascorbic acid. The resultant nanocomposites (or nanoshells) exhibited the absorption peak around 580 nm that was clearly red-shifted by ca. 60 nm as compared to gold nanoparticles. Surface morphology and plasmonic properties of chitosan–gold nanocomposites were characterized by transmission electron microscopy, field emission scanning electron microscopy (including EDX), ultraviolet–visible spectroscopy, and zeta-potential meter.


2020 ◽  
Vol 10 (01) ◽  
pp. 1-4
Author(s):  
ABM Helal Uddin ◽  
Abdelkader Hassani ◽  
Abul K. Azad ◽  
Hamid H. Enezei ◽  
Siti A. Hussain

The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further.


2020 ◽  
Vol 65 (17) ◽  
pp. 1489-1504
Author(s):  
Chen Yang ◽  
Nicholas Thomas Blum ◽  
Jing Lin ◽  
Junle Qu ◽  
Peng Huang

2012 ◽  
Vol 57 (SI-1 Track-S) ◽  
Author(s):  
K. Sternberg ◽  
S. Petersen ◽  
N. Grabow ◽  
F. Luderer ◽  
A. Bohl ◽  
...  

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