Silicon Micro-Photonic Structure for Ultra-Sensitive Biosensing

2003 ◽  
Vol 797 ◽  
Author(s):  
Bradley Schmidt ◽  
Vilson Almeida ◽  
Christina Manolatou ◽  
Stefan Preble ◽  
Michal Lipson
Keyword(s):  
Nano Particles ◽  
Particle Detection ◽  
Strong Light ◽  
Extinction Cross Section ◽  
Low Concentrations ◽  
Silicon Photonic ◽  
Micron Size ◽  
Planar Silicon ◽  
Single Particle Detection ◽  
Metal Nano Particles

ABSTRACTWe demonstrate a micron-size planar silicon photonic device that is able to detect low concentrations of metal nano-particles approaching single particle detection. This sensitivity is achieved by using strong light confining structures that enhance the extinction cross-section of metal nano-particles by orders of magnitude. Structures were fabricated and measurements of the transmission spectra of the devices demonstrate the detection of 10 nm diameter gold particles resting on the device with a density of fewer than 2 particles per 104 nm2 (the area of the sensing region surface). Using such a device, in a fluidic platform, one could detect the presence of a single metal nano-particle specifically bound to various analytes, enabling ultrasensitive detection of analytes including DNA, RNA, proteins, and antigens.

scholarly journals Modifications of the PAMONO-Sensor Help to Size and Quantify Low Number of Individual Biological and Non-Biological Nano-Particles

2021 ◽  
Vol 6 (1) ◽  
pp. 26
Author(s):  
Rahat Morad Talukder ◽  
Al Shahriar Hossain Rakib ◽  
Julija Skolnik ◽  
Zohair Usfoor ◽  
Katharina Kaufmann ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Nano Particles ◽  
Label Free ◽  
Specific Detection ◽  
Virus Like Particles ◽  
Low Concentrations ◽  
Challenging Tasks ◽  
Image Area

In a series of recently published works, we demonstrated that the plasmon-assisted microscopy of nano-objects (PAMONO) technique can be successfully employed for the sizing and quantification of single viruses, virus-like particles, microvesicles and charged non-biological particles. This approach enables label-free, but specific detection of biological nano-vesicles. Hence, the sensor, which was built up utilizing plasmon-assisted microscopy, possesses relative versatility and it can be used as a platform for cell-based assays. However, one of the challenging tasks for such a sensor was the ability to reach a homogeneous illumination of the whole surface of the gold sensor slide. Moreover, in order to enable the detection of even relatively low concentrations of nano-particles, the focused image area had to be expanded. Both tasks were solved via modifications of previously described PAMONO-sensor set ups. Taken together, our latest findings can help to develop a research and diagnostic platform based on the principles of the surface plasmon resonance (SPR)-assisted microscopy of nano-objects.

Metal nano-particles sizing by thermal annealing for the enhancement of surface plasmon effects in thin-film solar cells application

2016 ◽  
Vol 370 ◽  
pp. 85-90 ◽  
Author(s):  
Li-Zen Hsieh ◽  
Yuan-Fong Chou Chau ◽  
Chee Ming Lim ◽  
Mo-Hua Lin ◽  
Hung Ji Huang ◽  
...  
Keyword(s):  
Thin Film ◽  
Solar Cells ◽  
Thermal Annealing ◽  
Surface Plasmon ◽  
Nano Particles ◽  
Thin Film Solar Cells ◽  
Metal Nano Particles

Optical single-particle detection in nanoholes towards simple parallel detection of molecular binding events

2012 ◽  
Vol 93 (2) ◽  
pp. 140-151 ◽  
Author(s):  
Norbert Jahr ◽  
Nicole Hädrich ◽  
Mamuna Anwar ◽  
Andrea Csaki ◽  
Ondra Stranik ◽  
...  
Keyword(s):  
Single Particle ◽  
Particle Detection ◽  
Molecular Binding ◽  
Parallel Detection ◽  
Single Particle Detection

scholarly journals Metal nano-particles modernized layers and those with polymers for laser thermonuclear targets

2017 ◽  
Vol 907 ◽  
pp. 012018
Author(s):  
I V Akimova ◽  
A A Akunets ◽  
N G Borisenko ◽  
S Chaurasia ◽  
A I Gromov ◽  
...  
Keyword(s):  
Nano Particles ◽  
Metal Nano Particles

scholarly journals Preparation and Application of Metal Nanoparticals Elaborated Fiber Sensors

Sensors ◽  
2020 ◽  
Vol 20 (18) ◽  
pp. 5155
Author(s):  
Jin Li ◽  
Haoru Wang ◽  
Zhi Li ◽  
Zhengcheng Su ◽  
Yue Zhu
Keyword(s):  
Optical Fiber ◽  
Ph Value ◽  
Hot Spot ◽  
Incident Light ◽  
Environmental Parameters ◽  
Optical Diffraction ◽  
Nano Particles ◽  
Physical Parameters ◽  
Compact Structure ◽  
Metal Nano Particles

In recent years, surface plasmon resonance devices (SPR, or named plamonics) have attracted much more attention because of their great prospects in breaking through the optical diffraction limit and developing new photons and sensing devices. At the same time, the combination of SPR and optical fiber promotes the development of the compact micro-probes with high-performance and the integration of fiber and planar waveguide. Different from the long-range SPR of planar metal nano-films, the local-SPR (LSPR) effect can be excited by incident light on the surface of nano-scaled metal particles, resulting in local enhanced light field, i.e., optical hot spot. Metal nano-particles-modified optical fiber LSPR sensor has high sensitivity and compact structure, which can realize the real-time monitoring of physical parameters, environmental parameters (temperature, humidity), and biochemical molecules (pH value, gas-liquid concentration, protein molecules, viruses). In this paper, both fabrication and application of the metal nano-particles modified optical fiber LSPR sensor probe are reviewed, and its future development is predicted.

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